Immunotherapy of Human Neuroblastoma Using Umbilical Cord Blood-Derived Effector Cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-06

AUTHORS

Avadhut D. Joshi, Erin M. Clark, Peng Wang, Corey M. Munger, Ganapati V. Hegde, Sam Sanderson, Harish P. G. Dave, Shantaram S. Joshi

ABSTRACT

Tumors of the nervous system, including neuroblastoma and glioblastoma, are difficult to treat with current therapies. Despite the advances in cancer therapeutics, the outcomes in these patients remain poor and, therefore, new modalities are required. Recent literature demonstrates that cytotoxic effector cells can effectively kill tumors of the nervous system. In addition, we have previously shown that umbilical cord blood (UCB) contains precursors of antitumor cytotoxic effector cells. Therefore, to evaluate the antitumor potential of UCB-derived effector cells, studies were designed to compare the in vitro and in vivo antitumor effects of UCB- and peripheral blood (PB)-derived antigen-nonspecific and antigen-specific effector cells against tumors of the nervous system. Mononuclear cells (MNCs) from UCB were used to generate both interleukin-2 (IL-2)-activated killer (LAK) cells and tumor-specific cytotoxic T lymphocytes (CTLs). UCB-derived LAK cells showed a significant in vitro cytotoxicity against IMR-32, SK-NMC, and U-87 human neuroblastoma and glioblastoma, respectively. In addition, the CTLs generated using dendritic cells primed with IMR-32 tumor cell lysate showed a selective cytotoxicity in vitro against IMR-32 cells, but not against U-87 or MDA-231 cells. Furthermore, treatment of SCID mice bearing IMR-32 neuroblastoma with tumor-specific CTLs resulted in a significant (p < 0.01) inhibition of tumor growth and increased overall survival. Thus, these results demonstrate the potential of UCB-derived effector cells against human neuroblastoma and warrant further preclinical studies. More... »

PAGES

202-212

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11481-006-9038-y

DOI

http://dx.doi.org/10.1007/s11481-006-9038-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016430147

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18040845


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11481-006-9038-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11481-006-9038-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11481-006-9038-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11481-006-9038-y'


 

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296 schema:name Department of Genetics, Cell Biology and Anatomy, College of Medicine, University of Nebraska Medical Center, 68198-6395, Omaha, NE, USA
297 School of Allied Health Professions, College of Medicine, University of Nebraska Medical Center, 68198-6395, Omaha, NE, USA
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299 https://www.grid.ac/institutes/grid.413721.2 schema:alternateName Washington DC VA Medical Center
300 schema:name Veterans Administration Medical Center, Washington, DC, USA
301 rdf:type schema:Organization
 




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