An updated view on the differentiation of stem cells into endothelial cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-08

AUTHORS

YiJiang Zhou, Feng Yang, Ting Chen, YuTao Wu, Mei Yang, JianHua Zhu, Li Zhang

ABSTRACT

Endothelial cells form the internal barrier between circulating blood and the vessel wall. They regulate arterial activity and mediate pathological reactions to vascular injuries such as atherosclerosis and balloon angioplasty. The development and differentiation of endothelial cells is a complex and coordinated process involving multiple levels of signaling and transcriptional and post-transcriptional regulation. Elucidating the mechanism of endothelial differentiation will not only enhance our understanding of vascular disease pathogenesis, but also facilitate our ability to produce vessels cells from pluripotent stem cells for regeneration purposes. In this review, we discuss the current understanding of how stem cells differentiate into endothelial cells at the level of signaling, transcription and microRNA regulation. More... »

PAGES

763-773

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11427-014-4712-4

    DOI

    http://dx.doi.org/10.1007/s11427-014-4712-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006976244

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25104448


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