The role of the DLPFC in inductive reasoning of MCI patients and normal agings: An fMRI study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-08

AUTHORS

YanHui Yang, PeiPeng Liang, ShengFu Lu, KunCheng Li, Ning Zhong

ABSTRACT

Previous studies of young people have revealed that the left dorsolateral prefrontal cortex (DLPFC) plays an important role in inductive reasoning. An fMRI experiment was performed in this study to examine whether the left DLPFC was involved in inductive reasoning of MCI patients and normal aging, and whether the activation pattern of this region was different between MCI patients and normal aging. The fMRI results indicated that MCI patients had no difference from normal aging in behavior performance (reaction time and accuracy) and the activation pattern of DLPFC. However, the BOLD response of the DLPFC region for MCI patients was weaker than that for normal aging, and the functional connectivity between the bilateral DLPFC regions for MCI patients was significantly higher than for normal aging. Taken together, these results indicated that DLPFC plays an important role in inductive reasoning of aging, and the functional abnormity of DLPFC may be an earlier marker of MCI before structural alterations. More... »

PAGES

789-795

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11427-009-0089-1

DOI

http://dx.doi.org/10.1007/s11427-009-0089-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046631272

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19727598


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