Copper-thioguanine metallodrug with self-reinforcing circular catalysis for activatable MRI imaging and amplifying specificity of cancer therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-05-15

AUTHORS

Haifeng Yuan, Yan Zhao, Chan Yang, Cheng Zhang, Yue Yang, Hongmin Meng, Shuangyan Huan, Guosheng Song, Xiaobing Zhang

ABSTRACT

For chemotherapy, drug delivery systems often suffer from the inefficient drug loading capability, which usually cause systems toxicity and extra burden to excrete carrier itself. Moreover, the cancer therapeutic efficacy is also greatly limited by the specificity of tumor microenvironment for reactive oxygen species (ROS) based cancer therapeutic strategy (e.g., chemodynamic therapy). Herein, we have developed metal-drug coordination nanoplatform that can not only be responsive to tumor microenvironment but also modulate it, so as to achieve efficient treatment of cancer. Excitingly, by employing small molecule drug (6-thioguanine) as ligand copper ions, we achieve a high drug loading rate (60.1%) and 100% of utilization of metal-drug coordination nanoplatform (Cu-TG). Interestingly, Cu-TG possessed high-efficiently horseradish peroxidase-like, glutathione peroxidase-like and catalase-like activity. Under the tumor microenvironment, Cu-TG exhibited the self-reinforcing circular catalysis that is able to amplify the cellular oxidative stress, inducing notable cancer cellular apoptosis. Moreover, Cu-TG could be activated with glutathione (GSH) and facilitated for GSH triggered 6-TG release, higher selective therapeutic effect toward cancer cells, and GSH activated T1 weight-magnetic resonance imaging. Based on the above properties, Cu-TG exhibited magnetic resonance imaging (MRI) guiding, efficient and synergistic combination of chemodynamic and chemotherapy with self-reinforcing therapeutic outcomes in vivo. More... »

PAGES

924-935

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11426-020-9738-5

DOI

http://dx.doi.org/10.1007/s11426-020-9738-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1127703286


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, 410082, Changsha, China", 
          "id": "http://www.grid.ac/institutes/grid.67293.39", 
          "name": [
            "State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, 410082, Changsha, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yuan", 
        "givenName": "Haifeng", 
        "id": "sg:person.014214340415.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014214340415.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, 410082, Changsha, China", 
          "id": "http://www.grid.ac/institutes/grid.67293.39", 
          "name": [
            "State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, 410082, Changsha, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Yan", 
        "id": "sg:person.013720575520.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013720575520.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, 410082, Changsha, China", 
          "id": "http://www.grid.ac/institutes/grid.67293.39", 
          "name": [
            "State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, 410082, Changsha, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Chan", 
        "id": "sg:person.01144714715.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144714715.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, 410082, Changsha, China", 
          "id": "http://www.grid.ac/institutes/grid.67293.39", 
          "name": [
            "State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, 410082, Changsha, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Cheng", 
        "id": "sg:person.010610655336.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010610655336.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, 410082, Changsha, China", 
          "id": "http://www.grid.ac/institutes/grid.67293.39", 
          "name": [
            "State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, 410082, Changsha, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Yue", 
        "id": "sg:person.011572720563.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011572720563.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "College of Chemistry, Zhengzhou University, 450001, Zhengzhou, China", 
          "id": "http://www.grid.ac/institutes/grid.207374.5", 
          "name": [
            "College of Chemistry, Zhengzhou University, 450001, Zhengzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meng", 
        "givenName": "Hongmin", 
        "id": "sg:person.01255235617.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255235617.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, 410082, Changsha, China", 
          "id": "http://www.grid.ac/institutes/grid.67293.39", 
          "name": [
            "State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, 410082, Changsha, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huan", 
        "givenName": "Shuangyan", 
        "id": "sg:person.01240650331.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240650331.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, 410082, Changsha, China", 
          "id": "http://www.grid.ac/institutes/grid.67293.39", 
          "name": [
            "State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, 410082, Changsha, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "Guosheng", 
        "id": "sg:person.0720013145.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720013145.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, 410082, Changsha, China", 
          "id": "http://www.grid.ac/institutes/grid.67293.39", 
          "name": [
            "State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, 410082, Changsha, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Xiaobing", 
        "id": "sg:person.0624565657.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624565657.48"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nmat2608", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040302077", 
          "https://doi.org/10.1038/nmat2608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017656268", 
          "https://doi.org/10.1038/nrd2803"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-05-15", 
    "datePublishedReg": "2020-05-15", 
    "description": "For chemotherapy, drug delivery systems often suffer from the inefficient drug loading capability, which usually cause systems toxicity and extra burden to excrete carrier itself. Moreover, the cancer therapeutic efficacy is also greatly limited by the specificity of tumor microenvironment for reactive oxygen species (ROS) based cancer therapeutic strategy (e.g., chemodynamic therapy). Herein, we have developed metal-drug coordination nanoplatform that can not only be responsive to tumor microenvironment but also modulate it, so as to achieve efficient treatment of cancer. Excitingly, by employing small molecule drug (6-thioguanine) as ligand copper ions, we achieve a high drug loading rate (60.1%) and 100% of utilization of metal-drug coordination nanoplatform (Cu-TG). Interestingly, Cu-TG possessed high-efficiently horseradish peroxidase-like, glutathione peroxidase-like and catalase-like activity. Under the tumor microenvironment, Cu-TG exhibited the self-reinforcing circular catalysis that is able to amplify the cellular oxidative stress, inducing notable cancer cellular apoptosis. Moreover, Cu-TG could be activated with glutathione (GSH) and facilitated for GSH triggered 6-TG release, higher selective therapeutic effect toward cancer cells, and GSH activated T1 weight-magnetic resonance imaging. Based on the above properties, Cu-TG exhibited magnetic resonance imaging (MRI) guiding, efficient and synergistic combination of chemodynamic and chemotherapy with self-reinforcing therapeutic outcomes in vivo.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s11426-020-9738-5", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8156612", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8906443", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8931465", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8900421", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8903405", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1372722", 
        "issn": [
          "1674-7291", 
          "1869-1870"
        ], 
        "name": "Science China Chemistry", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "63"
      }
    ], 
    "keywords": [
      "high drug loading rate", 
      "drug loading capability", 
      "catalase-like activity", 
      "drug delivery systems", 
      "drug loading rate", 
      "small molecule drugs", 
      "copper ions", 
      "cancer cellular apoptosis", 
      "selective therapeutic effect", 
      "loading capability", 
      "molecule drugs", 
      "cancer therapeutic efficacy", 
      "delivery system", 
      "catalysis", 
      "nanoplatform", 
      "reactive oxygen species", 
      "synergistic combination", 
      "metallodrugs", 
      "cancer therapy", 
      "oxygen species", 
      "ions", 
      "Herein", 
      "above properties", 
      "efficient treatment", 
      "cellular oxidative stress", 
      "glutathione", 
      "properties", 
      "therapeutic efficacy", 
      "carriers", 
      "GSH", 
      "cancer therapeutic strategies", 
      "cancer cells", 
      "release", 
      "toxicity", 
      "species", 
      "drugs", 
      "microenvironment", 
      "activity", 
      "capability", 
      "specificity", 
      "loading rate", 
      "therapeutic outcomes", 
      "tumor microenvironment", 
      "utilization", 
      "therapeutic effect", 
      "combination", 
      "effect", 
      "system toxicity", 
      "system", 
      "cells", 
      "strategies", 
      "oxidative stress", 
      "cellular apoptosis", 
      "imaging", 
      "rate", 
      "vivo", 
      "treatment", 
      "guiding", 
      "efficacy", 
      "resonance imaging", 
      "chemotherapy", 
      "therapeutic strategies", 
      "stress", 
      "cancer", 
      "apoptosis", 
      "therapy", 
      "MRI", 
      "outcomes", 
      "burden", 
      "extra burden"
    ], 
    "name": "Copper-thioguanine metallodrug with self-reinforcing circular catalysis for activatable MRI imaging and amplifying specificity of cancer therapy", 
    "pagination": "924-935", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1127703286"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11426-020-9738-5"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11426-020-9738-5", 
      "https://app.dimensions.ai/details/publication/pub.1127703286"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T21:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_839.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s11426-020-9738-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11426-020-9738-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11426-020-9738-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11426-020-9738-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11426-020-9738-5'


 

This table displays all metadata directly associated to this object as RDF triples.

200 TRIPLES      21 PREDICATES      95 URIs      86 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11426-020-9738-5 schema:about anzsrc-for:03
2 schema:author Ndb9467debd714ac78c0ac6b2df49908c
3 schema:citation sg:pub.10.1038/nmat2608
4 sg:pub.10.1038/nrd2803
5 schema:datePublished 2020-05-15
6 schema:datePublishedReg 2020-05-15
7 schema:description For chemotherapy, drug delivery systems often suffer from the inefficient drug loading capability, which usually cause systems toxicity and extra burden to excrete carrier itself. Moreover, the cancer therapeutic efficacy is also greatly limited by the specificity of tumor microenvironment for reactive oxygen species (ROS) based cancer therapeutic strategy (e.g., chemodynamic therapy). Herein, we have developed metal-drug coordination nanoplatform that can not only be responsive to tumor microenvironment but also modulate it, so as to achieve efficient treatment of cancer. Excitingly, by employing small molecule drug (6-thioguanine) as ligand copper ions, we achieve a high drug loading rate (60.1%) and 100% of utilization of metal-drug coordination nanoplatform (Cu-TG). Interestingly, Cu-TG possessed high-efficiently horseradish peroxidase-like, glutathione peroxidase-like and catalase-like activity. Under the tumor microenvironment, Cu-TG exhibited the self-reinforcing circular catalysis that is able to amplify the cellular oxidative stress, inducing notable cancer cellular apoptosis. Moreover, Cu-TG could be activated with glutathione (GSH) and facilitated for GSH triggered 6-TG release, higher selective therapeutic effect toward cancer cells, and GSH activated T1 weight-magnetic resonance imaging. Based on the above properties, Cu-TG exhibited magnetic resonance imaging (MRI) guiding, efficient and synergistic combination of chemodynamic and chemotherapy with self-reinforcing therapeutic outcomes in vivo.
8 schema:genre article
9 schema:isAccessibleForFree false
10 schema:isPartOf N4744a1f9360247a7b5097d2963fa9f29
11 N76daca287ad2480cba071a32c02162a2
12 sg:journal.1372722
13 schema:keywords GSH
14 Herein
15 MRI
16 above properties
17 activity
18 apoptosis
19 burden
20 cancer
21 cancer cells
22 cancer cellular apoptosis
23 cancer therapeutic efficacy
24 cancer therapeutic strategies
25 cancer therapy
26 capability
27 carriers
28 catalase-like activity
29 catalysis
30 cells
31 cellular apoptosis
32 cellular oxidative stress
33 chemotherapy
34 combination
35 copper ions
36 delivery system
37 drug delivery systems
38 drug loading capability
39 drug loading rate
40 drugs
41 effect
42 efficacy
43 efficient treatment
44 extra burden
45 glutathione
46 guiding
47 high drug loading rate
48 imaging
49 ions
50 loading capability
51 loading rate
52 metallodrugs
53 microenvironment
54 molecule drugs
55 nanoplatform
56 outcomes
57 oxidative stress
58 oxygen species
59 properties
60 rate
61 reactive oxygen species
62 release
63 resonance imaging
64 selective therapeutic effect
65 small molecule drugs
66 species
67 specificity
68 strategies
69 stress
70 synergistic combination
71 system
72 system toxicity
73 therapeutic effect
74 therapeutic efficacy
75 therapeutic outcomes
76 therapeutic strategies
77 therapy
78 toxicity
79 treatment
80 tumor microenvironment
81 utilization
82 vivo
83 schema:name Copper-thioguanine metallodrug with self-reinforcing circular catalysis for activatable MRI imaging and amplifying specificity of cancer therapy
84 schema:pagination 924-935
85 schema:productId N489ce8c9ebf94bbd88f49ade84164f9a
86 Nceff6d676347492c9af745ff50ae1aba
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1127703286
88 https://doi.org/10.1007/s11426-020-9738-5
89 schema:sdDatePublished 2022-11-24T21:06
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher N08c699d5c0a64ccc86fc6986914cea42
92 schema:url https://doi.org/10.1007/s11426-020-9738-5
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N08c699d5c0a64ccc86fc6986914cea42 schema:name Springer Nature - SN SciGraph project
97 rdf:type schema:Organization
98 N1e754f91e7924be49cd6afc91e82a069 rdf:first sg:person.01240650331.15
99 rdf:rest N50682d13b65046f2bd5d227f6658f2fb
100 N34ce961d52a54ae1ac325fc35aab0417 rdf:first sg:person.01144714715.15
101 rdf:rest Nf47d0d643bbd4d73957fa210302bb686
102 N374bb004308b4e12a02857fabea5cec3 rdf:first sg:person.01255235617.96
103 rdf:rest N1e754f91e7924be49cd6afc91e82a069
104 N4744a1f9360247a7b5097d2963fa9f29 schema:issueNumber 7
105 rdf:type schema:PublicationIssue
106 N489ce8c9ebf94bbd88f49ade84164f9a schema:name dimensions_id
107 schema:value pub.1127703286
108 rdf:type schema:PropertyValue
109 N50682d13b65046f2bd5d227f6658f2fb rdf:first sg:person.0720013145.27
110 rdf:rest N90f1185ffdfa490f8564668b97b05c55
111 N76daca287ad2480cba071a32c02162a2 schema:volumeNumber 63
112 rdf:type schema:PublicationVolume
113 N77e9daa8729a40409771404d141e34c5 rdf:first sg:person.011572720563.36
114 rdf:rest N374bb004308b4e12a02857fabea5cec3
115 N90f1185ffdfa490f8564668b97b05c55 rdf:first sg:person.0624565657.48
116 rdf:rest rdf:nil
117 Naf8b7eb135cd4707a0b2dfff824d89e4 rdf:first sg:person.013720575520.87
118 rdf:rest N34ce961d52a54ae1ac325fc35aab0417
119 Nceff6d676347492c9af745ff50ae1aba schema:name doi
120 schema:value 10.1007/s11426-020-9738-5
121 rdf:type schema:PropertyValue
122 Ndb9467debd714ac78c0ac6b2df49908c rdf:first sg:person.014214340415.07
123 rdf:rest Naf8b7eb135cd4707a0b2dfff824d89e4
124 Nf47d0d643bbd4d73957fa210302bb686 rdf:first sg:person.010610655336.94
125 rdf:rest N77e9daa8729a40409771404d141e34c5
126 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
127 schema:name Chemical Sciences
128 rdf:type schema:DefinedTerm
129 sg:grant.8156612 http://pending.schema.org/fundedItem sg:pub.10.1007/s11426-020-9738-5
130 rdf:type schema:MonetaryGrant
131 sg:grant.8900421 http://pending.schema.org/fundedItem sg:pub.10.1007/s11426-020-9738-5
132 rdf:type schema:MonetaryGrant
133 sg:grant.8903405 http://pending.schema.org/fundedItem sg:pub.10.1007/s11426-020-9738-5
134 rdf:type schema:MonetaryGrant
135 sg:grant.8906443 http://pending.schema.org/fundedItem sg:pub.10.1007/s11426-020-9738-5
136 rdf:type schema:MonetaryGrant
137 sg:grant.8931465 http://pending.schema.org/fundedItem sg:pub.10.1007/s11426-020-9738-5
138 rdf:type schema:MonetaryGrant
139 sg:journal.1372722 schema:issn 1674-7291
140 1869-1870
141 schema:name Science China Chemistry
142 schema:publisher Springer Nature
143 rdf:type schema:Periodical
144 sg:person.010610655336.94 schema:affiliation grid-institutes:grid.67293.39
145 schema:familyName Zhang
146 schema:givenName Cheng
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010610655336.94
148 rdf:type schema:Person
149 sg:person.01144714715.15 schema:affiliation grid-institutes:grid.67293.39
150 schema:familyName Yang
151 schema:givenName Chan
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144714715.15
153 rdf:type schema:Person
154 sg:person.011572720563.36 schema:affiliation grid-institutes:grid.67293.39
155 schema:familyName Yang
156 schema:givenName Yue
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011572720563.36
158 rdf:type schema:Person
159 sg:person.01240650331.15 schema:affiliation grid-institutes:grid.67293.39
160 schema:familyName Huan
161 schema:givenName Shuangyan
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240650331.15
163 rdf:type schema:Person
164 sg:person.01255235617.96 schema:affiliation grid-institutes:grid.207374.5
165 schema:familyName Meng
166 schema:givenName Hongmin
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255235617.96
168 rdf:type schema:Person
169 sg:person.013720575520.87 schema:affiliation grid-institutes:grid.67293.39
170 schema:familyName Zhao
171 schema:givenName Yan
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013720575520.87
173 rdf:type schema:Person
174 sg:person.014214340415.07 schema:affiliation grid-institutes:grid.67293.39
175 schema:familyName Yuan
176 schema:givenName Haifeng
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014214340415.07
178 rdf:type schema:Person
179 sg:person.0624565657.48 schema:affiliation grid-institutes:grid.67293.39
180 schema:familyName Zhang
181 schema:givenName Xiaobing
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624565657.48
183 rdf:type schema:Person
184 sg:person.0720013145.27 schema:affiliation grid-institutes:grid.67293.39
185 schema:familyName Song
186 schema:givenName Guosheng
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720013145.27
188 rdf:type schema:Person
189 sg:pub.10.1038/nmat2608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040302077
190 https://doi.org/10.1038/nmat2608
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/nrd2803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017656268
193 https://doi.org/10.1038/nrd2803
194 rdf:type schema:CreativeWork
195 grid-institutes:grid.207374.5 schema:alternateName College of Chemistry, Zhengzhou University, 450001, Zhengzhou, China
196 schema:name College of Chemistry, Zhengzhou University, 450001, Zhengzhou, China
197 rdf:type schema:Organization
198 grid-institutes:grid.67293.39 schema:alternateName State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, 410082, Changsha, China
199 schema:name State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, 410082, Changsha, China
200 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...