Engineering a customized nanodrug delivery system at the cellular level for targeted cancer therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-01-11

AUTHORS

Jin Li, Liping Qiu, Sitao Xie, Jing Zhang, Liqin Zhang, Honglin Liu, Juan Li, Xiaobing Zhang, Weihong Tan

ABSTRACT

Drug administration customized to individual cells could intrinsically address cancer heterogeneity and provide a safe and effective method for delivering personalized treatment. To accomplish this, we developed a smart nanodrug delivery system characterized by cancer cell-targeted drug delivery and intracellular biomarker-responsive drug activation. This system was composed of a long-nicked DNA duplex formed by tandem hybridization of two extended antisense oligonucleotides whose ends were separately blocked with a cancer cell-specific aptamer, AS1411, and a replaceable anti-biomarker probe (ABP). We demonstrated that this DNA nanodrug was directed to cancer cells with the guidance power of AS1411 and then activated by the presence of a given intracellular biomarker. By using such a belt-and-braces strategy, this DNA nanodrug system could safely and efficiently accelerate apoptosis of target cancer cells. Moreover, since the expression level of biomarkers tends to indicate the specific physiological state of individual cells, biomarker-responsive activation of the nanodrug is expected to enable customized drug administration at the cellular level. More... »

PAGES

497-504

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11426-017-9176-3

DOI

http://dx.doi.org/10.1007/s11426-017-9176-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100349108

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30271427


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