Nanocarrier based on the assembly of protein and antisense oligonucleotide to combat multidrug resistance in tumor cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-08-11

AUTHORS

Xuan Yu, Liang Gong, Jing Zhang, Zilong Zhao, Xiaobing Zhang, Weihong Tan

ABSTRACT

Chemotherapy-induced multi-drug resistance (MDR) in tumors poses a huge challenge for clinical treatment of tumors. The downregulation of the multi-drug resistance relative protein, represented by P-glycoprotein (P-gp), can reverse MDR of cancer cells. In this study, we developed doxorubicin-loading nanocarrier based on the assembly of protein and antisense oligonucleotide (ASO) to combat MDR of cancer cells. The data demonstrate that the nanocarrier can efficiently deliver ASO to cytoplasm and downregulate the P-glycoprotein expression, subsequently improving the therapeutic effects of Dox in doxorubicin-resistant MCF-7/ADR cancer cells. The preparation is simple and effective, providing a powerful tool for gene delivery. Therefore, our nanocarrier shows high promise in cancer treatment. More... »

PAGES

1318-1323

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11426-017-9108-5

DOI

http://dx.doi.org/10.1007/s11426-017-9108-5

DIMENSIONS

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172 rdf:type schema:Organization
 




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