Single-molecule imaging reveals the stoichiometry change of epidermal growth factor receptor during transactivation by β2-adrenergic receptor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-10

AUTHORS

Mingliang Zhang, Kangmin He, Jimin Wu, Nan Li, Jinghe Yuan, Wei Zhou, Zi Ye, Zijian Li, Han Xiao, Zhizhen Lv, Youyi Zhang, Xiaohong Fang

ABSTRACT

Stimulation of G protein-coupled receptors (GPCRs) can lead to the transactivation of the epidermal growth factor receptors (EGFR). The cross-communication between the two signaling pathways regulates several important physiological or pathological processes. However, the molecule mechanism underlying EGFR transactivation remains poorly understood. Here, we aim to study the GPCR-mediated EGFR transactivation process using the single-molecule fluorescence imaging and tracking approach. We found that although EGFR existed as monomers at the plasma membrane of resting cells, they became dimers and thus diffused slower following the activation of β2-adrenergic receptor (β2-AR) by isoproterenol (ISO). We further proved that β2-AR-mediated changes of EGFR in stoichiometry and dynamics were mediated by Src kinase. Thus, the observations obtained via the single-molecule imaging and tracking methods shed new insights into the molecular mechanism of EGFR transactivation at single molecule level. More... »

PAGES

1310-1317

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11426-017-9072-5

DOI

http://dx.doi.org/10.1007/s11426-017-9072-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090366162


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