Cell-SELEX-based aptamer-conjugated nanomaterials for enhanced targeting of cancer cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-08-20

AUTHORS

RongMei Kong, Zhuo Chen, Mao Ye, XiaoBing Zhang, WeiHong Tan

ABSTRACT

Early detection and treatment of cancer depends on developing highly sensitive and specific methods for targeting cancer cells. To do this, aptamers, which are generated by a novel technique called cell-SELEX (systematic evolution of ligands by exponential enrichment), have been widely applied in cancer cell targeting based on such merits as high target affinity and specificity, small size, minimal immunogenicity, and ease of chemical modification. Furthermore, aptamers can gain more flexibility as cancer cell targeting tools when conjugated to nanomaterials, including metallic nanoparticles, quantum dots, silica nanoparticles, and carbon nanomaterials, among others. In this review, we discuss the use of cell-SELEX-based aptamer-nanomaterials conjugates as novel molecular tools for enhanced targeting of cancer cells. More... »

PAGES

1218

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11426-011-4336-5

DOI

http://dx.doi.org/10.1007/s11426-011-4336-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016637789


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