Mutagenetic and anti-allergic studies for evaluation of extracts of Coptis Rhizome produced by an artificial hydroponic system View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-07

AUTHORS

Hiroshi Akiyama, Mitsuhiko Nose, Hajime Takiguchi, Keiichi Sugiyama, Riho Tsutsui, Shinsuke Hisaka, Hiroyuki Fuchino, Takayuki Inui, Noriaki Kawano, Takaaki Taguchi, Tadashi Kudo, Nobuo Kawahara, Kayo Yoshimatsu

ABSTRACT

As a part of the investigation of the safety and efficacy of the cultivated Coptis japonica rhizome extracts using an artificial hydroponic cultivation system, the mutagenetic and anti-allergic activities were evaluated. Some extracts of commercial crude drugs of Coptis sp. were also evaluated for the comparison. None of the extracts showed a significant mutagenicity in Salmonella typhimurium TA102 by the Ames tests, but all the extracts showed in S. typhimurium TA98. The extracts of the hydroponically cultivated rhizomes showed anti-allergic activities against contact hypersensitivity as well as those of commercial crude drugs of Coptis sp. These results suggested the potential of the hydroponically cultivated rhizomes as one of the alternative sources for the medicinal usage. More... »

PAGES

1-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11418-019-01288-6

DOI

http://dx.doi.org/10.1007/s11418-019-01288-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112607156

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30847756


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