Sesquiterpenes from fruits of Torilis japonica with inhibitory activity on melanin synthesis in B16 cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-08-19

AUTHORS

Da Hye Song, Yang Hee Jo, Jong Hoon Ahn, Seon Beom Kim, Cheong-Yong Yun, Youngsoo Kim, Bang Yeon Hwang, Mi Kyeong Lee

ABSTRACT

Melanin, a dark macromolecular pigment, protects skin from harmful damage. However, abnormal accumulation is responsible for hyperpigmentation disorders. Melanogenesis inhibitors have therefore become important constituents in cosmetic products for depigmentation. Torilis japonica Decandolle (Umbelliferae) is a biennial plant which is distributed in East Asia. Fruits of this plant have been used for the treatment of skin disease and inflammation. In our previous study, torilin, a major sesquiterpene of T. japonica, showed an inhibitory effect on melanin production in α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells. Further extensive chromatographic separation resulted in thirteen compounds. On the basis of spectroscopic analysis, the structures of the compounds isolated were determined to be three new sesquiterpenes, viz. a guaiane-type, epoxytorilinol (1), a eudesmane-type, elematorilone (2) and a cadinane-type, cardinatoriloside (3), together with ten known sesquiterpenes (4–13). Of the compounds isolated, compounds 4–6 and 11–13 inhibited α-MSH-activated melanin production in B16 melanoma cells with IC50 values from 72.9 to 191.0 μM. More... »

PAGES

155-160

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11418-017-1123-4

DOI

http://dx.doi.org/10.1007/s11418-017-1123-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091245194

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28823078


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