Lignans from guaiac resin decrease nitric oxide production in interleukin 1β-treated hepatocytes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-01

AUTHORS

Yuki Nakano, Masaaki Nasu, Mana Kano, Hiroshi Kameoka, Tetsuya Okuyama, Mikio Nishizawa, Yukinobu Ikeya

ABSTRACT

Guaiac resin, extracted from the heartwood of Guaiacum officinale L. or G. sanctum L., is speculated to have anti-inflammatory effects. Lignans were purified from guaiac resin (also known as gum guaiacum) by monitoring the nitric oxide (NO) production in rat hepatocytes treated with an inflammatory cytokine interleukin-1β (IL-1β). Six lignans were purified from guaiac resin and identified as: dehydroguaiaretic acid (1), (+)-trans-1,2-dihydrodehydroguaiaretic acid (2), furoguaiaoxidin (3), meso-dihydroguaiaretic acid (4), furoguaiacin (i.e., α-guaiaconic acid) (5), and nectandrin B (6). To our knowledge, this is the first time that 1 has been isolated from guaiac resin as a non-derivative. Compounds 2 and 6 were first found in guaiac resin. Compound 3 was first isolated from a natural source as a non-derivative. Furthermore, 1-6 significantly suppressed NO production in IL-1β-treated hepatocytes. Because anti-inflammatory compounds suppress NO production, this system is often used to measure the anti-inflammatory effects of Kampo drugs and herbal constituents. The NO-suppressing activity of the six lignans isolated in this study indicates that guaiac resin has anti-inflammatory effects and that these lignans may be responsible for the anti-inflammatory effects of guaiac resin. More... »

PAGES

190-197

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11418-016-1048-3

DOI

http://dx.doi.org/10.1007/s11418-016-1048-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042911559

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27709321


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Guaiac", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-1beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lignans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nitric Oxide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Resins, Plant", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Ritsumeikan University", 
          "id": "https://www.grid.ac/institutes/grid.262576.2", 
          "name": [
            "Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, 525-8577, Kusatsu, Shiga, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakano", 
        "givenName": "Yuki", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ritsumeikan University", 
          "id": "https://www.grid.ac/institutes/grid.262576.2", 
          "name": [
            "Department of Pharmacy, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, 525-8577, Kusatsu, Shiga, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nasu", 
        "givenName": "Masaaki", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ritsumeikan University", 
          "id": "https://www.grid.ac/institutes/grid.262576.2", 
          "name": [
            "Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, 525-8577, Kusatsu, Shiga, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kano", 
        "givenName": "Mana", 
        "id": "sg:person.016416467774.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016416467774.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ritsumeikan University", 
          "id": "https://www.grid.ac/institutes/grid.262576.2", 
          "name": [
            "Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, 525-8577, Kusatsu, Shiga, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kameoka", 
        "givenName": "Hiroshi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ritsumeikan University", 
          "id": "https://www.grid.ac/institutes/grid.262576.2", 
          "name": [
            "Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, 525-8577, Kusatsu, Shiga, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okuyama", 
        "givenName": "Tetsuya", 
        "id": "sg:person.01220474212.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220474212.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ritsumeikan University", 
          "id": "https://www.grid.ac/institutes/grid.262576.2", 
          "name": [
            "Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, 525-8577, Kusatsu, Shiga, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishizawa", 
        "givenName": "Mikio", 
        "id": "sg:person.01323722167.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323722167.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Daiichi University of Pharmacy", 
          "id": "https://www.grid.ac/institutes/grid.417740.1", 
          "name": [
            "Department of Pharmacy, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, 525-8577, Kusatsu, Shiga, Japan", 
            "Department of Pharmacy Educational Assist Center, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, 815-8511, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ikeya", 
        "givenName": "Yukinobu", 
        "id": "sg:person.01170121431.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170121431.88"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.2042-7158.1994.tb03795.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005693545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/cpb.35.3315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011253996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/znb-2000-0216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011820775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrep.2015.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013923379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(82)90118-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015674611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tet.2006.03.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017198294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0031-9422(79)80188-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020002659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10620-014-3445-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021364222", 
          "https://doi.org/10.1007/s10620-014-3445-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10620-014-3445-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021364222", 
          "https://doi.org/10.1007/s10620-014-3445-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/09168451.2014.962474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024949373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0031-9422(90)85052-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025385790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0090-6980(93)90122-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027073324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11418-016-0969-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028374297", 
          "https://doi.org/10.1007/s11418-016-0969-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/jr9640004011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031941739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c39750000702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034060939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/cpb.50.844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034926083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0031-9422(00)89901-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036406697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.510230421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038598581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-6147(00)01499-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046034945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.homp.2013.08.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051816260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cad.0b013e3283081ac8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052787771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cad.0b013e3283081ac8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052787771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.niox.2012.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053043423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np100891y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056231489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np100891y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056231489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jhep.1996.v23.pm0008666334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057076625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1246/bcsj.71.475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064475450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7243/2050-0874-1-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073672257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081704618", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-01", 
    "datePublishedReg": "2017-01-01", 
    "description": "Guaiac resin, extracted from the heartwood of Guaiacum officinale L. or G. sanctum L., is speculated to have anti-inflammatory effects. Lignans were purified from guaiac resin (also known as gum guaiacum) by monitoring the nitric oxide (NO) production in rat hepatocytes treated with an inflammatory cytokine interleukin-1\u03b2 (IL-1\u03b2). Six lignans were purified from guaiac resin and identified as: dehydroguaiaretic acid (1), (+)-trans-1,2-dihydrodehydroguaiaretic acid (2), furoguaiaoxidin (3), meso-dihydroguaiaretic acid (4), furoguaiacin (i.e., \u03b1-guaiaconic acid) (5), and nectandrin B (6). To our knowledge, this is the first time that 1 has been isolated from guaiac resin as a non-derivative. Compounds 2 and 6 were first found in guaiac resin. Compound 3 was first isolated from a natural source as a non-derivative. Furthermore, 1-6 significantly suppressed NO production in IL-1\u03b2-treated hepatocytes. Because anti-inflammatory compounds suppress NO production, this system is often used to measure the anti-inflammatory effects of Kampo drugs and herbal constituents. The NO-suppressing activity of the six lignans isolated in this study indicates that guaiac resin has anti-inflammatory effects and that these lignans may be responsible for the anti-inflammatory effects of guaiac resin.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11418-016-1048-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1042407", 
        "issn": [
          "1340-3443", 
          "1861-0293"
        ], 
        "name": "Journal of Natural Medicines", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "71"
      }
    ], 
    "name": "Lignans from guaiac resin decrease nitric oxide production in interleukin 1\u03b2-treated hepatocytes", 
    "pagination": "190-197", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "cc676fed4a1cea1a44d72de5f13ac725803ed274fe738fef843b19f90f4944f2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27709321"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101518405"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11418-016-1048-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1042911559"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11418-016-1048-3", 
      "https://app.dimensions.ai/details/publication/pub.1042911559"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:28", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113641_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs11418-016-1048-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11418-016-1048-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11418-016-1048-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11418-016-1048-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11418-016-1048-3'


 

This table displays all metadata directly associated to this object as RDF triples.

228 TRIPLES      21 PREDICATES      64 URIs      30 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11418-016-1048-3 schema:about N2084c858e840467192187bb7570341d0
2 N354d31b69f0741848dadab55fe806f15
3 N37c1528067cc4ee39eaeae67a9d23140
4 N45b1ab5ec7fe4ed5b0ea051b9f31ada7
5 N5741e8cf6e354ca191d617f9196870e4
6 N5ff9a719cce14e74881f6e0f938104c7
7 N62942970a3f04e169840a954b90c703a
8 Nce56dd62ee0b4be7bb4182a623554afb
9 Nf26c554cb94c40ae9dd891ad90b9a583
10 anzsrc-for:11
11 anzsrc-for:1115
12 schema:author N85951e7d9dbc45f5aaa1d30c300f5044
13 schema:citation sg:pub.10.1007/s10620-014-3445-3
14 sg:pub.10.1007/s11418-016-0969-1
15 https://app.dimensions.ai/details/publication/pub.1081704618
16 https://doi.org/10.1002/hep.510230421
17 https://doi.org/10.1016/0003-2697(82)90118-x
18 https://doi.org/10.1016/0031-9422(79)80188-0
19 https://doi.org/10.1016/0031-9422(90)85052-h
20 https://doi.org/10.1016/0090-6980(93)90122-n
21 https://doi.org/10.1016/j.bbrep.2015.06.004
22 https://doi.org/10.1016/j.homp.2013.08.006
23 https://doi.org/10.1016/j.niox.2012.10.003
24 https://doi.org/10.1016/j.tet.2006.03.111
25 https://doi.org/10.1016/s0031-9422(00)89901-x
26 https://doi.org/10.1016/s0165-6147(00)01499-1
27 https://doi.org/10.1021/np100891y
28 https://doi.org/10.1039/c39750000702
29 https://doi.org/10.1039/jr9640004011
30 https://doi.org/10.1053/jhep.1996.v23.pm0008666334
31 https://doi.org/10.1080/09168451.2014.962474
32 https://doi.org/10.1097/cad.0b013e3283081ac8
33 https://doi.org/10.1111/j.2042-7158.1994.tb03795.x
34 https://doi.org/10.1246/bcsj.71.475
35 https://doi.org/10.1248/cpb.35.3315
36 https://doi.org/10.1248/cpb.50.844
37 https://doi.org/10.1515/znb-2000-0216
38 https://doi.org/10.7243/2050-0874-1-2
39 schema:datePublished 2017-01
40 schema:datePublishedReg 2017-01-01
41 schema:description Guaiac resin, extracted from the heartwood of Guaiacum officinale L. or G. sanctum L., is speculated to have anti-inflammatory effects. Lignans were purified from guaiac resin (also known as gum guaiacum) by monitoring the nitric oxide (NO) production in rat hepatocytes treated with an inflammatory cytokine interleukin-1β (IL-1β). Six lignans were purified from guaiac resin and identified as: dehydroguaiaretic acid (1), (+)-trans-1,2-dihydrodehydroguaiaretic acid (2), furoguaiaoxidin (3), meso-dihydroguaiaretic acid (4), furoguaiacin (i.e., α-guaiaconic acid) (5), and nectandrin B (6). To our knowledge, this is the first time that 1 has been isolated from guaiac resin as a non-derivative. Compounds 2 and 6 were first found in guaiac resin. Compound 3 was first isolated from a natural source as a non-derivative. Furthermore, 1-6 significantly suppressed NO production in IL-1β-treated hepatocytes. Because anti-inflammatory compounds suppress NO production, this system is often used to measure the anti-inflammatory effects of Kampo drugs and herbal constituents. The NO-suppressing activity of the six lignans isolated in this study indicates that guaiac resin has anti-inflammatory effects and that these lignans may be responsible for the anti-inflammatory effects of guaiac resin.
42 schema:genre research_article
43 schema:inLanguage en
44 schema:isAccessibleForFree false
45 schema:isPartOf N650ddbd778694583b0fbf0f43fc3452b
46 N96de1473500f4ffb8432b72d7c9c342f
47 sg:journal.1042407
48 schema:name Lignans from guaiac resin decrease nitric oxide production in interleukin 1β-treated hepatocytes
49 schema:pagination 190-197
50 schema:productId N105d1b1fe5864cb3ad54e54653dd131b
51 N1404eddba4cc4dfbadb23cdb3333fe65
52 N455b5f14664f48d18e6538f0eb97545b
53 N7ebcfc78088a463ca3e36c2c8e7328a2
54 Nacb91ec0f51d42a2a4a8a2a00eb20568
55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042911559
56 https://doi.org/10.1007/s11418-016-1048-3
57 schema:sdDatePublished 2019-04-11T10:28
58 schema:sdLicense https://scigraph.springernature.com/explorer/license/
59 schema:sdPublisher N7ade07e862a541389a8246a404b07d5d
60 schema:url https://link.springer.com/10.1007%2Fs11418-016-1048-3
61 sgo:license sg:explorer/license/
62 sgo:sdDataset articles
63 rdf:type schema:ScholarlyArticle
64 N105d1b1fe5864cb3ad54e54653dd131b schema:name readcube_id
65 schema:value cc676fed4a1cea1a44d72de5f13ac725803ed274fe738fef843b19f90f4944f2
66 rdf:type schema:PropertyValue
67 N11e0608d88a94562ba900bf9d7c114cc schema:affiliation https://www.grid.ac/institutes/grid.262576.2
68 schema:familyName Kameoka
69 schema:givenName Hiroshi
70 rdf:type schema:Person
71 N1404eddba4cc4dfbadb23cdb3333fe65 schema:name pubmed_id
72 schema:value 27709321
73 rdf:type schema:PropertyValue
74 N19bb9ac7bd544defa3329748de6ddef2 rdf:first Ne09263ab666d4fb08c3fb1562361a61c
75 rdf:rest N7651906c612740a6835dee8f2e4de524
76 N2084c858e840467192187bb7570341d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Lignans
78 rdf:type schema:DefinedTerm
79 N354d31b69f0741848dadab55fe806f15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Rats
81 rdf:type schema:DefinedTerm
82 N37c1528067cc4ee39eaeae67a9d23140 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Guaiac
84 rdf:type schema:DefinedTerm
85 N455b5f14664f48d18e6538f0eb97545b schema:name nlm_unique_id
86 schema:value 101518405
87 rdf:type schema:PropertyValue
88 N45b1ab5ec7fe4ed5b0ea051b9f31ada7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Male
90 rdf:type schema:DefinedTerm
91 N5741e8cf6e354ca191d617f9196870e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Animals
93 rdf:type schema:DefinedTerm
94 N5ff9a719cce14e74881f6e0f938104c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Interleukin-1beta
96 rdf:type schema:DefinedTerm
97 N62942970a3f04e169840a954b90c703a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Resins, Plant
99 rdf:type schema:DefinedTerm
100 N650ddbd778694583b0fbf0f43fc3452b schema:issueNumber 1
101 rdf:type schema:PublicationIssue
102 N657f47514f574ceea95339e16989b208 rdf:first sg:person.01220474212.88
103 rdf:rest N6d2e313a2c7d45ea8a87219bd340cf05
104 N6d2e313a2c7d45ea8a87219bd340cf05 rdf:first sg:person.01323722167.56
105 rdf:rest N79e164ab23eb4691aeb821cfaca4af3b
106 N7651906c612740a6835dee8f2e4de524 rdf:first sg:person.016416467774.12
107 rdf:rest Ndfc24683034c43f19120266cb1e0eb75
108 N79e164ab23eb4691aeb821cfaca4af3b rdf:first sg:person.01170121431.88
109 rdf:rest rdf:nil
110 N7ade07e862a541389a8246a404b07d5d schema:name Springer Nature - SN SciGraph project
111 rdf:type schema:Organization
112 N7ebcfc78088a463ca3e36c2c8e7328a2 schema:name dimensions_id
113 schema:value pub.1042911559
114 rdf:type schema:PropertyValue
115 N85951e7d9dbc45f5aaa1d30c300f5044 rdf:first N97f0081f32e84dcc8b7465a4feb16560
116 rdf:rest N19bb9ac7bd544defa3329748de6ddef2
117 N96de1473500f4ffb8432b72d7c9c342f schema:volumeNumber 71
118 rdf:type schema:PublicationVolume
119 N97f0081f32e84dcc8b7465a4feb16560 schema:affiliation https://www.grid.ac/institutes/grid.262576.2
120 schema:familyName Nakano
121 schema:givenName Yuki
122 rdf:type schema:Person
123 Nacb91ec0f51d42a2a4a8a2a00eb20568 schema:name doi
124 schema:value 10.1007/s11418-016-1048-3
125 rdf:type schema:PropertyValue
126 Nce56dd62ee0b4be7bb4182a623554afb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Nitric Oxide
128 rdf:type schema:DefinedTerm
129 Ndfc24683034c43f19120266cb1e0eb75 rdf:first N11e0608d88a94562ba900bf9d7c114cc
130 rdf:rest N657f47514f574ceea95339e16989b208
131 Ne09263ab666d4fb08c3fb1562361a61c schema:affiliation https://www.grid.ac/institutes/grid.262576.2
132 schema:familyName Nasu
133 schema:givenName Masaaki
134 rdf:type schema:Person
135 Nf26c554cb94c40ae9dd891ad90b9a583 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Hepatocytes
137 rdf:type schema:DefinedTerm
138 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
139 schema:name Medical and Health Sciences
140 rdf:type schema:DefinedTerm
141 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
142 schema:name Pharmacology and Pharmaceutical Sciences
143 rdf:type schema:DefinedTerm
144 sg:journal.1042407 schema:issn 1340-3443
145 1861-0293
146 schema:name Journal of Natural Medicines
147 rdf:type schema:Periodical
148 sg:person.01170121431.88 schema:affiliation https://www.grid.ac/institutes/grid.417740.1
149 schema:familyName Ikeya
150 schema:givenName Yukinobu
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170121431.88
152 rdf:type schema:Person
153 sg:person.01220474212.88 schema:affiliation https://www.grid.ac/institutes/grid.262576.2
154 schema:familyName Okuyama
155 schema:givenName Tetsuya
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220474212.88
157 rdf:type schema:Person
158 sg:person.01323722167.56 schema:affiliation https://www.grid.ac/institutes/grid.262576.2
159 schema:familyName Nishizawa
160 schema:givenName Mikio
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323722167.56
162 rdf:type schema:Person
163 sg:person.016416467774.12 schema:affiliation https://www.grid.ac/institutes/grid.262576.2
164 schema:familyName Kano
165 schema:givenName Mana
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016416467774.12
167 rdf:type schema:Person
168 sg:pub.10.1007/s10620-014-3445-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021364222
169 https://doi.org/10.1007/s10620-014-3445-3
170 rdf:type schema:CreativeWork
171 sg:pub.10.1007/s11418-016-0969-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028374297
172 https://doi.org/10.1007/s11418-016-0969-1
173 rdf:type schema:CreativeWork
174 https://app.dimensions.ai/details/publication/pub.1081704618 schema:CreativeWork
175 https://doi.org/10.1002/hep.510230421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038598581
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/0003-2697(82)90118-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015674611
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/0031-9422(79)80188-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020002659
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/0031-9422(90)85052-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1025385790
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/0090-6980(93)90122-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1027073324
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.bbrep.2015.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013923379
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/j.homp.2013.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051816260
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/j.niox.2012.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053043423
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/j.tet.2006.03.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017198294
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/s0031-9422(00)89901-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036406697
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/s0165-6147(00)01499-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046034945
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1021/np100891y schema:sameAs https://app.dimensions.ai/details/publication/pub.1056231489
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1039/c39750000702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034060939
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1039/jr9640004011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031941739
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1053/jhep.1996.v23.pm0008666334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057076625
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1080/09168451.2014.962474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024949373
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1097/cad.0b013e3283081ac8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052787771
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1111/j.2042-7158.1994.tb03795.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005693545
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1246/bcsj.71.475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064475450
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1248/cpb.35.3315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011253996
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1248/cpb.50.844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034926083
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1515/znb-2000-0216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011820775
218 rdf:type schema:CreativeWork
219 https://doi.org/10.7243/2050-0874-1-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073672257
220 rdf:type schema:CreativeWork
221 https://www.grid.ac/institutes/grid.262576.2 schema:alternateName Ritsumeikan University
222 schema:name Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, 525-8577, Kusatsu, Shiga, Japan
223 Department of Pharmacy, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, 525-8577, Kusatsu, Shiga, Japan
224 rdf:type schema:Organization
225 https://www.grid.ac/institutes/grid.417740.1 schema:alternateName Daiichi University of Pharmacy
226 schema:name Department of Pharmacy Educational Assist Center, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, 815-8511, Fukuoka, Japan
227 Department of Pharmacy, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, 525-8577, Kusatsu, Shiga, Japan
228 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...