Lignans from guaiac resin decrease nitric oxide production in interleukin 1β-treated hepatocytes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-01

AUTHORS

Yuki Nakano, Masaaki Nasu, Mana Kano, Hiroshi Kameoka, Tetsuya Okuyama, Mikio Nishizawa, Yukinobu Ikeya

ABSTRACT

Guaiac resin, extracted from the heartwood of Guaiacum officinale L. or G. sanctum L., is speculated to have anti-inflammatory effects. Lignans were purified from guaiac resin (also known as gum guaiacum) by monitoring the nitric oxide (NO) production in rat hepatocytes treated with an inflammatory cytokine interleukin-1β (IL-1β). Six lignans were purified from guaiac resin and identified as: dehydroguaiaretic acid (1), (+)-trans-1,2-dihydrodehydroguaiaretic acid (2), furoguaiaoxidin (3), meso-dihydroguaiaretic acid (4), furoguaiacin (i.e., α-guaiaconic acid) (5), and nectandrin B (6). To our knowledge, this is the first time that 1 has been isolated from guaiac resin as a non-derivative. Compounds 2 and 6 were first found in guaiac resin. Compound 3 was first isolated from a natural source as a non-derivative. Furthermore, 1-6 significantly suppressed NO production in IL-1β-treated hepatocytes. Because anti-inflammatory compounds suppress NO production, this system is often used to measure the anti-inflammatory effects of Kampo drugs and herbal constituents. The NO-suppressing activity of the six lignans isolated in this study indicates that guaiac resin has anti-inflammatory effects and that these lignans may be responsible for the anti-inflammatory effects of guaiac resin. More... »

PAGES

190-197

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11418-016-1048-3

DOI

http://dx.doi.org/10.1007/s11418-016-1048-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042911559

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27709321


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Guaiac", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-1beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lignans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nitric Oxide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Resins, Plant", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Ritsumeikan University", 
          "id": "https://www.grid.ac/institutes/grid.262576.2", 
          "name": [
            "Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, 525-8577, Kusatsu, Shiga, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakano", 
        "givenName": "Yuki", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ritsumeikan University", 
          "id": "https://www.grid.ac/institutes/grid.262576.2", 
          "name": [
            "Department of Pharmacy, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, 525-8577, Kusatsu, Shiga, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nasu", 
        "givenName": "Masaaki", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ritsumeikan University", 
          "id": "https://www.grid.ac/institutes/grid.262576.2", 
          "name": [
            "Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, 525-8577, Kusatsu, Shiga, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kano", 
        "givenName": "Mana", 
        "id": "sg:person.016416467774.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016416467774.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ritsumeikan University", 
          "id": "https://www.grid.ac/institutes/grid.262576.2", 
          "name": [
            "Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, 525-8577, Kusatsu, Shiga, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kameoka", 
        "givenName": "Hiroshi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ritsumeikan University", 
          "id": "https://www.grid.ac/institutes/grid.262576.2", 
          "name": [
            "Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, 525-8577, Kusatsu, Shiga, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okuyama", 
        "givenName": "Tetsuya", 
        "id": "sg:person.01220474212.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220474212.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ritsumeikan University", 
          "id": "https://www.grid.ac/institutes/grid.262576.2", 
          "name": [
            "Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, 525-8577, Kusatsu, Shiga, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishizawa", 
        "givenName": "Mikio", 
        "id": "sg:person.01323722167.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323722167.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Daiichi University of Pharmacy", 
          "id": "https://www.grid.ac/institutes/grid.417740.1", 
          "name": [
            "Department of Pharmacy, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, 525-8577, Kusatsu, Shiga, Japan", 
            "Department of Pharmacy Educational Assist Center, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, 815-8511, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ikeya", 
        "givenName": "Yukinobu", 
        "id": "sg:person.01170121431.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170121431.88"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.2042-7158.1994.tb03795.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005693545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/cpb.35.3315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011253996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/znb-2000-0216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011820775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrep.2015.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013923379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(82)90118-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015674611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tet.2006.03.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017198294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0031-9422(79)80188-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020002659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10620-014-3445-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021364222", 
          "https://doi.org/10.1007/s10620-014-3445-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10620-014-3445-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021364222", 
          "https://doi.org/10.1007/s10620-014-3445-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/09168451.2014.962474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024949373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0031-9422(90)85052-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025385790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0090-6980(93)90122-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027073324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11418-016-0969-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028374297", 
          "https://doi.org/10.1007/s11418-016-0969-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/jr9640004011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031941739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c39750000702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034060939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/cpb.50.844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034926083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0031-9422(00)89901-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036406697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.510230421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038598581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-6147(00)01499-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046034945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.homp.2013.08.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051816260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cad.0b013e3283081ac8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052787771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cad.0b013e3283081ac8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052787771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.niox.2012.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053043423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np100891y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056231489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np100891y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056231489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jhep.1996.v23.pm0008666334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057076625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1246/bcsj.71.475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064475450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7243/2050-0874-1-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073672257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081704618", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-01", 
    "datePublishedReg": "2017-01-01", 
    "description": "Guaiac resin, extracted from the heartwood of Guaiacum officinale L. or G. sanctum L., is speculated to have anti-inflammatory effects. Lignans were purified from guaiac resin (also known as gum guaiacum) by monitoring the nitric oxide (NO) production in rat hepatocytes treated with an inflammatory cytokine interleukin-1\u03b2 (IL-1\u03b2). Six lignans were purified from guaiac resin and identified as: dehydroguaiaretic acid (1), (+)-trans-1,2-dihydrodehydroguaiaretic acid (2), furoguaiaoxidin (3), meso-dihydroguaiaretic acid (4), furoguaiacin (i.e., \u03b1-guaiaconic acid) (5), and nectandrin B (6). To our knowledge, this is the first time that 1 has been isolated from guaiac resin as a non-derivative. Compounds 2 and 6 were first found in guaiac resin. Compound 3 was first isolated from a natural source as a non-derivative. Furthermore, 1-6 significantly suppressed NO production in IL-1\u03b2-treated hepatocytes. Because anti-inflammatory compounds suppress NO production, this system is often used to measure the anti-inflammatory effects of Kampo drugs and herbal constituents. The NO-suppressing activity of the six lignans isolated in this study indicates that guaiac resin has anti-inflammatory effects and that these lignans may be responsible for the anti-inflammatory effects of guaiac resin.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11418-016-1048-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1042407", 
        "issn": [
          "1340-3443", 
          "1861-0293"
        ], 
        "name": "Journal of Natural Medicines", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "71"
      }
    ], 
    "name": "Lignans from guaiac resin decrease nitric oxide production in interleukin 1\u03b2-treated hepatocytes", 
    "pagination": "190-197", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "cc676fed4a1cea1a44d72de5f13ac725803ed274fe738fef843b19f90f4944f2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27709321"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101518405"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11418-016-1048-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1042911559"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11418-016-1048-3", 
      "https://app.dimensions.ai/details/publication/pub.1042911559"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:28", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113641_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs11418-016-1048-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11418-016-1048-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11418-016-1048-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11418-016-1048-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11418-016-1048-3'


 

This table displays all metadata directly associated to this object as RDF triples.

228 TRIPLES      21 PREDICATES      64 URIs      30 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11418-016-1048-3 schema:about N1cb426ee0ca7417481ccbe28f212379e
2 N2dcdc7b3974a4681bf65901f19db1b8d
3 N45a7e8bba325477491a99d277e071ae3
4 N5a546380262b410f862b668526035cad
5 N6e62744823da4c5699d3513e36e98546
6 N7798c6d3cc604ed396750aa83c36e51c
7 Nac5dce40dad44a2bbd573fb316387bf7
8 Nd8804c14953140bd89b506e3578ce547
9 Nea21aa2248594831a92b3aa803117fc0
10 anzsrc-for:11
11 anzsrc-for:1115
12 schema:author Nb21d753f78bd43dfae32a148489bd8c2
13 schema:citation sg:pub.10.1007/s10620-014-3445-3
14 sg:pub.10.1007/s11418-016-0969-1
15 https://app.dimensions.ai/details/publication/pub.1081704618
16 https://doi.org/10.1002/hep.510230421
17 https://doi.org/10.1016/0003-2697(82)90118-x
18 https://doi.org/10.1016/0031-9422(79)80188-0
19 https://doi.org/10.1016/0031-9422(90)85052-h
20 https://doi.org/10.1016/0090-6980(93)90122-n
21 https://doi.org/10.1016/j.bbrep.2015.06.004
22 https://doi.org/10.1016/j.homp.2013.08.006
23 https://doi.org/10.1016/j.niox.2012.10.003
24 https://doi.org/10.1016/j.tet.2006.03.111
25 https://doi.org/10.1016/s0031-9422(00)89901-x
26 https://doi.org/10.1016/s0165-6147(00)01499-1
27 https://doi.org/10.1021/np100891y
28 https://doi.org/10.1039/c39750000702
29 https://doi.org/10.1039/jr9640004011
30 https://doi.org/10.1053/jhep.1996.v23.pm0008666334
31 https://doi.org/10.1080/09168451.2014.962474
32 https://doi.org/10.1097/cad.0b013e3283081ac8
33 https://doi.org/10.1111/j.2042-7158.1994.tb03795.x
34 https://doi.org/10.1246/bcsj.71.475
35 https://doi.org/10.1248/cpb.35.3315
36 https://doi.org/10.1248/cpb.50.844
37 https://doi.org/10.1515/znb-2000-0216
38 https://doi.org/10.7243/2050-0874-1-2
39 schema:datePublished 2017-01
40 schema:datePublishedReg 2017-01-01
41 schema:description Guaiac resin, extracted from the heartwood of Guaiacum officinale L. or G. sanctum L., is speculated to have anti-inflammatory effects. Lignans were purified from guaiac resin (also known as gum guaiacum) by monitoring the nitric oxide (NO) production in rat hepatocytes treated with an inflammatory cytokine interleukin-1β (IL-1β). Six lignans were purified from guaiac resin and identified as: dehydroguaiaretic acid (1), (+)-trans-1,2-dihydrodehydroguaiaretic acid (2), furoguaiaoxidin (3), meso-dihydroguaiaretic acid (4), furoguaiacin (i.e., α-guaiaconic acid) (5), and nectandrin B (6). To our knowledge, this is the first time that 1 has been isolated from guaiac resin as a non-derivative. Compounds 2 and 6 were first found in guaiac resin. Compound 3 was first isolated from a natural source as a non-derivative. Furthermore, 1-6 significantly suppressed NO production in IL-1β-treated hepatocytes. Because anti-inflammatory compounds suppress NO production, this system is often used to measure the anti-inflammatory effects of Kampo drugs and herbal constituents. The NO-suppressing activity of the six lignans isolated in this study indicates that guaiac resin has anti-inflammatory effects and that these lignans may be responsible for the anti-inflammatory effects of guaiac resin.
42 schema:genre research_article
43 schema:inLanguage en
44 schema:isAccessibleForFree false
45 schema:isPartOf N1393229ce72a4f82af3dc09e4e1c360a
46 N735044d0d31b4270935894b14d6c09ac
47 sg:journal.1042407
48 schema:name Lignans from guaiac resin decrease nitric oxide production in interleukin 1β-treated hepatocytes
49 schema:pagination 190-197
50 schema:productId N4aef66181303477abecca69581af831f
51 N6e2c7de43db24c52a8a17daf6e576309
52 Na1debe8bd9884650ad6e0a630ac7f141
53 Nbaa60357bd434acc829ff09d4535f543
54 Ndf0ac6cd2bc14a18acdd38c182c66219
55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042911559
56 https://doi.org/10.1007/s11418-016-1048-3
57 schema:sdDatePublished 2019-04-11T10:28
58 schema:sdLicense https://scigraph.springernature.com/explorer/license/
59 schema:sdPublisher N436179ba96454a4daa8c46d797d89394
60 schema:url https://link.springer.com/10.1007%2Fs11418-016-1048-3
61 sgo:license sg:explorer/license/
62 sgo:sdDataset articles
63 rdf:type schema:ScholarlyArticle
64 N1393229ce72a4f82af3dc09e4e1c360a schema:volumeNumber 71
65 rdf:type schema:PublicationVolume
66 N15d8d3f9be6b4ef49f6a7f0a0da0ae62 rdf:first sg:person.01170121431.88
67 rdf:rest rdf:nil
68 N1af962270f1b4fa3a4e88cf05072eed6 rdf:first sg:person.01220474212.88
69 rdf:rest N7c4e356fb95a4235acd02922c53829cd
70 N1cb426ee0ca7417481ccbe28f212379e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Hepatocytes
72 rdf:type schema:DefinedTerm
73 N2dcdc7b3974a4681bf65901f19db1b8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Resins, Plant
75 rdf:type schema:DefinedTerm
76 N436179ba96454a4daa8c46d797d89394 schema:name Springer Nature - SN SciGraph project
77 rdf:type schema:Organization
78 N45a7e8bba325477491a99d277e071ae3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Rats
80 rdf:type schema:DefinedTerm
81 N4aef66181303477abecca69581af831f schema:name doi
82 schema:value 10.1007/s11418-016-1048-3
83 rdf:type schema:PropertyValue
84 N58e53f39e6964f4498dd0960ee2acddb rdf:first N72101f0dc376416ea4b3d9b2c775aff9
85 rdf:rest Nbb5ad6a29b324087bd92d969dd33038d
86 N5a546380262b410f862b668526035cad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Nitric Oxide
88 rdf:type schema:DefinedTerm
89 N6e2c7de43db24c52a8a17daf6e576309 schema:name nlm_unique_id
90 schema:value 101518405
91 rdf:type schema:PropertyValue
92 N6e62744823da4c5699d3513e36e98546 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Male
94 rdf:type schema:DefinedTerm
95 N72101f0dc376416ea4b3d9b2c775aff9 schema:affiliation https://www.grid.ac/institutes/grid.262576.2
96 schema:familyName Nasu
97 schema:givenName Masaaki
98 rdf:type schema:Person
99 N735044d0d31b4270935894b14d6c09ac schema:issueNumber 1
100 rdf:type schema:PublicationIssue
101 N7798c6d3cc604ed396750aa83c36e51c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Animals
103 rdf:type schema:DefinedTerm
104 N7c4e356fb95a4235acd02922c53829cd rdf:first sg:person.01323722167.56
105 rdf:rest N15d8d3f9be6b4ef49f6a7f0a0da0ae62
106 N7ccc5cf09fe64681be8502cf100ed431 rdf:first Nec114ef366984546a6b4a5e4742d6662
107 rdf:rest N1af962270f1b4fa3a4e88cf05072eed6
108 Na1debe8bd9884650ad6e0a630ac7f141 schema:name dimensions_id
109 schema:value pub.1042911559
110 rdf:type schema:PropertyValue
111 Nac5dce40dad44a2bbd573fb316387bf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Interleukin-1beta
113 rdf:type schema:DefinedTerm
114 Nb21d753f78bd43dfae32a148489bd8c2 rdf:first Ne652401403f24fffa0602c0414f8ebd5
115 rdf:rest N58e53f39e6964f4498dd0960ee2acddb
116 Nbaa60357bd434acc829ff09d4535f543 schema:name readcube_id
117 schema:value cc676fed4a1cea1a44d72de5f13ac725803ed274fe738fef843b19f90f4944f2
118 rdf:type schema:PropertyValue
119 Nbb5ad6a29b324087bd92d969dd33038d rdf:first sg:person.016416467774.12
120 rdf:rest N7ccc5cf09fe64681be8502cf100ed431
121 Nd8804c14953140bd89b506e3578ce547 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Lignans
123 rdf:type schema:DefinedTerm
124 Ndf0ac6cd2bc14a18acdd38c182c66219 schema:name pubmed_id
125 schema:value 27709321
126 rdf:type schema:PropertyValue
127 Ne652401403f24fffa0602c0414f8ebd5 schema:affiliation https://www.grid.ac/institutes/grid.262576.2
128 schema:familyName Nakano
129 schema:givenName Yuki
130 rdf:type schema:Person
131 Nea21aa2248594831a92b3aa803117fc0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Guaiac
133 rdf:type schema:DefinedTerm
134 Nec114ef366984546a6b4a5e4742d6662 schema:affiliation https://www.grid.ac/institutes/grid.262576.2
135 schema:familyName Kameoka
136 schema:givenName Hiroshi
137 rdf:type schema:Person
138 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
139 schema:name Medical and Health Sciences
140 rdf:type schema:DefinedTerm
141 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
142 schema:name Pharmacology and Pharmaceutical Sciences
143 rdf:type schema:DefinedTerm
144 sg:journal.1042407 schema:issn 1340-3443
145 1861-0293
146 schema:name Journal of Natural Medicines
147 rdf:type schema:Periodical
148 sg:person.01170121431.88 schema:affiliation https://www.grid.ac/institutes/grid.417740.1
149 schema:familyName Ikeya
150 schema:givenName Yukinobu
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170121431.88
152 rdf:type schema:Person
153 sg:person.01220474212.88 schema:affiliation https://www.grid.ac/institutes/grid.262576.2
154 schema:familyName Okuyama
155 schema:givenName Tetsuya
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220474212.88
157 rdf:type schema:Person
158 sg:person.01323722167.56 schema:affiliation https://www.grid.ac/institutes/grid.262576.2
159 schema:familyName Nishizawa
160 schema:givenName Mikio
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323722167.56
162 rdf:type schema:Person
163 sg:person.016416467774.12 schema:affiliation https://www.grid.ac/institutes/grid.262576.2
164 schema:familyName Kano
165 schema:givenName Mana
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016416467774.12
167 rdf:type schema:Person
168 sg:pub.10.1007/s10620-014-3445-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021364222
169 https://doi.org/10.1007/s10620-014-3445-3
170 rdf:type schema:CreativeWork
171 sg:pub.10.1007/s11418-016-0969-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028374297
172 https://doi.org/10.1007/s11418-016-0969-1
173 rdf:type schema:CreativeWork
174 https://app.dimensions.ai/details/publication/pub.1081704618 schema:CreativeWork
175 https://doi.org/10.1002/hep.510230421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038598581
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/0003-2697(82)90118-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015674611
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/0031-9422(79)80188-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020002659
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/0031-9422(90)85052-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1025385790
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/0090-6980(93)90122-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1027073324
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.bbrep.2015.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013923379
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/j.homp.2013.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051816260
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/j.niox.2012.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053043423
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/j.tet.2006.03.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017198294
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/s0031-9422(00)89901-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036406697
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/s0165-6147(00)01499-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046034945
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1021/np100891y schema:sameAs https://app.dimensions.ai/details/publication/pub.1056231489
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1039/c39750000702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034060939
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1039/jr9640004011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031941739
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1053/jhep.1996.v23.pm0008666334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057076625
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1080/09168451.2014.962474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024949373
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1097/cad.0b013e3283081ac8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052787771
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1111/j.2042-7158.1994.tb03795.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005693545
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1246/bcsj.71.475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064475450
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1248/cpb.35.3315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011253996
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1248/cpb.50.844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034926083
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1515/znb-2000-0216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011820775
218 rdf:type schema:CreativeWork
219 https://doi.org/10.7243/2050-0874-1-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073672257
220 rdf:type schema:CreativeWork
221 https://www.grid.ac/institutes/grid.262576.2 schema:alternateName Ritsumeikan University
222 schema:name Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, 525-8577, Kusatsu, Shiga, Japan
223 Department of Pharmacy, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, 525-8577, Kusatsu, Shiga, Japan
224 rdf:type schema:Organization
225 https://www.grid.ac/institutes/grid.417740.1 schema:alternateName Daiichi University of Pharmacy
226 schema:name Department of Pharmacy Educational Assist Center, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, 815-8511, Fukuoka, Japan
227 Department of Pharmacy, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, 525-8577, Kusatsu, Shiga, Japan
228 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...