Lignans from guaiac resin decrease nitric oxide production in interleukin 1β-treated hepatocytes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-01

AUTHORS

Yuki Nakano, Masaaki Nasu, Mana Kano, Hiroshi Kameoka, Tetsuya Okuyama, Mikio Nishizawa, Yukinobu Ikeya

ABSTRACT

Guaiac resin, extracted from the heartwood of Guaiacum officinale L. or G. sanctum L., is speculated to have anti-inflammatory effects. Lignans were purified from guaiac resin (also known as gum guaiacum) by monitoring the nitric oxide (NO) production in rat hepatocytes treated with an inflammatory cytokine interleukin-1β (IL-1β). Six lignans were purified from guaiac resin and identified as: dehydroguaiaretic acid (1), (+)-trans-1,2-dihydrodehydroguaiaretic acid (2), furoguaiaoxidin (3), meso-dihydroguaiaretic acid (4), furoguaiacin (i.e., α-guaiaconic acid) (5), and nectandrin B (6). To our knowledge, this is the first time that 1 has been isolated from guaiac resin as a non-derivative. Compounds 2 and 6 were first found in guaiac resin. Compound 3 was first isolated from a natural source as a non-derivative. Furthermore, 1-6 significantly suppressed NO production in IL-1β-treated hepatocytes. Because anti-inflammatory compounds suppress NO production, this system is often used to measure the anti-inflammatory effects of Kampo drugs and herbal constituents. The NO-suppressing activity of the six lignans isolated in this study indicates that guaiac resin has anti-inflammatory effects and that these lignans may be responsible for the anti-inflammatory effects of guaiac resin. More... »

PAGES

190-197

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11418-016-1048-3

DOI

http://dx.doi.org/10.1007/s11418-016-1048-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042911559

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27709321


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