Artemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-07

AUTHORS

Paskorn Muangphrom, Hikaru Seki, Ery Odette Fukushima, Toshiya Muranaka

ABSTRACT

Malaria is a worldwide disease caused by Plasmodium parasites. A sesquiterpene endoperoxide artemisinin isolated from Artemisia annua was discovered and has been accepted for its use in artemisinin-based combinatorial therapies, as the most effective current antimalarial treatment. However, the quantity of this compound produced from the A. annua plant is very low, and the availability of artemisinin is insufficient to treat all infected patients. In addition, the emergence of artemisinin-resistant Plasmodium has been reported recently. Several techniques have been applied to enhance artemisinin availability, and studies related to its mode of action and the mechanism of resistance of malaria-causing parasites are ongoing. In this review, we summarize the application of modern technologies to improve the production of artemisinin, including our ongoing research on artemisinin biosynthetic genes in other Artemisia species. The current understanding of the mode of action of artemisinin as well as the mechanism of resistance against this compound in Plasmodium parasites is also presented. Finally, the current situation of malaria infection and the future direction of antimalarial drug development are discussed. More... »

PAGES

318-334

References to SciGraph publications

  • 2014-05. Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development in NATURE REVIEWS MICROBIOLOGY
  • 2015-11. The discovery of artemisinin and the Nobel Prize in Physiology or Medicine in SCIENCE CHINA LIFE SCIENCES
  • 2003-08. Artemisinins target the SERCA of Plasmodium falciparum in NATURE
  • 2015-05. Chemical signatures and new drug targets for gametocytocidal drug development in SCIENTIFIC REPORTS
  • 2013-07. The stacked over-expression of FPS, CYP71AV1 and CPR genes leads to the increase of artemisinin level in Artemisia annua L. in PLANT BIOTECHNOLOGY REPORTS
  • 2010-11. Overexpression of farnesyl pyrophosphate synthase (FPS) gene affected artemisinin content and growth of Artemisia annua L. in PLANT CELL, TISSUE AND ORGAN CULTURE (PCTOC)
  • 2010-08. In vitro antiplasmodial and phytochemical study of five Artemisia species from Iran and in vivo activity of two species in PARASITOLOGY RESEARCH
  • 2011-10. Effects of vegetative and flowering stages on the biosynthesis of artemisinin in Artemisia species in ARCHIVES OF PHARMACAL RESEARCH
  • 2013-01. Trichome-specific expression of the amorpha-4,11-diene 12-hydroxylase (cyp71av1) gene, encoding a key enzyme of artemisinin biosynthesis in Artemisia annua, as reported by a promoter-GUS fusion in PLANT MOLECULAR BIOLOGY
  • 2008-03. Effects of irradiance on growth, photosynthetic characteristics, and artemisinin content of Artemisia annua L. in PHOTOSYNTHETICA
  • 1998-11. Factors influencing Agrobacterium tumefaciens-mediated transformation of Artemisia annua L. in PLANT CELL REPORTS
  • 2014-02. Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach in NATURE CHEMISTRY
  • 2006-08. Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2013-04-10. High-level semi-synthetic production of the potent antimalarial artemisinin in NATURE
  • 2003-07. Engineering a mevalonate pathway in Escherichia coli for production of terpenoids in NATURE BIOTECHNOLOGY
  • 2011-10. Cloning and characterization of trichome-specific promoter of cpr71av1 gene involved in artemisinin biosynthesis in Artemisia annua L. in MOLECULAR BIOLOGY
  • 2013-02. Expression and Localization of Amorpha-4,11-diene Synthase in Artemisia annua L. in PLANT MOLECULAR BIOLOGY REPORTER
  • 2007-07. In vitro anti-plasmodial and in vivo anti-malarial activity of some plants traditionally used for the treatment of malaria by the Meru community in Kenya in JOURNAL OF NATURAL MEDICINES
  • 2006-04. Production of the Artemisinin Precursor Amorpha-4,11-diene by Engineered Saccharomyces cerevisiae in BIOTECHNOLOGY LETTERS
  • 2015-12. Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum in NATURE COMMUNICATIONS
  • 2011-06. Characterization of the Jasmonate Biosynthetic Gene Allene Oxide Cyclase in Artemisia annua L., Source of the Antimalarial Drug Artemisinin in PLANT MOLECULAR BIOLOGY REPORTER
  • 2014-10. Development of efficient miniprep transformation methods for Artemisia annua using Agrobacterium tumefaciens and Agrobacterium rhizogenes in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY - PLANT
  • 2007-12. Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways in PLANT CELL REPORTS
  • 2014-03. Metabolic engineering of chloroplasts for artemisinic acid biosynthesis and impact on plant growth in JOURNAL OF BIOSCIENCES
  • 2014-02. Molecular Cloning and Characterization of a Trichome-Specific Promoter of Artemisinic Aldehyde Δ11(13) Reductase (DBR2) in Artemisia annua in PLANT MOLECULAR BIOLOGY REPORTER
  • 2016-01. The discovery of Qinghaosu (artemisinin) as an effective anti-malaria drug: A unique China story in SCIENCE CHINA LIFE SCIENCES
  • 2015-12. PfMDR2 and PfMDR5 are dispensable for Plasmodium falciparum asexual parasite multiplication but change in vitro susceptibility to anti-malarial drugs in MALARIA JOURNAL
  • 2015-12. Enhanced artemisinin yield by expression of rol genes in Artemisia annua in MALARIA JOURNAL
  • 2015-05. Experimental design-aided systematic pathway optimization of glucose uptake and deoxyxylulose phosphate pathway for improved amorphadiene production in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2013-02. The effect of roots and media constituents on trichomes and artemisinin production in Artemisia annua L. in PLANT CELL REPORTS
  • 2007-05. Engineering Escherichia coli for production of functionalized terpenoids using plant P450s in NATURE CHEMICAL BIOLOGY
  • 2016-04. Efficient Agrobacterium-mediated transformation of Artemisia annua L. using young inflorescence in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY - PLANT
  • 2015-07. The activity of the artemisinic aldehyde Δ11(13) reductase promoter is important for artemisinin yield in different chemotypes of Artemisia annua L. in PLANT MOLECULAR BIOLOGY
  • 2016-02. Dual symbiosis between Piriformospora indica and Azotobacter chroococcum enhances the artemisinin content in Artemisia annua L. in WORLD JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
  • 2006-04. Production of the antimalarial drug precursor artemisinic acid in engineered yeast in NATURE
  • 2016-06. The effect of over-expression of rate limiting enzymes on the yield of artemisinin in Artemisia annua in RENDICONTI LINCEI. SCIENZE FISICHE E NATURALI
  • 2014-01. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria in NATURE
  • 2013-06. Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia in NATURE GENETICS
  • 2015-03. Enhancement of artemisinin content and relative expression of genes of artemisinin biosynthesis in Artemisia annua by exogenous MeJA treatment in PLANT GROWTH REGULATION
  • 2006-08. Determination of artemisinin in Artemisia sieberi and anticoccidial effects of the plant extract in broiler chickens in TROPICAL ANIMAL HEALTH AND PRODUCTION
  • 2011-12. Relative expression of genes of terpene metabolism in different tissues of Artemisia annuaL in BMC PLANT BIOLOGY
  • 2013-09. Enhancing isoprenoid production through systematically assembling and modulating efflux pumps in Escherichia coli in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2011-10. Over-expression of HMG-CoA reductase and amorpha-4,11-diene synthase genes in Artemisia annua L. and its influence on artemisinin content in PLANT CELL REPORTS
  • 2011-06. Trichomes + roots + ROS = artemisinin: regulating artemisinin biosynthesis in Artemisia annua L. in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY - PLANT
  • 2009-07. Salicylic acid activates artemisinin biosynthesis in Artemisia annua L. in PLANT CELL REPORTS
  • 2010-12. Survey of artemisinin production by diverse Artemisia species in northern Pakistan in MALARIA JOURNAL
  • 2014-12. A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase in NATURE COMMUNICATIONS
  • 2012-08. Identification of Putative Artemisia annua ABCG Transporter Unigenes Related to Artemisinin Yield Following Expression Analysis in Different Plant Tissues and in Response to Methyl Jasmonate and Abscisic Acid Treatments in PLANT MOLECULAR BIOLOGY REPORTER
  • 1996-09. Agrobacterium tumefaciens-mediated transformation of Artemisia annua L. and regeneration of transgenic plants in PLANT CELL REPORTS
  • 2011-10. The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine in NATURE MEDICINE
  • 2016-01. Updates on artemisinin: an insight to mode of actions and strategies for enhanced global production in PROTOPLASMA
  • 2006-07. Artemisinin: The biosynthetic pathway and its regulation in Artemisia annua, a terpenoid-rich species in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY - PLANT
  • 2008-12. Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid in BMC BIOTECHNOLOGY
  • 2015-04. A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria in NATURE
  • 2014-12. A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites in NATURE COMMUNICATIONS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11418-016-1008-y

    DOI

    http://dx.doi.org/10.1007/s11418-016-1008-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031091783

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27250562


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Microbiology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antimalarials", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Artemisinins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biotechnology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Metabolic Engineering", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Parasites", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Plasmodium", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Osaka University", 
              "id": "https://www.grid.ac/institutes/grid.136593.b", 
              "name": [
                "Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, 565-0871, Suita, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Muangphrom", 
            "givenName": "Paskorn", 
            "id": "sg:person.07670676301.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07670676301.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Osaka University", 
              "id": "https://www.grid.ac/institutes/grid.136593.b", 
              "name": [
                "Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, 565-0871, Suita, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Seki", 
            "givenName": "Hikaru", 
            "id": "sg:person.0763315570.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763315570.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Osaka University", 
              "id": "https://www.grid.ac/institutes/grid.136593.b", 
              "name": [
                "Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, 565-0871, Suita, Osaka, Japan", 
                "Continuing Professional Development Center, Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, 565-0871, Suita, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fukushima", 
            "givenName": "Ery Odette", 
            "id": "sg:person.01330221170.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330221170.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Osaka University", 
              "id": "https://www.grid.ac/institutes/grid.136593.b", 
              "name": [
                "Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, 565-0871, Suita, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Muranaka", 
            "givenName": "Toshiya", 
            "id": "sg:person.01037740266.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037740266.99"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1242/jcs.178830", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000121379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tet.2003.11.070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000596748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymben.2008.07.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000858257"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.abb.2005.07.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001586569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1314981", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001751558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.01868-12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001786963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cb900006h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003054512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11627-014-9607-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003504751", 
              "https://doi.org/10.1007/s11627-014-9607-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00299-007-0420-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004316397", 
              "https://doi.org/10.1007/s00299-007-0420-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00299-007-0420-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004316397", 
              "https://doi.org/10.1007/s00299-007-0420-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00299-007-0420-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004316397", 
              "https://doi.org/10.1007/s00299-007-0420-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1104063108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004713631"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11105-013-0603-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005387742", 
              "https://doi.org/10.1007/s11105-013-0603-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11103-015-0284-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005435442", 
              "https://doi.org/10.1007/s11103-015-0284-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/abbi.2000.1962", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006031526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04640", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006120611", 
              "https://doi.org/10.1038/nature04640"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04640", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006120611", 
              "https://doi.org/10.1038/nature04640"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04640", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006120611", 
              "https://doi.org/10.1038/nature04640"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/ba20080068", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007179350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11816-012-0262-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007921878", 
              "https://doi.org/10.1007/s11816-012-0262-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s1479262112000159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008035128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.plantsci.2004.07.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008068781"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11099-008-0004-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008523023", 
              "https://doi.org/10.1007/s11099-008-0004-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0031-9422(96)00369-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008968415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-9452(00)00217-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009036179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0056697", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009574310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-015-0951-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010018624", 
              "https://doi.org/10.1186/s12936-015-0951-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2229-11-45", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010053824", 
              "https://doi.org/10.1186/1471-2229-11-45"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12876", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010217292", 
              "https://doi.org/10.1038/nature12876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bit.21017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010657149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro3240", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011729637", 
              "https://doi.org/10.1038/nrmicro3240"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0808859", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011738279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s1399004714023128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011845254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00299-011-1099-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012304671", 
              "https://doi.org/10.1007/s00299-011-1099-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00299-011-1099-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012304671", 
              "https://doi.org/10.1007/s00299-011-1099-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11105-011-0400-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012535718", 
              "https://doi.org/10.1007/s11105-011-0400-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11105-011-0400-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012535718", 
              "https://doi.org/10.1007/s11105-011-0400-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jep.2007.09.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012661969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1218412110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012814194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0140266", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013538249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1469-8137.2010.03466.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013625346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11250-006-4390-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013731081", 
              "https://doi.org/10.1007/s11250-006-4390-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.1002132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013744886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2875-9-310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013975486", 
              "https://doi.org/10.1186/1475-2875-9-310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.00875-06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014271842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tet.2007.06.062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015204575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cbdd.12334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015434781"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1079/ivp2006782", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015827944", 
              "https://doi.org/10.1079/ivp2006782"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2624", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016345544", 
              "https://doi.org/10.1038/ng.2624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/febs.12803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016906124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0052746", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017187659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mib.2013.07.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017940954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.indcrop.2014.08.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017999531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10529-006-0015-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018831922", 
              "https://doi.org/10.1007/s10529-006-0015-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10529-006-0015-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018831922", 
              "https://doi.org/10.1007/s10529-006-0015-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.144188", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018832441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/btpr.27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019130535"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bab.1234", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020658308"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bcp.2012.10.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020903792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/abbi.2000.2061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021054109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2471", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021269701", 
              "https://doi.org/10.1038/nm.2471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1182612", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021530384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1182612", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021530384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1260403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022075703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022297654", 
              "https://doi.org/10.1038/nbt833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022297654", 
              "https://doi.org/10.1038/nbt833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-015-0581-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022713165", 
              "https://doi.org/10.1186/s12936-015-0581-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12936-015-0581-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022713165", 
              "https://doi.org/10.1186/s12936-015-0581-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1139/b09-032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022814400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01813", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023024453", 
              "https://doi.org/10.1038/nature01813"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01813", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023024453", 
              "https://doi.org/10.1038/nature01813"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ptr.1066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023561537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/b978-008045382-8.00065-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023599885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11418-007-0140-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023718507", 
              "https://doi.org/10.1007/s11418-007-0140-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0009582", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024083247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1438-8677.2009.00306.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024531373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1438-8677.2009.00306.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024531373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0061989", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025021662"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms5467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025489867", 
              "https://doi.org/10.1038/ncomms5467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s1399004714005598", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025965794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmc.2015.04.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026105193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep03743", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026373964", 
              "https://doi.org/10.1038/srep03743"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jac/dkt486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026937012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11105-010-0252-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027001038", 
              "https://doi.org/10.1007/s11105-010-0252-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymben.2006.11.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027070243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-013-5062-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027464651", 
              "https://doi.org/10.1007/s00253-013-5062-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00299-012-1355-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029390717", 
              "https://doi.org/10.1007/s00299-012-1355-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00299-012-1355-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029390717", 
              "https://doi.org/10.1007/s00299-012-1355-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.01466-13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030771765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/febs.13380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031174773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12272-011-1010-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031368287", 
              "https://doi.org/10.1007/s12272-011-1010-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14412", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031566267", 
              "https://doi.org/10.1038/nature14412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.273.26.16192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031568021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031919714", 
              "https://doi.org/10.1038/nature12051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/mp/ssr087", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032038209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.01255-15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032134640"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jphotobiol.2014.08.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032334523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11627-011-9343-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032351842", 
              "https://doi.org/10.1007/s11627-011-9343-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5511/plantbiotechnology.14.0807a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032954327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12210-015-0481-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033306062", 
              "https://doi.org/10.1007/s12210-015-0481-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12210-015-0481-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033306062", 
              "https://doi.org/10.1007/s12210-015-0481-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/nph.12207", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033354386"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00709-015-0805-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033671730", 
              "https://doi.org/10.1007/s00709-015-0805-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11105-012-0472-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033770592", 
              "https://doi.org/10.1007/s11105-012-0472-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0031-9422(99)00206-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033990835"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-006-0452-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034114354", 
              "https://doi.org/10.1007/s00253-006-0452-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-006-0452-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034114354", 
              "https://doi.org/10.1007/s00253-006-0452-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11427-015-4988-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034552921", 
              "https://doi.org/10.1007/s11427-015-4988-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.phytochem.2009.10.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034564902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jep.2008.09.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034702544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.indcrop.2012.12.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035061297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cmdc.201300202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035829031"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cmdc.201300202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035829031"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00299-009-0713-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035848932", 
              "https://doi.org/10.1007/s00299-009-0713-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00299-009-0713-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035848932", 
              "https://doi.org/10.1007/s00299-009-0713-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00299-009-0713-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035848932", 
              "https://doi.org/10.1007/s00299-009-0713-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00299-009-0713-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035848932", 
              "https://doi.org/10.1007/s00299-009-0713-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.50.2.480-489.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036198221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molp.2014.12.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036218770"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1134/s0026893311040145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036850928", 
              "https://doi.org/10.1134/s0026893311040145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11627-015-9744-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037607349", 
              "https://doi.org/10.1007/s11627-015-9744-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0004489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038454841"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.phytochem.2008.10.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039296549"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(84)92057-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039507712"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2012.11.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039603996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1590/s1677-04202010000100001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040366379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbiotec.2012.06.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040430376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cb5001263", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040795343"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchem.1830", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040949337", 
              "https://doi.org/10.1038/nchem.1830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bcp.2008.10.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041124509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10725-014-0004-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041567428", 
              "https://doi.org/10.1007/s10725-014-0004-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-010-1900-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041576051", 
              "https://doi.org/10.1007/s00436-010-1900-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-010-1900-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041576051", 
              "https://doi.org/10.1007/s00436-010-1900-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00436-010-1900-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041576051", 
              "https://doi.org/10.1007/s00436-010-1900-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1413127112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041853847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1079/pgr200585", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042070656"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.phymed.2009.07.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042439181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/molecules15117603", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042673117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/molecules15117603", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042673117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/00397911.2014.884225", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042859959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.indcrop.2015.01.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043123928"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms5833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044022202", 
              "https://doi.org/10.1038/ncomms5833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11274-015-1972-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044022993", 
              "https://doi.org/10.1007/s11274-015-1972-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1473-3099(13)70252-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044728686"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/pcp/pcp149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044955696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/molecules15031705", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045287428"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/molecules15031705", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045287428"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/znc-2008-1-218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045473942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms10111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045601085", 
              "https://doi.org/10.1038/ncomms10111"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1472-6750-8-83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046133241", 
              "https://doi.org/10.1186/1472-6750-8-83"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/nph.12274", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046257477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11240-010-9775-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046385398", 
              "https://doi.org/10.1007/s11240-010-9775-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11240-010-9775-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046385398", 
              "https://doi.org/10.1007/s11240-010-9775-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m114.612275", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046673907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3201/eid2103.140898", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046999637"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-015-6463-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047149634", 
              "https://doi.org/10.1007/s00253-015-6463-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1473-3099(12)70181-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047536348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1110740109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047548510"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002990050540", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047705585", 
              "https://doi.org/10.1007/s002990050540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002990050540", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047705585", 
              "https://doi.org/10.1007/s002990050540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1744-7909.2006.00381.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048288616"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00231590", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048345022", 
              "https://doi.org/10.1007/bf00231590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00231590", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048345022", 
              "https://doi.org/10.1007/bf00231590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4236/ajps.2011.24073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048365177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1211205110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048905833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jep.2014.03.037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049292582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.08.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050091726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/pcp/pcu090", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050104119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.phytochem.2014.02.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050123761"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cid/ciu1160", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050311113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m803090200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050318712"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2006.01.065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050451400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11427-015-4948-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050510330", 
              "https://doi.org/10.1007/s11427-015-4948-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11427-015-4948-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050510330", 
              "https://doi.org/10.1007/s11427-015-4948-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/molecules14125362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050652149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jep.2013.11.043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050667664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/pbi.12476", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050762800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0163-7258(02)00327-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051679924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0163-7258(02)00327-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051679924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1104/pp.110.162552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051838912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0165-6147(99)01302-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051906826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0014222", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051996230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1204556109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052394020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio875", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052396076", 
              "https://doi.org/10.1038/nchembio875"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio875", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052396076", 
              "https://doi.org/10.1038/nchembio875"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.apsoil.2011.06.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052564370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bit.25943", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053116472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11103-012-9986-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053196771", 
              "https://doi.org/10.1007/s11103-012-9986-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0075164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053386426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12038-013-9402-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053664099", 
              "https://doi.org/10.1007/s12038-013-9402-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.oprd.5b00048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055122073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jf063017v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055906072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jf063017v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055906072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm401774f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055954224"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm501987h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055955073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/np050356u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056230017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/np050356u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056230017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1055/s-0030-1249930", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1057215486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1055/s-2008-1034276", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1057530013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/acm.2008.0327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059218534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1215966", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062465793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1215966", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062465793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1260867", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062470826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15698/mic2015.01.181", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068038947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/14787210.2016.1106938", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068079186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/0929867013371635", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069159731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4172/2167-0412.1000125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072336827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4238/2012.september.12.13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072391182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4269/ajtmh.15-0477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072430808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5497/wjp.v3.i4.39", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072922121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078529242", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.17221/105/2012-cjgpb", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100962577"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-07", 
        "datePublishedReg": "2016-07-01", 
        "description": "Malaria is a worldwide disease caused by Plasmodium parasites. A sesquiterpene endoperoxide artemisinin isolated from Artemisia annua was discovered and has been accepted for its use in artemisinin-based combinatorial therapies, as the most effective current antimalarial treatment. However, the quantity of this compound produced from the A.\u00a0annua plant is very low, and the availability of artemisinin is insufficient to treat all infected patients. In addition, the emergence of artemisinin-resistant Plasmodium has been reported recently. Several techniques have been applied to enhance artemisinin availability, and studies related to its mode of action and the mechanism of resistance of malaria-causing parasites are ongoing. In this review, we summarize the application of modern technologies to improve the production of artemisinin, including our ongoing research on artemisinin biosynthetic genes in other Artemisia species. The current understanding of the mode of action of artemisinin as well as the mechanism of resistance against this compound in Plasmodium parasites is also presented. Finally, the current situation of malaria infection and the future direction of antimalarial drug development are discussed. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s11418-016-1008-y", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6077459", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1042407", 
            "issn": [
              "1340-3443", 
              "1861-0293"
            ], 
            "name": "Journal of Natural Medicines", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "70"
          }
        ], 
        "name": "Artemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites", 
        "pagination": "318-334", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "941e5a28da63035c84c4136a0ac1c943dd0c11fb01266db76952c45d1b20394a"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27250562"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101518405"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11418-016-1008-y"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1031091783"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11418-016-1008-y", 
          "https://app.dimensions.ai/details/publication/pub.1031091783"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T21:51", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000589.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs11418-016-1008-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11418-016-1008-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11418-016-1008-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11418-016-1008-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11418-016-1008-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    719 TRIPLES      21 PREDICATES      217 URIs      29 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11418-016-1008-y schema:about N5bc032732b204cf98566ee0591ab5a43
    2 N689fe619c2a748eeac22b19172bdf4cd
    3 N80fd3904e18a4d83abdb2b4898544f94
    4 N818ec396d7684edab84af05a68f0a131
    5 Nb018f0f55c7b4f4da234495a2f78b9e0
    6 Nb849b5945f7c49f396693c997787c993
    7 Nc7147d91a5794f0180627df022f9d157
    8 Nef6fb423a7614bd386b7b317d094fbb6
    9 anzsrc-for:11
    10 anzsrc-for:1108
    11 schema:author N31ea75aa9c624301982a9c608f3be549
    12 schema:citation sg:pub.10.1007/bf00231590
    13 sg:pub.10.1007/s00253-006-0452-0
    14 sg:pub.10.1007/s00253-013-5062-z
    15 sg:pub.10.1007/s00253-015-6463-y
    16 sg:pub.10.1007/s00299-007-0420-x
    17 sg:pub.10.1007/s00299-009-0713-3
    18 sg:pub.10.1007/s00299-011-1099-6
    19 sg:pub.10.1007/s00299-012-1355-4
    20 sg:pub.10.1007/s002990050540
    21 sg:pub.10.1007/s00436-010-1900-4
    22 sg:pub.10.1007/s00709-015-0805-6
    23 sg:pub.10.1007/s10529-006-0015-6
    24 sg:pub.10.1007/s10725-014-0004-z
    25 sg:pub.10.1007/s11099-008-0004-1
    26 sg:pub.10.1007/s11103-012-9986-y
    27 sg:pub.10.1007/s11103-015-0284-3
    28 sg:pub.10.1007/s11105-010-0252-7
    29 sg:pub.10.1007/s11105-011-0400-8
    30 sg:pub.10.1007/s11105-012-0472-0
    31 sg:pub.10.1007/s11105-013-0603-2
    32 sg:pub.10.1007/s11240-010-9775-8
    33 sg:pub.10.1007/s11250-006-4390-8
    34 sg:pub.10.1007/s11274-015-1972-5
    35 sg:pub.10.1007/s11418-007-0140-0
    36 sg:pub.10.1007/s11427-015-4948-7
    37 sg:pub.10.1007/s11427-015-4988-z
    38 sg:pub.10.1007/s11627-011-9343-x
    39 sg:pub.10.1007/s11627-014-9607-3
    40 sg:pub.10.1007/s11627-015-9744-3
    41 sg:pub.10.1007/s11816-012-0262-z
    42 sg:pub.10.1007/s12038-013-9402-z
    43 sg:pub.10.1007/s12210-015-0481-7
    44 sg:pub.10.1007/s12272-011-1010-6
    45 sg:pub.10.1038/nature01813
    46 sg:pub.10.1038/nature04640
    47 sg:pub.10.1038/nature12051
    48 sg:pub.10.1038/nature12876
    49 sg:pub.10.1038/nature14412
    50 sg:pub.10.1038/nbt833
    51 sg:pub.10.1038/nchem.1830
    52 sg:pub.10.1038/nchembio875
    53 sg:pub.10.1038/ncomms10111
    54 sg:pub.10.1038/ncomms5467
    55 sg:pub.10.1038/ncomms5833
    56 sg:pub.10.1038/ng.2624
    57 sg:pub.10.1038/nm.2471
    58 sg:pub.10.1038/nrmicro3240
    59 sg:pub.10.1038/srep03743
    60 sg:pub.10.1079/ivp2006782
    61 sg:pub.10.1134/s0026893311040145
    62 sg:pub.10.1186/1471-2229-11-45
    63 sg:pub.10.1186/1472-6750-8-83
    64 sg:pub.10.1186/1475-2875-9-310
    65 sg:pub.10.1186/s12936-015-0581-y
    66 sg:pub.10.1186/s12936-015-0951-5
    67 https://app.dimensions.ai/details/publication/pub.1078529242
    68 https://doi.org/10.1002/bab.1234
    69 https://doi.org/10.1002/bit.21017
    70 https://doi.org/10.1002/bit.25943
    71 https://doi.org/10.1002/btpr.27
    72 https://doi.org/10.1002/cmdc.201300202
    73 https://doi.org/10.1002/ptr.1066
    74 https://doi.org/10.1006/abbi.2000.1962
    75 https://doi.org/10.1006/abbi.2000.2061
    76 https://doi.org/10.1016/b978-008045382-8.00065-4
    77 https://doi.org/10.1016/j.abb.2005.07.015
    78 https://doi.org/10.1016/j.apsoil.2011.06.005
    79 https://doi.org/10.1016/j.bcp.2008.10.015
    80 https://doi.org/10.1016/j.bcp.2012.10.006
    81 https://doi.org/10.1016/j.bmc.2015.04.017
    82 https://doi.org/10.1016/j.cell.2011.08.024
    83 https://doi.org/10.1016/j.febslet.2006.01.065
    84 https://doi.org/10.1016/j.febslet.2012.11.031
    85 https://doi.org/10.1016/j.indcrop.2012.12.004
    86 https://doi.org/10.1016/j.indcrop.2014.08.033
    87 https://doi.org/10.1016/j.indcrop.2015.01.007
    88 https://doi.org/10.1016/j.jbiotec.2012.06.001
    89 https://doi.org/10.1016/j.jep.2007.09.021
    90 https://doi.org/10.1016/j.jep.2008.09.017
    91 https://doi.org/10.1016/j.jep.2013.11.043
    92 https://doi.org/10.1016/j.jep.2014.03.037
    93 https://doi.org/10.1016/j.jphotobiol.2014.08.013
    94 https://doi.org/10.1016/j.mib.2013.07.005
    95 https://doi.org/10.1016/j.molp.2014.12.004
    96 https://doi.org/10.1016/j.phymed.2009.07.016
    97 https://doi.org/10.1016/j.phytochem.2008.10.001
    98 https://doi.org/10.1016/j.phytochem.2009.10.015
    99 https://doi.org/10.1016/j.phytochem.2014.02.011
    100 https://doi.org/10.1016/j.plantsci.2004.07.020
    101 https://doi.org/10.1016/j.tet.2003.11.070
    102 https://doi.org/10.1016/j.tet.2007.06.062
    103 https://doi.org/10.1016/j.ymben.2006.11.002
    104 https://doi.org/10.1016/j.ymben.2008.07.007
    105 https://doi.org/10.1016/s0031-9422(96)00369-x
    106 https://doi.org/10.1016/s0031-9422(99)00206-x
    107 https://doi.org/10.1016/s0140-6736(84)92057-9
    108 https://doi.org/10.1016/s0163-7258(02)00327-3
    109 https://doi.org/10.1016/s0165-6147(99)01302-4
    110 https://doi.org/10.1016/s0168-9452(00)00217-x
    111 https://doi.org/10.1016/s1473-3099(12)70181-0
    112 https://doi.org/10.1016/s1473-3099(13)70252-4
    113 https://doi.org/10.1017/s1479262112000159
    114 https://doi.org/10.1021/acs.oprd.5b00048
    115 https://doi.org/10.1021/cb5001263
    116 https://doi.org/10.1021/cb900006h
    117 https://doi.org/10.1021/jf063017v
    118 https://doi.org/10.1021/jm401774f
    119 https://doi.org/10.1021/jm501987h
    120 https://doi.org/10.1021/np050356u
    121 https://doi.org/10.1042/ba20080068
    122 https://doi.org/10.1055/s-0030-1249930
    123 https://doi.org/10.1055/s-2008-1034276
    124 https://doi.org/10.1056/nejmoa0808859
    125 https://doi.org/10.1056/nejmoa1314981
    126 https://doi.org/10.1073/pnas.1104063108
    127 https://doi.org/10.1073/pnas.1110740109
    128 https://doi.org/10.1073/pnas.1204556109
    129 https://doi.org/10.1073/pnas.1211205110
    130 https://doi.org/10.1073/pnas.1218412110
    131 https://doi.org/10.1073/pnas.1413127112
    132 https://doi.org/10.1074/jbc.273.26.16192
    133 https://doi.org/10.1074/jbc.m110.144188
    134 https://doi.org/10.1074/jbc.m114.612275
    135 https://doi.org/10.1074/jbc.m803090200
    136 https://doi.org/10.1079/pgr200585
    137 https://doi.org/10.1080/00397911.2014.884225
    138 https://doi.org/10.1089/acm.2008.0327
    139 https://doi.org/10.1093/cid/ciu1160
    140 https://doi.org/10.1093/jac/dkt486
    141 https://doi.org/10.1093/mp/ssr087
    142 https://doi.org/10.1093/pcp/pcp149
    143 https://doi.org/10.1093/pcp/pcu090
    144 https://doi.org/10.1104/pp.110.162552
    145 https://doi.org/10.1107/s1399004714005598
    146 https://doi.org/10.1107/s1399004714023128
    147 https://doi.org/10.1111/cbdd.12334
    148 https://doi.org/10.1111/febs.12803
    149 https://doi.org/10.1111/febs.13380
    150 https://doi.org/10.1111/j.1438-8677.2009.00306.x
    151 https://doi.org/10.1111/j.1469-8137.2010.03466.x
    152 https://doi.org/10.1111/j.1744-7909.2006.00381.x
    153 https://doi.org/10.1111/nph.12207
    154 https://doi.org/10.1111/nph.12274
    155 https://doi.org/10.1111/pbi.12476
    156 https://doi.org/10.1126/science.1182612
    157 https://doi.org/10.1126/science.1215966
    158 https://doi.org/10.1126/science.1260403
    159 https://doi.org/10.1126/science.1260867
    160 https://doi.org/10.1128/aac.00875-06
    161 https://doi.org/10.1128/aac.01255-15
    162 https://doi.org/10.1128/aac.01466-13
    163 https://doi.org/10.1128/aac.01868-12
    164 https://doi.org/10.1128/aac.50.2.480-489.2006
    165 https://doi.org/10.1139/b09-032
    166 https://doi.org/10.1242/jcs.178830
    167 https://doi.org/10.1371/journal.pbio.1002132
    168 https://doi.org/10.1371/journal.pone.0004489
    169 https://doi.org/10.1371/journal.pone.0009582
    170 https://doi.org/10.1371/journal.pone.0014222
    171 https://doi.org/10.1371/journal.pone.0052746
    172 https://doi.org/10.1371/journal.pone.0056697
    173 https://doi.org/10.1371/journal.pone.0061989
    174 https://doi.org/10.1371/journal.pone.0075164
    175 https://doi.org/10.1371/journal.pone.0140266
    176 https://doi.org/10.1515/znc-2008-1-218
    177 https://doi.org/10.15698/mic2015.01.181
    178 https://doi.org/10.1586/14787210.2016.1106938
    179 https://doi.org/10.1590/s1677-04202010000100001
    180 https://doi.org/10.17221/105/2012-cjgpb
    181 https://doi.org/10.2174/0929867013371635
    182 https://doi.org/10.3201/eid2103.140898
    183 https://doi.org/10.3390/molecules14125362
    184 https://doi.org/10.3390/molecules15031705
    185 https://doi.org/10.3390/molecules15117603
    186 https://doi.org/10.4172/2167-0412.1000125
    187 https://doi.org/10.4236/ajps.2011.24073
    188 https://doi.org/10.4238/2012.september.12.13
    189 https://doi.org/10.4269/ajtmh.15-0477
    190 https://doi.org/10.5497/wjp.v3.i4.39
    191 https://doi.org/10.5511/plantbiotechnology.14.0807a
    192 schema:datePublished 2016-07
    193 schema:datePublishedReg 2016-07-01
    194 schema:description Malaria is a worldwide disease caused by Plasmodium parasites. A sesquiterpene endoperoxide artemisinin isolated from Artemisia annua was discovered and has been accepted for its use in artemisinin-based combinatorial therapies, as the most effective current antimalarial treatment. However, the quantity of this compound produced from the A. annua plant is very low, and the availability of artemisinin is insufficient to treat all infected patients. In addition, the emergence of artemisinin-resistant Plasmodium has been reported recently. Several techniques have been applied to enhance artemisinin availability, and studies related to its mode of action and the mechanism of resistance of malaria-causing parasites are ongoing. In this review, we summarize the application of modern technologies to improve the production of artemisinin, including our ongoing research on artemisinin biosynthetic genes in other Artemisia species. The current understanding of the mode of action of artemisinin as well as the mechanism of resistance against this compound in Plasmodium parasites is also presented. Finally, the current situation of malaria infection and the future direction of antimalarial drug development are discussed.
    195 schema:genre research_article
    196 schema:inLanguage en
    197 schema:isAccessibleForFree true
    198 schema:isPartOf N834b5102d7354412937cbe8f1c00e801
    199 Nc7a67f4847a0450cb8c54eb893bab0e1
    200 sg:journal.1042407
    201 schema:name Artemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites
    202 schema:pagination 318-334
    203 schema:productId N03b2c72d38b74bbd947630d48bd79ffe
    204 N33ffdd1c1bdf43c890ac81a4ab602396
    205 N3670df9b07e64eb1a9b7a96ba04a8746
    206 Nb11ff93f55dd43beb340bef30d535e4b
    207 Nd42da0234e544ed7bc92c46e56e69b74
    208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031091783
    209 https://doi.org/10.1007/s11418-016-1008-y
    210 schema:sdDatePublished 2019-04-10T21:51
    211 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    212 schema:sdPublisher N9ee25b16e2394d12b7d0b1dc244c1bd9
    213 schema:url http://link.springer.com/10.1007%2Fs11418-016-1008-y
    214 sgo:license sg:explorer/license/
    215 sgo:sdDataset articles
    216 rdf:type schema:ScholarlyArticle
    217 N03b2c72d38b74bbd947630d48bd79ffe schema:name readcube_id
    218 schema:value 941e5a28da63035c84c4136a0ac1c943dd0c11fb01266db76952c45d1b20394a
    219 rdf:type schema:PropertyValue
    220 N31ea75aa9c624301982a9c608f3be549 rdf:first sg:person.07670676301.95
    221 rdf:rest N5eb24626d4244dd5a0bd3fc859175932
    222 N33ffdd1c1bdf43c890ac81a4ab602396 schema:name pubmed_id
    223 schema:value 27250562
    224 rdf:type schema:PropertyValue
    225 N3670df9b07e64eb1a9b7a96ba04a8746 schema:name dimensions_id
    226 schema:value pub.1031091783
    227 rdf:type schema:PropertyValue
    228 N5bc032732b204cf98566ee0591ab5a43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    229 schema:name Artemisinins
    230 rdf:type schema:DefinedTerm
    231 N5eb24626d4244dd5a0bd3fc859175932 rdf:first sg:person.0763315570.57
    232 rdf:rest N93f3cb55ffd443fc8cd4109e8969c214
    233 N689fe619c2a748eeac22b19172bdf4cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    234 schema:name Plasmodium
    235 rdf:type schema:DefinedTerm
    236 N80fd3904e18a4d83abdb2b4898544f94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    237 schema:name Humans
    238 rdf:type schema:DefinedTerm
    239 N818ec396d7684edab84af05a68f0a131 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    240 schema:name Biotechnology
    241 rdf:type schema:DefinedTerm
    242 N834b5102d7354412937cbe8f1c00e801 schema:issueNumber 3
    243 rdf:type schema:PublicationIssue
    244 N93f3cb55ffd443fc8cd4109e8969c214 rdf:first sg:person.01330221170.41
    245 rdf:rest N98dcbc88b0d24e11a5ce4a8e97b407d0
    246 N98dcbc88b0d24e11a5ce4a8e97b407d0 rdf:first sg:person.01037740266.99
    247 rdf:rest rdf:nil
    248 N9ee25b16e2394d12b7d0b1dc244c1bd9 schema:name Springer Nature - SN SciGraph project
    249 rdf:type schema:Organization
    250 Nb018f0f55c7b4f4da234495a2f78b9e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    251 schema:name Antimalarials
    252 rdf:type schema:DefinedTerm
    253 Nb11ff93f55dd43beb340bef30d535e4b schema:name nlm_unique_id
    254 schema:value 101518405
    255 rdf:type schema:PropertyValue
    256 Nb849b5945f7c49f396693c997787c993 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    257 schema:name Animals
    258 rdf:type schema:DefinedTerm
    259 Nc7147d91a5794f0180627df022f9d157 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    260 schema:name Parasites
    261 rdf:type schema:DefinedTerm
    262 Nc7a67f4847a0450cb8c54eb893bab0e1 schema:volumeNumber 70
    263 rdf:type schema:PublicationVolume
    264 Nd42da0234e544ed7bc92c46e56e69b74 schema:name doi
    265 schema:value 10.1007/s11418-016-1008-y
    266 rdf:type schema:PropertyValue
    267 Nef6fb423a7614bd386b7b317d094fbb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    268 schema:name Metabolic Engineering
    269 rdf:type schema:DefinedTerm
    270 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    271 schema:name Medical and Health Sciences
    272 rdf:type schema:DefinedTerm
    273 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
    274 schema:name Medical Microbiology
    275 rdf:type schema:DefinedTerm
    276 sg:grant.6077459 http://pending.schema.org/fundedItem sg:pub.10.1007/s11418-016-1008-y
    277 rdf:type schema:MonetaryGrant
    278 sg:journal.1042407 schema:issn 1340-3443
    279 1861-0293
    280 schema:name Journal of Natural Medicines
    281 rdf:type schema:Periodical
    282 sg:person.01037740266.99 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
    283 schema:familyName Muranaka
    284 schema:givenName Toshiya
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037740266.99
    286 rdf:type schema:Person
    287 sg:person.01330221170.41 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
    288 schema:familyName Fukushima
    289 schema:givenName Ery Odette
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330221170.41
    291 rdf:type schema:Person
    292 sg:person.0763315570.57 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
    293 schema:familyName Seki
    294 schema:givenName Hikaru
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763315570.57
    296 rdf:type schema:Person
    297 sg:person.07670676301.95 schema:affiliation https://www.grid.ac/institutes/grid.136593.b
    298 schema:familyName Muangphrom
    299 schema:givenName Paskorn
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07670676301.95
    301 rdf:type schema:Person
    302 sg:pub.10.1007/bf00231590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048345022
    303 https://doi.org/10.1007/bf00231590
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1007/s00253-006-0452-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034114354
    306 https://doi.org/10.1007/s00253-006-0452-0
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1007/s00253-013-5062-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1027464651
    309 https://doi.org/10.1007/s00253-013-5062-z
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1007/s00253-015-6463-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1047149634
    312 https://doi.org/10.1007/s00253-015-6463-y
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1007/s00299-007-0420-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004316397
    315 https://doi.org/10.1007/s00299-007-0420-x
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1007/s00299-009-0713-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035848932
    318 https://doi.org/10.1007/s00299-009-0713-3
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1007/s00299-011-1099-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012304671
    321 https://doi.org/10.1007/s00299-011-1099-6
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1007/s00299-012-1355-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029390717
    324 https://doi.org/10.1007/s00299-012-1355-4
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1007/s002990050540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047705585
    327 https://doi.org/10.1007/s002990050540
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1007/s00436-010-1900-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041576051
    330 https://doi.org/10.1007/s00436-010-1900-4
    331 rdf:type schema:CreativeWork
    332 sg:pub.10.1007/s00709-015-0805-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033671730
    333 https://doi.org/10.1007/s00709-015-0805-6
    334 rdf:type schema:CreativeWork
    335 sg:pub.10.1007/s10529-006-0015-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018831922
    336 https://doi.org/10.1007/s10529-006-0015-6
    337 rdf:type schema:CreativeWork
    338 sg:pub.10.1007/s10725-014-0004-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1041567428
    339 https://doi.org/10.1007/s10725-014-0004-z
    340 rdf:type schema:CreativeWork
    341 sg:pub.10.1007/s11099-008-0004-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008523023
    342 https://doi.org/10.1007/s11099-008-0004-1
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1007/s11103-012-9986-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1053196771
    345 https://doi.org/10.1007/s11103-012-9986-y
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1007/s11103-015-0284-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005435442
    348 https://doi.org/10.1007/s11103-015-0284-3
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1007/s11105-010-0252-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027001038
    351 https://doi.org/10.1007/s11105-010-0252-7
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1007/s11105-011-0400-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012535718
    354 https://doi.org/10.1007/s11105-011-0400-8
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1007/s11105-012-0472-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033770592
    357 https://doi.org/10.1007/s11105-012-0472-0
    358 rdf:type schema:CreativeWork
    359 sg:pub.10.1007/s11105-013-0603-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005387742
    360 https://doi.org/10.1007/s11105-013-0603-2
    361 rdf:type schema:CreativeWork
    362 sg:pub.10.1007/s11240-010-9775-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046385398
    363 https://doi.org/10.1007/s11240-010-9775-8
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1007/s11250-006-4390-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013731081
    366 https://doi.org/10.1007/s11250-006-4390-8
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1007/s11274-015-1972-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044022993
    369 https://doi.org/10.1007/s11274-015-1972-5
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1007/s11418-007-0140-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023718507
    372 https://doi.org/10.1007/s11418-007-0140-0
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1007/s11427-015-4948-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050510330
    375 https://doi.org/10.1007/s11427-015-4948-7
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1007/s11427-015-4988-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1034552921
    378 https://doi.org/10.1007/s11427-015-4988-z
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1007/s11627-011-9343-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032351842
    381 https://doi.org/10.1007/s11627-011-9343-x
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1007/s11627-014-9607-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003504751
    384 https://doi.org/10.1007/s11627-014-9607-3
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1007/s11627-015-9744-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037607349
    387 https://doi.org/10.1007/s11627-015-9744-3
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1007/s11816-012-0262-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1007921878
    390 https://doi.org/10.1007/s11816-012-0262-z
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.1007/s12038-013-9402-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1053664099
    393 https://doi.org/10.1007/s12038-013-9402-z
    394 rdf:type schema:CreativeWork
    395 sg:pub.10.1007/s12210-015-0481-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033306062
    396 https://doi.org/10.1007/s12210-015-0481-7
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1007/s12272-011-1010-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031368287
    399 https://doi.org/10.1007/s12272-011-1010-6
    400 rdf:type schema:CreativeWork
    401 sg:pub.10.1038/nature01813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023024453
    402 https://doi.org/10.1038/nature01813
    403 rdf:type schema:CreativeWork
    404 sg:pub.10.1038/nature04640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006120611
    405 https://doi.org/10.1038/nature04640
    406 rdf:type schema:CreativeWork
    407 sg:pub.10.1038/nature12051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031919714
    408 https://doi.org/10.1038/nature12051
    409 rdf:type schema:CreativeWork
    410 sg:pub.10.1038/nature12876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010217292
    411 https://doi.org/10.1038/nature12876
    412 rdf:type schema:CreativeWork
    413 sg:pub.10.1038/nature14412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031566267
    414 https://doi.org/10.1038/nature14412
    415 rdf:type schema:CreativeWork
    416 sg:pub.10.1038/nbt833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022297654
    417 https://doi.org/10.1038/nbt833
    418 rdf:type schema:CreativeWork
    419 sg:pub.10.1038/nchem.1830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040949337
    420 https://doi.org/10.1038/nchem.1830
    421 rdf:type schema:CreativeWork
    422 sg:pub.10.1038/nchembio875 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052396076
    423 https://doi.org/10.1038/nchembio875
    424 rdf:type schema:CreativeWork
    425 sg:pub.10.1038/ncomms10111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045601085
    426 https://doi.org/10.1038/ncomms10111
    427 rdf:type schema:CreativeWork
    428 sg:pub.10.1038/ncomms5467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025489867
    429 https://doi.org/10.1038/ncomms5467
    430 rdf:type schema:CreativeWork
    431 sg:pub.10.1038/ncomms5833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044022202
    432 https://doi.org/10.1038/ncomms5833
    433 rdf:type schema:CreativeWork
    434 sg:pub.10.1038/ng.2624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016345544
    435 https://doi.org/10.1038/ng.2624
    436 rdf:type schema:CreativeWork
    437 sg:pub.10.1038/nm.2471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021269701
    438 https://doi.org/10.1038/nm.2471
    439 rdf:type schema:CreativeWork
    440 sg:pub.10.1038/nrmicro3240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011729637
    441 https://doi.org/10.1038/nrmicro3240
    442 rdf:type schema:CreativeWork
    443 sg:pub.10.1038/srep03743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026373964
    444 https://doi.org/10.1038/srep03743
    445 rdf:type schema:CreativeWork
    446 sg:pub.10.1079/ivp2006782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015827944
    447 https://doi.org/10.1079/ivp2006782
    448 rdf:type schema:CreativeWork
    449 sg:pub.10.1134/s0026893311040145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036850928
    450 https://doi.org/10.1134/s0026893311040145
    451 rdf:type schema:CreativeWork
    452 sg:pub.10.1186/1471-2229-11-45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010053824
    453 https://doi.org/10.1186/1471-2229-11-45
    454 rdf:type schema:CreativeWork
    455 sg:pub.10.1186/1472-6750-8-83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046133241
    456 https://doi.org/10.1186/1472-6750-8-83
    457 rdf:type schema:CreativeWork
    458 sg:pub.10.1186/1475-2875-9-310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013975486
    459 https://doi.org/10.1186/1475-2875-9-310
    460 rdf:type schema:CreativeWork
    461 sg:pub.10.1186/s12936-015-0581-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1022713165
    462 https://doi.org/10.1186/s12936-015-0581-y
    463 rdf:type schema:CreativeWork
    464 sg:pub.10.1186/s12936-015-0951-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010018624
    465 https://doi.org/10.1186/s12936-015-0951-5
    466 rdf:type schema:CreativeWork
    467 https://app.dimensions.ai/details/publication/pub.1078529242 schema:CreativeWork
    468 https://doi.org/10.1002/bab.1234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020658308
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1002/bit.21017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010657149
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1002/bit.25943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053116472
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1002/btpr.27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019130535
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1002/cmdc.201300202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035829031
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1002/ptr.1066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023561537
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.1006/abbi.2000.1962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006031526
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.1006/abbi.2000.2061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021054109
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1016/b978-008045382-8.00065-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023599885
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1016/j.abb.2005.07.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001586569
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1016/j.apsoil.2011.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052564370
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1016/j.bcp.2008.10.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041124509
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1016/j.bcp.2012.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020903792
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.1016/j.bmc.2015.04.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026105193
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.1016/j.cell.2011.08.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050091726
    497 rdf:type schema:CreativeWork
    498 https://doi.org/10.1016/j.febslet.2006.01.065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050451400
    499 rdf:type schema:CreativeWork
    500 https://doi.org/10.1016/j.febslet.2012.11.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039603996
    501 rdf:type schema:CreativeWork
    502 https://doi.org/10.1016/j.indcrop.2012.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035061297
    503 rdf:type schema:CreativeWork
    504 https://doi.org/10.1016/j.indcrop.2014.08.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017999531
    505 rdf:type schema:CreativeWork
    506 https://doi.org/10.1016/j.indcrop.2015.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043123928
    507 rdf:type schema:CreativeWork
    508 https://doi.org/10.1016/j.jbiotec.2012.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040430376
    509 rdf:type schema:CreativeWork
    510 https://doi.org/10.1016/j.jep.2007.09.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012661969
    511 rdf:type schema:CreativeWork
    512 https://doi.org/10.1016/j.jep.2008.09.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034702544
    513 rdf:type schema:CreativeWork
    514 https://doi.org/10.1016/j.jep.2013.11.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050667664
    515 rdf:type schema:CreativeWork
    516 https://doi.org/10.1016/j.jep.2014.03.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049292582
    517 rdf:type schema:CreativeWork
    518 https://doi.org/10.1016/j.jphotobiol.2014.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032334523
    519 rdf:type schema:CreativeWork
    520 https://doi.org/10.1016/j.mib.2013.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017940954
    521 rdf:type schema:CreativeWork
    522 https://doi.org/10.1016/j.molp.2014.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036218770
    523 rdf:type schema:CreativeWork
    524 https://doi.org/10.1016/j.phymed.2009.07.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042439181
    525 rdf:type schema:CreativeWork
    526 https://doi.org/10.1016/j.phytochem.2008.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039296549
    527 rdf:type schema:CreativeWork
    528 https://doi.org/10.1016/j.phytochem.2009.10.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034564902
    529 rdf:type schema:CreativeWork
    530 https://doi.org/10.1016/j.phytochem.2014.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050123761
    531 rdf:type schema:CreativeWork
    532 https://doi.org/10.1016/j.plantsci.2004.07.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008068781
    533 rdf:type schema:CreativeWork
    534 https://doi.org/10.1016/j.tet.2003.11.070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000596748
    535 rdf:type schema:CreativeWork
    536 https://doi.org/10.1016/j.tet.2007.06.062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015204575
    537 rdf:type schema:CreativeWork
    538 https://doi.org/10.1016/j.ymben.2006.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027070243
    539 rdf:type schema:CreativeWork
    540 https://doi.org/10.1016/j.ymben.2008.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000858257
    541 rdf:type schema:CreativeWork
    542 https://doi.org/10.1016/s0031-9422(96)00369-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008968415
    543 rdf:type schema:CreativeWork
    544 https://doi.org/10.1016/s0031-9422(99)00206-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033990835
    545 rdf:type schema:CreativeWork
    546 https://doi.org/10.1016/s0140-6736(84)92057-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039507712
    547 rdf:type schema:CreativeWork
    548 https://doi.org/10.1016/s0163-7258(02)00327-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051679924
    549 rdf:type schema:CreativeWork
    550 https://doi.org/10.1016/s0165-6147(99)01302-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051906826
    551 rdf:type schema:CreativeWork
    552 https://doi.org/10.1016/s0168-9452(00)00217-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009036179
    553 rdf:type schema:CreativeWork
    554 https://doi.org/10.1016/s1473-3099(12)70181-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047536348
    555 rdf:type schema:CreativeWork
    556 https://doi.org/10.1016/s1473-3099(13)70252-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044728686
    557 rdf:type schema:CreativeWork
    558 https://doi.org/10.1017/s1479262112000159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008035128
    559 rdf:type schema:CreativeWork
    560 https://doi.org/10.1021/acs.oprd.5b00048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055122073
    561 rdf:type schema:CreativeWork
    562 https://doi.org/10.1021/cb5001263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040795343
    563 rdf:type schema:CreativeWork
    564 https://doi.org/10.1021/cb900006h schema:sameAs https://app.dimensions.ai/details/publication/pub.1003054512
    565 rdf:type schema:CreativeWork
    566 https://doi.org/10.1021/jf063017v schema:sameAs https://app.dimensions.ai/details/publication/pub.1055906072
    567 rdf:type schema:CreativeWork
    568 https://doi.org/10.1021/jm401774f schema:sameAs https://app.dimensions.ai/details/publication/pub.1055954224
    569 rdf:type schema:CreativeWork
    570 https://doi.org/10.1021/jm501987h schema:sameAs https://app.dimensions.ai/details/publication/pub.1055955073
    571 rdf:type schema:CreativeWork
    572 https://doi.org/10.1021/np050356u schema:sameAs https://app.dimensions.ai/details/publication/pub.1056230017
    573 rdf:type schema:CreativeWork
    574 https://doi.org/10.1042/ba20080068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007179350
    575 rdf:type schema:CreativeWork
    576 https://doi.org/10.1055/s-0030-1249930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057215486
    577 rdf:type schema:CreativeWork
    578 https://doi.org/10.1055/s-2008-1034276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057530013
    579 rdf:type schema:CreativeWork
    580 https://doi.org/10.1056/nejmoa0808859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011738279
    581 rdf:type schema:CreativeWork
    582 https://doi.org/10.1056/nejmoa1314981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001751558
    583 rdf:type schema:CreativeWork
    584 https://doi.org/10.1073/pnas.1104063108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004713631
    585 rdf:type schema:CreativeWork
    586 https://doi.org/10.1073/pnas.1110740109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047548510
    587 rdf:type schema:CreativeWork
    588 https://doi.org/10.1073/pnas.1204556109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052394020
    589 rdf:type schema:CreativeWork
    590 https://doi.org/10.1073/pnas.1211205110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048905833
    591 rdf:type schema:CreativeWork
    592 https://doi.org/10.1073/pnas.1218412110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012814194
    593 rdf:type schema:CreativeWork
    594 https://doi.org/10.1073/pnas.1413127112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041853847
    595 rdf:type schema:CreativeWork
    596 https://doi.org/10.1074/jbc.273.26.16192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031568021
    597 rdf:type schema:CreativeWork
    598 https://doi.org/10.1074/jbc.m110.144188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018832441
    599 rdf:type schema:CreativeWork
    600 https://doi.org/10.1074/jbc.m114.612275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046673907
    601 rdf:type schema:CreativeWork
    602 https://doi.org/10.1074/jbc.m803090200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050318712
    603 rdf:type schema:CreativeWork
    604 https://doi.org/10.1079/pgr200585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042070656
    605 rdf:type schema:CreativeWork
    606 https://doi.org/10.1080/00397911.2014.884225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042859959
    607 rdf:type schema:CreativeWork
    608 https://doi.org/10.1089/acm.2008.0327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059218534
    609 rdf:type schema:CreativeWork
    610 https://doi.org/10.1093/cid/ciu1160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050311113
    611 rdf:type schema:CreativeWork
    612 https://doi.org/10.1093/jac/dkt486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026937012
    613 rdf:type schema:CreativeWork
    614 https://doi.org/10.1093/mp/ssr087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032038209
    615 rdf:type schema:CreativeWork
    616 https://doi.org/10.1093/pcp/pcp149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044955696
    617 rdf:type schema:CreativeWork
    618 https://doi.org/10.1093/pcp/pcu090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050104119
    619 rdf:type schema:CreativeWork
    620 https://doi.org/10.1104/pp.110.162552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051838912
    621 rdf:type schema:CreativeWork
    622 https://doi.org/10.1107/s1399004714005598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025965794
    623 rdf:type schema:CreativeWork
    624 https://doi.org/10.1107/s1399004714023128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011845254
    625 rdf:type schema:CreativeWork
    626 https://doi.org/10.1111/cbdd.12334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015434781
    627 rdf:type schema:CreativeWork
    628 https://doi.org/10.1111/febs.12803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016906124
    629 rdf:type schema:CreativeWork
    630 https://doi.org/10.1111/febs.13380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031174773
    631 rdf:type schema:CreativeWork
    632 https://doi.org/10.1111/j.1438-8677.2009.00306.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024531373
    633 rdf:type schema:CreativeWork
    634 https://doi.org/10.1111/j.1469-8137.2010.03466.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013625346
    635 rdf:type schema:CreativeWork
    636 https://doi.org/10.1111/j.1744-7909.2006.00381.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048288616
    637 rdf:type schema:CreativeWork
    638 https://doi.org/10.1111/nph.12207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033354386
    639 rdf:type schema:CreativeWork
    640 https://doi.org/10.1111/nph.12274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046257477
    641 rdf:type schema:CreativeWork
    642 https://doi.org/10.1111/pbi.12476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050762800
    643 rdf:type schema:CreativeWork
    644 https://doi.org/10.1126/science.1182612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021530384
    645 rdf:type schema:CreativeWork
    646 https://doi.org/10.1126/science.1215966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062465793
    647 rdf:type schema:CreativeWork
    648 https://doi.org/10.1126/science.1260403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022075703
    649 rdf:type schema:CreativeWork
    650 https://doi.org/10.1126/science.1260867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062470826
    651 rdf:type schema:CreativeWork
    652 https://doi.org/10.1128/aac.00875-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014271842
    653 rdf:type schema:CreativeWork
    654 https://doi.org/10.1128/aac.01255-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032134640
    655 rdf:type schema:CreativeWork
    656 https://doi.org/10.1128/aac.01466-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030771765
    657 rdf:type schema:CreativeWork
    658 https://doi.org/10.1128/aac.01868-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001786963
    659 rdf:type schema:CreativeWork
    660 https://doi.org/10.1128/aac.50.2.480-489.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036198221
    661 rdf:type schema:CreativeWork
    662 https://doi.org/10.1139/b09-032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022814400
    663 rdf:type schema:CreativeWork
    664 https://doi.org/10.1242/jcs.178830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000121379
    665 rdf:type schema:CreativeWork
    666 https://doi.org/10.1371/journal.pbio.1002132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013744886
    667 rdf:type schema:CreativeWork
    668 https://doi.org/10.1371/journal.pone.0004489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038454841
    669 rdf:type schema:CreativeWork
    670 https://doi.org/10.1371/journal.pone.0009582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024083247
    671 rdf:type schema:CreativeWork
    672 https://doi.org/10.1371/journal.pone.0014222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051996230
    673 rdf:type schema:CreativeWork
    674 https://doi.org/10.1371/journal.pone.0052746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017187659
    675 rdf:type schema:CreativeWork
    676 https://doi.org/10.1371/journal.pone.0056697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009574310
    677 rdf:type schema:CreativeWork
    678 https://doi.org/10.1371/journal.pone.0061989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025021662
    679 rdf:type schema:CreativeWork
    680 https://doi.org/10.1371/journal.pone.0075164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053386426
    681 rdf:type schema:CreativeWork
    682 https://doi.org/10.1371/journal.pone.0140266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013538249
    683 rdf:type schema:CreativeWork
    684 https://doi.org/10.1515/znc-2008-1-218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045473942
    685 rdf:type schema:CreativeWork
    686 https://doi.org/10.15698/mic2015.01.181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068038947
    687 rdf:type schema:CreativeWork
    688 https://doi.org/10.1586/14787210.2016.1106938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068079186
    689 rdf:type schema:CreativeWork
    690 https://doi.org/10.1590/s1677-04202010000100001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040366379
    691 rdf:type schema:CreativeWork
    692 https://doi.org/10.17221/105/2012-cjgpb schema:sameAs https://app.dimensions.ai/details/publication/pub.1100962577
    693 rdf:type schema:CreativeWork
    694 https://doi.org/10.2174/0929867013371635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069159731
    695 rdf:type schema:CreativeWork
    696 https://doi.org/10.3201/eid2103.140898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046999637
    697 rdf:type schema:CreativeWork
    698 https://doi.org/10.3390/molecules14125362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050652149
    699 rdf:type schema:CreativeWork
    700 https://doi.org/10.3390/molecules15031705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045287428
    701 rdf:type schema:CreativeWork
    702 https://doi.org/10.3390/molecules15117603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042673117
    703 rdf:type schema:CreativeWork
    704 https://doi.org/10.4172/2167-0412.1000125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072336827
    705 rdf:type schema:CreativeWork
    706 https://doi.org/10.4236/ajps.2011.24073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048365177
    707 rdf:type schema:CreativeWork
    708 https://doi.org/10.4238/2012.september.12.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072391182
    709 rdf:type schema:CreativeWork
    710 https://doi.org/10.4269/ajtmh.15-0477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072430808
    711 rdf:type schema:CreativeWork
    712 https://doi.org/10.5497/wjp.v3.i4.39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072922121
    713 rdf:type schema:CreativeWork
    714 https://doi.org/10.5511/plantbiotechnology.14.0807a schema:sameAs https://app.dimensions.ai/details/publication/pub.1032954327
    715 rdf:type schema:CreativeWork
    716 https://www.grid.ac/institutes/grid.136593.b schema:alternateName Osaka University
    717 schema:name Continuing Professional Development Center, Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, 565-0871, Suita, Osaka, Japan
    718 Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, 565-0871, Suita, Osaka, Japan
    719 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...