Triterpene esters from Uncaria rhynchophylla drive potent IL-12-dependent Th1 polarization View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-10

AUTHORS

Akemi Umeyama, Yoshinori Yahisa, Minori Okada, Eriko Okayama, Ayaka Uda, Noboru Shoji, Je-Jung Lee, Masao Takei, Toshihiro Hashimoto

ABSTRACT

Dendritic cells (DC) are key antigen-presenting cells that link innate and adaptive immunity and ultimately activate antigen-specific T cells. In the current study, we demonstrated that two triterpene esters, uncarinic acid C (1) and uncarinic acid D (2), which are isolated from the hooks of Uncaria rhynchophylla, activate phenotypic and cytokine production alterations in DC. We also show that 1 and 2 modulate human DC function in a fashion that favors Th1 cell polarization. The effect of 1 (E configuration at the 2' position) was approximately 20 times more potent than that of 2 (Z configuration at 2'). These results indicated that the configuration of the 2' double bond greatly effects activity. Thus, 1 and 2 may prove useful as DC-based vaccines for cancer immunotherapy. More... »

PAGES

506-509

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11418-010-0438-1

DOI

http://dx.doi.org/10.1007/s11418-010-0438-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050843558

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20585989


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