Triterpene esters from Uncaria rhynchophylla drive potent IL-12-dependent Th1 polarization View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-10

AUTHORS

Akemi Umeyama, Yoshinori Yahisa, Minori Okada, Eriko Okayama, Ayaka Uda, Noboru Shoji, Je-Jung Lee, Masao Takei, Toshihiro Hashimoto

ABSTRACT

Dendritic cells (DC) are key antigen-presenting cells that link innate and adaptive immunity and ultimately activate antigen-specific T cells. In the current study, we demonstrated that two triterpene esters, uncarinic acid C (1) and uncarinic acid D (2), which are isolated from the hooks of Uncaria rhynchophylla, activate phenotypic and cytokine production alterations in DC. We also show that 1 and 2 modulate human DC function in a fashion that favors Th1 cell polarization. The effect of 1 (E configuration at the 2' position) was approximately 20 times more potent than that of 2 (Z configuration at 2'). These results indicated that the configuration of the 2' double bond greatly effects activity. Thus, 1 and 2 may prove useful as DC-based vaccines for cancer immunotherapy. More... »

PAGES

506-509

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11418-010-0438-1

DOI

http://dx.doi.org/10.1007/s11418-010-0438-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050843558

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20585989


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Polarity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Esters", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HL-60 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-12", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plant Extracts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plant Structures", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Th1 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Triterpenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uncaria", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Tokushima Bunri University", 
          "id": "https://www.grid.ac/institutes/grid.412769.f", 
          "name": [
            "Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Umeyama", 
        "givenName": "Akemi", 
        "id": "sg:person.01101371400.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101371400.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokushima Bunri University", 
          "id": "https://www.grid.ac/institutes/grid.412769.f", 
          "name": [
            "Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yahisa", 
        "givenName": "Yoshinori", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokushima Bunri University", 
          "id": "https://www.grid.ac/institutes/grid.412769.f", 
          "name": [
            "Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okada", 
        "givenName": "Minori", 
        "id": "sg:person.01155765011.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155765011.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokushima Bunri University", 
          "id": "https://www.grid.ac/institutes/grid.412769.f", 
          "name": [
            "Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okayama", 
        "givenName": "Eriko", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokushima Bunri University", 
          "id": "https://www.grid.ac/institutes/grid.412769.f", 
          "name": [
            "Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uda", 
        "givenName": "Ayaka", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokushima Bunri University", 
          "id": "https://www.grid.ac/institutes/grid.412769.f", 
          "name": [
            "Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shoji", 
        "givenName": "Noboru", 
        "id": "sg:person.01067216455.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067216455.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University Hwasun Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411602.0", 
          "name": [
            "Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, Jeonnam, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Je-Jung", 
        "id": "sg:person.01204441075.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204441075.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chonnam National University Hwasun Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411602.0", 
          "name": [
            "Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, Jeonnam, South Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takei", 
        "givenName": "Masao", 
        "id": "sg:person.01305620125.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305620125.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokushima Bunri University", 
          "id": "https://www.grid.ac/institutes/grid.412769.f", 
          "name": [
            "Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hashimoto", 
        "givenName": "Toshihiro", 
        "id": "sg:person.01251245123.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251245123.30"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.bcp.2004.04.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002595169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lfs.2004.08.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011283697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016434628", 
          "https://doi.org/10.1038/nm1551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00210-003-0854-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016809671", 
          "https://doi.org/10.1007/s00210-003-0854-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2006.02.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021736294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2008.02.157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029077386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np8000305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056237308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np8000305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056237308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np990478k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056239912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np990478k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056239912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2007-969846", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057502613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2008-1081348", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057571020"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-10", 
    "datePublishedReg": "2010-10-01", 
    "description": "Dendritic cells (DC) are key antigen-presenting cells that link innate and adaptive immunity and ultimately activate antigen-specific T cells. In the current study, we demonstrated that two triterpene esters, uncarinic acid C (1) and uncarinic acid D (2), which are isolated from the hooks of Uncaria rhynchophylla, activate phenotypic and cytokine production alterations in DC. We also show that 1 and 2 modulate human DC function in a fashion that favors Th1 cell polarization. The effect of 1 (E configuration at the 2' position) was approximately 20 times more potent than that of 2 (Z configuration at 2'). These results indicated that the configuration of the 2' double bond greatly effects activity. Thus, 1 and 2 may prove useful as DC-based vaccines for cancer immunotherapy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11418-010-0438-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1042407", 
        "issn": [
          "1340-3443", 
          "1861-0293"
        ], 
        "name": "Journal of Natural Medicines", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "64"
      }
    ], 
    "name": "Triterpene esters from Uncaria rhynchophylla drive potent IL-12-dependent Th1 polarization", 
    "pagination": "506-509", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f232c7a24b53bf4d4515d45be2f55ffcb79fb874c6554eb8fc386436692435dc"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20585989"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101518405"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11418-010-0438-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1050843558"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11418-010-0438-1", 
      "https://app.dimensions.ai/details/publication/pub.1050843558"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:33", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113658_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11418-010-0438-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11418-010-0438-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11418-010-0438-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11418-010-0438-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11418-010-0438-1'


 

This table displays all metadata directly associated to this object as RDF triples.

197 TRIPLES      21 PREDICATES      49 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11418-010-0438-1 schema:about N2f1db42efd00470f8b197244d65ac85c
2 N43702513cd4f46f1bc10a24e91ee5d4d
3 N4dcdbc74689949a39179a6a21dd092f5
4 N59c8af2539a54d2db1f4c4fc935ec7bc
5 N8c19791246ff4f54872ff077269e5153
6 Na8718c5472394d9c8abd721f89902c4f
7 Nc80939b2437d411ca5818ca6f763cf87
8 Ncad56f614d2c4ae7a446ea9ee1f722c8
9 Ncd7abbea26ff48869ea93667ac5ee131
10 Ncf501dfca98546939cb5ed51d69ea9a6
11 anzsrc-for:11
12 anzsrc-for:1107
13 schema:author Ne1afd4da16514f86877b4dd7638b11f1
14 schema:citation sg:pub.10.1007/s00210-003-0854-9
15 sg:pub.10.1038/nm1551
16 https://doi.org/10.1016/j.bbrc.2008.02.157
17 https://doi.org/10.1016/j.bcp.2004.04.015
18 https://doi.org/10.1016/j.ejphar.2006.02.047
19 https://doi.org/10.1016/j.lfs.2004.08.012
20 https://doi.org/10.1021/np8000305
21 https://doi.org/10.1021/np990478k
22 https://doi.org/10.1055/s-2007-969846
23 https://doi.org/10.1055/s-2008-1081348
24 schema:datePublished 2010-10
25 schema:datePublishedReg 2010-10-01
26 schema:description Dendritic cells (DC) are key antigen-presenting cells that link innate and adaptive immunity and ultimately activate antigen-specific T cells. In the current study, we demonstrated that two triterpene esters, uncarinic acid C (1) and uncarinic acid D (2), which are isolated from the hooks of Uncaria rhynchophylla, activate phenotypic and cytokine production alterations in DC. We also show that 1 and 2 modulate human DC function in a fashion that favors Th1 cell polarization. The effect of 1 (E configuration at the 2' position) was approximately 20 times more potent than that of 2 (Z configuration at 2'). These results indicated that the configuration of the 2' double bond greatly effects activity. Thus, 1 and 2 may prove useful as DC-based vaccines for cancer immunotherapy.
27 schema:genre research_article
28 schema:inLanguage en
29 schema:isAccessibleForFree false
30 schema:isPartOf N1a9d5fba62684066a2ccf65eff2db27f
31 N930bf2b340f44d01ada4e4c880a4dba9
32 sg:journal.1042407
33 schema:name Triterpene esters from Uncaria rhynchophylla drive potent IL-12-dependent Th1 polarization
34 schema:pagination 506-509
35 schema:productId N148bb57132bf40838cddeeddd7f5e7b5
36 N94faba9e01a94558a10ff0fe3b4c81f3
37 N9ccb5b1fef0f41349f9b086511f38671
38 Nd2ee1eb4ae344490a2dbd7d8611fb77b
39 Neca8a9b2f8b2480f84a7b0fc01518bcf
40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050843558
41 https://doi.org/10.1007/s11418-010-0438-1
42 schema:sdDatePublished 2019-04-11T10:33
43 schema:sdLicense https://scigraph.springernature.com/explorer/license/
44 schema:sdPublisher N4a8c49622b914c65bf1cd02dbba683b0
45 schema:url http://link.springer.com/10.1007%2Fs11418-010-0438-1
46 sgo:license sg:explorer/license/
47 sgo:sdDataset articles
48 rdf:type schema:ScholarlyArticle
49 N11d464362beb43d7bc1ff3273b316a76 rdf:first N519036be138640e3ac9a71680b422169
50 rdf:rest N9c83e07323584776b96c518ccecfb6d9
51 N148bb57132bf40838cddeeddd7f5e7b5 schema:name dimensions_id
52 schema:value pub.1050843558
53 rdf:type schema:PropertyValue
54 N1a9d5fba62684066a2ccf65eff2db27f schema:volumeNumber 64
55 rdf:type schema:PublicationVolume
56 N2f1db42efd00470f8b197244d65ac85c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
57 schema:name Cell Polarity
58 rdf:type schema:DefinedTerm
59 N4243d7f31f4c47baa675dd40f06c3277 rdf:first sg:person.01204441075.42
60 rdf:rest N7beca3ad747246bc8ed95db98efb7e12
61 N43702513cd4f46f1bc10a24e91ee5d4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
62 schema:name Plant Structures
63 rdf:type schema:DefinedTerm
64 N4a8c49622b914c65bf1cd02dbba683b0 schema:name Springer Nature - SN SciGraph project
65 rdf:type schema:Organization
66 N4dcdbc74689949a39179a6a21dd092f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Th1 Cells
68 rdf:type schema:DefinedTerm
69 N519036be138640e3ac9a71680b422169 schema:affiliation https://www.grid.ac/institutes/grid.412769.f
70 schema:familyName Uda
71 schema:givenName Ayaka
72 rdf:type schema:Person
73 N59c8af2539a54d2db1f4c4fc935ec7bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Plant Extracts
75 rdf:type schema:DefinedTerm
76 N6701ca319550447a964fef1803a9cc11 rdf:first N7ae12b5073b543e18d2c902f49ae7e89
77 rdf:rest N11d464362beb43d7bc1ff3273b316a76
78 N6c79b11cdf944c34ab88ddd318cc3e83 schema:affiliation https://www.grid.ac/institutes/grid.412769.f
79 schema:familyName Yahisa
80 schema:givenName Yoshinori
81 rdf:type schema:Person
82 N7ae12b5073b543e18d2c902f49ae7e89 schema:affiliation https://www.grid.ac/institutes/grid.412769.f
83 schema:familyName Okayama
84 schema:givenName Eriko
85 rdf:type schema:Person
86 N7beca3ad747246bc8ed95db98efb7e12 rdf:first sg:person.01305620125.23
87 rdf:rest Na7aef9c191cc4367809c5fbba4ba7c17
88 N8c19791246ff4f54872ff077269e5153 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Interleukin-12
90 rdf:type schema:DefinedTerm
91 N930bf2b340f44d01ada4e4c880a4dba9 schema:issueNumber 4
92 rdf:type schema:PublicationIssue
93 N94faba9e01a94558a10ff0fe3b4c81f3 schema:name readcube_id
94 schema:value f232c7a24b53bf4d4515d45be2f55ffcb79fb874c6554eb8fc386436692435dc
95 rdf:type schema:PropertyValue
96 N9c83e07323584776b96c518ccecfb6d9 rdf:first sg:person.01067216455.55
97 rdf:rest N4243d7f31f4c47baa675dd40f06c3277
98 N9ccb5b1fef0f41349f9b086511f38671 schema:name pubmed_id
99 schema:value 20585989
100 rdf:type schema:PropertyValue
101 Na7aef9c191cc4367809c5fbba4ba7c17 rdf:first sg:person.01251245123.30
102 rdf:rest rdf:nil
103 Na8718c5472394d9c8abd721f89902c4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Humans
105 rdf:type schema:DefinedTerm
106 Nbcb6edb84c3e477fbc99a8bb52d13ea5 rdf:first N6c79b11cdf944c34ab88ddd318cc3e83
107 rdf:rest Nf2d29b487de5416c8090aa3ce1e3eb1a
108 Nc80939b2437d411ca5818ca6f763cf87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Esters
110 rdf:type schema:DefinedTerm
111 Ncad56f614d2c4ae7a446ea9ee1f722c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name HL-60 Cells
113 rdf:type schema:DefinedTerm
114 Ncd7abbea26ff48869ea93667ac5ee131 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Triterpenes
116 rdf:type schema:DefinedTerm
117 Ncf501dfca98546939cb5ed51d69ea9a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Uncaria
119 rdf:type schema:DefinedTerm
120 Nd2ee1eb4ae344490a2dbd7d8611fb77b schema:name doi
121 schema:value 10.1007/s11418-010-0438-1
122 rdf:type schema:PropertyValue
123 Ne1afd4da16514f86877b4dd7638b11f1 rdf:first sg:person.01101371400.62
124 rdf:rest Nbcb6edb84c3e477fbc99a8bb52d13ea5
125 Neca8a9b2f8b2480f84a7b0fc01518bcf schema:name nlm_unique_id
126 schema:value 101518405
127 rdf:type schema:PropertyValue
128 Nf2d29b487de5416c8090aa3ce1e3eb1a rdf:first sg:person.01155765011.02
129 rdf:rest N6701ca319550447a964fef1803a9cc11
130 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
131 schema:name Medical and Health Sciences
132 rdf:type schema:DefinedTerm
133 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
134 schema:name Immunology
135 rdf:type schema:DefinedTerm
136 sg:journal.1042407 schema:issn 1340-3443
137 1861-0293
138 schema:name Journal of Natural Medicines
139 rdf:type schema:Periodical
140 sg:person.01067216455.55 schema:affiliation https://www.grid.ac/institutes/grid.412769.f
141 schema:familyName Shoji
142 schema:givenName Noboru
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067216455.55
144 rdf:type schema:Person
145 sg:person.01101371400.62 schema:affiliation https://www.grid.ac/institutes/grid.412769.f
146 schema:familyName Umeyama
147 schema:givenName Akemi
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101371400.62
149 rdf:type schema:Person
150 sg:person.01155765011.02 schema:affiliation https://www.grid.ac/institutes/grid.412769.f
151 schema:familyName Okada
152 schema:givenName Minori
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155765011.02
154 rdf:type schema:Person
155 sg:person.01204441075.42 schema:affiliation https://www.grid.ac/institutes/grid.411602.0
156 schema:familyName Lee
157 schema:givenName Je-Jung
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204441075.42
159 rdf:type schema:Person
160 sg:person.01251245123.30 schema:affiliation https://www.grid.ac/institutes/grid.412769.f
161 schema:familyName Hashimoto
162 schema:givenName Toshihiro
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251245123.30
164 rdf:type schema:Person
165 sg:person.01305620125.23 schema:affiliation https://www.grid.ac/institutes/grid.411602.0
166 schema:familyName Takei
167 schema:givenName Masao
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305620125.23
169 rdf:type schema:Person
170 sg:pub.10.1007/s00210-003-0854-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016809671
171 https://doi.org/10.1007/s00210-003-0854-9
172 rdf:type schema:CreativeWork
173 sg:pub.10.1038/nm1551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016434628
174 https://doi.org/10.1038/nm1551
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/j.bbrc.2008.02.157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029077386
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.bcp.2004.04.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002595169
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.ejphar.2006.02.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021736294
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.lfs.2004.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011283697
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1021/np8000305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056237308
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1021/np990478k schema:sameAs https://app.dimensions.ai/details/publication/pub.1056239912
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1055/s-2007-969846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057502613
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1055/s-2008-1081348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057571020
191 rdf:type schema:CreativeWork
192 https://www.grid.ac/institutes/grid.411602.0 schema:alternateName Chonnam National University Hwasun Hospital
193 schema:name Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, Jeonnam, South Korea
194 rdf:type schema:Organization
195 https://www.grid.ac/institutes/grid.412769.f schema:alternateName Tokushima Bunri University
196 schema:name Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan
197 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...