Polyacetylene diols with antiproliferative and driving Th1 polarization effects from the marine sponge Callyspongia sp. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-01

AUTHORS

Akemi Umeyama, Nanae Matsuoka, Rieko Mine, Akemi Nakata, Eri Arimoto, Miwa Matsui, Noboru Shoji, Shigenobu Arihara, Masao Takei, Toshihiro Hashimoto

ABSTRACT

A screening of 30 crude extracts of marine sponges against human promyelocytic leukemia cells (HL-60) yielded an EtOAc extract of the sponge Callyspongia sp. (Callyspongiidae) with significant activity. Further bioassay-guided fractionation of the EtOAc extract led to the isolation of three polyacetylene metabolites: a new polyacetylene diol, callyspongidiol (1), along with two known compounds, siphonodiol (2) and 14,15-dihydrosiphonodiol (3). Their structures were determined by a combination of spectroscopic analyses. Compounds 1-3 exhibited antiproliferative activity against HL-60 with IC(50) values of 6.5, 2.8, and 6.5 microg/ml, respectively. These metabolites induce apoptosis in HL-60 cells. Dendritic cells (DC) differentiated with 1-3 enhance the differentiation of naïve T cells towards the Th1 type. More... »

PAGES

93

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11418-009-0363-3

DOI

http://dx.doi.org/10.1007/s11418-009-0363-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042618595

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19802655


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