Mikrobiom und Immuntherapien bei Tumorerkrankungen View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-02

AUTHORS

E. Holler, D. Weber, D. Heudobler, D. Wolff, W. Herr

ABSTRACT

Das intestinale Mikrobiom ist in den letzten 5 Jahren als ein wesentlicher Modulator der intestinalen und systemischen Immunregulation beschrieben worden. In der vorliegenden Arbeit werden deshalb die experimentelle und klinische Evidenz in aktueller Literatur und eigenen Arbeiten für eine Modulation der Tumorimmuntherapie durch das Mikrobiom zusammengefasst. Vor allem in der allogenen Stammzelltransplantation, aber auch bei der Gabe von Checkpointinhibitoren sind immunologische Nebenwirkungen erheblich mikrobiomabhängig. Auch die Tumorkontrolle und damit das langfristige Überleben können durch Mikrobiomverschiebungen stark beeinflusst werden. Eine exakte Entschlüsselung der zugrunde liegenden Mechanismen auf Stamm- und Metabolitenebene ist erforderlich, um in Zukunft gezielt durch Veränderungen des Mikrobioms die Wirkung von Immuntherapeutika zu verbessern und ihre Nebenwirkungen effektiver kontrollieren zu können. More... »

PAGES

1-5

Journal

TITLE

Der Gastroenterologe

ISSUE

N/A

VOLUME

N/A

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11377-019-0344-3

DOI

http://dx.doi.org/10.1007/s11377-019-0344-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113199830


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