Radiotherapie und Radiochemotherapie des Rektumkarzinoms View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-03

AUTHORS

C. Rödel

ABSTRACT

Bei optimierter Lokalbehandlung, die eine präoperative Kurzzeitradiotherapie oder präoperative Radiochemotherapie sowie die qualitätsgesicherte Operation mit totaler mesorektaler Exzision voraussetzt, rücken beim Rektumkarzinom in den UICC-Stadien II und III Fernmetastasen als primäre Rezidivorte in den Vordergrund. Capecitabin, Oxaliplatin, Irinotecan und die molekular-zielgerichten Substanzen haben die Ergebnisse bei der Behandlung des kolorektalen Karzinoms in der metastasierten und adjuvanten Situation verbessert. Diese Substanzen sind mittlerweile auch in Phase-I/II-Studien für das Rektumkarzinom getestet worden. Eine Herausforderung wird sein, die optimale Sequenz aller Behandlungsbausteine zu finden. Phase-III-Studien müssen klären, ob die Integration einer Kombinationschemotherapie tatsächlich einen Vorteil gegenüber der Standardbehandlung mit 5-Fluorouracil (5-FU) aufweist. More... »

PAGES

126-134

References to SciGraph publications

Journal

TITLE

Der Gastroenterologe

ISSUE

2

VOLUME

3

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11377-008-0177-y

DOI

http://dx.doi.org/10.1007/s11377-008-0177-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019133397


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