The Oxygen Paradox, the French Paradox, and age-related diseases View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12-21

AUTHORS

Joanna M. S. Davies, Josiane Cillard, Bertrand Friguet, Enrique Cadenas, Jean Cadet, Rachael Cayce, Andrew Fishmann, David Liao, Anne-Laure Bulteau, Frédéric Derbré, Amélie Rébillard, Steven Burstein, Etienne Hirsch, Robert A. Kloner, Michael Jakowec, Giselle Petzinger, Delphine Sauce, Florian Sennlaub, Isabelle Limon, Fulvio Ursini, Matilde Maiorino, Christina Economides, Christian J. Pike, Pinchas Cohen, Anne Negre Salvayre, Matthew R. Halliday, Adam J. Lundquist, Nicolaus A. Jakowec, Fatima Mechta-Grigoriou, Mathias Mericskay, Jean Mariani, Zhenlin Li, David Huang, Ellsworth Grant, Henry J. Forman, Caleb E. Finch, Patrick Y. Sun, Laura C. D. Pomatto, Onnik Agbulut, David Warburton, Christian Neri, Mustapha Rouis, Pierre Cillard, Jacqueline Capeau, Jean Rosenbaum, Kelvin J. A. Davies

ABSTRACT

A paradox is a seemingly absurd or impossible concept, proposition, or theory that is often difficult to understand or explain, sometimes apparently self-contradictory, and yet ultimately correct or true. How is it possible, for example, that oxygen “a toxic environmental poison” could be also indispensable for life (Beckman and Ames Physiol Rev 78(2):547–81, 1998; Stadtman and Berlett Chem Res Toxicol 10(5):485–94, 1997)?: the so-called Oxygen Paradox (Davies and Ursini 1995; Davies Biochem Soc Symp 61:1–31, 1995). How can French people apparently disregard the rule that high dietary intakes of cholesterol and saturated fats (e.g., cheese and paté) will result in an early death from cardiovascular diseases (Renaud and de Lorgeril Lancet 339(8808):1523–6, 1992; Catalgol et al. Front Pharmacol 3:141, 2012; Eisenberg et al. Nat Med 22(12):1428–1438, 2016)?: the so-called, French Paradox. Doubtless, the truth is not a duality and epistemological bias probably generates apparently self-contradictory conclusions. Perhaps nowhere in biology are there so many apparently contradictory views, and even experimental results, affecting human physiology and pathology as in the fields of free radicals and oxidative stress, antioxidants, foods and drinks, and dietary recommendations; this is particularly true when issues such as disease-susceptibility or avoidance, “healthspan,” “lifespan,” and ageing are involved. Consider, for example, the apparently paradoxical observation that treatment with low doses of a substance that is toxic at high concentrations may actually induce transient adaptations that protect against a subsequent exposure to the same (or similar) toxin. This particular paradox is now mechanistically explained as “Adaptive Homeostasis” (Davies Mol Asp Med 49:1–7, 2016; Pomatto et al. 2017a; Lomeli et al. Clin Sci (Lond) 131(21):2573–2599, 2017; Pomatto and Davies 2017); the non-damaging process by which an apparent toxicant can activate biological signal transduction pathways to increase expression of protective genes, by mechanisms that are completely different from those by which the same agent induces toxicity at high concentrations. In this review, we explore the influences and effects of paradoxes such as the Oxygen Paradox and the French Paradox on the etiology, progression, and outcomes of many of the major human age-related diseases, as well as the basic biological phenomenon of ageing itself. More... »

PAGES

499-550

References to SciGraph publications

  • 2016-10-06. Cardioprotection: Where to from here? in CARDIOVASCULAR DRUGS AND THERAPY
  • 2007-01-30. Prospective study showing that dietary vitamin C reduced the risk of age-related cataracts in a middle-aged Japanese population in EUROPEAN JOURNAL OF NUTRITION
  • 2007-09-06. Total oxidative/anti-oxidative status and relation to bone mineral density in osteoporosis in RHEUMATOLOGY INTERNATIONAL
  • 2003-05. Osteoclast differentiation and activation in NATURE
  • 2008-05-06. Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies in NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE
  • 2014-03-17. Oxidative stress and its biomarkers in systemic lupus erythematosus in JOURNAL OF BIOMEDICAL SCIENCE
  • 2010-12-06. 8-oxo-7,8-dihydro-2'-deoxyguanosine as a biomarker of oxidative damage in oesophageal cancer patients: lack of association with antioxidant vitamins and polymorphism of hOGG1 and GST in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
  • 2016-06-09. ROS homeostasis and metabolism: a dangerous liason in cancer cells in CELL DEATH & DISEASE
  • 2006-08-29. Lycopene consumption decreases oxidative stress and bone resorption markers in postmenopausal women in OSTEOPOROSIS INTERNATIONAL
  • 2016-01-04. Regulation of miR-200c/141 expression by intergenic DNA-looping and transcriptional read-through in NATURE COMMUNICATIONS
  • 1994-01. Genetic associations with human longevity at the APOE and ACE loci in NATURE GENETICS
  • 1992-10. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis in NATURE
  • 2008-12-09. Nuclear oxidative damage correlates with poor survival in colorectal cancer in BRITISH JOURNAL OF CANCER
  • 2012-03-27. Measurement of oxidatively generated base damage to nucleic acids in cells: facts and artifacts in BIOANALYTICAL REVIEWS
  • 1988-10. Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain in JOURNAL OF NEURAL TRANMISSION
  • 1996-06. Cancer risk and oxidative DNA damage in man in JOURNAL OF MOLECULAR MEDICINE
  • 2015-09-30. Prebiotic and Probiotic Regulation of Bone Health: Role of the Intestine and its Microbiome in CURRENT OSTEOPOROSIS REPORTS
  • 2006-07-14. Role of antioxidant systems, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2015-10-12. MAP3K8/TPL-2/COT is a potential predictive marker for MEK inhibitor treatment in high-grade serous ovarian carcinomas in NATURE COMMUNICATIONS
  • 1988-11. Apolipoprotein E polymorphism in the Netherlands and its effect on plasma lipid and apolipoprotein levels in HUMAN GENETICS
  • 2016-05-14. Dementias of the Alzheimer Type: Views Through the Lens of Evolutionary Biology Suggest Amyloid-Driven Brain Aging Is Balanced Against Host Defense in EVOLUTIONARY THINKING IN MEDICINE
  • 2016-10-27. Protein oxidation, nitration and glycation biomarkers for early-stage diagnosis of osteoarthritis of the knee and typing and progression of arthritic disease in ARTHRITIS RESEARCH & THERAPY
  • 2017-01-31. Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models in TRANSLATIONAL PSYCHIATRY
  • 2005-08-23. Enzyme estimates of infarct size correlate with functional and clinical outcomes in the setting of ST-segment elevation myocardial infarction in TRIALS
  • 1992. The role of alterations in free radical metabolism in mediating cognitive impairments in Down’s syndrome in FREE RADICALS AND AGING
  • 2013-12-28. Possible relations between oxidative damage and apoptosis in benign prostate hyperplasia and prostate cancer patients in TUMOR BIOLOGY
  • 2007-04-29. p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway in NATURE GENETICS
  • 2013-11-29. Modulation of oxidative stress as an anticancer strategy in NATURE REVIEWS DRUG DISCOVERY
  • 2014-05-15. Genetic polymorphism 609C>T in NAD(P)H:quinone oxidoreductase 1 enhances the risk of proximal colon cancer in JOURNAL OF HUMAN GENETICS
  • 2010-12-13. Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis in BMC OPHTHALMOLOGY
  • 2016-11-14. Cardioprotection and lifespan extension by the natural polyamine spermidine in NATURE MEDICINE
  • 2007-12-19. Oxidative stress as a risk factor for osteoporosis in elderly Mexicans as characterized by antioxidant enzymes in BMC MUSCULOSKELETAL DISORDERS
  • 2014-01-26. An abundant dysfunctional apolipoprotein A1 in human atheroma in NATURE MEDICINE
  • 2011-11-03. The role of diet and physical activity in breast, colorectal, and prostate cancer survivorship: a review of the literature in BRITISH JOURNAL OF CANCER
  • 2000-03. Cellular and molecular mechanisms of aging and age related diseases in PATHOLOGY & ONCOLOGY RESEARCH
  • 2012-09-19. Small interfering RNA-mediated suppression of Ccl2 in Müller cells attenuates microglial recruitment and photoreceptor death following retinal degeneration in JOURNAL OF NEUROINFLAMMATION
  • 2015-09-12. Mitochondrial Lon protease at the crossroads of oxidative stress, ageing and cancer in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 1998-10. Nicotinamide Adenine Dinucleotide Phosphate Oxidase in the Formation of Superoxide in Osteoclasts in CALCIFIED TISSUE INTERNATIONAL
  • 1988-07-01. Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease in NATURE
  • 2015-07-07. Abundance of infiltrating CD163+ cells in the retina of postmortem eyes with dry and neovascular age-related macular degeneration in GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • 2011-11-20. miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response in NATURE MEDICINE
  • 2017-09-14. Vimentin knockout results in increased expression of sub-endothelial basement membrane components and carotid stiffness in mice in SCIENTIFIC REPORTS
  • 2016-06-03. The Antioxidant Effect of Exercise: A Systematic Review and Meta-Analysis in SPORTS MEDICINE
  • 2011-04-29. miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition in CELL DEATH & DIFFERENTIATION
  • 2015-10-14. Oxidative stress inhibits distant metastasis by human melanoma cells in NATURE
  • 2012-10-14. α-Tocopherol prevents lymphoma by improving antioxidant defence system of mice in MOLECULAR BIOLOGY REPORTS
  • 2000-10. Apolipoprotein E receptors: linking brain development and alzheimer's disease in NATURE REVIEWS NEUROSCIENCE
  • 2009-08. Signal integration by JNK and p38 MAPK pathways in cancer development in NATURE REVIEWS CANCER
  • Journal

    TITLE

    GeroScience

    ISSUE

    5-6

    VOLUME

    39

    Author Affiliations

  • Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, 90089-0191, Los Angeles, CA, USA
  • Lab de Biologie Cellulaire et Végétale, Faculté de Pharmacie, Université de Rennes, 35043, Rennes Cedex, France
  • INSERM ERL U1164, 75005, Paris, France
  • Department of Biochemistry & Molecular Medicine, Keck School of Medicine of USC, University of Southern California, 90033, Los Angeles, CA, USA
  • Département de Médecine nucléaire et Radiobiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, J1H 5N4, Sherbrooke, Québec, Canada
  • The Medical Group, Internal Medicine, Rheumatology & Osteoporosis, Dermatology, Pulmonology, Ophthalmology, and Cardiology; the Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA
  • Institut de Génomique Fonctionnelle de Lyon,ENS de Lyon, CNRS, 69364, Lyon Cedex 07, France
  • Laboratory for Movement, Sport and Health Sciences-EA 1274, M2S, Université de Rennes 2-ENS, Bruz, 35170, Rennes, France
  • INSERM UMR 1127-CNRS UMR 7225, Institut du cerveau et de la moelle épinière-ICM Thérapeutique Expérimentale de la Maladie de Parkinson, Université Pierre et Marie Curie, 75651, Paris Cedex 13, France
  • Huntington Medical Research Institutes, 91105, Pasadena, CA, USA
  • Department of Neurology, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA
  • Chronic infections and Immune ageing, INSERM U1135, Hopital Pitie-Salpetriere, Pierre et Marie Curie University, 75013, Paris, France
  • INSERM Equipe 14 Institut de la Vision, 75012, Paris, France
  • Institut de Biologie Paris-Seine (IBPS), UMR CNRS 8256, Biological Adaptation and Ageing, Sorbonne Universités, UPMC Univ Paris 06, 75005, Paris, France
  • Department of Molecular Medicine, University of Padova, 35121, Padova, Italy
  • Los Angeles Cardiology Associates, Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA
  • Division of Neurobiology, Department of Biological Sciences of the Dornsife College of Letters, Arts, and Sciences, University of Southern California, 90089-0191, Los Angeles, CA, USA
  • Keck School of Medicine of USC, University of Southern California, 90033, Los Angeles, CA, USA
  • Lipid peroxidation, Signalling and Vascular Diseases INSERM U1048, 31432, Toulouse Cedex 4, France
  • Stress and Cancer Laboratory, Institut Curie-Inserm U830, 75248, Paris Cedex 05, France
  • Laboratoire de Signalisation et Physiopathologie Cardiovasculaire-Inserm UMR-S 1180, Faculté de Pharmacie, Université Paris-Sud, 92296 Châtenay-Malabry, Paris, France
  • Department of Radiation Oncology, Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA
  • Department of Oncology & Hematology, Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA
  • Division of Molecular & Computational Biology, Department of Biological Sciences of the Dornsife College of Letters, Arts, and Sciences, University of Southern California, 90089-0191, Los Angeles, CA, USA
  • Department of Pediatrics, Keck School of Medicine of USC, University of Southern California, 90033, Los Angeles, CA, USA
  • DR Saint-Antoine UMR_S938, UPMC, Inserm Faculté de Médecine, Université Pierre et Marie Curie, 75012, Paris, France
  • Scientific Service of the Embassy of France in the USA, Consulate General of France in Los Angeles, 90025, Los Angeles, CA, USA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11357-017-0002-y

    DOI

    http://dx.doi.org/10.1007/s11357-017-0002-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1099908603

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29270905


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adaptation, Physiological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diet, High-Protein", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "France", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Free Radicals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Geriatric Assessment", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hypercholesterolemia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oxidative Stress", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oxygen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Assessment", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, 90089-0191, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.42505.36", 
              "name": [
                "The Medical Group, Internal Medicine, Rheumatology & Osteoporosis, Dermatology, Pulmonology, Ophthalmology, and Cardiology; the Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA", 
                "Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, 90089-0191, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Davies", 
            "givenName": "Joanna M. S.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lab de Biologie Cellulaire et V\u00e9g\u00e9tale, Facult\u00e9 de Pharmacie, Universit\u00e9 de Rennes, 35043, Rennes Cedex, France", 
              "id": "http://www.grid.ac/institutes/grid.410368.8", 
              "name": [
                "Lab de Biologie Cellulaire et V\u00e9g\u00e9tale, Facult\u00e9 de Pharmacie, Universit\u00e9 de Rennes, 35043, Rennes Cedex, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cillard", 
            "givenName": "Josiane", 
            "id": "sg:person.065703244.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.065703244.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "INSERM ERL U1164, 75005, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.7429.8", 
              "name": [
                "Institut de Biologie Paris-Seine (IBPS), UMR CNRS 8256, Biological Adaptation and Ageing, Sorbonne Universit\u00e9s, UPMC Univ Paris 06, 75005, Paris, France", 
                "INSERM ERL U1164, 75005, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Friguet", 
            "givenName": "Bertrand", 
            "id": "sg:person.01275671273.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275671273.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biochemistry & Molecular Medicine, Keck School of Medicine of USC, University of Southern California, 90033, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.42505.36", 
              "name": [
                "Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, 90089-0191, Los Angeles, CA, USA", 
                "School of Pharmacy, University of Southern California, 90089-9121, Los Angeles, CA, USA", 
                "Department of Biochemistry & Molecular Medicine, Keck School of Medicine of USC, University of Southern California, 90033, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cadenas", 
            "givenName": "Enrique", 
            "id": "sg:person.01111540064.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111540064.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "D\u00e9partement de M\u00e9decine nucl\u00e9aire et Radiobiologie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, J1H 5N4, Sherbrooke, Qu\u00e9bec, Canada", 
              "id": "http://www.grid.ac/institutes/grid.86715.3d", 
              "name": [
                "D\u00e9partement de M\u00e9decine nucl\u00e9aire et Radiobiologie, Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9, Universit\u00e9 de Sherbrooke, J1H 5N4, Sherbrooke, Qu\u00e9bec, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cadet", 
            "givenName": "Jean", 
            "id": "sg:person.01324450712.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324450712.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Medical Group, Internal Medicine, Rheumatology & Osteoporosis, Dermatology, Pulmonology, Ophthalmology, and Cardiology; the Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.413117.1", 
              "name": [
                "The Medical Group, Internal Medicine, Rheumatology & Osteoporosis, Dermatology, Pulmonology, Ophthalmology, and Cardiology; the Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cayce", 
            "givenName": "Rachael", 
            "id": "sg:person.0731707076.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731707076.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Medical Group, Internal Medicine, Rheumatology & Osteoporosis, Dermatology, Pulmonology, Ophthalmology, and Cardiology; the Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.413117.1", 
              "name": [
                "The Medical Group, Internal Medicine, Rheumatology & Osteoporosis, Dermatology, Pulmonology, Ophthalmology, and Cardiology; the Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fishmann", 
            "givenName": "Andrew", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Medical Group, Internal Medicine, Rheumatology & Osteoporosis, Dermatology, Pulmonology, Ophthalmology, and Cardiology; the Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.413117.1", 
              "name": [
                "The Medical Group, Internal Medicine, Rheumatology & Osteoporosis, Dermatology, Pulmonology, Ophthalmology, and Cardiology; the Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liao", 
            "givenName": "David", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut de G\u00e9nomique Fonctionnelle de Lyon,ENS de Lyon, CNRS, 69364, Lyon Cedex 07, France", 
              "id": "http://www.grid.ac/institutes/grid.462143.6", 
              "name": [
                "Institut de G\u00e9nomique Fonctionnelle de Lyon,ENS de Lyon, CNRS, 69364, Lyon Cedex 07, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bulteau", 
            "givenName": "Anne-Laure", 
            "id": "sg:person.0651050210.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651050210.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory for Movement, Sport and Health Sciences-EA 1274, M2S, Universit\u00e9 de Rennes 2-ENS, Bruz, 35170, Rennes, France", 
              "id": "http://www.grid.ac/institutes/grid.463984.4", 
              "name": [
                "Laboratory for Movement, Sport and Health Sciences-EA 1274, M2S, Universit\u00e9 de Rennes 2-ENS, Bruz, 35170, Rennes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Derbr\u00e9", 
            "givenName": "Fr\u00e9d\u00e9ric", 
            "id": "sg:person.01002456011.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002456011.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory for Movement, Sport and Health Sciences-EA 1274, M2S, Universit\u00e9 de Rennes 2-ENS, Bruz, 35170, Rennes, France", 
              "id": "http://www.grid.ac/institutes/grid.463984.4", 
              "name": [
                "Laboratory for Movement, Sport and Health Sciences-EA 1274, M2S, Universit\u00e9 de Rennes 2-ENS, Bruz, 35170, Rennes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "R\u00e9billard", 
            "givenName": "Am\u00e9lie", 
            "id": "sg:person.0613112625.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613112625.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Medical Group, Internal Medicine, Rheumatology & Osteoporosis, Dermatology, Pulmonology, Ophthalmology, and Cardiology; the Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.413117.1", 
              "name": [
                "The Medical Group, Internal Medicine, Rheumatology & Osteoporosis, Dermatology, Pulmonology, Ophthalmology, and Cardiology; the Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Burstein", 
            "givenName": "Steven", 
            "id": "sg:person.01012352561.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012352561.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "INSERM UMR 1127-CNRS UMR 7225, Institut du cerveau et de la moelle \u00e9pini\u00e8re-ICM Th\u00e9rapeutique Exp\u00e9rimentale de la Maladie de Parkinson, Universit\u00e9 Pierre et Marie Curie, 75651, Paris Cedex 13, France", 
              "id": "http://www.grid.ac/institutes/grid.462844.8", 
              "name": [
                "INSERM UMR 1127-CNRS UMR 7225, Institut du cerveau et de la moelle \u00e9pini\u00e8re-ICM Th\u00e9rapeutique Exp\u00e9rimentale de la Maladie de Parkinson, Universit\u00e9 Pierre et Marie Curie, 75651, Paris Cedex 13, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hirsch", 
            "givenName": "Etienne", 
            "id": "sg:person.014512332322.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014512332322.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Huntington Medical Research Institutes, 91105, Pasadena, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.280933.3", 
              "name": [
                "Huntington Medical Research Institutes, 91105, Pasadena, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kloner", 
            "givenName": "Robert A.", 
            "id": "sg:person.01156126366.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156126366.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurology, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.42505.36", 
              "name": [
                "Department of Neurology, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jakowec", 
            "givenName": "Michael", 
            "id": "sg:person.01022504153.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022504153.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurology, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.42505.36", 
              "name": [
                "Department of Neurology, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Petzinger", 
            "givenName": "Giselle", 
            "id": "sg:person.0732762611.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732762611.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Chronic infections and Immune ageing, INSERM U1135, Hopital Pitie-Salpetriere, Pierre et Marie Curie University, 75013, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.462844.8", 
              "name": [
                "Chronic infections and Immune ageing, INSERM U1135, Hopital Pitie-Salpetriere, Pierre et Marie Curie University, 75013, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sauce", 
            "givenName": "Delphine", 
            "id": "sg:person.0646167115.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646167115.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "INSERM Equipe 14 Institut de la Vision, 75012, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.418241.a", 
              "name": [
                "INSERM Equipe 14 Institut de la Vision, 75012, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sennlaub", 
            "givenName": "Florian", 
            "id": "sg:person.01356263054.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356263054.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut de Biologie Paris-Seine (IBPS), UMR CNRS 8256, Biological Adaptation and Ageing, Sorbonne Universit\u00e9s, UPMC Univ Paris 06, 75005, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.503253.2", 
              "name": [
                "Institut de Biologie Paris-Seine (IBPS), UMR CNRS 8256, Biological Adaptation and Ageing, Sorbonne Universit\u00e9s, UPMC Univ Paris 06, 75005, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Limon", 
            "givenName": "Isabelle", 
            "id": "sg:person.0741451637.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741451637.73"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Medicine, University of Padova, 35121, Padova, Italy", 
              "id": "http://www.grid.ac/institutes/grid.5608.b", 
              "name": [
                "Department of Molecular Medicine, University of Padova, 35121, Padova, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ursini", 
            "givenName": "Fulvio", 
            "id": "sg:person.01161327342.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161327342.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular Medicine, University of Padova, 35121, Padova, Italy", 
              "id": "http://www.grid.ac/institutes/grid.5608.b", 
              "name": [
                "Department of Molecular Medicine, University of Padova, 35121, Padova, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maiorino", 
            "givenName": "Matilde", 
            "id": "sg:person.01227442542.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227442542.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Los Angeles Cardiology Associates, Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.413117.1", 
              "name": [
                "Los Angeles Cardiology Associates, Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Economides", 
            "givenName": "Christina", 
            "id": "sg:person.0730301427.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730301427.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Neurobiology, Department of Biological Sciences of the Dornsife College of Letters, Arts, and Sciences, University of Southern California, 90089-0191, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.42505.36", 
              "name": [
                "Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, 90089-0191, Los Angeles, CA, USA", 
                "Division of Neurobiology, Department of Biological Sciences of the Dornsife College of Letters, Arts, and Sciences, University of Southern California, 90089-0191, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pike", 
            "givenName": "Christian J.", 
            "id": "sg:person.0667244644.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667244644.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Keck School of Medicine of USC, University of Southern California, 90033, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.42505.36", 
              "name": [
                "Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, 90089-0191, Los Angeles, CA, USA", 
                "Keck School of Medicine of USC, University of Southern California, 90033, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cohen", 
            "givenName": "Pinchas", 
            "id": "sg:person.015554331142.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015554331142.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lipid peroxidation, Signalling and Vascular Diseases INSERM U1048, 31432, Toulouse Cedex 4, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Lipid peroxidation, Signalling and Vascular Diseases INSERM U1048, 31432, Toulouse Cedex 4, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Salvayre", 
            "givenName": "Anne Negre", 
            "id": "sg:person.01121137540.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121137540.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurology, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.42505.36", 
              "name": [
                "Department of Neurology, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Halliday", 
            "givenName": "Matthew R.", 
            "id": "sg:person.0652543442.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652543442.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurology, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.42505.36", 
              "name": [
                "Department of Neurology, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lundquist", 
            "givenName": "Adam J.", 
            "id": "sg:person.012224235521.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012224235521.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Neurology, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.42505.36", 
              "name": [
                "Department of Neurology, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jakowec", 
            "givenName": "Nicolaus A.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stress and Cancer Laboratory, Institut Curie-Inserm U830, 75248, Paris Cedex 05, France", 
              "id": "http://www.grid.ac/institutes/grid.418596.7", 
              "name": [
                "Stress and Cancer Laboratory, Institut Curie-Inserm U830, 75248, Paris Cedex 05, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mechta-Grigoriou", 
            "givenName": "Fatima", 
            "id": "sg:person.01354431452.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354431452.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratoire de Signalisation et Physiopathologie Cardiovasculaire-Inserm UMR-S 1180, Facult\u00e9 de Pharmacie, Universit\u00e9 Paris-Sud, 92296 Ch\u00e2tenay-Malabry, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.5842.b", 
              "name": [
                "Laboratoire de Signalisation et Physiopathologie Cardiovasculaire-Inserm UMR-S 1180, Facult\u00e9 de Pharmacie, Universit\u00e9 Paris-Sud, 92296 Ch\u00e2tenay-Malabry, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mericskay", 
            "givenName": "Mathias", 
            "id": "sg:person.0772476065.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772476065.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut de Biologie Paris-Seine (IBPS), UMR CNRS 8256, Biological Adaptation and Ageing, Sorbonne Universit\u00e9s, UPMC Univ Paris 06, 75005, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.503253.2", 
              "name": [
                "Institut de Biologie Paris-Seine (IBPS), UMR CNRS 8256, Biological Adaptation and Ageing, Sorbonne Universit\u00e9s, UPMC Univ Paris 06, 75005, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mariani", 
            "givenName": "Jean", 
            "id": "sg:person.0634526633.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634526633.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "INSERM ERL U1164, 75005, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.7429.8", 
              "name": [
                "Institut de Biologie Paris-Seine (IBPS), UMR CNRS 8256, Biological Adaptation and Ageing, Sorbonne Universit\u00e9s, UPMC Univ Paris 06, 75005, Paris, France", 
                "INSERM ERL U1164, 75005, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Zhenlin", 
            "id": "sg:person.01353454532.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353454532.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Radiation Oncology, Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.413117.1", 
              "name": [
                "Department of Radiation Oncology, Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huang", 
            "givenName": "David", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Oncology & Hematology, Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.413117.1", 
              "name": [
                "Department of Oncology & Hematology, Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Grant", 
            "givenName": "Ellsworth", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, 90089-0191, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.42505.36", 
              "name": [
                "Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, 90089-0191, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Forman", 
            "givenName": "Henry J.", 
            "id": "sg:person.01031737152.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031737152.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Molecular & Computational Biology, Department of Biological Sciences of the Dornsife College of Letters, Arts, and Sciences, University of Southern California, 90089-0191, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.42505.36", 
              "name": [
                "Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, 90089-0191, Los Angeles, CA, USA", 
                "Los Angeles Cardiology Associates, Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA", 
                "Division of Molecular & Computational Biology, Department of Biological Sciences of the Dornsife College of Letters, Arts, and Sciences, University of Southern California, 90089-0191, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Finch", 
            "givenName": "Caleb E.", 
            "id": "sg:person.011574135302.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011574135302.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Molecular & Computational Biology, Department of Biological Sciences of the Dornsife College of Letters, Arts, and Sciences, University of Southern California, 90089-0191, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.42505.36", 
              "name": [
                "Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, 90089-0191, Los Angeles, CA, USA", 
                "Division of Molecular & Computational Biology, Department of Biological Sciences of the Dornsife College of Letters, Arts, and Sciences, University of Southern California, 90089-0191, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sun", 
            "givenName": "Patrick Y.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Molecular & Computational Biology, Department of Biological Sciences of the Dornsife College of Letters, Arts, and Sciences, University of Southern California, 90089-0191, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.42505.36", 
              "name": [
                "Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, 90089-0191, Los Angeles, CA, USA", 
                "Division of Molecular & Computational Biology, Department of Biological Sciences of the Dornsife College of Letters, Arts, and Sciences, University of Southern California, 90089-0191, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pomatto", 
            "givenName": "Laura C. D.", 
            "id": "sg:person.0706467510.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706467510.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut de Biologie Paris-Seine (IBPS), UMR CNRS 8256, Biological Adaptation and Ageing, Sorbonne Universit\u00e9s, UPMC Univ Paris 06, 75005, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.503253.2", 
              "name": [
                "Institut de Biologie Paris-Seine (IBPS), UMR CNRS 8256, Biological Adaptation and Ageing, Sorbonne Universit\u00e9s, UPMC Univ Paris 06, 75005, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Agbulut", 
            "givenName": "Onnik", 
            "id": "sg:person.01161137362.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161137362.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pediatrics, Keck School of Medicine of USC, University of Southern California, 90033, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.42505.36", 
              "name": [
                "Children\u2019s Hospital of Los Angeles, Developmental Biology, Regenerative Medicine and Stem Cell Therapeutics program and the Center for Environmental Impact on Global Health Across the Lifespan at The Saban Research Institute, 90027, Los Angeles, CA, USA", 
                "Department of Pediatrics, Keck School of Medicine of USC, University of Southern California, 90033, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Warburton", 
            "givenName": "David", 
            "id": "sg:person.01241203466.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241203466.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut de Biologie Paris-Seine (IBPS), UMR CNRS 8256, Biological Adaptation and Ageing, Sorbonne Universit\u00e9s, UPMC Univ Paris 06, 75005, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.503253.2", 
              "name": [
                "Institut de Biologie Paris-Seine (IBPS), UMR CNRS 8256, Biological Adaptation and Ageing, Sorbonne Universit\u00e9s, UPMC Univ Paris 06, 75005, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Neri", 
            "givenName": "Christian", 
            "id": "sg:person.0764374023.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764374023.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "INSERM ERL U1164, 75005, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.7429.8", 
              "name": [
                "Institut de Biologie Paris-Seine (IBPS), UMR CNRS 8256, Biological Adaptation and Ageing, Sorbonne Universit\u00e9s, UPMC Univ Paris 06, 75005, Paris, France", 
                "INSERM ERL U1164, 75005, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rouis", 
            "givenName": "Mustapha", 
            "id": "sg:person.0746571476.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746571476.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lab de Biologie Cellulaire et V\u00e9g\u00e9tale, Facult\u00e9 de Pharmacie, Universit\u00e9 de Rennes, 35043, Rennes Cedex, France", 
              "id": "http://www.grid.ac/institutes/grid.410368.8", 
              "name": [
                "Lab de Biologie Cellulaire et V\u00e9g\u00e9tale, Facult\u00e9 de Pharmacie, Universit\u00e9 de Rennes, 35043, Rennes Cedex, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cillard", 
            "givenName": "Pierre", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "DR Saint-Antoine UMR_S938, UPMC, Inserm Facult\u00e9 de M\u00e9decine, Universit\u00e9 Pierre et Marie Curie, 75012, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.462844.8", 
              "name": [
                "DR Saint-Antoine UMR_S938, UPMC, Inserm Facult\u00e9 de M\u00e9decine, Universit\u00e9 Pierre et Marie Curie, 75012, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Capeau", 
            "givenName": "Jacqueline", 
            "id": "sg:person.01131415770.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131415770.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Scientific Service of the Embassy of France in the USA, Consulate General of France in Los Angeles, 90025, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Scientific Service of the Embassy of France in the USA, Consulate General of France in Los Angeles, 90025, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rosenbaum", 
            "givenName": "Jean", 
            "id": "sg:person.01274511475.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274511475.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Molecular & Computational Biology, Department of Biological Sciences of the Dornsife College of Letters, Arts, and Sciences, University of Southern California, 90089-0191, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.42505.36", 
              "name": [
                "Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, 90089-0191, Los Angeles, CA, USA", 
                "Department of Biochemistry & Molecular Medicine, Keck School of Medicine of USC, University of Southern California, 90033, Los Angeles, CA, USA", 
                "Division of Molecular & Computational Biology, Department of Biological Sciences of the Dornsife College of Letters, Arts, and Sciences, University of Southern California, 90089-0191, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Davies", 
            "givenName": "Kelvin J. A.", 
            "id": "sg:person.010220077412.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010220077412.32"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/bf01790099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023649409", 
              "https://doi.org/10.1007/bf01790099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01658", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019910253", 
              "https://doi.org/10.1038/nature01658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tp.2016.280", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083396828", 
              "https://doi.org/10.1038/tp.2016.280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6604821", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038562100", 
              "https://doi.org/10.1038/sj.bjc.6604821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1423-0127-21-23", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040159435", 
              "https://doi.org/10.1186/1423-0127-21-23"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2011.423", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048138150", 
              "https://doi.org/10.1038/bjc.2011.423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-015-2039-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003030546", 
              "https://doi.org/10.1007/s00018-015-2039-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13277-013-1560-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008200197", 
              "https://doi.org/10.1007/s13277-013-1560-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12566-012-0029-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016213747", 
              "https://doi.org/10.1007/s12566-012-0029-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11010-006-9270-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020315348", 
              "https://doi.org/10.1007/s11010-006-9270-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11914-015-0292-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006901294", 
              "https://doi.org/10.1007/s11914-015-0292-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017854633", 
              "https://doi.org/10.1038/nm.3459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40279-016-0566-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050887703", 
              "https://doi.org/10.1007/s40279-016-0566-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00296-007-0452-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048314145", 
              "https://doi.org/10.1007/s00296-007-0452-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncpcardio1211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053591814", 
              "https://doi.org/10.1038/ncpcardio1211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-12024-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091665810", 
              "https://doi.org/10.1038/s41598-017-12024-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01244786", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004050650", 
              "https://doi.org/10.1007/bf01244786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-319-29716-3_19", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001099636", 
              "https://doi.org/10.1007/978-3-319-29716-3_19"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13075-016-1154-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016730965", 
              "https://doi.org/10.1186/s13075-016-1154-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-0348-7460-1_19", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017970709", 
              "https://doi.org/10.1007/978-3-0348-7460-1_19"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2016.105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033345780", 
              "https://doi.org/10.1038/cddis.2016.105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms9583", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037508938", 
              "https://doi.org/10.1038/ncomms9583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10557-016-6691-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044933139", 
              "https://doi.org/10.1007/s10557-016-6691-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1468-6708-6-12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038331684", 
              "https://doi.org/10.1186/1468-6708-6-12"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2011.42", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039166416", 
              "https://doi.org/10.1038/cdd.2011.42"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00394-006-0641-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034023638", 
              "https://doi.org/10.1007/s00394-006-0641-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00417-015-3094-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033155207", 
              "https://doi.org/10.1007/s00417-015-3094-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng2033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047923424", 
              "https://doi.org/10.1038/ng2033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature15726", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029461127", 
              "https://doi.org/10.1038/nature15726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2474-8-124", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030426900", 
              "https://doi.org/10.1186/1471-2474-8-124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00198-006-0205-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049224357", 
              "https://doi.org/10.1007/s00198-006-0205-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms9959", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027412191", 
              "https://doi.org/10.1038/ncomms9959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jhg.2014.38", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018513467", 
              "https://doi.org/10.1038/jhg.2014.38"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1742-2094-9-221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046575601", 
              "https://doi.org/10.1186/1742-2094-9-221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1756-9966-29-157", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000220313", 
              "https://doi.org/10.1186/1756-9966-29-157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35036221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018866968", 
              "https://doi.org/10.1038/35036221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2694", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046607600", 
              "https://doi.org/10.1038/nrc2694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd4002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005500014", 
              "https://doi.org/10.1038/nrd4002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002239900538", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039290480", 
              "https://doi.org/10.1007/s002239900538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0194-29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044395319", 
              "https://doi.org/10.1038/ng0194-29"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/359843a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028884048", 
              "https://doi.org/10.1038/359843a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/334345a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052129772", 
              "https://doi.org/10.1038/334345a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2512", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027416078", 
              "https://doi.org/10.1038/nm.2512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11033-012-2123-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035244201", 
              "https://doi.org/10.1007/s11033-012-2123-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00207507", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012549146", 
              "https://doi.org/10.1007/bf00207507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.4222", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022273867", 
              "https://doi.org/10.1038/nm.4222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03032651", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036248588", 
              "https://doi.org/10.1007/bf03032651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2415-10-31", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032215433", 
              "https://doi.org/10.1186/1471-2415-10-31"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-12-21", 
        "datePublishedReg": "2017-12-21", 
        "description": "A paradox is a seemingly absurd or impossible concept, proposition, or theory that is often difficult to understand or explain, sometimes apparently self-contradictory, and yet ultimately correct or true. How is it possible, for example, that oxygen \u201ca toxic environmental poison\u201d could be also indispensable for life (Beckman and Ames Physiol Rev 78(2):547\u201381, 1998; Stadtman and Berlett Chem Res Toxicol 10(5):485\u201394, 1997)?: the so-called Oxygen Paradox (Davies and Ursini 1995; Davies Biochem Soc Symp 61:1\u201331, 1995). How can French people apparently disregard the rule that high dietary intakes of cholesterol and saturated fats (e.g., cheese and pat\u00e9) will result in an early death from cardiovascular diseases (Renaud and de Lorgeril Lancet 339(8808):1523\u20136, 1992; Catalgol et al. Front Pharmacol 3:141, 2012; Eisenberg et al. Nat Med 22(12):1428\u20131438, 2016)?: the so-called, French Paradox. Doubtless, the truth is not a duality and epistemological bias probably generates apparently self-contradictory conclusions. Perhaps nowhere in biology are there so many apparently contradictory views, and even experimental results, affecting human physiology and pathology as in the fields of free radicals and oxidative stress, antioxidants, foods and drinks, and dietary recommendations; this is particularly true when issues such as disease-susceptibility or avoidance, \u201chealthspan,\u201d \u201clifespan,\u201d and ageing are involved. Consider, for example, the apparently paradoxical observation that treatment with low doses of a substance that is toxic at high concentrations may actually induce transient adaptations that protect against a subsequent exposure to the same (or similar) toxin. This particular paradox is now mechanistically explained as \u201cAdaptive Homeostasis\u201d (Davies Mol Asp Med 49:1\u20137, 2016; Pomatto et al. 2017a; Lomeli et al. Clin Sci (Lond) 131(21):2573\u20132599, 2017; Pomatto and Davies 2017); the non-damaging process by which an apparent toxicant can activate biological signal transduction pathways to increase expression of protective genes, by mechanisms that are completely different from those by which the same agent induces toxicity at high concentrations. In this review, we explore the influences and effects of paradoxes such as the Oxygen Paradox and the French Paradox on the etiology, progression, and outcomes of many of the major human age-related diseases, as well as the basic biological phenomenon of ageing itself.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s11357-017-0002-y", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2502477", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2434816", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7144992", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2667600", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2448615", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2596843", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2504205", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3624803", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3478976", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7028702", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2620242", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3625401", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3867418", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5124507", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2354599", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2440010", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1023731", 
            "issn": [
              "2509-2715", 
              "2509-2723"
            ], 
            "name": "GeroScience", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5-6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "39"
          }
        ], 
        "keywords": [
          "French paradox", 
          "age-related diseases", 
          "oxygen paradox", 
          "high dietary intake", 
          "dietary intake", 
          "early death", 
          "cardiovascular disease", 
          "dietary recommendations", 
          "low doses", 
          "environmental poisons", 
          "disease", 
          "human physiology", 
          "free radicals", 
          "oxidative stress", 
          "paradoxical observation", 
          "high concentrations", 
          "transient adaptation", 
          "subsequent exposure", 
          "same toxin", 
          "adaptive homeostasis", 
          "signal transduction pathways", 
          "transduction pathways", 
          "protective genes", 
          "same agents", 
          "etiology", 
          "human age-related diseases", 
          "life", 
          "French people", 
          "intake", 
          "cholesterol", 
          "fat", 
          "death", 
          "conclusion", 
          "physiology", 
          "pathology", 
          "antioxidants", 
          "food", 
          "drinks", 
          "recommendations", 
          "healthspan", 
          "lifespan", 
          "treatment", 
          "doses", 
          "substances", 
          "concentration", 
          "exposure", 
          "toxin", 
          "homeostasis", 
          "toxicants", 
          "pathway", 
          "expression", 
          "genes", 
          "agents", 
          "toxicity", 
          "review", 
          "progression", 
          "outcomes", 
          "paradox", 
          "poisons", 
          "people", 
          "bias", 
          "biology", 
          "contradictory views", 
          "results", 
          "radicals", 
          "stress", 
          "avoidance", 
          "observations", 
          "adaptation", 
          "biological signal transduction pathways", 
          "mechanism", 
          "influence", 
          "effects of paradox", 
          "effect", 
          "basic biological phenomena", 
          "biological phenomena", 
          "impossible concept", 
          "concept", 
          "example", 
          "oxygen", 
          "doubtless", 
          "view", 
          "field", 
          "issues", 
          "particular paradox", 
          "process", 
          "phenomenon", 
          "proposition", 
          "theory", 
          "rules", 
          "truth", 
          "duality", 
          "epistemological bias", 
          "experimental results"
        ], 
        "name": "The Oxygen Paradox, the French Paradox, and age-related diseases", 
        "pagination": "499-550", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1099908603"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11357-017-0002-y"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29270905"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11357-017-0002-y", 
          "https://app.dimensions.ai/details/publication/pub.1099908603"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-10T10:19", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_730.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s11357-017-0002-y"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11357-017-0002-y'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11357-017-0002-y'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11357-017-0002-y'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11357-017-0002-y'


     

    This table displays all metadata directly associated to this object as RDF triples.

    822 TRIPLES      22 PREDICATES      184 URIs      128 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11357-017-0002-y schema:about N1162eb5465b14804acec7b716ac260d0
    2 N15c378dbb835488ba5e6bc6ea78b6d48
    3 N1c2e0e9cc95a4506934c992b495a96ac
    4 N314ae5d04c324c9fb342b15cea777e27
    5 N4f2847e13b6a4a0b9c45870a9f45bb5b
    6 N50f070f8bc004003b9bf6129f2468042
    7 N7005ee8baec44fe7aa70b595abb8b496
    8 N7a97059027f249809e29300415da67db
    9 N8dd353bcb7a246cda4a7b9b434fc2421
    10 N9262907b81974e999acc66dd282653ae
    11 N97f449122cd74b09b9c99f39d50e74da
    12 N9c3e1ac3fde64d2b81d198e01928b3df
    13 N9da61837fac541dd898b14e750f488c3
    14 Naa93e01ddbbb4bae9050893eeff012cb
    15 Nd30c5a43e8514bceaf9b9d616cd35473
    16 Nfd4aedf4fa3341ba9b623ff011310b40
    17 anzsrc-for:06
    18 anzsrc-for:0601
    19 schema:author Ne341f34e4de74846a726a96d393bf33c
    20 schema:citation sg:pub.10.1007/978-3-0348-7460-1_19
    21 sg:pub.10.1007/978-3-319-29716-3_19
    22 sg:pub.10.1007/bf00207507
    23 sg:pub.10.1007/bf01244786
    24 sg:pub.10.1007/bf01790099
    25 sg:pub.10.1007/bf03032651
    26 sg:pub.10.1007/s00018-015-2039-3
    27 sg:pub.10.1007/s00198-006-0205-z
    28 sg:pub.10.1007/s002239900538
    29 sg:pub.10.1007/s00296-007-0452-0
    30 sg:pub.10.1007/s00394-006-0641-8
    31 sg:pub.10.1007/s00417-015-3094-z
    32 sg:pub.10.1007/s10557-016-6691-0
    33 sg:pub.10.1007/s11010-006-9270-z
    34 sg:pub.10.1007/s11033-012-2123-9
    35 sg:pub.10.1007/s11914-015-0292-x
    36 sg:pub.10.1007/s12566-012-0029-6
    37 sg:pub.10.1007/s13277-013-1560-y
    38 sg:pub.10.1007/s40279-016-0566-1
    39 sg:pub.10.1038/334345a0
    40 sg:pub.10.1038/35036221
    41 sg:pub.10.1038/359843a0
    42 sg:pub.10.1038/bjc.2011.423
    43 sg:pub.10.1038/cdd.2011.42
    44 sg:pub.10.1038/cddis.2016.105
    45 sg:pub.10.1038/jhg.2014.38
    46 sg:pub.10.1038/nature01658
    47 sg:pub.10.1038/nature15726
    48 sg:pub.10.1038/ncomms9583
    49 sg:pub.10.1038/ncomms9959
    50 sg:pub.10.1038/ncpcardio1211
    51 sg:pub.10.1038/ng0194-29
    52 sg:pub.10.1038/ng2033
    53 sg:pub.10.1038/nm.2512
    54 sg:pub.10.1038/nm.3459
    55 sg:pub.10.1038/nm.4222
    56 sg:pub.10.1038/nrc2694
    57 sg:pub.10.1038/nrd4002
    58 sg:pub.10.1038/s41598-017-12024-z
    59 sg:pub.10.1038/sj.bjc.6604821
    60 sg:pub.10.1038/tp.2016.280
    61 sg:pub.10.1186/1423-0127-21-23
    62 sg:pub.10.1186/1468-6708-6-12
    63 sg:pub.10.1186/1471-2415-10-31
    64 sg:pub.10.1186/1471-2474-8-124
    65 sg:pub.10.1186/1742-2094-9-221
    66 sg:pub.10.1186/1756-9966-29-157
    67 sg:pub.10.1186/s13075-016-1154-3
    68 schema:datePublished 2017-12-21
    69 schema:datePublishedReg 2017-12-21
    70 schema:description A paradox is a seemingly absurd or impossible concept, proposition, or theory that is often difficult to understand or explain, sometimes apparently self-contradictory, and yet ultimately correct or true. How is it possible, for example, that oxygen “a toxic environmental poison” could be also indispensable for life (Beckman and Ames Physiol Rev 78(2):547–81, 1998; Stadtman and Berlett Chem Res Toxicol 10(5):485–94, 1997)?: the so-called Oxygen Paradox (Davies and Ursini 1995; Davies Biochem Soc Symp 61:1–31, 1995). How can French people apparently disregard the rule that high dietary intakes of cholesterol and saturated fats (e.g., cheese and paté) will result in an early death from cardiovascular diseases (Renaud and de Lorgeril Lancet 339(8808):1523–6, 1992; Catalgol et al. Front Pharmacol 3:141, 2012; Eisenberg et al. Nat Med 22(12):1428–1438, 2016)?: the so-called, French Paradox. Doubtless, the truth is not a duality and epistemological bias probably generates apparently self-contradictory conclusions. Perhaps nowhere in biology are there so many apparently contradictory views, and even experimental results, affecting human physiology and pathology as in the fields of free radicals and oxidative stress, antioxidants, foods and drinks, and dietary recommendations; this is particularly true when issues such as disease-susceptibility or avoidance, “healthspan,” “lifespan,” and ageing are involved. Consider, for example, the apparently paradoxical observation that treatment with low doses of a substance that is toxic at high concentrations may actually induce transient adaptations that protect against a subsequent exposure to the same (or similar) toxin. This particular paradox is now mechanistically explained as “Adaptive Homeostasis” (Davies Mol Asp Med 49:1–7, 2016; Pomatto et al. 2017a; Lomeli et al. Clin Sci (Lond) 131(21):2573–2599, 2017; Pomatto and Davies 2017); the non-damaging process by which an apparent toxicant can activate biological signal transduction pathways to increase expression of protective genes, by mechanisms that are completely different from those by which the same agent induces toxicity at high concentrations. In this review, we explore the influences and effects of paradoxes such as the Oxygen Paradox and the French Paradox on the etiology, progression, and outcomes of many of the major human age-related diseases, as well as the basic biological phenomenon of ageing itself.
    71 schema:genre article
    72 schema:inLanguage en
    73 schema:isAccessibleForFree true
    74 schema:isPartOf N473552517aae4ed5bfd7c5e709f1d168
    75 Nbdb418837ea1449faee95a34bf146deb
    76 sg:journal.1023731
    77 schema:keywords French paradox
    78 French people
    79 adaptation
    80 adaptive homeostasis
    81 age-related diseases
    82 agents
    83 antioxidants
    84 avoidance
    85 basic biological phenomena
    86 bias
    87 biological phenomena
    88 biological signal transduction pathways
    89 biology
    90 cardiovascular disease
    91 cholesterol
    92 concentration
    93 concept
    94 conclusion
    95 contradictory views
    96 death
    97 dietary intake
    98 dietary recommendations
    99 disease
    100 doses
    101 doubtless
    102 drinks
    103 duality
    104 early death
    105 effect
    106 effects of paradox
    107 environmental poisons
    108 epistemological bias
    109 etiology
    110 example
    111 experimental results
    112 exposure
    113 expression
    114 fat
    115 field
    116 food
    117 free radicals
    118 genes
    119 healthspan
    120 high concentrations
    121 high dietary intake
    122 homeostasis
    123 human age-related diseases
    124 human physiology
    125 impossible concept
    126 influence
    127 intake
    128 issues
    129 life
    130 lifespan
    131 low doses
    132 mechanism
    133 observations
    134 outcomes
    135 oxidative stress
    136 oxygen
    137 oxygen paradox
    138 paradox
    139 paradoxical observation
    140 particular paradox
    141 pathology
    142 pathway
    143 people
    144 phenomenon
    145 physiology
    146 poisons
    147 process
    148 progression
    149 proposition
    150 protective genes
    151 radicals
    152 recommendations
    153 results
    154 review
    155 rules
    156 same agents
    157 same toxin
    158 signal transduction pathways
    159 stress
    160 subsequent exposure
    161 substances
    162 theory
    163 toxicants
    164 toxicity
    165 toxin
    166 transduction pathways
    167 transient adaptation
    168 treatment
    169 truth
    170 view
    171 schema:name The Oxygen Paradox, the French Paradox, and age-related diseases
    172 schema:pagination 499-550
    173 schema:productId N78d39e3f8125446ea8330a59d04ec6be
    174 Nb8c8fb88f7c84a17afade60a3e4150be
    175 Ncf67c1e1ce324cbb9967835c22335514
    176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099908603
    177 https://doi.org/10.1007/s11357-017-0002-y
    178 schema:sdDatePublished 2022-05-10T10:19
    179 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    180 schema:sdPublisher N294555b15f6a46098610e786a859b902
    181 schema:url https://doi.org/10.1007/s11357-017-0002-y
    182 sgo:license sg:explorer/license/
    183 sgo:sdDataset articles
    184 rdf:type schema:ScholarlyArticle
    185 N01a05713b8424fabb639ff0f42b7b129 rdf:first N2986baafa4744d3a97a663307883234f
    186 rdf:rest N8072d5877e044243af05980f489a071c
    187 N110114a20edb497db2e7f5ac117eda43 rdf:first sg:person.012224235521.99
    188 rdf:rest N90c579af16e849fba8c3e9442a177eb3
    189 N1162eb5465b14804acec7b716ac260d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Adaptation, Physiological
    191 rdf:type schema:DefinedTerm
    192 N11ff77f08643436e9e2fc9ad1fdd624f rdf:first sg:person.01274511475.11
    193 rdf:rest N3f053c2d5f814ef2a8a60f990cfb41c4
    194 N15c378dbb835488ba5e6bc6ea78b6d48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Female
    196 rdf:type schema:DefinedTerm
    197 N1c2e0e9cc95a4506934c992b495a96ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Hypercholesterolemia
    199 rdf:type schema:DefinedTerm
    200 N294555b15f6a46098610e786a859b902 schema:name Springer Nature - SN SciGraph project
    201 rdf:type schema:Organization
    202 N2986baafa4744d3a97a663307883234f schema:affiliation grid-institutes:grid.413117.1
    203 schema:familyName Huang
    204 schema:givenName David
    205 rdf:type schema:Person
    206 N2a9a9b688b6d440da27ecc9279cb4661 rdf:first sg:person.01241203466.53
    207 rdf:rest N43ec78f352db4c32bb65b68563b39f5a
    208 N2e2b77ceebff43f0b23019ea34f1e858 rdf:first sg:person.0730301427.65
    209 rdf:rest Na96dd314c1c64dca840a9f00e53b9f1c
    210 N314ae5d04c324c9fb342b15cea777e27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    211 schema:name France
    212 rdf:type schema:DefinedTerm
    213 N3f053c2d5f814ef2a8a60f990cfb41c4 rdf:first sg:person.010220077412.32
    214 rdf:rest rdf:nil
    215 N43ec78f352db4c32bb65b68563b39f5a rdf:first sg:person.0764374023.90
    216 rdf:rest Nb71ce0a0dde54a3baf0465546bbb71aa
    217 N473552517aae4ed5bfd7c5e709f1d168 schema:issueNumber 5-6
    218 rdf:type schema:PublicationIssue
    219 N481e5742428f44a3a398988c21a63e5e schema:affiliation grid-institutes:grid.413117.1
    220 schema:familyName Liao
    221 schema:givenName David
    222 rdf:type schema:Person
    223 N4be27236354341a490154de7de640775 rdf:first sg:person.01227442542.62
    224 rdf:rest N2e2b77ceebff43f0b23019ea34f1e858
    225 N4f2847e13b6a4a0b9c45870a9f45bb5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    226 schema:name Humans
    227 rdf:type schema:DefinedTerm
    228 N50f070f8bc004003b9bf6129f2468042 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    229 schema:name Oxygen
    230 rdf:type schema:DefinedTerm
    231 N569421739a44419e86dd7e50051c41bc rdf:first sg:person.0732762611.43
    232 rdf:rest N84f8b489e58145a6b42cd4ed08e9e0b5
    233 N5b39132afa4b4f6982bd7dd89bdc7ee9 rdf:first sg:person.01356263054.39
    234 rdf:rest N64dcbf46652b4ae6aa68a83d870aefe3
    235 N5c48804c9aa14739bf9b7b72960d9976 rdf:first sg:person.01353454532.42
    236 rdf:rest N01a05713b8424fabb639ff0f42b7b129
    237 N5d45272b36684fa5ae97a8d5f00a5fec rdf:first sg:person.01324450712.56
    238 rdf:rest Nad5c7530646e4d59bcbf38e3c6d3767e
    239 N64dcbf46652b4ae6aa68a83d870aefe3 rdf:first sg:person.0741451637.73
    240 rdf:rest Nee7fee41eaea4c22b0cb4dfb052e8fb3
    241 N6529549437d944a18a7b5ca36d5a1777 schema:affiliation grid-institutes:grid.42505.36
    242 schema:familyName Sun
    243 schema:givenName Patrick Y.
    244 rdf:type schema:Person
    245 N668abb18fdb94b6e9071e5be91f919e9 rdf:first sg:person.0613112625.05
    246 rdf:rest Nf417e547764347a39aa106e2d396b39e
    247 N6c85769de55d45a5824217431e448fce schema:affiliation grid-institutes:grid.413117.1
    248 schema:familyName Grant
    249 schema:givenName Ellsworth
    250 rdf:type schema:Person
    251 N7005ee8baec44fe7aa70b595abb8b496 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    252 schema:name Middle Aged
    253 rdf:type schema:DefinedTerm
    254 N764194505f404624bfe37d5a6fc6b80f rdf:first sg:person.01002456011.24
    255 rdf:rest N668abb18fdb94b6e9071e5be91f919e9
    256 N78d29c22a18443239ff0b2a78e260afe rdf:first sg:person.01031737152.78
    257 rdf:rest Nbfe9931848fd4f338ee5fc079f767d32
    258 N78d39e3f8125446ea8330a59d04ec6be schema:name doi
    259 schema:value 10.1007/s11357-017-0002-y
    260 rdf:type schema:PropertyValue
    261 N7a97059027f249809e29300415da67db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    262 schema:name Free Radicals
    263 rdf:type schema:DefinedTerm
    264 N8072d5877e044243af05980f489a071c rdf:first N6c85769de55d45a5824217431e448fce
    265 rdf:rest N78d29c22a18443239ff0b2a78e260afe
    266 N84f8b489e58145a6b42cd4ed08e9e0b5 rdf:first sg:person.0646167115.12
    267 rdf:rest N5b39132afa4b4f6982bd7dd89bdc7ee9
    268 N852a5b294ecb49eda583d914462e0458 rdf:first sg:person.01121137540.46
    269 rdf:rest Ne3c1eea30dfd4dc6a0870cd1061c1ad4
    270 N860699f68c33418787990ca741eb13f7 schema:affiliation grid-institutes:grid.42505.36
    271 schema:familyName Davies
    272 schema:givenName Joanna M. S.
    273 rdf:type schema:Person
    274 N8652a9bd8cdc4b0dbecea6c5e0a27ab8 rdf:first N91383eaf24604e87b414c501bdcd248e
    275 rdf:rest Na853243111564f3e8a255bef0e1847cd
    276 N8837b5fa2d8f47d0a82af5e872fbb3f0 rdf:first sg:person.01156126366.97
    277 rdf:rest Nee3a6d6e9d3042a0a057426a1757580b
    278 N8dd353bcb7a246cda4a7b9b434fc2421 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    279 schema:name Risk Assessment
    280 rdf:type schema:DefinedTerm
    281 N90c579af16e849fba8c3e9442a177eb3 rdf:first Nc3793d9d5bf844d3a7589b05fdd50cce
    282 rdf:rest Ne7f702124dc4430da14af4cc22c9663c
    283 N911d6edeeed84a78973a49df42b66258 rdf:first sg:person.015554331142.09
    284 rdf:rest N852a5b294ecb49eda583d914462e0458
    285 N91383eaf24604e87b414c501bdcd248e schema:affiliation grid-institutes:grid.413117.1
    286 schema:familyName Fishmann
    287 schema:givenName Andrew
    288 rdf:type schema:Person
    289 N9185bc326b34478b92b51f58cd9b89b5 rdf:first sg:person.01131415770.01
    290 rdf:rest N11ff77f08643436e9e2fc9ad1fdd624f
    291 N9262907b81974e999acc66dd282653ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    292 schema:name Aged, 80 and over
    293 rdf:type schema:DefinedTerm
    294 N97f449122cd74b09b9c99f39d50e74da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    295 schema:name Diet, High-Protein
    296 rdf:type schema:DefinedTerm
    297 N9c3e1ac3fde64d2b81d198e01928b3df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    298 schema:name Geriatric Assessment
    299 rdf:type schema:DefinedTerm
    300 N9da61837fac541dd898b14e750f488c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    301 schema:name Male
    302 rdf:type schema:DefinedTerm
    303 Na3d23edb01d54358bb33aa107333de5d schema:affiliation grid-institutes:grid.410368.8
    304 schema:familyName Cillard
    305 schema:givenName Pierre
    306 rdf:type schema:Person
    307 Na853243111564f3e8a255bef0e1847cd rdf:first N481e5742428f44a3a398988c21a63e5e
    308 rdf:rest Nc6668a70fa7544ddb57b69bdd12ca440
    309 Na96dd314c1c64dca840a9f00e53b9f1c rdf:first sg:person.0667244644.14
    310 rdf:rest N911d6edeeed84a78973a49df42b66258
    311 Naa93e01ddbbb4bae9050893eeff012cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    312 schema:name Aged
    313 rdf:type schema:DefinedTerm
    314 Naa97a0a052c74d399970300f401009de rdf:first sg:person.01275671273.10
    315 rdf:rest Nf1f0814feb974ba690971ddab9eb3cec
    316 Nad5c7530646e4d59bcbf38e3c6d3767e rdf:first sg:person.0731707076.11
    317 rdf:rest N8652a9bd8cdc4b0dbecea6c5e0a27ab8
    318 Nb71ce0a0dde54a3baf0465546bbb71aa rdf:first sg:person.0746571476.49
    319 rdf:rest Ndbe705aea788456c866e948848fa47d3
    320 Nb81f801d445945ed8a116c2d67051b0b rdf:first sg:person.0706467510.50
    321 rdf:rest Nec6fab1d891645609075859ad6b4309d
    322 Nb8c8fb88f7c84a17afade60a3e4150be schema:name dimensions_id
    323 schema:value pub.1099908603
    324 rdf:type schema:PropertyValue
    325 Nbdb418837ea1449faee95a34bf146deb schema:volumeNumber 39
    326 rdf:type schema:PublicationVolume
    327 Nbfe9931848fd4f338ee5fc079f767d32 rdf:first sg:person.011574135302.77
    328 rdf:rest Nef59f190ca9c4d6f97b28c9ba16d3c9d
    329 Nc3793d9d5bf844d3a7589b05fdd50cce schema:affiliation grid-institutes:grid.42505.36
    330 schema:familyName Jakowec
    331 schema:givenName Nicolaus A.
    332 rdf:type schema:Person
    333 Nc6668a70fa7544ddb57b69bdd12ca440 rdf:first sg:person.0651050210.11
    334 rdf:rest N764194505f404624bfe37d5a6fc6b80f
    335 Ncf67c1e1ce324cbb9967835c22335514 schema:name pubmed_id
    336 schema:value 29270905
    337 rdf:type schema:PropertyValue
    338 Nd30c5a43e8514bceaf9b9d616cd35473 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    339 schema:name Aging
    340 rdf:type schema:DefinedTerm
    341 Ndbe705aea788456c866e948848fa47d3 rdf:first Na3d23edb01d54358bb33aa107333de5d
    342 rdf:rest N9185bc326b34478b92b51f58cd9b89b5
    343 Ndce2359b292d4cb69fb5575d02ed298c rdf:first sg:person.014512332322.58
    344 rdf:rest N8837b5fa2d8f47d0a82af5e872fbb3f0
    345 Ne341f34e4de74846a726a96d393bf33c rdf:first N860699f68c33418787990ca741eb13f7
    346 rdf:rest Nfbd04f85d705461296e480477509c292
    347 Ne3c1eea30dfd4dc6a0870cd1061c1ad4 rdf:first sg:person.0652543442.92
    348 rdf:rest N110114a20edb497db2e7f5ac117eda43
    349 Ne7f702124dc4430da14af4cc22c9663c rdf:first sg:person.01354431452.48
    350 rdf:rest Nf8b1984be2304e19abf01bbab65030ca
    351 Nec6fab1d891645609075859ad6b4309d rdf:first sg:person.01161137362.27
    352 rdf:rest N2a9a9b688b6d440da27ecc9279cb4661
    353 Nee3a6d6e9d3042a0a057426a1757580b rdf:first sg:person.01022504153.10
    354 rdf:rest N569421739a44419e86dd7e50051c41bc
    355 Nee7fee41eaea4c22b0cb4dfb052e8fb3 rdf:first sg:person.01161327342.12
    356 rdf:rest N4be27236354341a490154de7de640775
    357 Nef59f190ca9c4d6f97b28c9ba16d3c9d rdf:first N6529549437d944a18a7b5ca36d5a1777
    358 rdf:rest Nb81f801d445945ed8a116c2d67051b0b
    359 Nf1f0814feb974ba690971ddab9eb3cec rdf:first sg:person.01111540064.20
    360 rdf:rest N5d45272b36684fa5ae97a8d5f00a5fec
    361 Nf2428f380bd54073b0e1a5cb8ba2dc0f rdf:first sg:person.0634526633.60
    362 rdf:rest N5c48804c9aa14739bf9b7b72960d9976
    363 Nf417e547764347a39aa106e2d396b39e rdf:first sg:person.01012352561.63
    364 rdf:rest Ndce2359b292d4cb69fb5575d02ed298c
    365 Nf8b1984be2304e19abf01bbab65030ca rdf:first sg:person.0772476065.25
    366 rdf:rest Nf2428f380bd54073b0e1a5cb8ba2dc0f
    367 Nfbd04f85d705461296e480477509c292 rdf:first sg:person.065703244.23
    368 rdf:rest Naa97a0a052c74d399970300f401009de
    369 Nfd4aedf4fa3341ba9b623ff011310b40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    370 schema:name Oxidative Stress
    371 rdf:type schema:DefinedTerm
    372 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    373 schema:name Biological Sciences
    374 rdf:type schema:DefinedTerm
    375 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    376 schema:name Biochemistry and Cell Biology
    377 rdf:type schema:DefinedTerm
    378 sg:grant.2354599 http://pending.schema.org/fundedItem sg:pub.10.1007/s11357-017-0002-y
    379 rdf:type schema:MonetaryGrant
    380 sg:grant.2434816 http://pending.schema.org/fundedItem sg:pub.10.1007/s11357-017-0002-y
    381 rdf:type schema:MonetaryGrant
    382 sg:grant.2440010 http://pending.schema.org/fundedItem sg:pub.10.1007/s11357-017-0002-y
    383 rdf:type schema:MonetaryGrant
    384 sg:grant.2448615 http://pending.schema.org/fundedItem sg:pub.10.1007/s11357-017-0002-y
    385 rdf:type schema:MonetaryGrant
    386 sg:grant.2502477 http://pending.schema.org/fundedItem sg:pub.10.1007/s11357-017-0002-y
    387 rdf:type schema:MonetaryGrant
    388 sg:grant.2504205 http://pending.schema.org/fundedItem sg:pub.10.1007/s11357-017-0002-y
    389 rdf:type schema:MonetaryGrant
    390 sg:grant.2596843 http://pending.schema.org/fundedItem sg:pub.10.1007/s11357-017-0002-y
    391 rdf:type schema:MonetaryGrant
    392 sg:grant.2620242 http://pending.schema.org/fundedItem sg:pub.10.1007/s11357-017-0002-y
    393 rdf:type schema:MonetaryGrant
    394 sg:grant.2667600 http://pending.schema.org/fundedItem sg:pub.10.1007/s11357-017-0002-y
    395 rdf:type schema:MonetaryGrant
    396 sg:grant.3478976 http://pending.schema.org/fundedItem sg:pub.10.1007/s11357-017-0002-y
    397 rdf:type schema:MonetaryGrant
    398 sg:grant.3624803 http://pending.schema.org/fundedItem sg:pub.10.1007/s11357-017-0002-y
    399 rdf:type schema:MonetaryGrant
    400 sg:grant.3625401 http://pending.schema.org/fundedItem sg:pub.10.1007/s11357-017-0002-y
    401 rdf:type schema:MonetaryGrant
    402 sg:grant.3867418 http://pending.schema.org/fundedItem sg:pub.10.1007/s11357-017-0002-y
    403 rdf:type schema:MonetaryGrant
    404 sg:grant.5124507 http://pending.schema.org/fundedItem sg:pub.10.1007/s11357-017-0002-y
    405 rdf:type schema:MonetaryGrant
    406 sg:grant.7028702 http://pending.schema.org/fundedItem sg:pub.10.1007/s11357-017-0002-y
    407 rdf:type schema:MonetaryGrant
    408 sg:grant.7144992 http://pending.schema.org/fundedItem sg:pub.10.1007/s11357-017-0002-y
    409 rdf:type schema:MonetaryGrant
    410 sg:journal.1023731 schema:issn 2509-2715
    411 2509-2723
    412 schema:name GeroScience
    413 schema:publisher Springer Nature
    414 rdf:type schema:Periodical
    415 sg:person.01002456011.24 schema:affiliation grid-institutes:grid.463984.4
    416 schema:familyName Derbré
    417 schema:givenName Frédéric
    418 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002456011.24
    419 rdf:type schema:Person
    420 sg:person.01012352561.63 schema:affiliation grid-institutes:grid.413117.1
    421 schema:familyName Burstein
    422 schema:givenName Steven
    423 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012352561.63
    424 rdf:type schema:Person
    425 sg:person.010220077412.32 schema:affiliation grid-institutes:grid.42505.36
    426 schema:familyName Davies
    427 schema:givenName Kelvin J. A.
    428 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010220077412.32
    429 rdf:type schema:Person
    430 sg:person.01022504153.10 schema:affiliation grid-institutes:grid.42505.36
    431 schema:familyName Jakowec
    432 schema:givenName Michael
    433 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022504153.10
    434 rdf:type schema:Person
    435 sg:person.01031737152.78 schema:affiliation grid-institutes:grid.42505.36
    436 schema:familyName Forman
    437 schema:givenName Henry J.
    438 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031737152.78
    439 rdf:type schema:Person
    440 sg:person.01111540064.20 schema:affiliation grid-institutes:grid.42505.36
    441 schema:familyName Cadenas
    442 schema:givenName Enrique
    443 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111540064.20
    444 rdf:type schema:Person
    445 sg:person.01121137540.46 schema:affiliation grid-institutes:None
    446 schema:familyName Salvayre
    447 schema:givenName Anne Negre
    448 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121137540.46
    449 rdf:type schema:Person
    450 sg:person.01131415770.01 schema:affiliation grid-institutes:grid.462844.8
    451 schema:familyName Capeau
    452 schema:givenName Jacqueline
    453 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131415770.01
    454 rdf:type schema:Person
    455 sg:person.01156126366.97 schema:affiliation grid-institutes:grid.280933.3
    456 schema:familyName Kloner
    457 schema:givenName Robert A.
    458 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156126366.97
    459 rdf:type schema:Person
    460 sg:person.011574135302.77 schema:affiliation grid-institutes:grid.42505.36
    461 schema:familyName Finch
    462 schema:givenName Caleb E.
    463 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011574135302.77
    464 rdf:type schema:Person
    465 sg:person.01161137362.27 schema:affiliation grid-institutes:grid.503253.2
    466 schema:familyName Agbulut
    467 schema:givenName Onnik
    468 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161137362.27
    469 rdf:type schema:Person
    470 sg:person.01161327342.12 schema:affiliation grid-institutes:grid.5608.b
    471 schema:familyName Ursini
    472 schema:givenName Fulvio
    473 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161327342.12
    474 rdf:type schema:Person
    475 sg:person.012224235521.99 schema:affiliation grid-institutes:grid.42505.36
    476 schema:familyName Lundquist
    477 schema:givenName Adam J.
    478 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012224235521.99
    479 rdf:type schema:Person
    480 sg:person.01227442542.62 schema:affiliation grid-institutes:grid.5608.b
    481 schema:familyName Maiorino
    482 schema:givenName Matilde
    483 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227442542.62
    484 rdf:type schema:Person
    485 sg:person.01241203466.53 schema:affiliation grid-institutes:grid.42505.36
    486 schema:familyName Warburton
    487 schema:givenName David
    488 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241203466.53
    489 rdf:type schema:Person
    490 sg:person.01274511475.11 schema:affiliation grid-institutes:None
    491 schema:familyName Rosenbaum
    492 schema:givenName Jean
    493 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274511475.11
    494 rdf:type schema:Person
    495 sg:person.01275671273.10 schema:affiliation grid-institutes:grid.7429.8
    496 schema:familyName Friguet
    497 schema:givenName Bertrand
    498 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275671273.10
    499 rdf:type schema:Person
    500 sg:person.01324450712.56 schema:affiliation grid-institutes:grid.86715.3d
    501 schema:familyName Cadet
    502 schema:givenName Jean
    503 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324450712.56
    504 rdf:type schema:Person
    505 sg:person.01353454532.42 schema:affiliation grid-institutes:grid.7429.8
    506 schema:familyName Li
    507 schema:givenName Zhenlin
    508 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353454532.42
    509 rdf:type schema:Person
    510 sg:person.01354431452.48 schema:affiliation grid-institutes:grid.418596.7
    511 schema:familyName Mechta-Grigoriou
    512 schema:givenName Fatima
    513 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354431452.48
    514 rdf:type schema:Person
    515 sg:person.01356263054.39 schema:affiliation grid-institutes:grid.418241.a
    516 schema:familyName Sennlaub
    517 schema:givenName Florian
    518 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356263054.39
    519 rdf:type schema:Person
    520 sg:person.014512332322.58 schema:affiliation grid-institutes:grid.462844.8
    521 schema:familyName Hirsch
    522 schema:givenName Etienne
    523 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014512332322.58
    524 rdf:type schema:Person
    525 sg:person.015554331142.09 schema:affiliation grid-institutes:grid.42505.36
    526 schema:familyName Cohen
    527 schema:givenName Pinchas
    528 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015554331142.09
    529 rdf:type schema:Person
    530 sg:person.0613112625.05 schema:affiliation grid-institutes:grid.463984.4
    531 schema:familyName Rébillard
    532 schema:givenName Amélie
    533 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613112625.05
    534 rdf:type schema:Person
    535 sg:person.0634526633.60 schema:affiliation grid-institutes:grid.503253.2
    536 schema:familyName Mariani
    537 schema:givenName Jean
    538 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634526633.60
    539 rdf:type schema:Person
    540 sg:person.0646167115.12 schema:affiliation grid-institutes:grid.462844.8
    541 schema:familyName Sauce
    542 schema:givenName Delphine
    543 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646167115.12
    544 rdf:type schema:Person
    545 sg:person.0651050210.11 schema:affiliation grid-institutes:grid.462143.6
    546 schema:familyName Bulteau
    547 schema:givenName Anne-Laure
    548 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651050210.11
    549 rdf:type schema:Person
    550 sg:person.0652543442.92 schema:affiliation grid-institutes:grid.42505.36
    551 schema:familyName Halliday
    552 schema:givenName Matthew R.
    553 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652543442.92
    554 rdf:type schema:Person
    555 sg:person.065703244.23 schema:affiliation grid-institutes:grid.410368.8
    556 schema:familyName Cillard
    557 schema:givenName Josiane
    558 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.065703244.23
    559 rdf:type schema:Person
    560 sg:person.0667244644.14 schema:affiliation grid-institutes:grid.42505.36
    561 schema:familyName Pike
    562 schema:givenName Christian J.
    563 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667244644.14
    564 rdf:type schema:Person
    565 sg:person.0706467510.50 schema:affiliation grid-institutes:grid.42505.36
    566 schema:familyName Pomatto
    567 schema:givenName Laura C. D.
    568 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706467510.50
    569 rdf:type schema:Person
    570 sg:person.0730301427.65 schema:affiliation grid-institutes:grid.413117.1
    571 schema:familyName Economides
    572 schema:givenName Christina
    573 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730301427.65
    574 rdf:type schema:Person
    575 sg:person.0731707076.11 schema:affiliation grid-institutes:grid.413117.1
    576 schema:familyName Cayce
    577 schema:givenName Rachael
    578 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731707076.11
    579 rdf:type schema:Person
    580 sg:person.0732762611.43 schema:affiliation grid-institutes:grid.42505.36
    581 schema:familyName Petzinger
    582 schema:givenName Giselle
    583 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732762611.43
    584 rdf:type schema:Person
    585 sg:person.0741451637.73 schema:affiliation grid-institutes:grid.503253.2
    586 schema:familyName Limon
    587 schema:givenName Isabelle
    588 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741451637.73
    589 rdf:type schema:Person
    590 sg:person.0746571476.49 schema:affiliation grid-institutes:grid.7429.8
    591 schema:familyName Rouis
    592 schema:givenName Mustapha
    593 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746571476.49
    594 rdf:type schema:Person
    595 sg:person.0764374023.90 schema:affiliation grid-institutes:grid.503253.2
    596 schema:familyName Neri
    597 schema:givenName Christian
    598 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764374023.90
    599 rdf:type schema:Person
    600 sg:person.0772476065.25 schema:affiliation grid-institutes:grid.5842.b
    601 schema:familyName Mericskay
    602 schema:givenName Mathias
    603 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772476065.25
    604 rdf:type schema:Person
    605 sg:pub.10.1007/978-3-0348-7460-1_19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017970709
    606 https://doi.org/10.1007/978-3-0348-7460-1_19
    607 rdf:type schema:CreativeWork
    608 sg:pub.10.1007/978-3-319-29716-3_19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001099636
    609 https://doi.org/10.1007/978-3-319-29716-3_19
    610 rdf:type schema:CreativeWork
    611 sg:pub.10.1007/bf00207507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012549146
    612 https://doi.org/10.1007/bf00207507
    613 rdf:type schema:CreativeWork
    614 sg:pub.10.1007/bf01244786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004050650
    615 https://doi.org/10.1007/bf01244786
    616 rdf:type schema:CreativeWork
    617 sg:pub.10.1007/bf01790099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023649409
    618 https://doi.org/10.1007/bf01790099
    619 rdf:type schema:CreativeWork
    620 sg:pub.10.1007/bf03032651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036248588
    621 https://doi.org/10.1007/bf03032651
    622 rdf:type schema:CreativeWork
    623 sg:pub.10.1007/s00018-015-2039-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003030546
    624 https://doi.org/10.1007/s00018-015-2039-3
    625 rdf:type schema:CreativeWork
    626 sg:pub.10.1007/s00198-006-0205-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1049224357
    627 https://doi.org/10.1007/s00198-006-0205-z
    628 rdf:type schema:CreativeWork
    629 sg:pub.10.1007/s002239900538 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039290480
    630 https://doi.org/10.1007/s002239900538
    631 rdf:type schema:CreativeWork
    632 sg:pub.10.1007/s00296-007-0452-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048314145
    633 https://doi.org/10.1007/s00296-007-0452-0
    634 rdf:type schema:CreativeWork
    635 sg:pub.10.1007/s00394-006-0641-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034023638
    636 https://doi.org/10.1007/s00394-006-0641-8
    637 rdf:type schema:CreativeWork
    638 sg:pub.10.1007/s00417-015-3094-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1033155207
    639 https://doi.org/10.1007/s00417-015-3094-z
    640 rdf:type schema:CreativeWork
    641 sg:pub.10.1007/s10557-016-6691-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044933139
    642 https://doi.org/10.1007/s10557-016-6691-0
    643 rdf:type schema:CreativeWork
    644 sg:pub.10.1007/s11010-006-9270-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1020315348
    645 https://doi.org/10.1007/s11010-006-9270-z
    646 rdf:type schema:CreativeWork
    647 sg:pub.10.1007/s11033-012-2123-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035244201
    648 https://doi.org/10.1007/s11033-012-2123-9
    649 rdf:type schema:CreativeWork
    650 sg:pub.10.1007/s11914-015-0292-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006901294
    651 https://doi.org/10.1007/s11914-015-0292-x
    652 rdf:type schema:CreativeWork
    653 sg:pub.10.1007/s12566-012-0029-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016213747
    654 https://doi.org/10.1007/s12566-012-0029-6
    655 rdf:type schema:CreativeWork
    656 sg:pub.10.1007/s13277-013-1560-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1008200197
    657 https://doi.org/10.1007/s13277-013-1560-y
    658 rdf:type schema:CreativeWork
    659 sg:pub.10.1007/s40279-016-0566-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050887703
    660 https://doi.org/10.1007/s40279-016-0566-1
    661 rdf:type schema:CreativeWork
    662 sg:pub.10.1038/334345a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052129772
    663 https://doi.org/10.1038/334345a0
    664 rdf:type schema:CreativeWork
    665 sg:pub.10.1038/35036221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018866968
    666 https://doi.org/10.1038/35036221
    667 rdf:type schema:CreativeWork
    668 sg:pub.10.1038/359843a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028884048
    669 https://doi.org/10.1038/359843a0
    670 rdf:type schema:CreativeWork
    671 sg:pub.10.1038/bjc.2011.423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048138150
    672 https://doi.org/10.1038/bjc.2011.423
    673 rdf:type schema:CreativeWork
    674 sg:pub.10.1038/cdd.2011.42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039166416
    675 https://doi.org/10.1038/cdd.2011.42
    676 rdf:type schema:CreativeWork
    677 sg:pub.10.1038/cddis.2016.105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033345780
    678 https://doi.org/10.1038/cddis.2016.105
    679 rdf:type schema:CreativeWork
    680 sg:pub.10.1038/jhg.2014.38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018513467
    681 https://doi.org/10.1038/jhg.2014.38
    682 rdf:type schema:CreativeWork
    683 sg:pub.10.1038/nature01658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019910253
    684 https://doi.org/10.1038/nature01658
    685 rdf:type schema:CreativeWork
    686 sg:pub.10.1038/nature15726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029461127
    687 https://doi.org/10.1038/nature15726
    688 rdf:type schema:CreativeWork
    689 sg:pub.10.1038/ncomms9583 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037508938
    690 https://doi.org/10.1038/ncomms9583
    691 rdf:type schema:CreativeWork
    692 sg:pub.10.1038/ncomms9959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027412191
    693 https://doi.org/10.1038/ncomms9959
    694 rdf:type schema:CreativeWork
    695 sg:pub.10.1038/ncpcardio1211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053591814
    696 https://doi.org/10.1038/ncpcardio1211
    697 rdf:type schema:CreativeWork
    698 sg:pub.10.1038/ng0194-29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044395319
    699 https://doi.org/10.1038/ng0194-29
    700 rdf:type schema:CreativeWork
    701 sg:pub.10.1038/ng2033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047923424
    702 https://doi.org/10.1038/ng2033
    703 rdf:type schema:CreativeWork
    704 sg:pub.10.1038/nm.2512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027416078
    705 https://doi.org/10.1038/nm.2512
    706 rdf:type schema:CreativeWork
    707 sg:pub.10.1038/nm.3459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017854633
    708 https://doi.org/10.1038/nm.3459
    709 rdf:type schema:CreativeWork
    710 sg:pub.10.1038/nm.4222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022273867
    711 https://doi.org/10.1038/nm.4222
    712 rdf:type schema:CreativeWork
    713 sg:pub.10.1038/nrc2694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046607600
    714 https://doi.org/10.1038/nrc2694
    715 rdf:type schema:CreativeWork
    716 sg:pub.10.1038/nrd4002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005500014
    717 https://doi.org/10.1038/nrd4002
    718 rdf:type schema:CreativeWork
    719 sg:pub.10.1038/s41598-017-12024-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1091665810
    720 https://doi.org/10.1038/s41598-017-12024-z
    721 rdf:type schema:CreativeWork
    722 sg:pub.10.1038/sj.bjc.6604821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038562100
    723 https://doi.org/10.1038/sj.bjc.6604821
    724 rdf:type schema:CreativeWork
    725 sg:pub.10.1038/tp.2016.280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083396828
    726 https://doi.org/10.1038/tp.2016.280
    727 rdf:type schema:CreativeWork
    728 sg:pub.10.1186/1423-0127-21-23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040159435
    729 https://doi.org/10.1186/1423-0127-21-23
    730 rdf:type schema:CreativeWork
    731 sg:pub.10.1186/1468-6708-6-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038331684
    732 https://doi.org/10.1186/1468-6708-6-12
    733 rdf:type schema:CreativeWork
    734 sg:pub.10.1186/1471-2415-10-31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032215433
    735 https://doi.org/10.1186/1471-2415-10-31
    736 rdf:type schema:CreativeWork
    737 sg:pub.10.1186/1471-2474-8-124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030426900
    738 https://doi.org/10.1186/1471-2474-8-124
    739 rdf:type schema:CreativeWork
    740 sg:pub.10.1186/1742-2094-9-221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046575601
    741 https://doi.org/10.1186/1742-2094-9-221
    742 rdf:type schema:CreativeWork
    743 sg:pub.10.1186/1756-9966-29-157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000220313
    744 https://doi.org/10.1186/1756-9966-29-157
    745 rdf:type schema:CreativeWork
    746 sg:pub.10.1186/s13075-016-1154-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016730965
    747 https://doi.org/10.1186/s13075-016-1154-3
    748 rdf:type schema:CreativeWork
    749 grid-institutes:None schema:alternateName Lipid peroxidation, Signalling and Vascular Diseases INSERM U1048, 31432, Toulouse Cedex 4, France
    750 Scientific Service of the Embassy of France in the USA, Consulate General of France in Los Angeles, 90025, Los Angeles, CA, USA
    751 schema:name Lipid peroxidation, Signalling and Vascular Diseases INSERM U1048, 31432, Toulouse Cedex 4, France
    752 Scientific Service of the Embassy of France in the USA, Consulate General of France in Los Angeles, 90025, Los Angeles, CA, USA
    753 rdf:type schema:Organization
    754 grid-institutes:grid.280933.3 schema:alternateName Huntington Medical Research Institutes, 91105, Pasadena, CA, USA
    755 schema:name Huntington Medical Research Institutes, 91105, Pasadena, CA, USA
    756 rdf:type schema:Organization
    757 grid-institutes:grid.410368.8 schema:alternateName Lab de Biologie Cellulaire et Végétale, Faculté de Pharmacie, Université de Rennes, 35043, Rennes Cedex, France
    758 schema:name Lab de Biologie Cellulaire et Végétale, Faculté de Pharmacie, Université de Rennes, 35043, Rennes Cedex, France
    759 rdf:type schema:Organization
    760 grid-institutes:grid.413117.1 schema:alternateName Department of Oncology & Hematology, Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA
    761 Department of Radiation Oncology, Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA
    762 Los Angeles Cardiology Associates, Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA
    763 The Medical Group, Internal Medicine, Rheumatology & Osteoporosis, Dermatology, Pulmonology, Ophthalmology, and Cardiology; the Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA
    764 schema:name Department of Oncology & Hematology, Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA
    765 Department of Radiation Oncology, Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA
    766 Los Angeles Cardiology Associates, Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA
    767 The Medical Group, Internal Medicine, Rheumatology & Osteoporosis, Dermatology, Pulmonology, Ophthalmology, and Cardiology; the Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA
    768 rdf:type schema:Organization
    769 grid-institutes:grid.418241.a schema:alternateName INSERM Equipe 14 Institut de la Vision, 75012, Paris, France
    770 schema:name INSERM Equipe 14 Institut de la Vision, 75012, Paris, France
    771 rdf:type schema:Organization
    772 grid-institutes:grid.418596.7 schema:alternateName Stress and Cancer Laboratory, Institut Curie-Inserm U830, 75248, Paris Cedex 05, France
    773 schema:name Stress and Cancer Laboratory, Institut Curie-Inserm U830, 75248, Paris Cedex 05, France
    774 rdf:type schema:Organization
    775 grid-institutes:grid.42505.36 schema:alternateName Department of Biochemistry & Molecular Medicine, Keck School of Medicine of USC, University of Southern California, 90033, Los Angeles, CA, USA
    776 Department of Neurology, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA
    777 Department of Pediatrics, Keck School of Medicine of USC, University of Southern California, 90033, Los Angeles, CA, USA
    778 Division of Molecular & Computational Biology, Department of Biological Sciences of the Dornsife College of Letters, Arts, and Sciences, University of Southern California, 90089-0191, Los Angeles, CA, USA
    779 Division of Neurobiology, Department of Biological Sciences of the Dornsife College of Letters, Arts, and Sciences, University of Southern California, 90089-0191, Los Angeles, CA, USA
    780 Keck School of Medicine of USC, University of Southern California, 90033, Los Angeles, CA, USA
    781 Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, 90089-0191, Los Angeles, CA, USA
    782 schema:name Children’s Hospital of Los Angeles, Developmental Biology, Regenerative Medicine and Stem Cell Therapeutics program and the Center for Environmental Impact on Global Health Across the Lifespan at The Saban Research Institute, 90027, Los Angeles, CA, USA
    783 Department of Biochemistry & Molecular Medicine, Keck School of Medicine of USC, University of Southern California, 90033, Los Angeles, CA, USA
    784 Department of Neurology, Keck School of Medicine, University of Southern California, 90033, Los Angeles, CA, USA
    785 Department of Pediatrics, Keck School of Medicine of USC, University of Southern California, 90033, Los Angeles, CA, USA
    786 Division of Molecular & Computational Biology, Department of Biological Sciences of the Dornsife College of Letters, Arts, and Sciences, University of Southern California, 90089-0191, Los Angeles, CA, USA
    787 Division of Neurobiology, Department of Biological Sciences of the Dornsife College of Letters, Arts, and Sciences, University of Southern California, 90089-0191, Los Angeles, CA, USA
    788 Keck School of Medicine of USC, University of Southern California, 90033, Los Angeles, CA, USA
    789 Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, University of Southern California, 90089-0191, Los Angeles, CA, USA
    790 Los Angeles Cardiology Associates, Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA
    791 School of Pharmacy, University of Southern California, 90089-9121, Los Angeles, CA, USA
    792 The Medical Group, Internal Medicine, Rheumatology & Osteoporosis, Dermatology, Pulmonology, Ophthalmology, and Cardiology; the Hospital of the Good Samaritan, 90017, Los Angeles, CA, USA
    793 rdf:type schema:Organization
    794 grid-institutes:grid.462143.6 schema:alternateName Institut de Génomique Fonctionnelle de Lyon,ENS de Lyon, CNRS, 69364, Lyon Cedex 07, France
    795 schema:name Institut de Génomique Fonctionnelle de Lyon,ENS de Lyon, CNRS, 69364, Lyon Cedex 07, France
    796 rdf:type schema:Organization
    797 grid-institutes:grid.462844.8 schema:alternateName Chronic infections and Immune ageing, INSERM U1135, Hopital Pitie-Salpetriere, Pierre et Marie Curie University, 75013, Paris, France
    798 DR Saint-Antoine UMR_S938, UPMC, Inserm Faculté de Médecine, Université Pierre et Marie Curie, 75012, Paris, France
    799 INSERM UMR 1127-CNRS UMR 7225, Institut du cerveau et de la moelle épinière-ICM Thérapeutique Expérimentale de la Maladie de Parkinson, Université Pierre et Marie Curie, 75651, Paris Cedex 13, France
    800 schema:name Chronic infections and Immune ageing, INSERM U1135, Hopital Pitie-Salpetriere, Pierre et Marie Curie University, 75013, Paris, France
    801 DR Saint-Antoine UMR_S938, UPMC, Inserm Faculté de Médecine, Université Pierre et Marie Curie, 75012, Paris, France
    802 INSERM UMR 1127-CNRS UMR 7225, Institut du cerveau et de la moelle épinière-ICM Thérapeutique Expérimentale de la Maladie de Parkinson, Université Pierre et Marie Curie, 75651, Paris Cedex 13, France
    803 rdf:type schema:Organization
    804 grid-institutes:grid.463984.4 schema:alternateName Laboratory for Movement, Sport and Health Sciences-EA 1274, M2S, Université de Rennes 2-ENS, Bruz, 35170, Rennes, France
    805 schema:name Laboratory for Movement, Sport and Health Sciences-EA 1274, M2S, Université de Rennes 2-ENS, Bruz, 35170, Rennes, France
    806 rdf:type schema:Organization
    807 grid-institutes:grid.503253.2 schema:alternateName Institut de Biologie Paris-Seine (IBPS), UMR CNRS 8256, Biological Adaptation and Ageing, Sorbonne Universités, UPMC Univ Paris 06, 75005, Paris, France
    808 schema:name Institut de Biologie Paris-Seine (IBPS), UMR CNRS 8256, Biological Adaptation and Ageing, Sorbonne Universités, UPMC Univ Paris 06, 75005, Paris, France
    809 rdf:type schema:Organization
    810 grid-institutes:grid.5608.b schema:alternateName Department of Molecular Medicine, University of Padova, 35121, Padova, Italy
    811 schema:name Department of Molecular Medicine, University of Padova, 35121, Padova, Italy
    812 rdf:type schema:Organization
    813 grid-institutes:grid.5842.b schema:alternateName Laboratoire de Signalisation et Physiopathologie Cardiovasculaire-Inserm UMR-S 1180, Faculté de Pharmacie, Université Paris-Sud, 92296 Châtenay-Malabry, Paris, France
    814 schema:name Laboratoire de Signalisation et Physiopathologie Cardiovasculaire-Inserm UMR-S 1180, Faculté de Pharmacie, Université Paris-Sud, 92296 Châtenay-Malabry, Paris, France
    815 rdf:type schema:Organization
    816 grid-institutes:grid.7429.8 schema:alternateName INSERM ERL U1164, 75005, Paris, France
    817 schema:name INSERM ERL U1164, 75005, Paris, France
    818 Institut de Biologie Paris-Seine (IBPS), UMR CNRS 8256, Biological Adaptation and Ageing, Sorbonne Universités, UPMC Univ Paris 06, 75005, Paris, France
    819 rdf:type schema:Organization
    820 grid-institutes:grid.86715.3d schema:alternateName Département de Médecine nucléaire et Radiobiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, J1H 5N4, Sherbrooke, Québec, Canada
    821 schema:name Département de Médecine nucléaire et Radiobiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, J1H 5N4, Sherbrooke, Québec, Canada
    822 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...