Skin aging modulates percutaneous drug absorption: the impact of ultraviolet irradiation and ovariectomy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-04

AUTHORS

Chi-Feng Hung, Wei-Yu Chen, Ibrahim A. Aljuffali, Yin-Ku Lin, Hui-Chi Shih, Jia-You Fang

ABSTRACT

Ultraviolet (UV) exposure and menopause are known as the inducers of damage to the skin structure. The combination of these two factors accelerates the skin aging process. In this study, we aimed to evaluate the influence of UV and ovariectomy (OVX) on the permeation of drugs through the skin. The role of tight junctions (TJs) and adherens junctions (AJs) in the cutaneous absorption of extremely lipophilic permeants and macromolecules was explored. The OVX nude mouse underwent bilateral ovary removal. Both UVA and UVB were employed to irradiate the skin. The physiological and biochemical changes of the skin structure were examined with focus on transepidermal water loss (TEWL), skin color, immunohistochemistry, and mRNA levels of proteins. UVB and OVX increased TEWL, resulting in stratum corneum (SC) integrity disruption and dehydration. A hyperproliferative epidermis was produced by UVB. UVA caused a pale skin color tone due to keratinocyte apoptosis in the epidermis. E-cadherin and β-catenin showed a significant loss by both UVA and UVB. OVX downregulated the expression of filaggrin and involucrin. A further reduction was observed when UV and OVX were combined. The in vitro cutaneous absorption demonstrated that UV increased the skin permeation of tretinoin by about twofold. However, skin accumulation and flux of estradiol were not modified by photoaging. OVX basically revealed a negligible effect on altering the permeation of small permeants. OVX increased tretinoin uptake by the appendages from 1.36 to 3.52 μg/cm(2). A synergistic effect on tretinoin follicular uptake enhancement was observed for combined UV and OVX. However, the intervention of OVX to photoaged skin resulted in less macromolecule (dextran, molecular weight = 4 kDa) accumulation in the skin reservoir because of retarded partitioning into dry skin. The in vivo percutaneous absorption of lipophilic dye examined by confocal microscopy had indicated that the SC was still important to controlling topical delivery, although the role of epidermal junctions could not be simply ignored. More... »

PAGES

21

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11357-015-9757-1

DOI

http://dx.doi.org/10.1007/s11357-015-9757-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004036209

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25721687


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adherens Junctions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorimetry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Environmental Exposure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme-Linked Immunosorbent Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Menopause", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovariectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin Aging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tight Junctions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tretinoin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ultraviolet Rays", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Water Loss, Insensible", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Fu Jen Catholic University", 
          "id": "https://www.grid.ac/institutes/grid.256105.5", 
          "name": [
            "School of Medicine, Fu Jen Catholic University, Hsinchuang, New Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hung", 
        "givenName": "Chi-Feng", 
        "id": "sg:person.01137645717.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137645717.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Taipei Medical University", 
          "id": "https://www.grid.ac/institutes/grid.412896.0", 
          "name": [
            "Department of Pathology, College of Medicine, Taipei Medical University, Taipei, Taiwan", 
            "Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Wei-Yu", 
        "id": "sg:person.01247023755.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247023755.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "King Saud University", 
          "id": "https://www.grid.ac/institutes/grid.56302.32", 
          "name": [
            "Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aljuffali", 
        "givenName": "Ibrahim A.", 
        "id": "sg:person.01314541352.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314541352.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chang Gung University", 
          "id": "https://www.grid.ac/institutes/grid.145695.a", 
          "name": [
            "Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan", 
            "School of Traditional Chinese Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Yin-Ku", 
        "id": "sg:person.01364467140.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364467140.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chang Gung University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.418428.3", 
          "name": [
            "Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, 259 Wen-Hwa 1st Road, Kweishan, Taoyuan, Taiwan", 
            "Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shih", 
        "givenName": "Hui-Chi", 
        "id": "sg:person.01330434616.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330434616.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chang Gung University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.418428.3", 
          "name": [
            "Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, 259 Wen-Hwa 1st Road, Kweishan, Taoyuan, Taiwan", 
            "Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Kweishan, Taoyuan, Taiwan", 
            "Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fang", 
        "givenName": "Jia-You", 
        "id": "sg:person.0617150155.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617150155.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1159/000288163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000905254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ars.2012.5149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001949412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejpb.2008.11.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002143977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00128071-200910020-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004873633", 
          "https://doi.org/10.2165/00128071-200910020-00001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1467-2494.2004.00241.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005894725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005992506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2012.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006802090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00403-007-0817-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007024311", 
          "https://doi.org/10.1007/s00403-007-0817-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00403-007-0817-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007024311", 
          "https://doi.org/10.1007/s00403-007-0817-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.0022-202x.2005.23779.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007201964", 
          "https://doi.org/10.1111/j.0022-202x.2005.23779.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/13697137.2012.669624", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010509111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jid.2010.385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013837244", 
          "https://doi.org/10.1038/jid.2010.385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaad.2005.06.052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015524690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2012.01.068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016646077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/ijgm.s4336", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017165572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.2009.09342.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017735609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.2009.09342.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017735609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10103-012-1257-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020326749", 
          "https://doi.org/10.1007/s10103-012-1257-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.jid.5700865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020369335", 
          "https://doi.org/10.1038/sj.jid.5700865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1747.2000.00103.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020747810", 
          "https://doi.org/10.1046/j.1523-1747.2000.00103.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/bpb.28.2302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022291315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/bpb.28.2302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022291315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1110813", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023026651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.201212140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023133950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/bpb.b12-00793", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025655039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jdermsci.2012.09.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026636698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/09513590.2011.613970", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028583561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-4725.2005.31731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030028414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jdermsci.2006.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031839931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11095-012-0946-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032110173", 
          "https://doi.org/10.1007/s11095-012-0946-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112.353151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033314178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.det.2006.01.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036397753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0378-5173(00)00669-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036474743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/11530210-000000000-00000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037055607", 
          "https://doi.org/10.2165/11530210-000000000-00000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/11530210-000000000-00000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037055607", 
          "https://doi.org/10.2165/11530210-000000000-00000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0625.2008.00786.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039542095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00266-012-9903-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039842961", 
          "https://doi.org/10.1007/s00266-012-9903-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsbmb.2007.07.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043516230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.2004.06203.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048214085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejcb.2010.07.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051401403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1258/175404507780796325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064536333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1258/175404507780796325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064536333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/15672050113109990202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069188140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078344943", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078803708", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-04", 
    "datePublishedReg": "2015-04-01", 
    "description": "Ultraviolet (UV) exposure and menopause are known as the inducers of damage to the skin structure. The combination of these two factors accelerates the skin aging process. In this study, we aimed to evaluate the influence of UV and ovariectomy (OVX) on the permeation of drugs through the skin. The role of tight junctions (TJs) and adherens junctions (AJs) in the cutaneous absorption of extremely lipophilic permeants and macromolecules was explored. The OVX nude mouse underwent bilateral ovary removal. Both UVA and UVB were employed to irradiate the skin. The physiological and biochemical changes of the skin structure were examined with focus on transepidermal water loss (TEWL), skin color, immunohistochemistry, and mRNA levels of proteins. UVB and OVX increased TEWL, resulting in stratum corneum (SC) integrity disruption and dehydration. A hyperproliferative epidermis was produced by UVB. UVA caused a pale skin color tone due to keratinocyte apoptosis in the epidermis. E-cadherin and \u03b2-catenin showed a significant loss by both UVA and UVB. OVX downregulated the expression of filaggrin and involucrin. A further reduction was observed when UV and OVX were combined. The in vitro cutaneous absorption demonstrated that UV increased the skin permeation of tretinoin by about twofold. However, skin accumulation and flux of estradiol were not modified by photoaging. OVX basically revealed a negligible effect on altering the permeation of small permeants. OVX increased tretinoin uptake by the appendages from 1.36 to 3.52 \u03bcg/cm(2). A synergistic effect on tretinoin follicular uptake enhancement was observed for combined UV and OVX. However, the intervention of OVX to photoaged skin resulted in less macromolecule (dextran, molecular weight\u2009=\u20094 kDa) accumulation in the skin reservoir because of retarded partitioning into dry skin. The in vivo percutaneous absorption of lipophilic dye examined by confocal microscopy had indicated that the SC was still important to controlling topical delivery, although the role of epidermal junctions could not be simply ignored.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11357-015-9757-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1023731", 
        "issn": [
          "2509-2715", 
          "2509-2723"
        ], 
        "name": "GeroScience", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "37"
      }
    ], 
    "name": "Skin aging modulates percutaneous drug absorption: the impact of ultraviolet irradiation and ovariectomy", 
    "pagination": "21", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "133b0b42fca19674557951e3bfb542cf502720a854b67a7d8b1054cf148d4efe"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25721687"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101250497"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11357-015-9757-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004036209"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11357-015-9757-1", 
      "https://app.dimensions.ai/details/publication/pub.1004036209"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000520.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11357-015-9757-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11357-015-9757-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11357-015-9757-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11357-015-9757-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11357-015-9757-1'


 

This table displays all metadata directly associated to this object as RDF triples.

317 TRIPLES      21 PREDICATES      86 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11357-015-9757-1 schema:about N02e72721fb274a66a5d95b1df867623a
2 N19b08bda097f4211b162f87541a413b9
3 N2e2c0a6d5d0746cb869fdd5ec19ad836
4 N31e10f55dd54495eb4ee54a58e28342e
5 N4a6c4523916043d4b2cdacec11317ebd
6 N4c6f109875064da9991e9d87ccd03c5c
7 N59eedd31911f46bc819ef058c14bfb3d
8 N660023ce30ff4839b1b8cfd2dbf54634
9 N78ca9fbafdb94390bade7ea4aeb2316b
10 N7b5257eebd5d42658029557654f89be2
11 N82ee99fa24f9451889316a8966958eb6
12 Nb0e56a0246e3472a9965698c50c4ad5a
13 Ncd3c64b270b84762ba22f965af65b870
14 Ndc7af736c6c742a38d299a30345ddeae
15 Ne444e161d47546bc8aa568071865c0c8
16 Ne5a125244b874e0f9dc59c357d52d770
17 Nf08d0b69562044cea15f9e9f0dabb779
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author N9d7343ae56e842f9b1ea577009b86b9f
21 schema:citation sg:pub.10.1007/s00266-012-9903-4
22 sg:pub.10.1007/s00403-007-0817-y
23 sg:pub.10.1007/s10103-012-1257-2
24 sg:pub.10.1007/s11095-012-0946-7
25 sg:pub.10.1038/jid.2010.385
26 sg:pub.10.1038/sj.jid.5700865
27 sg:pub.10.1046/j.1523-1747.2000.00103.x
28 sg:pub.10.1111/j.0022-202x.2005.23779.x
29 sg:pub.10.2165/00128071-200910020-00001
30 sg:pub.10.2165/11530210-000000000-00000
31 https://app.dimensions.ai/details/publication/pub.1078344943
32 https://app.dimensions.ai/details/publication/pub.1078803708
33 https://doi.org/10.1016/j.ajpath.2012.06.005
34 https://doi.org/10.1016/j.det.2006.01.012
35 https://doi.org/10.1016/j.ejcb.2010.07.010
36 https://doi.org/10.1016/j.ejpb.2008.11.001
37 https://doi.org/10.1016/j.jaad.2005.06.052
38 https://doi.org/10.1016/j.jaci.2012.01.068
39 https://doi.org/10.1016/j.jdermsci.2006.06.003
40 https://doi.org/10.1016/j.jdermsci.2012.09.005
41 https://doi.org/10.1016/j.jsbmb.2007.07.004
42 https://doi.org/10.1016/s0378-5173(00)00669-4
43 https://doi.org/10.1038/sj.emboj.7600605
44 https://doi.org/10.1056/nejmoa1110813
45 https://doi.org/10.1074/jbc.m112.353151
46 https://doi.org/10.1083/jcb.201212140
47 https://doi.org/10.1089/ars.2012.5149
48 https://doi.org/10.1111/j.1365-2133.2004.06203.x
49 https://doi.org/10.1111/j.1365-2133.2009.09342.x
50 https://doi.org/10.1111/j.1467-2494.2004.00241.x
51 https://doi.org/10.1111/j.1524-4725.2005.31731
52 https://doi.org/10.1111/j.1600-0625.2008.00786.x
53 https://doi.org/10.1159/000288163
54 https://doi.org/10.1248/bpb.28.2302
55 https://doi.org/10.1248/bpb.b12-00793
56 https://doi.org/10.1258/175404507780796325
57 https://doi.org/10.2147/ijgm.s4336
58 https://doi.org/10.2174/15672050113109990202
59 https://doi.org/10.3109/09513590.2011.613970
60 https://doi.org/10.3109/13697137.2012.669624
61 schema:datePublished 2015-04
62 schema:datePublishedReg 2015-04-01
63 schema:description Ultraviolet (UV) exposure and menopause are known as the inducers of damage to the skin structure. The combination of these two factors accelerates the skin aging process. In this study, we aimed to evaluate the influence of UV and ovariectomy (OVX) on the permeation of drugs through the skin. The role of tight junctions (TJs) and adherens junctions (AJs) in the cutaneous absorption of extremely lipophilic permeants and macromolecules was explored. The OVX nude mouse underwent bilateral ovary removal. Both UVA and UVB were employed to irradiate the skin. The physiological and biochemical changes of the skin structure were examined with focus on transepidermal water loss (TEWL), skin color, immunohistochemistry, and mRNA levels of proteins. UVB and OVX increased TEWL, resulting in stratum corneum (SC) integrity disruption and dehydration. A hyperproliferative epidermis was produced by UVB. UVA caused a pale skin color tone due to keratinocyte apoptosis in the epidermis. E-cadherin and β-catenin showed a significant loss by both UVA and UVB. OVX downregulated the expression of filaggrin and involucrin. A further reduction was observed when UV and OVX were combined. The in vitro cutaneous absorption demonstrated that UV increased the skin permeation of tretinoin by about twofold. However, skin accumulation and flux of estradiol were not modified by photoaging. OVX basically revealed a negligible effect on altering the permeation of small permeants. OVX increased tretinoin uptake by the appendages from 1.36 to 3.52 μg/cm(2). A synergistic effect on tretinoin follicular uptake enhancement was observed for combined UV and OVX. However, the intervention of OVX to photoaged skin resulted in less macromolecule (dextran, molecular weight = 4 kDa) accumulation in the skin reservoir because of retarded partitioning into dry skin. The in vivo percutaneous absorption of lipophilic dye examined by confocal microscopy had indicated that the SC was still important to controlling topical delivery, although the role of epidermal junctions could not be simply ignored.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree true
67 schema:isPartOf N5225e15b913b43d99ff602c92b14c1b0
68 N618cb7250d034dbb89a12c0aff792aad
69 sg:journal.1023731
70 schema:name Skin aging modulates percutaneous drug absorption: the impact of ultraviolet irradiation and ovariectomy
71 schema:pagination 21
72 schema:productId N80c183883ebb406c8b1b7c2b2e20a0b2
73 N85fedf76d4124a148c0d359a1eb8c4e1
74 N9626c20e98604f99a1f7efb52af2f5ca
75 Nb6cca92ef87a4819ace5b8e363eca413
76 Ndf1f5e5a870b4aeebe289b92e0f3dd01
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004036209
78 https://doi.org/10.1007/s11357-015-9757-1
79 schema:sdDatePublished 2019-04-10T14:11
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N6e3a549681fe4f9c9feb9bb76044200d
82 schema:url http://link.springer.com/10.1007%2Fs11357-015-9757-1
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N02e72721fb274a66a5d95b1df867623a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Ovariectomy
88 rdf:type schema:DefinedTerm
89 N18ca51c4ecb94926b382767a7ac90a32 rdf:first sg:person.01330434616.14
90 rdf:rest N343578f3e4d54b4392f5eb8f2771c57b
91 N19b08bda097f4211b162f87541a413b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Female
93 rdf:type schema:DefinedTerm
94 N2e2c0a6d5d0746cb869fdd5ec19ad836 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Skin
96 rdf:type schema:DefinedTerm
97 N31e10f55dd54495eb4ee54a58e28342e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Skin Aging
99 rdf:type schema:DefinedTerm
100 N343578f3e4d54b4392f5eb8f2771c57b rdf:first sg:person.0617150155.43
101 rdf:rest rdf:nil
102 N4a6c4523916043d4b2cdacec11317ebd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Tretinoin
104 rdf:type schema:DefinedTerm
105 N4c6f109875064da9991e9d87ccd03c5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Mice
107 rdf:type schema:DefinedTerm
108 N5225e15b913b43d99ff602c92b14c1b0 schema:issueNumber 2
109 rdf:type schema:PublicationIssue
110 N59eedd31911f46bc819ef058c14bfb3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Adherens Junctions
112 rdf:type schema:DefinedTerm
113 N618cb7250d034dbb89a12c0aff792aad schema:volumeNumber 37
114 rdf:type schema:PublicationVolume
115 N660023ce30ff4839b1b8cfd2dbf54634 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Reverse Transcriptase Polymerase Chain Reaction
117 rdf:type schema:DefinedTerm
118 N6e3a549681fe4f9c9feb9bb76044200d schema:name Springer Nature - SN SciGraph project
119 rdf:type schema:Organization
120 N78ca9fbafdb94390bade7ea4aeb2316b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Tight Junctions
122 rdf:type schema:DefinedTerm
123 N7b5257eebd5d42658029557654f89be2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Colorimetry
125 rdf:type schema:DefinedTerm
126 N80c183883ebb406c8b1b7c2b2e20a0b2 schema:name doi
127 schema:value 10.1007/s11357-015-9757-1
128 rdf:type schema:PropertyValue
129 N82ee99fa24f9451889316a8966958eb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Mice, Nude
131 rdf:type schema:DefinedTerm
132 N85fedf76d4124a148c0d359a1eb8c4e1 schema:name dimensions_id
133 schema:value pub.1004036209
134 rdf:type schema:PropertyValue
135 N9626c20e98604f99a1f7efb52af2f5ca schema:name nlm_unique_id
136 schema:value 101250497
137 rdf:type schema:PropertyValue
138 N9d7343ae56e842f9b1ea577009b86b9f rdf:first sg:person.01137645717.03
139 rdf:rest N9f3b32581786430f96894350476be2d4
140 N9f3b32581786430f96894350476be2d4 rdf:first sg:person.01247023755.43
141 rdf:rest Nec8e964751ac4815915f85b826abfbb1
142 Nb0e56a0246e3472a9965698c50c4ad5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Environmental Exposure
144 rdf:type schema:DefinedTerm
145 Nb6cca92ef87a4819ace5b8e363eca413 schema:name readcube_id
146 schema:value 133b0b42fca19674557951e3bfb542cf502720a854b67a7d8b1054cf148d4efe
147 rdf:type schema:PropertyValue
148 Ncd3c64b270b84762ba22f965af65b870 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Enzyme-Linked Immunosorbent Assay
150 rdf:type schema:DefinedTerm
151 Ndc7af736c6c742a38d299a30345ddeae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Ultraviolet Rays
153 rdf:type schema:DefinedTerm
154 Ndf1f5e5a870b4aeebe289b92e0f3dd01 schema:name pubmed_id
155 schema:value 25721687
156 rdf:type schema:PropertyValue
157 Ne444e161d47546bc8aa568071865c0c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Water Loss, Insensible
159 rdf:type schema:DefinedTerm
160 Ne4716044fb40449fad12e0a8bea98c77 rdf:first sg:person.01364467140.67
161 rdf:rest N18ca51c4ecb94926b382767a7ac90a32
162 Ne5a125244b874e0f9dc59c357d52d770 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Menopause
164 rdf:type schema:DefinedTerm
165 Nec8e964751ac4815915f85b826abfbb1 rdf:first sg:person.01314541352.84
166 rdf:rest Ne4716044fb40449fad12e0a8bea98c77
167 Nf08d0b69562044cea15f9e9f0dabb779 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Animals
169 rdf:type schema:DefinedTerm
170 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
171 schema:name Medical and Health Sciences
172 rdf:type schema:DefinedTerm
173 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
174 schema:name Clinical Sciences
175 rdf:type schema:DefinedTerm
176 sg:journal.1023731 schema:issn 2509-2715
177 2509-2723
178 schema:name GeroScience
179 rdf:type schema:Periodical
180 sg:person.01137645717.03 schema:affiliation https://www.grid.ac/institutes/grid.256105.5
181 schema:familyName Hung
182 schema:givenName Chi-Feng
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137645717.03
184 rdf:type schema:Person
185 sg:person.01247023755.43 schema:affiliation https://www.grid.ac/institutes/grid.412896.0
186 schema:familyName Chen
187 schema:givenName Wei-Yu
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247023755.43
189 rdf:type schema:Person
190 sg:person.01314541352.84 schema:affiliation https://www.grid.ac/institutes/grid.56302.32
191 schema:familyName Aljuffali
192 schema:givenName Ibrahim A.
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314541352.84
194 rdf:type schema:Person
195 sg:person.01330434616.14 schema:affiliation https://www.grid.ac/institutes/grid.418428.3
196 schema:familyName Shih
197 schema:givenName Hui-Chi
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330434616.14
199 rdf:type schema:Person
200 sg:person.01364467140.67 schema:affiliation https://www.grid.ac/institutes/grid.145695.a
201 schema:familyName Lin
202 schema:givenName Yin-Ku
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364467140.67
204 rdf:type schema:Person
205 sg:person.0617150155.43 schema:affiliation https://www.grid.ac/institutes/grid.418428.3
206 schema:familyName Fang
207 schema:givenName Jia-You
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617150155.43
209 rdf:type schema:Person
210 sg:pub.10.1007/s00266-012-9903-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039842961
211 https://doi.org/10.1007/s00266-012-9903-4
212 rdf:type schema:CreativeWork
213 sg:pub.10.1007/s00403-007-0817-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1007024311
214 https://doi.org/10.1007/s00403-007-0817-y
215 rdf:type schema:CreativeWork
216 sg:pub.10.1007/s10103-012-1257-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020326749
217 https://doi.org/10.1007/s10103-012-1257-2
218 rdf:type schema:CreativeWork
219 sg:pub.10.1007/s11095-012-0946-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032110173
220 https://doi.org/10.1007/s11095-012-0946-7
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/jid.2010.385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013837244
223 https://doi.org/10.1038/jid.2010.385
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/sj.jid.5700865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020369335
226 https://doi.org/10.1038/sj.jid.5700865
227 rdf:type schema:CreativeWork
228 sg:pub.10.1046/j.1523-1747.2000.00103.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020747810
229 https://doi.org/10.1046/j.1523-1747.2000.00103.x
230 rdf:type schema:CreativeWork
231 sg:pub.10.1111/j.0022-202x.2005.23779.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007201964
232 https://doi.org/10.1111/j.0022-202x.2005.23779.x
233 rdf:type schema:CreativeWork
234 sg:pub.10.2165/00128071-200910020-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004873633
235 https://doi.org/10.2165/00128071-200910020-00001
236 rdf:type schema:CreativeWork
237 sg:pub.10.2165/11530210-000000000-00000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037055607
238 https://doi.org/10.2165/11530210-000000000-00000
239 rdf:type schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1078344943 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1078803708 schema:CreativeWork
242 https://doi.org/10.1016/j.ajpath.2012.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006802090
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/j.det.2006.01.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036397753
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.ejcb.2010.07.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051401403
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.ejpb.2008.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002143977
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.jaad.2005.06.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015524690
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.jaci.2012.01.068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016646077
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.jdermsci.2006.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031839931
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.jdermsci.2012.09.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026636698
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.jsbmb.2007.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043516230
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/s0378-5173(00)00669-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036474743
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1038/sj.emboj.7600605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005992506
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1056/nejmoa1110813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023026651
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1074/jbc.m112.353151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033314178
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1083/jcb.201212140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023133950
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1089/ars.2012.5149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001949412
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1111/j.1365-2133.2004.06203.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048214085
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1111/j.1365-2133.2009.09342.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017735609
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1111/j.1467-2494.2004.00241.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005894725
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1111/j.1524-4725.2005.31731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030028414
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1111/j.1600-0625.2008.00786.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039542095
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1159/000288163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000905254
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1248/bpb.28.2302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022291315
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1248/bpb.b12-00793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025655039
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1258/175404507780796325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064536333
289 rdf:type schema:CreativeWork
290 https://doi.org/10.2147/ijgm.s4336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017165572
291 rdf:type schema:CreativeWork
292 https://doi.org/10.2174/15672050113109990202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069188140
293 rdf:type schema:CreativeWork
294 https://doi.org/10.3109/09513590.2011.613970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028583561
295 rdf:type schema:CreativeWork
296 https://doi.org/10.3109/13697137.2012.669624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010509111
297 rdf:type schema:CreativeWork
298 https://www.grid.ac/institutes/grid.145695.a schema:alternateName Chang Gung University
299 schema:name Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan
300 School of Traditional Chinese Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan
301 rdf:type schema:Organization
302 https://www.grid.ac/institutes/grid.256105.5 schema:alternateName Fu Jen Catholic University
303 schema:name School of Medicine, Fu Jen Catholic University, Hsinchuang, New Taipei, Taiwan
304 rdf:type schema:Organization
305 https://www.grid.ac/institutes/grid.412896.0 schema:alternateName Taipei Medical University
306 schema:name Department of Pathology, College of Medicine, Taipei Medical University, Taipei, Taiwan
307 Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
308 rdf:type schema:Organization
309 https://www.grid.ac/institutes/grid.418428.3 schema:alternateName Chang Gung University of Science and Technology
310 schema:name Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Kweishan, Taoyuan, Taiwan
311 Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan
312 Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, 259 Wen-Hwa 1st Road, Kweishan, Taoyuan, Taiwan
313 Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan
314 rdf:type schema:Organization
315 https://www.grid.ac/institutes/grid.56302.32 schema:alternateName King Saud University
316 schema:name Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
317 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...