Protective role of antioxidants capacity of Hyrtiosaff. Erectus sponge extract against mixture of persistent organic pollutants (POPs)-induced hepatic toxicity in ... View Full Text


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Article Info

DATE

2017-08-08

AUTHORS

Nehad M. Abd El-Moneam, Mohamed A. Shreadah, Samy A. El-Assar, Asmaa Nabil-Adam

ABSTRACT

The current study investigates the hepatoprotective effect of Hyrtios aff. Erectus sponge extract against POPs intoxication on endogenous antioxidant enzymes and lipid peroxidation in mice liver tissue. In the present study, the mice BALB/C were assigned into four groups: group I: received saline subcutaneously for 7 days and served as negative control; group II: received subcutaneously for 7 days, 130.6 mg/100 g/b. w/day POPs mixture(mixture of PCB 28, PCB 52,, PCB 101, PCB 118, PCB 153, PCB 138 and PCB 180, alpha-Hexachlorocyclohexane, beta-Hexachloro-cyclohexane, gamma-hexachlorocyclohexane, Aldrin, O,P′-DDE, Dieldrin, P,p DDE, O,P DDD, Endrin, P,p DDD and P,pDDT were extracted from sediments collected from Lake Mariout), and served as induced group; group III: pretreated with Hyrtios aff. Erectus sponge extract for 7 days, as a protection dose and then treated with POPs as group II and served as protective group; and group IV: received i.p Hyrtios aff. Erectus sponge extract of dose 0.7 mg/100 g b.wt/day for 7 days and served as positive control. After 7 days (experimental period), mice were scarified and the liver was harvested for biochemical estimation. Significant reduction in lipid peroxidation (p < 0.002) was noticed compared to POPs-protected group. The antioxidant biomarkers levels were significantly increase as the hepatic GSH and GST increased by 69.9 and 89.9%, respectively. Such increase was accompanied by a decrease in tyrosine kinase activity by 59.82%, additionally remarkable histopathological changes in liver tissue indicate the protective effect of Hyrtios aff. Erectus sponge extract. The results of this study revealed that the Hyrtios aff. Erectus sponge extract has the potential to diminish the destructive effect of POPs intoxication through enhancement of the endogenous antioxidant status. The hepatoprotective activity of Hyrtios aff. Erectus sponge extract is mediated, by the antioxidant effect of its active constituents. The active constituents of Hyrtios aff. Erectus sponge extract were identified by LC-MS/MS. More... »

PAGES

22061-22072

References to SciGraph publications

  • 2007-06-30. Histopathological Effects of Dimethoate on Testes of Rats in BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • 2016-01-09. Reporting back environmental exposure data and free choice learning in ENVIRONMENTAL HEALTH
  • 2014-12-10. 2β-hydroxybetulinic acid 3β-caprylate: an active principle from Euryale Ferox Salisb. seeds with antidiabetic, antioxidant, pancreas & hepatoprotective potential in streptozotocin induced diabetic rats in JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
  • 2013-02-12. Anti-cancer potential of flavonoids: recent trends and future perspectives in 3 BIOTECH
  • 2004-03. Trace Metals in the Water Columns of the Red Sea and the Gulf of Aqaba, Egypt in WATER, AIR, & SOIL POLLUTION
  • 1984-12. Effects of zinc, copper, and lead toxicity on α-aminolevulinic acid dehydratase activity in BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • 2003. New Cancer Biomarkers Deriving from NCI Early Detection Research in TUMOR PREVENTION AND GENETICS
  • 2015-07-10. Epigenetic activities of flavonoids in the prevention and treatment of cancer in CLINICAL EPIGENETICS
  • 2016-02-10. Biological Activity of Japanese Quince Extract and Its Interactions with Lipids, Erythrocyte Membrane, and Human Albumin in THE JOURNAL OF MEMBRANE BIOLOGY
  • 2007-10-16. The interactions of flavonoids within neuronal signalling pathways in GENES & NUTRITION
  • 1998-11. Species and Organ Dependence of PCB Contamination in Fish, Foxes, Roe Deer, and Humans in ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • 2008-05-09. Organochlorine Contaminants in Water, Sediment and Fish of Lake Burullus, Egyptian Mediterranean Sea in BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • 2014-07-16. Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on streptozotocin induced diabetic rats in BMC COMPLEMENTARY MEDICINE AND THERAPIES
  • 2014-03-28. Hepatoprotective effect of curcumin and alpha-tocopherol against cisplatin-induced oxidative stress in BMC COMPLEMENTARY MEDICINE AND THERAPIES
  • 2010-11-13. Nigrostriatal neuronal death following chronic dichlorvos exposure: crosstalk between mitochondrial impairments, α synuclein aggregation, oxidative damage and behavioral changes in MOLECULAR BRAIN
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    http://scigraph.springernature.com/pub.10.1007/s11356-017-9805-8

    DOI

    http://dx.doi.org/10.1007/s11356-017-9805-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091105932

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28791578


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    33 schema:description The current study investigates the hepatoprotective effect of Hyrtios aff. Erectus sponge extract against POPs intoxication on endogenous antioxidant enzymes and lipid peroxidation in mice liver tissue. In the present study, the mice BALB/C were assigned into four groups: group I: received saline subcutaneously for 7 days and served as negative control; group II: received subcutaneously for 7 days, 130.6 mg/100 g/b. w/day POPs mixture(mixture of PCB 28, PCB 52,, PCB 101, PCB 118, PCB 153, PCB 138 and PCB 180, alpha-Hexachlorocyclohexane, beta-Hexachloro-cyclohexane, gamma-hexachlorocyclohexane, Aldrin, O,P′-DDE, Dieldrin, P,p DDE, O,P DDD, Endrin, P,p DDD and P,pDDT were extracted from sediments collected from Lake Mariout), and served as induced group; group III: pretreated with Hyrtios aff. Erectus sponge extract for 7 days, as a protection dose and then treated with POPs as group II and served as protective group; and group IV: received i.p Hyrtios aff. Erectus sponge extract of dose 0.7 mg/100 g b.wt/day for 7 days and served as positive control. After 7 days (experimental period), mice were scarified and the liver was harvested for biochemical estimation. Significant reduction in lipid peroxidation (p < 0.002) was noticed compared to POPs-protected group. The antioxidant biomarkers levels were significantly increase as the hepatic GSH and GST increased by 69.9 and 89.9%, respectively. Such increase was accompanied by a decrease in tyrosine kinase activity by 59.82%, additionally remarkable histopathological changes in liver tissue indicate the protective effect of Hyrtios aff. Erectus sponge extract. The results of this study revealed that the Hyrtios aff. Erectus sponge extract has the potential to diminish the destructive effect of POPs intoxication through enhancement of the endogenous antioxidant status. The hepatoprotective activity of Hyrtios aff. Erectus sponge extract is mediated, by the antioxidant effect of its active constituents. The active constituents of Hyrtios aff. Erectus sponge extract were identified by LC-MS/MS.
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