Cell cycle synchronization reveals greater G2/M-phase accumulation of lung epithelial cells exposed to titanium dioxide nanoparticles View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-11-26

AUTHORS

Estefany I. Medina-Reyes, Laura Bucio-López, Verónica Freyre-Fonseca, Yesennia Sánchez-Pérez, Claudia M. García-Cuéllar, Rocío Morales-Bárcenas, José Pedraza-Chaverri, Yolanda I. Chirino

ABSTRACT

Titanium dioxide has been classified in the 2B group as a possible human carcinogen by the International Agency for Research on Cancer, and amid concerns of its exposure, cell cycle alterations are an important one. However, several studies show inconclusive effects, mainly because it is difficult to compare cell cycle effects caused by TiO2 nanoparticle (NP) exposure between different shapes and sizes of NP, cell culture types, and time of exposure. In addition, cell cycle is frequently analyzed without cell cycle synchronization, which may also mask some effects. We hypothesized that synchronization after TiO2 NP exposure could reveal dissimilar cell cycle progression when compared with unsynchronized cell population. To test our hypothesis, we exposed lung epithelial cells to 1 and 10 μg/cm2 TiO2 NPs for 7 days and one population was synchronized by serum starvation and inhibition of ribonucleotide reductase using hydroxyurea. Another cell population was exposed to TiO2 NPs under the same experimental conditions, but after treatments, cell cycle was analyzed without synchronization. Our results showed that TiO2 NP-exposed cells without synchronization had no changes in cell cycle distribution; however, cell population synchronized after 1 and 10 μg/cm2 TiO2 NP treatment showed a 1.5-fold and 1.66-fold increase, respectively, in proliferation. Synchronized cells also reveal a faster capability of TiO2 NP-exposed cells to increase cell population in the G2/M phase in the following 9 h after synchronization. We conclude that synchronization discloses a greater percentage of cells in the G2/M phase and higher proliferation than TiO2 NP-synchronized cells. More... »

PAGES

3976-3982

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11356-014-3871-y

DOI

http://dx.doi.org/10.1007/s11356-014-3871-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011320010

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25422119


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