Diet associated with exercise improves baroreflex control of sympathetic nerve activity in metabolic syndrome and sleep apnea patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Edgar Toschi-Dias, Ivani C. Trombetta, Valdo J. D. Silva, Cristiane Maki-Nunes, Felipe X. Cepeda, Maria Janieire N. N. Alves, Glauce L. Carvalho, Luciano F. Drager, Geraldo Lorenzi-Filho, Carlos E. Negrão, Maria Urbana P. B. Rondon

ABSTRACT

PURPOSE: We tested the hypothesis that (i) diet associated with exercise would improve arterial baroreflex (ABR) control in metabolic syndrome (MetS) patients with and without obstructive sleep apnea (OSA) and (ii) the effects of this intervention would be more pronounced in patients with OSA. METHODS: Forty-six MetS patients without (noOSA) and with OSA (apnea-hypopnea index, AHI > 15 events/h) were allocated to no treatment (control, C) or hypocaloric diet (- 500 kcal/day) associated with exercise (40 min, bicycle exercise, 3 times/week) for 4 months (treatment, T), resulting in four groups: noOSA-C (n = 10), OSA-C (n = 12), noOSA-T (n = 13), and OSA-T (n = 11). Muscle sympathetic nerve activity (MSNA), beat-to-beat BP, and spontaneous arterial baroreflex function of MSNA (ABRMSNA, gain and time delay) were assessed at study entry and end. RESULTS: No significant changes occurred in C groups. In contrast, treatment in both patients with and without OSA led to a significant decrease in weight (P < 0.05) and the number of MetS factors (P = 0.03). AHI declined only in the OSA-T group (31 ± 5 to 17 ± 4 events/h, P < 0.05). Systolic BP decreased in both treatment groups, and diastolic BP decreased significantly only in the noOSA-T group. Treatment decreased MSNA in both groups. Compared with baseline, ABRMSNA gain increased in both OSA-T (13 ± 1 vs. 24 ± 2 a.u./mmHg, P = 0.01) and noOSA-T (27 ± 3 vs. 37 ± 3 a.u./mmHg, P = 0.03) groups. The time delay of ABRMSNA was reduced only in the OSA-T group (4.1 ± 0.2 s vs. 2.8 ± 0.3 s, P = 0.04). CONCLUSIONS: Diet associated with exercise improves baroreflex control of sympathetic nerve activity and MetS components in patients with MetS regardless of OSA. More... »

PAGES

143-151

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11325-018-1675-x

DOI

http://dx.doi.org/10.1007/s11325-018-1675-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104519393

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29948856


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    "description": "PURPOSE: We tested the hypothesis that (i) diet associated with exercise would improve arterial baroreflex (ABR) control in metabolic syndrome (MetS) patients with and without obstructive sleep apnea (OSA) and (ii) the effects of this intervention would be more pronounced in patients with OSA.\nMETHODS: Forty-six MetS patients without (noOSA) and with OSA (apnea-hypopnea index, AHI >\u200915\u00a0events/h) were allocated to no treatment (control, C) or hypocaloric diet (-\u2009500\u00a0kcal/day) associated with exercise (40\u00a0min, bicycle exercise, 3 times/week) for 4\u00a0months (treatment, T), resulting in four groups: noOSA-C (n\u2009=\u200910), OSA-C (n\u2009=\u200912), noOSA-T (n\u2009=\u200913), and OSA-T (n\u2009=\u200911). Muscle sympathetic nerve activity (MSNA), beat-to-beat BP, and spontaneous arterial baroreflex function of MSNA (ABRMSNA, gain and time delay) were assessed at study entry and end.\nRESULTS: No significant changes occurred in C groups. In contrast, treatment in both patients with and without OSA led to a significant decrease in weight (P\u2009<\u20090.05) and the number of MetS factors (P\u2009=\u20090.03). AHI declined only in the OSA-T group (31\u2009\u00b1\u20095 to 17\u2009\u00b1\u20094\u00a0events/h, P\u2009<\u20090.05). Systolic BP decreased in both treatment groups, and diastolic BP decreased significantly only in the noOSA-T group. Treatment decreased MSNA in both groups. Compared with baseline, ABRMSNA gain increased in both OSA-T (13\u2009\u00b1\u20091 vs. 24\u2009\u00b1\u20092\u00a0a.u./mmHg, P\u2009=\u20090.01) and noOSA-T (27\u2009\u00b1\u20093 vs. 37\u2009\u00b1\u20093\u00a0a.u./mmHg, P\u2009=\u20090.03) groups. The time delay of ABRMSNA was reduced only in the OSA-T group (4.1\u2009\u00b1\u20090.2\u00a0s vs. 2.8\u2009\u00b1\u20090.3\u00a0s, P\u2009=\u20090.04).\nCONCLUSIONS: Diet associated with exercise improves baroreflex control of sympathetic nerve activity and MetS components in patients with MetS regardless of OSA.", 
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