Co-upregulation of Toll-like receptors 2 and 6 on peripheral blood cells in patients with obstructive sleep apnea View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-01-22

AUTHORS

Yung-Che Chen, Mao-Chang Su, Chia-Wei Liou, Shih-Feng Liu, Chung-Jen Chen, Hsin-Ching Lin, Chang-Chun Hsiao, Ting-Ya Wang, Chin-Chou Wang, Chien-Hung Chin, Kuo-Tung Huang, An-Shen Lin, Meng-Chih Lin

ABSTRACT

PurposeToll-like receptor (TLR) 2 can heterodimerise with TLR6 to detect diacylated lipoproteins. Hypoxia inducible factor-1 α co-ordinates selective induction of TLR2 and TLR6 during persistent hypoxia. We hypothesized that TLR 2/6 co-expression may be upregulated by chronic intermittent hypoxia with re-oxygenation (IHR) in obstructive sleep apnea (OSA).MethodsTLR2/6 expressions on blood immune cells were measured in 144 patients with sleep-disordered breathing (SDB), including primary snoring (PS, n = 24), moderate to severe OSA (MSO, n = 60), very severe OSA (VSO, n = 36), and very severe OSA on continuous positive airway pressure (CPAP) treatment (VSOC, n = 24). An in vitro IHR experiment was also undertaken.ResultsPatients in both the MSO and VSO groups had increased TLR2/6 co-expression on CD16+ neutrophil than those in the PS group. Patients in the VSOC group had reduced TLR2/6 co-expression on neutrophil than those in either the MSO or VSO group. Blood absolute neutrophil count was positively but weakly correlated with TLR2/6 co-expression on neutrophil. TLR2/6 co-expressions on both CD14+ monocyte and CD3+CD4+T helper cell, and TLR2 expressions on both monocyte and T helper cell in SDB patients with low Minimum SaO2 (≦70 %) were all higher than those with high Minimum SaO2. In vitro IHR for 1–4 days resulted in TLR2/6 co-upregulation on both neutrophil and monocyte.ConclusionsOSA patients had increased TLR2/6 co-expressions on blood immune cells, which were related to their immune cell counts and could be reversed with CPAP treatment. In vitro IHR could induce TLR2/6 co-upregulation. More... »

PAGES

873-882

Journal

TITLE

Sleep and Breathing

ISSUE

3

VOLUME

19

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11325-014-1116-4

DOI

http://dx.doi.org/10.1007/s11325-014-1116-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045015488

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25604476


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25 schema:description PurposeToll-like receptor (TLR) 2 can heterodimerise with TLR6 to detect diacylated lipoproteins. Hypoxia inducible factor-1 α co-ordinates selective induction of TLR2 and TLR6 during persistent hypoxia. We hypothesized that TLR 2/6 co-expression may be upregulated by chronic intermittent hypoxia with re-oxygenation (IHR) in obstructive sleep apnea (OSA).MethodsTLR2/6 expressions on blood immune cells were measured in 144 patients with sleep-disordered breathing (SDB), including primary snoring (PS, n = 24), moderate to severe OSA (MSO, n = 60), very severe OSA (VSO, n = 36), and very severe OSA on continuous positive airway pressure (CPAP) treatment (VSOC, n = 24). An in vitro IHR experiment was also undertaken.ResultsPatients in both the MSO and VSO groups had increased TLR2/6 co-expression on CD16+ neutrophil than those in the PS group. Patients in the VSOC group had reduced TLR2/6 co-expression on neutrophil than those in either the MSO or VSO group. Blood absolute neutrophil count was positively but weakly correlated with TLR2/6 co-expression on neutrophil. TLR2/6 co-expressions on both CD14+ monocyte and CD3+CD4+T helper cell, and TLR2 expressions on both monocyte and T helper cell in SDB patients with low Minimum SaO2 (≦70 %) were all higher than those with high Minimum SaO2. In vitro IHR for 1–4 days resulted in TLR2/6 co-upregulation on both neutrophil and monocyte.ConclusionsOSA patients had increased TLR2/6 co-expressions on blood immune cells, which were related to their immune cell counts and could be reversed with CPAP treatment. In vitro IHR could induce TLR2/6 co-upregulation.
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31 schema:keywords CD14
32 CD16
33 CPAP treatment
34 ConclusionsOSAS patients
35 IHR
36 MSO
37 PS group
38 ResultsPatients
39 SDB patients
40 SaO2
41 T helper cells
42 TLR 2/6
43 TLR2
44 TLR2 expression
45 TLR2/6
46 TLR6
47 Toll-like receptor 2
48 VSO groups
49 absolute neutrophil count
50 apnea
51 blood absolute neutrophil count
52 blood cells
53 blood immune cells
54 breathing
55 cell count
56 cells
57 chronic intermittent hypoxia
58 continuous positive airway pressure (CPAP) treatment
59 count
60 days
61 experiments
62 expression
63 group
64 helper cells
65 hypoxia
66 immune cell counts
67 immune cells
68 induction
69 intermittent hypoxia
70 lipoprotein
71 lower minimum SaO2
72 minimum SaO2
73 monocytes
74 neutrophil count
75 neutrophils
76 obstructive sleep apnea
77 patients
78 peripheral blood cells
79 persistent hypoxia
80 positive airway pressure treatment
81 pressure treatment
82 primary snoring
83 receptor 2
84 selective induction
85 severe obstructive sleep apnea
86 sleep apnea
87 sleep-disordered breathing
88 snoring
89 treatment
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