Preclinical Comparison of the Amyloid-β Radioligands [11C]Pittsburgh compound B and [18F]florbetaben in Aged APPPS1-21 and BRI1-42 Mouse Models of Cerebral ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-10

AUTHORS

Ann-Marie Waldron, Jeroen Verhaeghe, Leonie wyffels, Mark Schmidt, Xavier Langlois, Annemie Van Der Linden, Sigrid Stroobants, Steven Staelens

ABSTRACT

PURPOSE: The aim of this study was to compare [(11)C]Pittsburgh compound B ([(11)C]PiB) and [(18)F]florbetaben ([(18)F]FBB) for preclinical investigations of amyloid-β pathology. PROCEDURES: We investigated two aged animal models of cerebral amyloidosis with contrasting levels of amyloid-β relating to "high" (APPPS1-21 n = 6, wild type (WT) n = 7) and "low" (BRI1-42 n = 6, WT n = 6) target states, respectively. RESULTS: APPPS1-21 mice (high target state) demonstrated extensive fibrillar amyloid-β deposition that translated to significantly increased retention of [(11)C]PiB and [(18)F]FBB in comparison to their wild type. The retention pattern of [(11)C]PiB and [(18)F]FBB in this cohort displayed a significant correlation. However, the relative difference in tracer uptake between diseased and healthy mice was substantially higher for [(11)C]PiB than for [(18)F]FBB. Although immunohistochemistry confirmed the high plaque load in APPPS1-21 mice, correlation between tracer uptake and ex vivo quantification of amyloid-β was poor for both tracers. BRI1-42 mice (low target state) did not demonstrate increased tracer uptake. CONCLUSIONS: In cases of high fibrillar amyloid-β burden, both tracers detected significant differences between diseased and healthy mice, with [(11)C]PiB showing a larger dynamic range. More... »

PAGES

688-696

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11307-015-0833-9

DOI

http://dx.doi.org/10.1007/s11307-015-0833-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012337478

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25701131


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alzheimer Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amyloid beta-Peptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aniline Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Positron-Emission Tomography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiopharmaceuticals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stilbenes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thiazoles", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Antwerp", 
          "id": "https://www.grid.ac/institutes/grid.5284.b", 
          "name": [
            "Molecular Imaging Center Antwerp, University of Antwerp, Campus Drie Eiken \u2013 UC, Universiteitsplein 1, 2610, Wilrijk, Antwerp, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Waldron", 
        "givenName": "Ann-Marie", 
        "id": "sg:person.01057265277.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057265277.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Antwerp", 
          "id": "https://www.grid.ac/institutes/grid.5284.b", 
          "name": [
            "Molecular Imaging Center Antwerp, University of Antwerp, Campus Drie Eiken \u2013 UC, Universiteitsplein 1, 2610, Wilrijk, Antwerp, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verhaeghe", 
        "givenName": "Jeroen", 
        "id": "sg:person.01351646132.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351646132.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Antwerp University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411414.5", 
          "name": [
            "Molecular Imaging Center Antwerp, University of Antwerp, Campus Drie Eiken \u2013 UC, Universiteitsplein 1, 2610, Wilrijk, Antwerp, Belgium", 
            "Nuclear Medicine, University Hospital Antwerp, Antwerp, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "wyffels", 
        "givenName": "Leonie", 
        "id": "sg:person.01152202111.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152202111.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Janssen (Belgium)", 
          "id": "https://www.grid.ac/institutes/grid.419619.2", 
          "name": [
            "Department of Neuroscience, Janssen Pharmaceutica NV, Beerse, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmidt", 
        "givenName": "Mark", 
        "id": "sg:person.013503776107.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013503776107.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Janssen (Belgium)", 
          "id": "https://www.grid.ac/institutes/grid.419619.2", 
          "name": [
            "Department of Neuroscience, Janssen Pharmaceutica NV, Beerse, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Langlois", 
        "givenName": "Xavier", 
        "id": "sg:person.0717147273.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717147273.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Antwerp", 
          "id": "https://www.grid.ac/institutes/grid.5284.b", 
          "name": [
            "Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van Der Linden", 
        "givenName": "Annemie", 
        "id": "sg:person.01337037323.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337037323.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Antwerp University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411414.5", 
          "name": [
            "Nuclear Medicine, University Hospital Antwerp, Antwerp, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stroobants", 
        "givenName": "Sigrid", 
        "id": "sg:person.01234564630.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234564630.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Antwerp", 
          "id": "https://www.grid.ac/institutes/grid.5284.b", 
          "name": [
            "Molecular Imaging Center Antwerp, University of Antwerp, Campus Drie Eiken \u2013 UC, Universiteitsplein 1, 2610, Wilrijk, Antwerp, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Staelens", 
        "givenName": "Steven", 
        "id": "sg:person.01235417532.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235417532.22"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.2967/jnumed.111.094029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001072974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(91)90052-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003143181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.2990-05.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003907894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0031310", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008536272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.06-6463fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011899876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(08)70001-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012432155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0914904107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012832214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2005.06.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013891767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2005.06.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013891767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.112.110163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014348291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tips.2009.05.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014425184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/alzrt96", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014790939", 
          "https://doi.org/10.1186/alzrt96"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2011.12.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015065032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.112.114785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016132530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2011.11.075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018279584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-005-1780-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018362785", 
          "https://doi.org/10.1007/s00259-005-1780-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-005-1780-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018362785", 
          "https://doi.org/10.1007/s00259-005-1780-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.20009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019367853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(12)70142-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023875103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awm191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025003371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2012.12.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025817652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2007.06.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027087744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.112.114660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028541256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.0673-07.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028644428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2011.12.055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029104038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.109.063305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029411711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029758258", 
          "https://doi.org/10.1038/nm.3734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11307-012-0583-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031995292", 
          "https://doi.org/10.1007/s11307-012-0583-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.jcbfm.9600146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036289302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.jcbfm.9600146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036289302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.jcbfm.9600146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036289302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.embor.7400784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037974845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2010.04.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039551403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awt142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040124857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.108.057984", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040437726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10967-010-0514-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047053486", 
          "https://doi.org/10.1007/s10967-010-0514-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10967-010-0514-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047053486", 
          "https://doi.org/10.1007/s10967-010-0514-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.112.109009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048558096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2967/jnumed.109.069088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050014413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11307-013-0625-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050160707", 
          "https://doi.org/10.1007/s11307-013-0625-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-012-2178-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051567226", 
          "https://doi.org/10.1007/s00259-012-2178-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-012-2088-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052452029", 
          "https://doi.org/10.1007/s00259-012-2088-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2013.09.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053293639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/23.873020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061132533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/42.363108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061170278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/42.563660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061170511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000228230.26044.a4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064348348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000228230.26044.a4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064348348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000228230.26044.a4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064348348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jad-130485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078725782"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-10", 
    "datePublishedReg": "2015-10-01", 
    "description": "PURPOSE: The aim of this study was to compare [(11)C]Pittsburgh compound B ([(11)C]PiB) and [(18)F]florbetaben ([(18)F]FBB) for preclinical investigations of amyloid-\u03b2 pathology.\nPROCEDURES: We investigated two aged animal models of cerebral amyloidosis with contrasting levels of amyloid-\u03b2 relating to \"high\" (APPPS1-21 n\u2009=\u20096, wild type (WT) n\u2009=\u20097) and \"low\" (BRI1-42 n\u2009=\u20096, WT n\u2009=\u20096) target states, respectively.\nRESULTS: APPPS1-21 mice (high target state) demonstrated extensive fibrillar amyloid-\u03b2 deposition that translated to significantly increased retention of [(11)C]PiB and [(18)F]FBB in comparison to their wild type. The retention pattern of [(11)C]PiB and [(18)F]FBB in this cohort displayed a significant correlation. However, the relative difference in tracer uptake between diseased and healthy mice was substantially higher for [(11)C]PiB than for [(18)F]FBB. Although immunohistochemistry confirmed the high plaque load in APPPS1-21 mice, correlation between tracer uptake and ex vivo quantification of amyloid-\u03b2 was poor for both tracers. BRI1-42 mice (low target state) did not demonstrate increased tracer uptake.\nCONCLUSIONS: In cases of high fibrillar amyloid-\u03b2 burden, both tracers detected significant differences between diseased and healthy mice, with [(11)C]PiB showing a larger dynamic range.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11307-015-0833-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1118463", 
        "issn": [
          "1536-1632", 
          "1878-5751"
        ], 
        "name": "Molecular Imaging and Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Preclinical Comparison of the Amyloid-\u03b2 Radioligands [11C]Pittsburgh compound B and [18F]florbetaben in Aged APPPS1-21 and BRI1-42 Mouse Models of Cerebral Amyloidosis", 
    "pagination": "688-696", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3ac786ce0194c60b0ebf1667db4bc5ec0cee893b905000107c6bfc84b74bad0f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25701131"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101125610"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11307-015-0833-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012337478"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11307-015-0833-9", 
      "https://app.dimensions.ai/details/publication/pub.1012337478"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000520.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11307-015-0833-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11307-015-0833-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11307-015-0833-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11307-015-0833-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11307-015-0833-9'


 

This table displays all metadata directly associated to this object as RDF triples.

307 TRIPLES      21 PREDICATES      83 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11307-015-0833-9 schema:about N03a22a9ade4b44cfa3aea4db772b290a
2 N078bdebbefbf42659b9181725742f7b7
3 N1163c53598aa48c086f26c60c8a855f1
4 N28b83af9886d4394ad14153f8f346fdf
5 N68c35040343c4103bfaa78510f906925
6 N740c1124d23a4ccbb78695164452aaad
7 N90ec0df39cc24429a07997a9dd06b955
8 N94ae7f6a69704d92937c594167075522
9 Na4b7be8e07fd457abf8eb90111ee8fd7
10 Nb3ba847ccc2d411f855ae97b980cf7b2
11 Nfcc6625ac0bb4aa8a28b84e1fee1c11f
12 anzsrc-for:11
13 anzsrc-for:1109
14 schema:author Nc01b371ea5c04f158992a1e9641b7ab7
15 schema:citation sg:pub.10.1007/s00259-005-1780-5
16 sg:pub.10.1007/s00259-012-2088-x
17 sg:pub.10.1007/s00259-012-2178-9
18 sg:pub.10.1007/s10967-010-0514-8
19 sg:pub.10.1007/s11307-012-0583-x
20 sg:pub.10.1007/s11307-013-0625-z
21 sg:pub.10.1038/nm.3734
22 sg:pub.10.1186/alzrt96
23 https://doi.org/10.1002/ana.20009
24 https://doi.org/10.1016/0896-6273(91)90052-2
25 https://doi.org/10.1016/j.neurobiolaging.2010.04.007
26 https://doi.org/10.1016/j.neurobiolaging.2011.12.024
27 https://doi.org/10.1016/j.neurobiolaging.2012.12.027
28 https://doi.org/10.1016/j.neuroimage.2007.06.032
29 https://doi.org/10.1016/j.neuroimage.2011.11.075
30 https://doi.org/10.1016/j.neuroimage.2011.12.055
31 https://doi.org/10.1016/j.neuroimage.2013.09.017
32 https://doi.org/10.1016/j.neuron.2005.06.030
33 https://doi.org/10.1016/j.tips.2009.05.005
34 https://doi.org/10.1016/s1474-4422(08)70001-2
35 https://doi.org/10.1016/s1474-4422(12)70142-4
36 https://doi.org/10.1038/sj.embor.7400784
37 https://doi.org/10.1038/sj.jcbfm.9600146
38 https://doi.org/10.1073/pnas.0914904107
39 https://doi.org/10.1093/brain/awm191
40 https://doi.org/10.1093/brain/awt142
41 https://doi.org/10.1096/fj.06-6463fje
42 https://doi.org/10.1109/23.873020
43 https://doi.org/10.1109/42.363108
44 https://doi.org/10.1109/42.563660
45 https://doi.org/10.1212/01.wnl.0000228230.26044.a4
46 https://doi.org/10.1371/journal.pone.0031310
47 https://doi.org/10.1523/jneurosci.0673-07.2007
48 https://doi.org/10.1523/jneurosci.2990-05.2005
49 https://doi.org/10.2967/jnumed.108.057984
50 https://doi.org/10.2967/jnumed.109.063305
51 https://doi.org/10.2967/jnumed.109.069088
52 https://doi.org/10.2967/jnumed.111.094029
53 https://doi.org/10.2967/jnumed.112.109009
54 https://doi.org/10.2967/jnumed.112.110163
55 https://doi.org/10.2967/jnumed.112.114660
56 https://doi.org/10.2967/jnumed.112.114785
57 https://doi.org/10.3233/jad-130485
58 schema:datePublished 2015-10
59 schema:datePublishedReg 2015-10-01
60 schema:description PURPOSE: The aim of this study was to compare [(11)C]Pittsburgh compound B ([(11)C]PiB) and [(18)F]florbetaben ([(18)F]FBB) for preclinical investigations of amyloid-β pathology. PROCEDURES: We investigated two aged animal models of cerebral amyloidosis with contrasting levels of amyloid-β relating to "high" (APPPS1-21 n = 6, wild type (WT) n = 7) and "low" (BRI1-42 n = 6, WT n = 6) target states, respectively. RESULTS: APPPS1-21 mice (high target state) demonstrated extensive fibrillar amyloid-β deposition that translated to significantly increased retention of [(11)C]PiB and [(18)F]FBB in comparison to their wild type. The retention pattern of [(11)C]PiB and [(18)F]FBB in this cohort displayed a significant correlation. However, the relative difference in tracer uptake between diseased and healthy mice was substantially higher for [(11)C]PiB than for [(18)F]FBB. Although immunohistochemistry confirmed the high plaque load in APPPS1-21 mice, correlation between tracer uptake and ex vivo quantification of amyloid-β was poor for both tracers. BRI1-42 mice (low target state) did not demonstrate increased tracer uptake. CONCLUSIONS: In cases of high fibrillar amyloid-β burden, both tracers detected significant differences between diseased and healthy mice, with [(11)C]PiB showing a larger dynamic range.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree false
64 schema:isPartOf N7af329a275ce418da211a6972ddb62dc
65 Ndd4dd4e31d7542eaafff63078a5478d1
66 sg:journal.1118463
67 schema:name Preclinical Comparison of the Amyloid-β Radioligands [11C]Pittsburgh compound B and [18F]florbetaben in Aged APPPS1-21 and BRI1-42 Mouse Models of Cerebral Amyloidosis
68 schema:pagination 688-696
69 schema:productId N005fe5715dcc46ca996a6637ea757b0f
70 N510ca538276e41cc8bab374b03764e99
71 Na3b6c2741c414c74848200abbb73ce90
72 Naed2a41bd42249c992a5873af62c1718
73 Ne1ca068841a04c95864de1129591f6a4
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012337478
75 https://doi.org/10.1007/s11307-015-0833-9
76 schema:sdDatePublished 2019-04-10T14:12
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher N6e6a470202f741959f75a953248821a5
79 schema:url http://link.springer.com/10.1007%2Fs11307-015-0833-9
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N005fe5715dcc46ca996a6637ea757b0f schema:name dimensions_id
84 schema:value pub.1012337478
85 rdf:type schema:PropertyValue
86 N03a22a9ade4b44cfa3aea4db772b290a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Mice
88 rdf:type schema:DefinedTerm
89 N06a905fe55f74b7396973fcd0bacfa15 rdf:first sg:person.01351646132.39
90 rdf:rest N6619b06f44c54c749ee9e669b3738c3a
91 N078bdebbefbf42659b9181725742f7b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Amyloid beta-Peptides
93 rdf:type schema:DefinedTerm
94 N1163c53598aa48c086f26c60c8a855f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Disease Models, Animal
96 rdf:type schema:DefinedTerm
97 N28b83af9886d4394ad14153f8f346fdf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Stilbenes
99 rdf:type schema:DefinedTerm
100 N2947f180a9fa4b5c87925feb22ce8d39 rdf:first sg:person.01234564630.64
101 rdf:rest N7d59e311196c4c6389d72309c635efc5
102 N2d323c71d847442e95dec3b98ff4c416 rdf:first sg:person.01337037323.16
103 rdf:rest N2947f180a9fa4b5c87925feb22ce8d39
104 N33eb2c3315594b0693c93e2509e77a66 rdf:first sg:person.0717147273.74
105 rdf:rest N2d323c71d847442e95dec3b98ff4c416
106 N510ca538276e41cc8bab374b03764e99 schema:name nlm_unique_id
107 schema:value 101125610
108 rdf:type schema:PropertyValue
109 N6619b06f44c54c749ee9e669b3738c3a rdf:first sg:person.01152202111.09
110 rdf:rest Nc5993e4c22bb4c1f94a6054ea278e4e7
111 N68c35040343c4103bfaa78510f906925 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Animals
113 rdf:type schema:DefinedTerm
114 N6e6a470202f741959f75a953248821a5 schema:name Springer Nature - SN SciGraph project
115 rdf:type schema:Organization
116 N740c1124d23a4ccbb78695164452aaad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Immunohistochemistry
118 rdf:type schema:DefinedTerm
119 N7af329a275ce418da211a6972ddb62dc schema:volumeNumber 17
120 rdf:type schema:PublicationVolume
121 N7d59e311196c4c6389d72309c635efc5 rdf:first sg:person.01235417532.22
122 rdf:rest rdf:nil
123 N90ec0df39cc24429a07997a9dd06b955 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Radiopharmaceuticals
125 rdf:type schema:DefinedTerm
126 N94ae7f6a69704d92937c594167075522 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Alzheimer Disease
128 rdf:type schema:DefinedTerm
129 Na3b6c2741c414c74848200abbb73ce90 schema:name readcube_id
130 schema:value 3ac786ce0194c60b0ebf1667db4bc5ec0cee893b905000107c6bfc84b74bad0f
131 rdf:type schema:PropertyValue
132 Na4b7be8e07fd457abf8eb90111ee8fd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Positron-Emission Tomography
134 rdf:type schema:DefinedTerm
135 Naed2a41bd42249c992a5873af62c1718 schema:name pubmed_id
136 schema:value 25701131
137 rdf:type schema:PropertyValue
138 Nb3ba847ccc2d411f855ae97b980cf7b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Thiazoles
140 rdf:type schema:DefinedTerm
141 Nc01b371ea5c04f158992a1e9641b7ab7 rdf:first sg:person.01057265277.87
142 rdf:rest N06a905fe55f74b7396973fcd0bacfa15
143 Nc5993e4c22bb4c1f94a6054ea278e4e7 rdf:first sg:person.013503776107.97
144 rdf:rest N33eb2c3315594b0693c93e2509e77a66
145 Ndd4dd4e31d7542eaafff63078a5478d1 schema:issueNumber 5
146 rdf:type schema:PublicationIssue
147 Ne1ca068841a04c95864de1129591f6a4 schema:name doi
148 schema:value 10.1007/s11307-015-0833-9
149 rdf:type schema:PropertyValue
150 Nfcc6625ac0bb4aa8a28b84e1fee1c11f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Aniline Compounds
152 rdf:type schema:DefinedTerm
153 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
154 schema:name Medical and Health Sciences
155 rdf:type schema:DefinedTerm
156 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
157 schema:name Neurosciences
158 rdf:type schema:DefinedTerm
159 sg:journal.1118463 schema:issn 1536-1632
160 1878-5751
161 schema:name Molecular Imaging and Biology
162 rdf:type schema:Periodical
163 sg:person.01057265277.87 schema:affiliation https://www.grid.ac/institutes/grid.5284.b
164 schema:familyName Waldron
165 schema:givenName Ann-Marie
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057265277.87
167 rdf:type schema:Person
168 sg:person.01152202111.09 schema:affiliation https://www.grid.ac/institutes/grid.411414.5
169 schema:familyName wyffels
170 schema:givenName Leonie
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152202111.09
172 rdf:type schema:Person
173 sg:person.01234564630.64 schema:affiliation https://www.grid.ac/institutes/grid.411414.5
174 schema:familyName Stroobants
175 schema:givenName Sigrid
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234564630.64
177 rdf:type schema:Person
178 sg:person.01235417532.22 schema:affiliation https://www.grid.ac/institutes/grid.5284.b
179 schema:familyName Staelens
180 schema:givenName Steven
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235417532.22
182 rdf:type schema:Person
183 sg:person.01337037323.16 schema:affiliation https://www.grid.ac/institutes/grid.5284.b
184 schema:familyName Van Der Linden
185 schema:givenName Annemie
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337037323.16
187 rdf:type schema:Person
188 sg:person.013503776107.97 schema:affiliation https://www.grid.ac/institutes/grid.419619.2
189 schema:familyName Schmidt
190 schema:givenName Mark
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013503776107.97
192 rdf:type schema:Person
193 sg:person.01351646132.39 schema:affiliation https://www.grid.ac/institutes/grid.5284.b
194 schema:familyName Verhaeghe
195 schema:givenName Jeroen
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351646132.39
197 rdf:type schema:Person
198 sg:person.0717147273.74 schema:affiliation https://www.grid.ac/institutes/grid.419619.2
199 schema:familyName Langlois
200 schema:givenName Xavier
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717147273.74
202 rdf:type schema:Person
203 sg:pub.10.1007/s00259-005-1780-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018362785
204 https://doi.org/10.1007/s00259-005-1780-5
205 rdf:type schema:CreativeWork
206 sg:pub.10.1007/s00259-012-2088-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052452029
207 https://doi.org/10.1007/s00259-012-2088-x
208 rdf:type schema:CreativeWork
209 sg:pub.10.1007/s00259-012-2178-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051567226
210 https://doi.org/10.1007/s00259-012-2178-9
211 rdf:type schema:CreativeWork
212 sg:pub.10.1007/s10967-010-0514-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047053486
213 https://doi.org/10.1007/s10967-010-0514-8
214 rdf:type schema:CreativeWork
215 sg:pub.10.1007/s11307-012-0583-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031995292
216 https://doi.org/10.1007/s11307-012-0583-x
217 rdf:type schema:CreativeWork
218 sg:pub.10.1007/s11307-013-0625-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1050160707
219 https://doi.org/10.1007/s11307-013-0625-z
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/nm.3734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029758258
222 https://doi.org/10.1038/nm.3734
223 rdf:type schema:CreativeWork
224 sg:pub.10.1186/alzrt96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014790939
225 https://doi.org/10.1186/alzrt96
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1002/ana.20009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019367853
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/0896-6273(91)90052-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003143181
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/j.neurobiolaging.2010.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039551403
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/j.neurobiolaging.2011.12.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015065032
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/j.neurobiolaging.2012.12.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025817652
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/j.neuroimage.2007.06.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027087744
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/j.neuroimage.2011.11.075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018279584
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/j.neuroimage.2011.12.055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029104038
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/j.neuroimage.2013.09.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053293639
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.neuron.2005.06.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013891767
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/j.tips.2009.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014425184
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/s1474-4422(08)70001-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012432155
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/s1474-4422(12)70142-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023875103
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1038/sj.embor.7400784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037974845
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1038/sj.jcbfm.9600146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036289302
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1073/pnas.0914904107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012832214
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1093/brain/awm191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025003371
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1093/brain/awt142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040124857
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1096/fj.06-6463fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1011899876
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1109/23.873020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061132533
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1109/42.363108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061170278
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1109/42.563660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061170511
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1212/01.wnl.0000228230.26044.a4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064348348
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1371/journal.pone.0031310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008536272
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1523/jneurosci.0673-07.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028644428
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1523/jneurosci.2990-05.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003907894
278 rdf:type schema:CreativeWork
279 https://doi.org/10.2967/jnumed.108.057984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040437726
280 rdf:type schema:CreativeWork
281 https://doi.org/10.2967/jnumed.109.063305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029411711
282 rdf:type schema:CreativeWork
283 https://doi.org/10.2967/jnumed.109.069088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050014413
284 rdf:type schema:CreativeWork
285 https://doi.org/10.2967/jnumed.111.094029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001072974
286 rdf:type schema:CreativeWork
287 https://doi.org/10.2967/jnumed.112.109009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048558096
288 rdf:type schema:CreativeWork
289 https://doi.org/10.2967/jnumed.112.110163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014348291
290 rdf:type schema:CreativeWork
291 https://doi.org/10.2967/jnumed.112.114660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028541256
292 rdf:type schema:CreativeWork
293 https://doi.org/10.2967/jnumed.112.114785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016132530
294 rdf:type schema:CreativeWork
295 https://doi.org/10.3233/jad-130485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078725782
296 rdf:type schema:CreativeWork
297 https://www.grid.ac/institutes/grid.411414.5 schema:alternateName Antwerp University Hospital
298 schema:name Molecular Imaging Center Antwerp, University of Antwerp, Campus Drie Eiken – UC, Universiteitsplein 1, 2610, Wilrijk, Antwerp, Belgium
299 Nuclear Medicine, University Hospital Antwerp, Antwerp, Belgium
300 rdf:type schema:Organization
301 https://www.grid.ac/institutes/grid.419619.2 schema:alternateName Janssen (Belgium)
302 schema:name Department of Neuroscience, Janssen Pharmaceutica NV, Beerse, Belgium
303 rdf:type schema:Organization
304 https://www.grid.ac/institutes/grid.5284.b schema:alternateName University of Antwerp
305 schema:name Bio-Imaging Lab, University of Antwerp, Antwerp, Belgium
306 Molecular Imaging Center Antwerp, University of Antwerp, Campus Drie Eiken – UC, Universiteitsplein 1, 2610, Wilrijk, Antwerp, Belgium
307 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...