A Hyaluronic Acid-Conjugated Gadolinium Hepatocyte-Specific T1 Contrast Agent for Liver Magnetic Resonance Imaging View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-08

AUTHORS

MyeongJu Moon, Reju George Thomas, Seon-u Heo, Myong-Suk Park, Woo Kyun Bae, Suk Hee Heo, Nam Yeol Yim, Yong Yeon Jeong

ABSTRACT

PURPOSE: In this study, we synthesized hyaluronic acid-conjugated gadolinium (HA-diethylene triamine pentaacetic acid (DTPA)-Gd) and evaluated as hepatocyte-specific magnetic resonance imaging (MRI) contrast agent for the diagnosis of hepatic metastasis. PROCEDURES: We conducted Fourier transform (FT)-IR analysis to determine the conjugation of HA and DTPA and performed cell viability assays using NIH3T3 and FL83B cell lines. We also conducted T1-weighted MRI of HA-DTPA-Gd and gadoxetic acid to compare the paramagnetic properties of both. RESULTS: HA-DTPA-Gd had a higher efficiency in liver MRI compared with the commercially available liver-specific contrast agent (p < 0.001). HA-DTPA-Gd, which possessed a higher T1 relaxivity, showed excellent capability for the diagnosis of hepatic metastasis through an in vivo MRI study in comparison with gadoxetic acid (p < 0.001). CONCLUSION: Based on this study, we believe that HA-DTPA-Gd has promising potential for use as a contrast agent for liver MRI of hepatic metastases. More... »

PAGES

497-503

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11307-014-0819-z

DOI

http://dx.doi.org/10.1007/s11307-014-0819-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006913069

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25604386


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