Monitoring Tumor Response After Histone Deacetylase Inhibitor Treatment Using 3′-Deoxy-3′-[18F]-fluorothymidine PET View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-06

AUTHORS

Pei-Chia Chan, Chun-Yi Wu, Lin-Shan Chou, Chung-Hsien Ho, Chi-Wei Chang, Shih-Hwa Chiou, Wuu-Jyh Lin, Fu-Du Chen, C. Allen Chang, Jeng-Jong Hwang, Ren-Shyan Liu, Hsin-Ell Wang

ABSTRACT

PURPOSE: This study employed 3'-deoxy-3'-[(18)F]-fluorothymidine ([(18)F]FLT) microPET scanning to assess the treatment response of histone deacetylase inhibitors (HDACi), e.g., N1-hydroxy-N8-phenyloctanediamide (SAHA) and its iodinated derivative ISAHA, in a hepatoma mouse model. PROCEDURES: The in vitro cytotoxicity of HDACi in various hepatoma cell lines was determined by MTT assay and flow cytometry. ISAHA and SAHA were used to treat HepG2 hepatoma xenograft-bearing mice. The treatment responses were characterized in terms of tumor burden, microPET imaging, and immunohistochemical staining of tumor sections. RESULTS: ISAHA effectively inhibited HepG2 hepatoma cell survival and tumor growth. A significantly reduced tumor uptake during HDACi treatment was noticed in [(18)F]FLT microPET imaging, which was consistent with the findings in immunohistochemical staining. CONCLUSIONS: ISAHA can suppress tumor cell proliferation both in vitro and in vivo. [(18)F]FLT PET is a promising modality for evaluating the in vivo therapeutic efficacy of HDACi at the early stage of treatment. More... »

PAGES

394-402

References to SciGraph publications

  • 2006-01. Epigenetic therapy of cancer: past, present and future in NATURE REVIEWS DRUG DISCOVERY
  • 2011-06. A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer in BRITISH JOURNAL OF CANCER
  • 2007-06. PET imaging with [18F]3′-deoxy-3′-fluorothymidine for prediction of response to neoadjuvant treatment in patients with rectal cancer in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2006-05. Positron Emission Tomography Measurement of Tumor Metabolism and Growth: Its Expanding Role in Oncology in MOLECULAR IMAGING AND BIOLOGY
  • 2011-03. Potentiation of apoptosis by histone deacetylase inhibitors and doxorubicin combination: cytoplasmic cathepsin B as a mediator of apoptosis in multiple myeloma in BRITISH JOURNAL OF CANCER
  • 2011-08. The histone deacetylase inhibitor PXD101 increases the efficacy of irinotecan in in vitro and in vivo colon cancer models in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2013-06. Monitoring Tumor Response with Radiolabeled Nucleoside Analogs in a Hepatoma-Bearing Mouse Model Early After Doxisome® Treatment in MOLECULAR IMAGING AND BIOLOGY
  • 2007-07. SAHA induces apoptosis in hepatoma cells and synergistically interacts with the proteasome inhibitor Bortezomib in APOPTOSIS
  • 2010-12. Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents in JOURNAL OF HEMATOLOGY & ONCOLOGY
  • 2012-03. A randomized phase II study of two doses of vorinostat in combination with 5-FU/LV in patients with refractory colorectal cancer in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2004-12. [18F]FLT-PET in oncology: current status and opportunities in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11307-014-0774-8

    DOI

    http://dx.doi.org/10.1007/s11307-014-0774-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007885379

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25323103


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma, Hepatocellular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Cycle", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Survival", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Models, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fluorodeoxyglucose F18", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hep G2 Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Histone Deacetylase Inhibitors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hydroxamic Acids", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunohistochemistry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Liver Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Transplantation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Positron-Emission Tomography", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "National Yang Ming University", 
              "id": "https://www.grid.ac/institutes/grid.260770.4", 
              "name": [
                "Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan", 
                "Biophotonics & Molecular Imaging Research Center, National Yang-Ming University, Taipei, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chan", 
            "givenName": "Pei-Chia", 
            "id": "sg:person.01114773736.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114773736.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "China Medical University", 
              "id": "https://www.grid.ac/institutes/grid.254145.3", 
              "name": [
                "Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wu", 
            "givenName": "Chun-Yi", 
            "id": "sg:person.01046660536.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046660536.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Yang Ming University", 
              "id": "https://www.grid.ac/institutes/grid.260770.4", 
              "name": [
                "Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chou", 
            "givenName": "Lin-Shan", 
            "id": "sg:person.01065454507.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065454507.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Yang Ming University", 
              "id": "https://www.grid.ac/institutes/grid.260770.4", 
              "name": [
                "Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ho", 
            "givenName": "Chung-Hsien", 
            "id": "sg:person.01201703107.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201703107.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Taipei Veterans General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.278247.c", 
              "name": [
                "National PET/Cyclotron Center, Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chang", 
            "givenName": "Chi-Wei", 
            "id": "sg:person.01272364674.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272364674.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Yang Ming University", 
              "id": "https://www.grid.ac/institutes/grid.260770.4", 
              "name": [
                "Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chiou", 
            "givenName": "Shih-Hwa", 
            "id": "sg:person.01200063632.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200063632.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Nuclear Energy Research", 
              "id": "https://www.grid.ac/institutes/grid.482644.8", 
              "name": [
                "Institute of Nuclear Energy Research, Atomic Energy Council, Tao-Yuan County, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lin", 
            "givenName": "Wuu-Jyh", 
            "id": "sg:person.01324436246.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324436246.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Chinese Culture University", 
              "id": "https://www.grid.ac/institutes/grid.411531.3", 
              "name": [
                "Graduate Institute of Biotechnology, Chinese Culture University, Taipei, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Fu-Du", 
            "id": "sg:person.01362026704.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362026704.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Yang Ming University", 
              "id": "https://www.grid.ac/institutes/grid.260770.4", 
              "name": [
                "Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan", 
                "Biophotonics & Molecular Imaging Research Center, National Yang-Ming University, Taipei, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chang", 
            "givenName": "C. Allen", 
            "id": "sg:person.01027641254.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027641254.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Yang Ming University", 
              "id": "https://www.grid.ac/institutes/grid.260770.4", 
              "name": [
                "Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hwang", 
            "givenName": "Jeng-Jong", 
            "id": "sg:person.01040235623.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040235623.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Yang Ming University", 
              "id": "https://www.grid.ac/institutes/grid.260770.4", 
              "name": [
                "National PET/Cyclotron Center, Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan", 
                "Department of Nuclear Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan", 
                "Taiwan Mouse Clinic, National Comprehensive Mouse Phenotyping and Drug Testing Center, Taipei, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "Ren-Shyan", 
            "id": "sg:person.01067077604.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067077604.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Yang Ming University", 
              "id": "https://www.grid.ac/institutes/grid.260770.4", 
              "name": [
                "Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan", 
                "Biophotonics & Molecular Imaging Research Center, National Yang-Ming University, Taipei, Taiwan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Hsin-Ell", 
            "id": "sg:person.0706754007.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706754007.00"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s11307-012-0604-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001233059", 
              "https://doi.org/10.1007/s11307-012-0604-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1947601912440170", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003154491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1947601912440170", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003154491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-06-1802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003190855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-4297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004752219"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.01.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009285166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2006-06-025999", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009387348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2011.42", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009637114", 
              "https://doi.org/10.1038/bjc.2011.42"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jchromb.2006.04.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011794121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcp.22574", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013028110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-004-1687-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014510428", 
              "https://doi.org/10.1007/s00259-004-1687-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.25.13.5429-5444.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015346639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-05-3962", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016643271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-006-0292-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017008016", 
              "https://doi.org/10.1007/s00259-006-0292-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-006-0292-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017008016", 
              "https://doi.org/10.1007/s00259-006-0292-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11307-006-0039-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018933115", 
              "https://doi.org/10.1007/s11307-006-0039-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11307-006-0039-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018933115", 
              "https://doi.org/10.1007/s11307-006-0039-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgp220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020405617"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgp220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020405617"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1930", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021896263", 
              "https://doi.org/10.1038/nrd1930"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1930", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021896263", 
              "https://doi.org/10.1038/nrd1930"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1117544108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025116497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-010-1495-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026202228", 
              "https://doi.org/10.1007/s00280-010-1495-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10495-007-0063-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030234699", 
              "https://doi.org/10.1007/s10495-007-0063-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10495-007-0063-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030234699", 
              "https://doi.org/10.1007/s10495-007-0063-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2008.03.073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033665787"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-0540", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038054706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.14.167", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040412110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2011.156", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040609384", 
              "https://doi.org/10.1038/bjc.2011.156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1756-8722-3-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042777321", 
              "https://doi.org/10.1186/1756-8722-3-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijpharm.2008.05.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043267612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.exphem.2004.09.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044886310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmcl.2004.10.074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049197578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-011-1762-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052047364", 
              "https://doi.org/10.1007/s00280-011-1762-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja0646895", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055842820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja0646895", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055842820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm00008a020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055932402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/cbr.2009.0709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059243025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijo.32.1.177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071516739"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076570553", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-06", 
        "datePublishedReg": "2015-06-01", 
        "description": "PURPOSE: This study employed 3'-deoxy-3'-[(18)F]-fluorothymidine ([(18)F]FLT) microPET scanning to assess the treatment response of histone deacetylase inhibitors (HDACi), e.g., N1-hydroxy-N8-phenyloctanediamide (SAHA) and its iodinated derivative ISAHA, in a hepatoma mouse model.\nPROCEDURES: The in vitro cytotoxicity of HDACi in various hepatoma cell lines was determined by MTT assay and flow cytometry. ISAHA and SAHA were used to treat HepG2 hepatoma xenograft-bearing mice. The treatment responses were characterized in terms of tumor burden, microPET imaging, and immunohistochemical staining of tumor sections.\nRESULTS: ISAHA effectively inhibited HepG2 hepatoma cell survival and tumor growth. A significantly reduced tumor uptake during HDACi treatment was noticed in [(18)F]FLT microPET imaging, which was consistent with the findings in immunohistochemical staining.\nCONCLUSIONS: ISAHA can suppress tumor cell proliferation both in vitro and in vivo. [(18)F]FLT PET is a promising modality for evaluating the in vivo therapeutic efficacy of HDACi at the early stage of treatment.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s11307-014-0774-8", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1118463", 
            "issn": [
              "1536-1632", 
              "1878-5751"
            ], 
            "name": "Molecular Imaging and Biology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "17"
          }
        ], 
        "name": "Monitoring Tumor Response After Histone Deacetylase Inhibitor Treatment Using 3\u2032-Deoxy-3\u2032-[18F]-fluorothymidine PET", 
        "pagination": "394-402", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "2590219d08943221e31944c16a60b40b1c2148a509cce57ffa45aa50c9082a89"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25323103"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101125610"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11307-014-0774-8"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1007885379"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11307-014-0774-8", 
          "https://app.dimensions.ai/details/publication/pub.1007885379"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T19:10", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000520.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs11307-014-0774-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11307-014-0774-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11307-014-0774-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11307-014-0774-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11307-014-0774-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    340 TRIPLES      21 PREDICATES      79 URIs      38 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11307-014-0774-8 schema:about N0cd71b10f8b7419daf66c7fac2dfa456
    2 N16aa5fa10a454c94933d0a91f335043b
    3 N340793f7227f438b95d444ad9e6a917c
    4 N411a9a38673b4de5ab54bbd2fa7f5c72
    5 N53dd49daa2634919a40f8e9919f67929
    6 N5db00a8ceac64128bd8920ebd1cedb65
    7 N658f9b0e3712497f9c6447250d4d9e6c
    8 N6b4cc9f1b0474a578d164d9034586772
    9 N7b20227a403e49729793ad731b6f3dae
    10 N8ad6b9c13dda461ab6766eabf0b67d51
    11 Na3e15efee53f4e07a5fa74d97a231267
    12 Na75b0ec924c34f4f8c2e2a65b118635f
    13 Nae3097dbf68f47838ad28583f8db22ad
    14 Nc9f13b47063546e7b30d84a5b473d302
    15 Ne49e385cf3c44615bca7e573a47492f0
    16 Neae325b5d14b44c1ba668d37e1dfff29
    17 Nf0f3c6be20bb44b2a6c16161e03137e1
    18 anzsrc-for:11
    19 anzsrc-for:1112
    20 schema:author Nefbb9e71d1ca43288b1879d955030273
    21 schema:citation sg:pub.10.1007/s00259-004-1687-6
    22 sg:pub.10.1007/s00259-006-0292-2
    23 sg:pub.10.1007/s00280-010-1495-6
    24 sg:pub.10.1007/s00280-011-1762-1
    25 sg:pub.10.1007/s10495-007-0063-y
    26 sg:pub.10.1007/s11307-006-0039-2
    27 sg:pub.10.1007/s11307-012-0604-9
    28 sg:pub.10.1038/bjc.2011.156
    29 sg:pub.10.1038/bjc.2011.42
    30 sg:pub.10.1038/nrd1930
    31 sg:pub.10.1186/1756-8722-3-5
    32 https://app.dimensions.ai/details/publication/pub.1076570553
    33 https://doi.org/10.1002/jcp.22574
    34 https://doi.org/10.1016/j.bmcl.2004.10.074
    35 https://doi.org/10.1016/j.cell.2007.01.029
    36 https://doi.org/10.1016/j.exphem.2004.09.008
    37 https://doi.org/10.1016/j.ijpharm.2008.05.001
    38 https://doi.org/10.1016/j.jchromb.2006.04.044
    39 https://doi.org/10.1021/ja0646895
    40 https://doi.org/10.1021/jm00008a020
    41 https://doi.org/10.1053/j.gastro.2008.03.073
    42 https://doi.org/10.1073/pnas.1117544108
    43 https://doi.org/10.1089/cbr.2009.0709
    44 https://doi.org/10.1093/carcin/bgp220
    45 https://doi.org/10.1128/mcb.25.13.5429-5444.2005
    46 https://doi.org/10.1158/0008-5472.can-04-0540
    47 https://doi.org/10.1158/0008-5472.can-04-4297
    48 https://doi.org/10.1158/0008-5472.can-05-3962
    49 https://doi.org/10.1158/1078-0432.ccr-06-1802
    50 https://doi.org/10.1177/1947601912440170
    51 https://doi.org/10.1182/blood-2006-06-025999
    52 https://doi.org/10.1200/jco.2005.14.167
    53 https://doi.org/10.3892/ijo.32.1.177
    54 schema:datePublished 2015-06
    55 schema:datePublishedReg 2015-06-01
    56 schema:description PURPOSE: This study employed 3'-deoxy-3'-[(18)F]-fluorothymidine ([(18)F]FLT) microPET scanning to assess the treatment response of histone deacetylase inhibitors (HDACi), e.g., N1-hydroxy-N8-phenyloctanediamide (SAHA) and its iodinated derivative ISAHA, in a hepatoma mouse model. PROCEDURES: The in vitro cytotoxicity of HDACi in various hepatoma cell lines was determined by MTT assay and flow cytometry. ISAHA and SAHA were used to treat HepG2 hepatoma xenograft-bearing mice. The treatment responses were characterized in terms of tumor burden, microPET imaging, and immunohistochemical staining of tumor sections. RESULTS: ISAHA effectively inhibited HepG2 hepatoma cell survival and tumor growth. A significantly reduced tumor uptake during HDACi treatment was noticed in [(18)F]FLT microPET imaging, which was consistent with the findings in immunohistochemical staining. CONCLUSIONS: ISAHA can suppress tumor cell proliferation both in vitro and in vivo. [(18)F]FLT PET is a promising modality for evaluating the in vivo therapeutic efficacy of HDACi at the early stage of treatment.
    57 schema:genre research_article
    58 schema:inLanguage en
    59 schema:isAccessibleForFree false
    60 schema:isPartOf N43b3e44563ad4685a0582b85fc77a53f
    61 N628d1155398548fba8e425ff9bd9d8c6
    62 sg:journal.1118463
    63 schema:name Monitoring Tumor Response After Histone Deacetylase Inhibitor Treatment Using 3′-Deoxy-3′-[18F]-fluorothymidine PET
    64 schema:pagination 394-402
    65 schema:productId N244f06a0a2dc43cd870023db57e330cc
    66 N278fd9745e2644b2bd4c513844b5146e
    67 N4b3b28460c1441cc9ddf845cad02cc74
    68 N68ca639a49a746bbb6ef63a8c0eab9bc
    69 Nc2c1de97eeb34916b97629a5a401992c
    70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007885379
    71 https://doi.org/10.1007/s11307-014-0774-8
    72 schema:sdDatePublished 2019-04-10T19:10
    73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    74 schema:sdPublisher Ne987002a3d7346d2b048fe2a5cc5296a
    75 schema:url http://link.springer.com/10.1007%2Fs11307-014-0774-8
    76 sgo:license sg:explorer/license/
    77 sgo:sdDataset articles
    78 rdf:type schema:ScholarlyArticle
    79 N0cd71b10f8b7419daf66c7fac2dfa456 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    80 schema:name Histone Deacetylase Inhibitors
    81 rdf:type schema:DefinedTerm
    82 N12024a8e643d4db39afe0d849fa200ea rdf:first sg:person.01362026704.52
    83 rdf:rest N39b53bad827549e5b3a2cd236e8d78fd
    84 N141d77226074459ea316412e0fdd23fc rdf:first sg:person.01046660536.34
    85 rdf:rest Nafc825c958e14fceb6220a13a8c1488c
    86 N16aa5fa10a454c94933d0a91f335043b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    87 schema:name Male
    88 rdf:type schema:DefinedTerm
    89 N244f06a0a2dc43cd870023db57e330cc schema:name pubmed_id
    90 schema:value 25323103
    91 rdf:type schema:PropertyValue
    92 N278fd9745e2644b2bd4c513844b5146e schema:name dimensions_id
    93 schema:value pub.1007885379
    94 rdf:type schema:PropertyValue
    95 N340793f7227f438b95d444ad9e6a917c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Disease Models, Animal
    97 rdf:type schema:DefinedTerm
    98 N39b53bad827549e5b3a2cd236e8d78fd rdf:first sg:person.01027641254.54
    99 rdf:rest Nc4a6024eccf64317b92a9bde92a1ebd2
    100 N411a9a38673b4de5ab54bbd2fa7f5c72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name Carcinoma, Hepatocellular
    102 rdf:type schema:DefinedTerm
    103 N43b3e44563ad4685a0582b85fc77a53f schema:issueNumber 3
    104 rdf:type schema:PublicationIssue
    105 N4b3b28460c1441cc9ddf845cad02cc74 schema:name readcube_id
    106 schema:value 2590219d08943221e31944c16a60b40b1c2148a509cce57ffa45aa50c9082a89
    107 rdf:type schema:PropertyValue
    108 N53dd49daa2634919a40f8e9919f67929 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name Cell Cycle
    110 rdf:type schema:DefinedTerm
    111 N5db00a8ceac64128bd8920ebd1cedb65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Mice
    113 rdf:type schema:DefinedTerm
    114 N5f564fdbaffb42b99085fe32bfbbdcfd rdf:first sg:person.01272364674.46
    115 rdf:rest Nc64e6036a1aa4d33948925bfba63e401
    116 N628d1155398548fba8e425ff9bd9d8c6 schema:volumeNumber 17
    117 rdf:type schema:PublicationVolume
    118 N658f9b0e3712497f9c6447250d4d9e6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Cell Survival
    120 rdf:type schema:DefinedTerm
    121 N68ca639a49a746bbb6ef63a8c0eab9bc schema:name nlm_unique_id
    122 schema:value 101125610
    123 rdf:type schema:PropertyValue
    124 N6b4cc9f1b0474a578d164d9034586772 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Positron-Emission Tomography
    126 rdf:type schema:DefinedTerm
    127 N7221bf3c5b124699a29c7cd8869df568 rdf:first sg:person.01201703107.30
    128 rdf:rest N5f564fdbaffb42b99085fe32bfbbdcfd
    129 N7b20227a403e49729793ad731b6f3dae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Fluorodeoxyglucose F18
    131 rdf:type schema:DefinedTerm
    132 N812420abb7e64be682dbe50d611ef4fe rdf:first sg:person.01067077604.43
    133 rdf:rest N8e79ad4878ed459e8162302eea41c928
    134 N8ad6b9c13dda461ab6766eabf0b67d51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Humans
    136 rdf:type schema:DefinedTerm
    137 N8e79ad4878ed459e8162302eea41c928 rdf:first sg:person.0706754007.00
    138 rdf:rest rdf:nil
    139 Na3e15efee53f4e07a5fa74d97a231267 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Liver Neoplasms
    141 rdf:type schema:DefinedTerm
    142 Na75b0ec924c34f4f8c2e2a65b118635f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Animals
    144 rdf:type schema:DefinedTerm
    145 Nae3097dbf68f47838ad28583f8db22ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Cell Proliferation
    147 rdf:type schema:DefinedTerm
    148 Nafc825c958e14fceb6220a13a8c1488c rdf:first sg:person.01065454507.16
    149 rdf:rest N7221bf3c5b124699a29c7cd8869df568
    150 Nb50191a9e60f470fb32aed8bdc3d7e84 rdf:first sg:person.01324436246.31
    151 rdf:rest N12024a8e643d4db39afe0d849fa200ea
    152 Nc2c1de97eeb34916b97629a5a401992c schema:name doi
    153 schema:value 10.1007/s11307-014-0774-8
    154 rdf:type schema:PropertyValue
    155 Nc4a6024eccf64317b92a9bde92a1ebd2 rdf:first sg:person.01040235623.08
    156 rdf:rest N812420abb7e64be682dbe50d611ef4fe
    157 Nc64e6036a1aa4d33948925bfba63e401 rdf:first sg:person.01200063632.84
    158 rdf:rest Nb50191a9e60f470fb32aed8bdc3d7e84
    159 Nc9f13b47063546e7b30d84a5b473d302 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Immunohistochemistry
    161 rdf:type schema:DefinedTerm
    162 Ne49e385cf3c44615bca7e573a47492f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Hep G2 Cells
    164 rdf:type schema:DefinedTerm
    165 Ne987002a3d7346d2b048fe2a5cc5296a schema:name Springer Nature - SN SciGraph project
    166 rdf:type schema:Organization
    167 Neae325b5d14b44c1ba668d37e1dfff29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Hydroxamic Acids
    169 rdf:type schema:DefinedTerm
    170 Nefbb9e71d1ca43288b1879d955030273 rdf:first sg:person.01114773736.21
    171 rdf:rest N141d77226074459ea316412e0fdd23fc
    172 Nf0f3c6be20bb44b2a6c16161e03137e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Neoplasm Transplantation
    174 rdf:type schema:DefinedTerm
    175 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    176 schema:name Medical and Health Sciences
    177 rdf:type schema:DefinedTerm
    178 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    179 schema:name Oncology and Carcinogenesis
    180 rdf:type schema:DefinedTerm
    181 sg:journal.1118463 schema:issn 1536-1632
    182 1878-5751
    183 schema:name Molecular Imaging and Biology
    184 rdf:type schema:Periodical
    185 sg:person.01027641254.54 schema:affiliation https://www.grid.ac/institutes/grid.260770.4
    186 schema:familyName Chang
    187 schema:givenName C. Allen
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027641254.54
    189 rdf:type schema:Person
    190 sg:person.01040235623.08 schema:affiliation https://www.grid.ac/institutes/grid.260770.4
    191 schema:familyName Hwang
    192 schema:givenName Jeng-Jong
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040235623.08
    194 rdf:type schema:Person
    195 sg:person.01046660536.34 schema:affiliation https://www.grid.ac/institutes/grid.254145.3
    196 schema:familyName Wu
    197 schema:givenName Chun-Yi
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046660536.34
    199 rdf:type schema:Person
    200 sg:person.01065454507.16 schema:affiliation https://www.grid.ac/institutes/grid.260770.4
    201 schema:familyName Chou
    202 schema:givenName Lin-Shan
    203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065454507.16
    204 rdf:type schema:Person
    205 sg:person.01067077604.43 schema:affiliation https://www.grid.ac/institutes/grid.260770.4
    206 schema:familyName Liu
    207 schema:givenName Ren-Shyan
    208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067077604.43
    209 rdf:type schema:Person
    210 sg:person.01114773736.21 schema:affiliation https://www.grid.ac/institutes/grid.260770.4
    211 schema:familyName Chan
    212 schema:givenName Pei-Chia
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114773736.21
    214 rdf:type schema:Person
    215 sg:person.01200063632.84 schema:affiliation https://www.grid.ac/institutes/grid.260770.4
    216 schema:familyName Chiou
    217 schema:givenName Shih-Hwa
    218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200063632.84
    219 rdf:type schema:Person
    220 sg:person.01201703107.30 schema:affiliation https://www.grid.ac/institutes/grid.260770.4
    221 schema:familyName Ho
    222 schema:givenName Chung-Hsien
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201703107.30
    224 rdf:type schema:Person
    225 sg:person.01272364674.46 schema:affiliation https://www.grid.ac/institutes/grid.278247.c
    226 schema:familyName Chang
    227 schema:givenName Chi-Wei
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272364674.46
    229 rdf:type schema:Person
    230 sg:person.01324436246.31 schema:affiliation https://www.grid.ac/institutes/grid.482644.8
    231 schema:familyName Lin
    232 schema:givenName Wuu-Jyh
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324436246.31
    234 rdf:type schema:Person
    235 sg:person.01362026704.52 schema:affiliation https://www.grid.ac/institutes/grid.411531.3
    236 schema:familyName Chen
    237 schema:givenName Fu-Du
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362026704.52
    239 rdf:type schema:Person
    240 sg:person.0706754007.00 schema:affiliation https://www.grid.ac/institutes/grid.260770.4
    241 schema:familyName Wang
    242 schema:givenName Hsin-Ell
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706754007.00
    244 rdf:type schema:Person
    245 sg:pub.10.1007/s00259-004-1687-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014510428
    246 https://doi.org/10.1007/s00259-004-1687-6
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1007/s00259-006-0292-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017008016
    249 https://doi.org/10.1007/s00259-006-0292-2
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1007/s00280-010-1495-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026202228
    252 https://doi.org/10.1007/s00280-010-1495-6
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1007/s00280-011-1762-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052047364
    255 https://doi.org/10.1007/s00280-011-1762-1
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1007/s10495-007-0063-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1030234699
    258 https://doi.org/10.1007/s10495-007-0063-y
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1007/s11307-006-0039-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018933115
    261 https://doi.org/10.1007/s11307-006-0039-2
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1007/s11307-012-0604-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001233059
    264 https://doi.org/10.1007/s11307-012-0604-9
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/bjc.2011.156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040609384
    267 https://doi.org/10.1038/bjc.2011.156
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/bjc.2011.42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009637114
    270 https://doi.org/10.1038/bjc.2011.42
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/nrd1930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021896263
    273 https://doi.org/10.1038/nrd1930
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1186/1756-8722-3-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042777321
    276 https://doi.org/10.1186/1756-8722-3-5
    277 rdf:type schema:CreativeWork
    278 https://app.dimensions.ai/details/publication/pub.1076570553 schema:CreativeWork
    279 https://doi.org/10.1002/jcp.22574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013028110
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/j.bmcl.2004.10.074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049197578
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.cell.2007.01.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009285166
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.exphem.2004.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044886310
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/j.ijpharm.2008.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043267612
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/j.jchromb.2006.04.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011794121
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1021/ja0646895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055842820
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1021/jm00008a020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055932402
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1053/j.gastro.2008.03.073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033665787
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1073/pnas.1117544108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025116497
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1089/cbr.2009.0709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059243025
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1093/carcin/bgp220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020405617
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1128/mcb.25.13.5429-5444.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015346639
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1158/0008-5472.can-04-0540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038054706
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1158/0008-5472.can-04-4297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004752219
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1158/0008-5472.can-05-3962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016643271
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1158/1078-0432.ccr-06-1802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003190855
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1177/1947601912440170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003154491
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1182/blood-2006-06-025999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009387348
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1200/jco.2005.14.167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040412110
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.3892/ijo.32.1.177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071516739
    320 rdf:type schema:CreativeWork
    321 https://www.grid.ac/institutes/grid.254145.3 schema:alternateName China Medical University
    322 schema:name Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan
    323 rdf:type schema:Organization
    324 https://www.grid.ac/institutes/grid.260770.4 schema:alternateName National Yang Ming University
    325 schema:name Biophotonics & Molecular Imaging Research Center, National Yang-Ming University, Taipei, Taiwan
    326 Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan
    327 Department of Nuclear Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
    328 Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan
    329 National PET/Cyclotron Center, Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    330 Taiwan Mouse Clinic, National Comprehensive Mouse Phenotyping and Drug Testing Center, Taipei, Taiwan
    331 rdf:type schema:Organization
    332 https://www.grid.ac/institutes/grid.278247.c schema:alternateName Taipei Veterans General Hospital
    333 schema:name National PET/Cyclotron Center, Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    334 rdf:type schema:Organization
    335 https://www.grid.ac/institutes/grid.411531.3 schema:alternateName Chinese Culture University
    336 schema:name Graduate Institute of Biotechnology, Chinese Culture University, Taipei, Taiwan
    337 rdf:type schema:Organization
    338 https://www.grid.ac/institutes/grid.482644.8 schema:alternateName Institute of Nuclear Energy Research
    339 schema:name Institute of Nuclear Energy Research, Atomic Energy Council, Tao-Yuan County, Taiwan
    340 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...