6-[18F]Fluoro-l-DOPA Uptake in the Rat Pancreas is Dependent on the Tracer Metabolism View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-11-12

AUTHORS

Teemu Kalliokoski, Johanna Tuomela, Laura Haavisto, Sarita Forsback, Anniina Snellman, Semi Helin, Tove J. Grönroos, Olof Solin, Merja Haaparanta-Solin

ABSTRACT

Purpose6-[18F]fluoro-l-3,4-dihydroxyphenyl alanine ([18F]FDOPA) positron emission tomography (PET) is a diagnostic tool which can detect malignancies of the pancreas. We aimed to study whether the manipulation of the [18F]FDOPA metabolic pathway would change the 18F-behavior to provide a biochemical foundation for PET imaging of rat pancreas with [18F]FDOPA.ProceduresInhibitors of aromatic amino acid decarboxylase, catechol-O-methyltransferase, monoamine oxidases A and B, or their combinations on [18F]FDOPA uptake, metabolism, and the regional distribution in the rat pancreas was evaluated using in vivo PET/computed tomography imaging, chromatographic metabolite analyses, and autoradiography.ResultsEnzyme inhibition generally increased the uptake of [18F]FDOPA derived 18F-radioactivity in rat pancreas. Dependent on which enzymatic pathway is blocked (or a combination of pathways), different radiolabeled metabolites in pancreas are responsible for this increase in uptake.ConclusionsAltering the metabolism of [18F]FDOPA by using various enzymatic inhibitors increased the radioactivity uptake and changed the radiometabolic profile in the pancreas allowing better discrimination between pancreas and surrounding tissues of rat. However, these manipulations did not separate islets from the exocrine pancreas. Elucidating the metabolic behavior of [18F]FDOPA provides a biochemical foundation of PET imaging of the rat pancreas. More... »

PAGES

403-411

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11307-013-0701-4

DOI

http://dx.doi.org/10.1007/s11307-013-0701-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032589512

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24217945


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