Ontology type: schema:ScholarlyArticle
2014-02
AUTHORSChun-Yi Wu, Pei-Chia Chan, Lin-Shan Chou, Chi-Wei Chang, Feng-Yi Yang, Ren-Shyan Liu, Shih-Hwa Chiou, Yi-Wei Chen, Sang-Hue Yen, Hsin-Ell Wang
ABSTRACTPURPOSE: This study aims to demonstrate that pulsed high-intensity focused ultrasound (pulsed-HIFU) may enhance the fructose-conjugated 4-borono-L-phenylalanine (BPA-Fr) accumulation in tumor lesion using (18)F-FBPA-Fr microPET scans. PROCEDURES: To the mice bearing orthotopic SASC03 human tongue squamous carcinoma xenograft, a 2-min pulsed-HIFU was applied to tumor. Immediately after pulsed-HIFU treatment, (18)F-FBPA-Fr was intravenously injected, and biological characterizations including microPET imaging and biodistribution were conducted. RESULTS: Both biodistribution studies and microPET imaging performed after intravenous injection of (18)F-FBPA-Fr revealed higher tumor uptake in HIFU-treated mice than that of the control. CD31 and Ki-67 histochemical staining of tumor sections and H&E staining of nearby normal tissues revealed no significant difference between the pulsed-HIFU-treated mice and the control. CONCLUSION: This study demonstrated that pulsed-HIFU was beneficial to the accumulation of boron drug in the head and neck tumor lesion and may enhance the therapeutic efficacy of clinical BNCT. More... »
PAGES95-101
http://scigraph.springernature.com/pub.10.1007/s11307-013-0675-2
DOIhttp://dx.doi.org/10.1007/s11307-013-0675-2
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