Magnetomotive Optical Coherence Tomography for the Assessment of Atherosclerotic Lesions Using αvβ3 Integrin-Targeted Microspheres View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-02

AUTHORS

Jongsik Kim, Adeel Ahmad, Marina Marjanovic, Eric J. Chaney, Joanne Li, Jonathan Rasio, Zita Hubler, Darold Spillman, Kenneth S. Suslick, Stephen A. Boppart

ABSTRACT

PURPOSE: We investigated the early-stage fatty streaks/plaques detection using magnetomotive optical coherence tomography (MM-OCT) in conjunction with αvβ3 integrin-targeted magnetic microspheres (MSs). The targeting of functionalized MSs was investigated by perfusing ex vivo aortas from an atherosclerotic rabbit model in a custom-designed flow chamber at physiologically relevant pulsatile flow rates and pressures. PROCEDURES: Aortas were extracted and placed in a flow chamber. Magnetic MS contrast agents were perfused through the aortas and MM-OCT, fluorescence confocal, and bright field microscopy were performed on the ex vivo aorta specimens for localizing the MSs. RESULTS: The results showed a statistically significant and stronger MM-OCT signal (3.30 ± 1.73 dB) from the aorta segment perfused with targeted MSs, compared with the nontargeted MSs (1.18 ± 0.94 dB) and control (0.78 ± 0.41 dB) aortas. In addition, there was a good co-registration of MM-OCT signals with confocal microscopy. CONCLUSIONS: Early-stage fatty streaks/plaques have been successfully detected using MM-OCT in conjunction with αvβ3 integrin-targeted magnetic MSs. More... »

PAGES

36-43

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11307-013-0671-6

DOI

http://dx.doi.org/10.1007/s11307-013-0671-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005728900

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23907212


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290 Department of Bioengineering, University of Illinois at Urbana-Champaign, 1304 West Springfield Avenue, 61801, Urbana, IL, USA
291 Department of Chemistry, University of Illinois at Urbana-Champaign, 505 South Mathews Avenue, 61801, Urbana, IL, USA
292 Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 1406 West Green Street, 61801, Urbana, IL, USA
293 Department of Internal Medicine, University of Illinois at Urbana-Champaign, 506 South Mathews Avenue, 61801, Urbana, IL, USA
294 Department of Nuclear, Plasma and Radiological Engineering, University of Illinois at Urbana-Champaign, 104 South Wright Street, 61801, Urbana, IL, USA
295 rdf:type schema:Organization
 




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