Monitoring Tumor Response with Radiolabeled Nucleoside Analogs in a Hepatoma-Bearing Mouse Model Early After Doxisome® Treatment View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-06

AUTHORS

Chun-Yi Wu, Lin-Shan Chou, Pei-Chia Chan, Chung-Hsien Ho, Ming-Hsien Lin, Chih-Chieh Shen, Ren-Shyan Liu, Wuu-Jyh Lin, Hsin-Ell Wang

ABSTRACT

PURPOSE: This study aims to demonstrate that 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) positron emission tomography (PET) is a promising modality for noninvasively monitoring the therapeutic efficacy of Doxisome(®) in a subcutaneous hepatoma mouse model. PROCEDURES: Male BALB/c nu/nu mice were inoculated with HepG2 hepatoma xenograft in the right flank. Doxisome(®) (5 mg/kg, three times a week for 2 weeks) was intravenously administrated for treatment. (18)F-FLT-microPET, biodistribution studies, and immunohistochemistry of Ki-67 were performed. RESULTS: A significant difference (p < 0.05) in tumor volume was observed on day 5 between treated and control groups. The tumor-to-muscle ratio derived from (18)F-FLT-PET and (123)I-ICdR-microSPECT images of Doxisome(®)-treated mice dropped from 12.55 ± 0.76 to 3.81 ± 0.31 and from 2.48 ± 0.42 to 1.59 ± 0.08 after a three-dose treatment, respectively, while that of the control group remained steady. The retarded proliferation rate of treated xenograft was confirmed by Ki-67 immunohistochemistry staining. CONCLUSIONS: This study clearly demonstrated that Doxisome(®) is an effective anti-cancer drug against the growth of HepG2 hepatoma and that (18)F-FLT-PET could provide early information of tumor response during treatment. More... »

PAGES

326-335

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11307-012-0604-9

DOI

http://dx.doi.org/10.1007/s11307-012-0604-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001233059

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23247923


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

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curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11307-012-0604-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11307-012-0604-9'

Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11307-012-0604-9'


 

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316 https://www.grid.ac/institutes/grid.413846.c schema:alternateName Cheng Hsin General Hospital
317 schema:name Department of Nuclear Medicine, Cheng Hsin General Hospital, Taipei, Taiwan
318 rdf:type schema:Organization
319 https://www.grid.ac/institutes/grid.482644.8 schema:alternateName Institute of Nuclear Energy Research
320 schema:name Atomic Energy Council, Institute of Nuclear Energy Research, Tao-Yuan, Taiwan
321 rdf:type schema:Organization
 




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