Cross-validation of Input Functions Obtained by H215O PET Imaging of Rat Heart and a Blood Flow-through Detector View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-08

AUTHORS

Nobuyuki Kudomi, Hannu Sipilä, Anu Autio, Vesa Oikonen, Heidi Liljenbäck, Miikka Tarkia, Jarno Laivola, Jarkko Johansson, Mika Teräs, Anne Roivainen

ABSTRACT

PURPOSE: Positron emission tomography (PET) with ¹⁵O-labeled water (H₂ ¹⁵O) facilitates the visualization and quantification of blood flow in clinical investigations and also in small animals. The quantification of blood flow requires an input function, which is generally obtained by measuring radioactivity in arterial blood withdrawn during PET scanning. However, this approach is not always feasible, because abundant blood sampling may affect the physiological process being measured. The purpose of the present study was to develop and cross-validate two methods, namely, a blood- and an image-based method for obtaining the input function for blood flow studies from rat H₂ ¹⁵O PET. METHODS: The study material consisted of two separate groups of rats. Group 1 rats were imaged twice by a high-resolution research tomograph PET camera at resting condition for a test-retest study (n = 4), and group 2 rats were imaged with and without adenosine infusion for a rest-stress study (n = 4). In group 1, radioactivity concentration in arterial blood was measured with a new flow-through detector during imaging and a blood-based input function was obtained. The image-based input function was estimated using time-activity curves from the left ventricle and myocardial regions. To validate the two input function methods, myocardial blood flow (MBF) and cerebral blood flow (CBF) were computed, and the methods were tested for reproducibility (test-retest study) and changes (rest-stress study). RESULTS: The blood- and image-based input functions were similar, and the corresponding CBF values differed only by -6.9 ± 8.1%. In the test-retest study, both MBF and CBF showed good reproducibility, and in the rest-stress study, adenosine significantly increased both MBF (P = 0.035) and CBF (P = 0.029), compared with the resting condition. CONCLUSION: It is possible both to measure the input function from rat arteria femoralis during H₂ ¹⁵O PET imaging and to estimate the input function from rat H₂ ¹⁵O PET images, thereby facilitating the assessment of blood flow in organs visible in PET images. More... »

PAGES

509-516

References to SciGraph publications

  • 2003-12. Quantitative Cerebral Blood Flow Measurements in the Rat Using a Beta-Probe and H215O in JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM
  • 1995-05. Combinations of methods for monitoring the microcirculation of the brain in NEUROSCIENCE AND BEHAVIORAL PHYSIOLOGY
  • 2011-12. Extraction of Input Function from Rat [18F]FDG PET Images in MOLECULAR IMAGING AND BIOLOGY
  • 2002-03. A femoral arteriovenous shunt facilitates arterial whole blood sampling in animals in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2009-12. Non-invasive estimation of hepatic glucose uptake from [18F]FDG PET images using tissue-derived input functions in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11307-011-0511-5

    DOI

    http://dx.doi.org/10.1007/s11307-011-0511-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005194803

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21811861


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    276 schema:name Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    277 rdf:type schema:Organization
     




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