18F-FDG PET/CT Imaging Detects Therapy Efficacy of Anti-EMMPRIN Antibody and Gemcitabine in Orthotopic Pancreatic Tumor Xenografts View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-04-15

AUTHORS

Nemil Shah, Guihua Zhai, Joseph A. Knowles, Cecil R. Stockard, William E. Grizzle, Naomi Fineberg, Tong Zhou, Kurt R. Zinn, Eben L. Rosenthal, Hyunki Kim

ABSTRACT

PurposeThe objective of this study is to evaluate the therapeutic response to a novel monoclonal antibody targeting human extracellular matrix metalloproteinase inducer (EMMPRIN) in combination with gemcitabine in a pancreatic-tumor xenograft murine model by sequential 2-deoxy-2-[18F]fluoro-d-glucose (18F-FDG) positron emission tomography/computed tomgraphy (PET/CT) imaging.ProceduresFour groups of SCID mice bearing orthotopic pancreatic tumor xenografts were injected with phosphate-buffered saline, gemcitabine (120 mg/kg BW), anti-EMMPRIN antibody (0.2 mg), or combination, respectively, twice weekly for 2 weeks, while 18F-FDG PET/CT imaging was performed weekly for 3 weeks. Changes in mean standardized uptake value (SUVmean) of 18F-FDG and volume of tumors were determined.ResultsThe tumor SUVmean change in the group receiving combination therapy was significantly lower than those of the other groups. Tumor-volume changes of groups treated with anti-EMMPRIN monotherapy or combined therapy were significantly lower than that of the control group.ConclusionsThese data provide support for clinical studies of anti-EMMPRIN therapy with gemcitabine for pancreatic cancer treatment. More... »

PAGES

237-244

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11307-011-0491-5

DOI

http://dx.doi.org/10.1007/s11307-011-0491-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020412706

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21494920


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