Tracer Level Electrophilic Synthesis and Pharmacokinetics of the Hypoxia Tracer [18F]EF5 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-03-30

AUTHORS

Olli Eskola, Tove J. Grönroos, Sarita Forsback, Johanna Tuomela, Gaber Komar, Jörgen Bergman, Pirkko Härkönen, Merja Haaparanta, Heikki Minn, Olof Solin

ABSTRACT

Purpose2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)-acetamide labeled with [18F]-fluorine ([18F]EF5), a promising tracer for tumor hypoxia, has previously been synthesized in low yields and low specific radioactivity. In pharmacokinetic evaluations, in the presence of non-radioactive EF5, a uniform and low background uptake and high in vivo stability of [18F]EF5 have been demonstrated. Our purpose was to increase the specific radioactivity of [18F]EF5 to enable to study the pharmacokinetics at trace level.Procedures[18F]EF5 was synthesized using high specific radioactivity electrophilic [18F]F2 as labelling reagent. Biodistribution of [18F]EF5 was determined in a prostate tumor mouse model, and formation of radiolabelled metabolites was studied in mouse, rat and human plasma.ResultsOn average, 595 ± 153 MBq of [18F]EF5 was produced. Specific radioactivity was 6.6 ± 1.9 GBq/μmol and the radiochemical purity exceeded 99.0%. [18F]EF5 was distributed uniformly in tissues, with highest uptake in liver, kidney, and intestine. Several radiolabelled metabolites were detected in mouse plasma and tissues, whereas low amounts of metabolites were detected in human and rat plasma.Conclusions[18F]EF5 was synthesized by electrophilic labelling with high quality and high yields. Pharmacokinetics of [18F]EF5 was determined at trace level in several species. Our results suggest that the trace-level approach does not affect the biodistribution of [18F]EF5. Extensive metabolism was seen in mouse. More... »

PAGES

205-212

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11307-011-0484-4

DOI

http://dx.doi.org/10.1007/s11307-011-0484-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046913665

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21448777


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Hypoxia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatography, High Pressure Liquid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatography, Thin Layer", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Etanidazole", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorine Radioisotopes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrocarbons, Fluorinated", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Isomerism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radioactive Tracers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Distribution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenograft Model Antitumor Assays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Turku PET Centre, Radiopharmaceutical Chemistry Laboratory, University of Turku, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.470895.7", 
          "name": [
            "Turku PET Centre, Radiopharmaceutical Chemistry Laboratory, University of Turku, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eskola", 
        "givenName": "Olli", 
        "id": "sg:person.01310420600.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310420600.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku PET Centre, Medicity/PET Preclinical Imaging, University of Turku, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.470895.7", 
          "name": [
            "Turku PET Centre, Medicity/PET Preclinical Imaging, University of Turku, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gr\u00f6nroos", 
        "givenName": "Tove J.", 
        "id": "sg:person.01102756462.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102756462.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku PET Centre, Radiopharmaceutical Chemistry Laboratory, University of Turku, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.470895.7", 
          "name": [
            "Turku PET Centre, Radiopharmaceutical Chemistry Laboratory, University of Turku, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Forsback", 
        "givenName": "Sarita", 
        "id": "sg:person.01071362053.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071362053.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pharmatest Services Ltd, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.452714.1", 
          "name": [
            "Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Turku, Finland", 
            "Pharmatest Services Ltd, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tuomela", 
        "givenName": "Johanna", 
        "id": "sg:person.01244231205.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244231205.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology and Radiotherapy and Turku PET Centre, University of Turku, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.1374.1", 
          "name": [
            "Department of Oncology and Radiotherapy and Turku PET Centre, University of Turku, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Komar", 
        "givenName": "Gaber", 
        "id": "sg:person.01045317743.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045317743.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku PET Centre, Accelerator Laboratory, \u00c5bo Akademi University, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.470895.7", 
          "name": [
            "Turku PET Centre, Radiopharmaceutical Chemistry Laboratory, University of Turku, Turku, Finland", 
            "Turku PET Centre, Accelerator Laboratory, \u00c5bo Akademi University, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bergman", 
        "givenName": "J\u00f6rgen", 
        "id": "sg:person.011221263002.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011221263002.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Laboratory Medicine, MAS University Hospital, Lund University, Lund, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.4514.4", 
          "name": [
            "Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Turku, Finland", 
            "Department of Laboratory Medicine, MAS University Hospital, Lund University, Lund, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "H\u00e4rk\u00f6nen", 
        "givenName": "Pirkko", 
        "id": "sg:person.01131663575.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131663575.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku PET Centre, Medicity/PET Preclinical Imaging, University of Turku, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.470895.7", 
          "name": [
            "Turku PET Centre, Medicity/PET Preclinical Imaging, University of Turku, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haaparanta", 
        "givenName": "Merja", 
        "id": "sg:person.01205342410.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205342410.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology and Radiotherapy and Turku PET Centre, University of Turku, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.1374.1", 
          "name": [
            "Department of Oncology and Radiotherapy and Turku PET Centre, University of Turku, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Minn", 
        "givenName": "Heikki", 
        "id": "sg:person.0700413711.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700413711.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku PET Centre, Accelerator Laboratory, \u00c5bo Akademi University, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.470895.7", 
          "name": [
            "Turku PET Centre, Radiopharmaceutical Chemistry Laboratory, University of Turku, Turku, Finland", 
            "Turku PET Centre, Accelerator Laboratory, \u00c5bo Akademi University, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Solin", 
        "givenName": "Olof", 
        "id": "sg:person.0656631675.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656631675.01"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf01081524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020842283", 
          "https://doi.org/10.1007/bf01081524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052255963", 
          "https://doi.org/10.1038/nrc1367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-004-1573-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039480227", 
          "https://doi.org/10.1007/s00259-004-1573-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-008-0907-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023774517", 
          "https://doi.org/10.1007/s00259-008-0907-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-002-1037-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029511921", 
          "https://doi.org/10.1007/s00259-002-1037-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4615-0205-0_47", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030408834", 
          "https://doi.org/10.1007/978-1-4615-0205-0_47"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002800100324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002101901", 
          "https://doi.org/10.1007/s002800100324"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-03-30", 
    "datePublishedReg": "2011-03-30", 
    "description": "Purpose2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)-acetamide labeled with [18F]-fluorine ([18F]EF5), a promising tracer for tumor hypoxia, has previously been synthesized in low yields and low specific radioactivity. In pharmacokinetic evaluations, in the presence of non-radioactive EF5, a uniform and low background uptake and high in vivo stability of [18F]EF5 have been demonstrated. Our purpose was to increase the specific radioactivity of [18F]EF5 to enable to study the pharmacokinetics at trace level.Procedures[18F]EF5 was synthesized using high specific radioactivity electrophilic [18F]F2 as labelling reagent. Biodistribution of [18F]EF5 was determined in a prostate tumor mouse model, and formation of radiolabelled metabolites was studied in mouse, rat and human plasma.ResultsOn average, 595\u2009\u00b1\u2009153\u00a0MBq of [18F]EF5 was produced. Specific radioactivity was 6.6\u2009\u00b1\u20091.9\u00a0GBq/\u03bcmol and the radiochemical purity exceeded 99.0%. [18F]EF5 was distributed uniformly in tissues, with highest uptake in liver, kidney, and intestine. Several radiolabelled metabolites were detected in mouse plasma and tissues, whereas low amounts of metabolites were detected in human and rat plasma.Conclusions[18F]EF5 was synthesized by electrophilic labelling with high quality and high yields. Pharmacokinetics of [18F]EF5 was determined at trace level in several species. Our results suggest that the trace-level approach does not affect the biodistribution of [18F]EF5. Extensive metabolism was seen in mouse.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s11307-011-0484-4", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1412891", 
        "issn": [
          "1536-1632", 
          "1878-5751"
        ], 
        "name": "Molecular Imaging and Biology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "keywords": [
      "prostate tumor mouse model", 
      "radiolabelled metabolites", 
      "low background uptake", 
      "tumor mouse model", 
      "specific radioactivity", 
      "pharmacokinetic evaluation", 
      "mouse model", 
      "extensive metabolism", 
      "background uptake", 
      "tumor hypoxia", 
      "hypoxia tracer", 
      "pharmacokinetics", 
      "ResultsOn average", 
      "mouse plasma", 
      "high uptake", 
      "low specific radioactivity", 
      "promising tracer", 
      "mice", 
      "human plasma", 
      "rat plasma", 
      "GBq/", 
      "biodistribution", 
      "electrophilic synthesis", 
      "vivo stability", 
      "metabolites", 
      "radiochemical purity", 
      "tissue", 
      "radioactivity", 
      "rats", 
      "kidney", 
      "liver", 
      "plasma", 
      "hypoxia", 
      "uptake", 
      "intestine", 
      "MBq", 
      "levels", 
      "nitro-1H", 
      "Purpose2", 
      "metabolism", 
      "EF5", 
      "electrophilic labelling", 
      "humans", 
      "low amounts", 
      "tracer", 
      "evaluation", 
      "imidazol-1", 
      "labeling", 
      "presence", 
      "average", 
      "purpose", 
      "quality", 
      "high quality", 
      "labeling reagent", 
      "results", 
      "trace levels", 
      "amount", 
      "model", 
      "formation", 
      "reagents", 
      "synthesis", 
      "approach", 
      "acetamide", 
      "low yield", 
      "high yields", 
      "species", 
      "electrophilic", 
      "yield", 
      "fluorine", 
      "purity", 
      "stability"
    ], 
    "name": "Tracer Level Electrophilic Synthesis and Pharmacokinetics of the Hypoxia Tracer [18F]EF5", 
    "pagination": "205-212", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046913665"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11307-011-0484-4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21448777"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11307-011-0484-4", 
      "https://app.dimensions.ai/details/publication/pub.1046913665"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_533.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s11307-011-0484-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11307-011-0484-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11307-011-0484-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11307-011-0484-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11307-011-0484-4'


 

This table displays all metadata directly associated to this object as RDF triples.

302 TRIPLES      21 PREDICATES      119 URIs      104 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11307-011-0484-4 schema:about N20866e8aeb8c47ccb08100619c280608
2 N24d7df27410741a39e142a8cda03d3e4
3 N308cf91154ad48cc86d73fe62651b4f1
4 N3598901c80764aeea6ed0a2e3b3e30b3
5 N656fc144c0504209befff12b5ad03c53
6 N6f17f5456bba478b81816f6c135aa67d
7 Na0e0a09efb394ee6844359123ade6336
8 Na26e86d57f7a4479af8848118f09c2f3
9 Na6487ea381a2424f8f803221100b0133
10 Naae4c3a923eb4341851de89dcddb1b5d
11 Nab272b6b8f45436d95a8e5cdd3d632f3
12 Naf65f0a35bf14baf9b12841d0368d27a
13 Nb565bfc06c684b2bb7c2dc43e70d2a25
14 Nb73cf89aa5a94585960354f5827d4d09
15 Nb86b94db425b4050b374e9c30f53d9c9
16 Neaab506614254aeebd3e9e27855b466e
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author Nfe058eb388ab4d16807066f6f1baa0e1
20 schema:citation sg:pub.10.1007/978-1-4615-0205-0_47
21 sg:pub.10.1007/bf01081524
22 sg:pub.10.1007/s00259-002-1037-5
23 sg:pub.10.1007/s00259-004-1573-2
24 sg:pub.10.1007/s00259-008-0907-x
25 sg:pub.10.1007/s002800100324
26 sg:pub.10.1038/nrc1367
27 schema:datePublished 2011-03-30
28 schema:datePublishedReg 2011-03-30
29 schema:description Purpose2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)-acetamide labeled with [18F]-fluorine ([18F]EF5), a promising tracer for tumor hypoxia, has previously been synthesized in low yields and low specific radioactivity. In pharmacokinetic evaluations, in the presence of non-radioactive EF5, a uniform and low background uptake and high in vivo stability of [18F]EF5 have been demonstrated. Our purpose was to increase the specific radioactivity of [18F]EF5 to enable to study the pharmacokinetics at trace level.Procedures[18F]EF5 was synthesized using high specific radioactivity electrophilic [18F]F2 as labelling reagent. Biodistribution of [18F]EF5 was determined in a prostate tumor mouse model, and formation of radiolabelled metabolites was studied in mouse, rat and human plasma.ResultsOn average, 595 ± 153 MBq of [18F]EF5 was produced. Specific radioactivity was 6.6 ± 1.9 GBq/μmol and the radiochemical purity exceeded 99.0%. [18F]EF5 was distributed uniformly in tissues, with highest uptake in liver, kidney, and intestine. Several radiolabelled metabolites were detected in mouse plasma and tissues, whereas low amounts of metabolites were detected in human and rat plasma.Conclusions[18F]EF5 was synthesized by electrophilic labelling with high quality and high yields. Pharmacokinetics of [18F]EF5 was determined at trace level in several species. Our results suggest that the trace-level approach does not affect the biodistribution of [18F]EF5. Extensive metabolism was seen in mouse.
30 schema:genre article
31 schema:isAccessibleForFree false
32 schema:isPartOf Ndab57e29c017472b9799685efc634482
33 Nf5a1d474847449309f2315883ec214cd
34 sg:journal.1412891
35 schema:keywords EF5
36 GBq/
37 MBq
38 Purpose2
39 ResultsOn average
40 acetamide
41 amount
42 approach
43 average
44 background uptake
45 biodistribution
46 electrophilic
47 electrophilic labelling
48 electrophilic synthesis
49 evaluation
50 extensive metabolism
51 fluorine
52 formation
53 high quality
54 high uptake
55 high yields
56 human plasma
57 humans
58 hypoxia
59 hypoxia tracer
60 imidazol-1
61 intestine
62 kidney
63 labeling
64 labeling reagent
65 levels
66 liver
67 low amounts
68 low background uptake
69 low specific radioactivity
70 low yield
71 metabolism
72 metabolites
73 mice
74 model
75 mouse model
76 mouse plasma
77 nitro-1H
78 pharmacokinetic evaluation
79 pharmacokinetics
80 plasma
81 presence
82 promising tracer
83 prostate tumor mouse model
84 purity
85 purpose
86 quality
87 radioactivity
88 radiochemical purity
89 radiolabelled metabolites
90 rat plasma
91 rats
92 reagents
93 results
94 species
95 specific radioactivity
96 stability
97 synthesis
98 tissue
99 trace levels
100 tracer
101 tumor hypoxia
102 tumor mouse model
103 uptake
104 vivo stability
105 yield
106 schema:name Tracer Level Electrophilic Synthesis and Pharmacokinetics of the Hypoxia Tracer [18F]EF5
107 schema:pagination 205-212
108 schema:productId N1d11096aca3640fbb89363cec02cbf5e
109 N6f5f9f27c8f448c0a9ff96831a3b945f
110 Nac44b9bf02354f48ac3e52ba157d2b35
111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046913665
112 https://doi.org/10.1007/s11307-011-0484-4
113 schema:sdDatePublished 2022-09-02T15:54
114 schema:sdLicense https://scigraph.springernature.com/explorer/license/
115 schema:sdPublisher N1b9561e600a04f5d8ca1b31027602cdb
116 schema:url https://doi.org/10.1007/s11307-011-0484-4
117 sgo:license sg:explorer/license/
118 sgo:sdDataset articles
119 rdf:type schema:ScholarlyArticle
120 N0d24963754cc4823a77d00f4f5234668 rdf:first sg:person.011221263002.14
121 rdf:rest Na00fe1bc60224fd8b4cbec7f3bcecf5a
122 N139bbb0177624b9c8ce27c04bfd56828 rdf:first sg:person.01244231205.07
123 rdf:rest N5c10b9caef824b0d9c1e6912e5c1c747
124 N1b9561e600a04f5d8ca1b31027602cdb schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 N1d11096aca3640fbb89363cec02cbf5e schema:name doi
127 schema:value 10.1007/s11307-011-0484-4
128 rdf:type schema:PropertyValue
129 N20866e8aeb8c47ccb08100619c280608 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Cell Line, Tumor
131 rdf:type schema:DefinedTerm
132 N24d7df27410741a39e142a8cda03d3e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Xenograft Model Antitumor Assays
134 rdf:type schema:DefinedTerm
135 N308cf91154ad48cc86d73fe62651b4f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Male
137 rdf:type schema:DefinedTerm
138 N355bfdab034e402c8917539bc6b64034 rdf:first sg:person.01071362053.45
139 rdf:rest N139bbb0177624b9c8ce27c04bfd56828
140 N3598901c80764aeea6ed0a2e3b3e30b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Animals
142 rdf:type schema:DefinedTerm
143 N48ebba89111e4df1bbb7a518a8c68546 rdf:first sg:person.01205342410.46
144 rdf:rest N500ba9674cdf4582a9206e1f1c2b3652
145 N500ba9674cdf4582a9206e1f1c2b3652 rdf:first sg:person.0700413711.55
146 rdf:rest Nacf379c9b04c4422bb3370fff4a56df0
147 N5c10b9caef824b0d9c1e6912e5c1c747 rdf:first sg:person.01045317743.33
148 rdf:rest N0d24963754cc4823a77d00f4f5234668
149 N656fc144c0504209befff12b5ad03c53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Etanidazole
151 rdf:type schema:DefinedTerm
152 N6f17f5456bba478b81816f6c135aa67d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Fluorine Radioisotopes
154 rdf:type schema:DefinedTerm
155 N6f5f9f27c8f448c0a9ff96831a3b945f schema:name pubmed_id
156 schema:value 21448777
157 rdf:type schema:PropertyValue
158 N9e51e00f125a4d12acffe25cc576f58a rdf:first sg:person.01102756462.43
159 rdf:rest N355bfdab034e402c8917539bc6b64034
160 Na00fe1bc60224fd8b4cbec7f3bcecf5a rdf:first sg:person.01131663575.79
161 rdf:rest N48ebba89111e4df1bbb7a518a8c68546
162 Na0e0a09efb394ee6844359123ade6336 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Tissue Distribution
164 rdf:type schema:DefinedTerm
165 Na26e86d57f7a4479af8848118f09c2f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Chromatography, High Pressure Liquid
167 rdf:type schema:DefinedTerm
168 Na6487ea381a2424f8f803221100b0133 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Mice
170 rdf:type schema:DefinedTerm
171 Naae4c3a923eb4341851de89dcddb1b5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Hydrocarbons, Fluorinated
173 rdf:type schema:DefinedTerm
174 Nab272b6b8f45436d95a8e5cdd3d632f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Cell Hypoxia
176 rdf:type schema:DefinedTerm
177 Nac44b9bf02354f48ac3e52ba157d2b35 schema:name dimensions_id
178 schema:value pub.1046913665
179 rdf:type schema:PropertyValue
180 Nacf379c9b04c4422bb3370fff4a56df0 rdf:first sg:person.0656631675.01
181 rdf:rest rdf:nil
182 Naf65f0a35bf14baf9b12841d0368d27a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Rats
184 rdf:type schema:DefinedTerm
185 Nb565bfc06c684b2bb7c2dc43e70d2a25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Radioactive Tracers
187 rdf:type schema:DefinedTerm
188 Nb73cf89aa5a94585960354f5827d4d09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Humans
190 rdf:type schema:DefinedTerm
191 Nb86b94db425b4050b374e9c30f53d9c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Chromatography, Thin Layer
193 rdf:type schema:DefinedTerm
194 Ndab57e29c017472b9799685efc634482 schema:issueNumber 2
195 rdf:type schema:PublicationIssue
196 Neaab506614254aeebd3e9e27855b466e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Isomerism
198 rdf:type schema:DefinedTerm
199 Nf5a1d474847449309f2315883ec214cd schema:volumeNumber 14
200 rdf:type schema:PublicationVolume
201 Nfe058eb388ab4d16807066f6f1baa0e1 rdf:first sg:person.01310420600.55
202 rdf:rest N9e51e00f125a4d12acffe25cc576f58a
203 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
204 schema:name Medical and Health Sciences
205 rdf:type schema:DefinedTerm
206 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
207 schema:name Clinical Sciences
208 rdf:type schema:DefinedTerm
209 sg:journal.1412891 schema:issn 1536-1632
210 1878-5751
211 schema:name Molecular Imaging and Biology
212 schema:publisher Springer Nature
213 rdf:type schema:Periodical
214 sg:person.01045317743.33 schema:affiliation grid-institutes:grid.1374.1
215 schema:familyName Komar
216 schema:givenName Gaber
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045317743.33
218 rdf:type schema:Person
219 sg:person.01071362053.45 schema:affiliation grid-institutes:grid.470895.7
220 schema:familyName Forsback
221 schema:givenName Sarita
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071362053.45
223 rdf:type schema:Person
224 sg:person.01102756462.43 schema:affiliation grid-institutes:grid.470895.7
225 schema:familyName Grönroos
226 schema:givenName Tove J.
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102756462.43
228 rdf:type schema:Person
229 sg:person.011221263002.14 schema:affiliation grid-institutes:grid.470895.7
230 schema:familyName Bergman
231 schema:givenName Jörgen
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011221263002.14
233 rdf:type schema:Person
234 sg:person.01131663575.79 schema:affiliation grid-institutes:grid.4514.4
235 schema:familyName Härkönen
236 schema:givenName Pirkko
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131663575.79
238 rdf:type schema:Person
239 sg:person.01205342410.46 schema:affiliation grid-institutes:grid.470895.7
240 schema:familyName Haaparanta
241 schema:givenName Merja
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205342410.46
243 rdf:type schema:Person
244 sg:person.01244231205.07 schema:affiliation grid-institutes:grid.452714.1
245 schema:familyName Tuomela
246 schema:givenName Johanna
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244231205.07
248 rdf:type schema:Person
249 sg:person.01310420600.55 schema:affiliation grid-institutes:grid.470895.7
250 schema:familyName Eskola
251 schema:givenName Olli
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310420600.55
253 rdf:type schema:Person
254 sg:person.0656631675.01 schema:affiliation grid-institutes:grid.470895.7
255 schema:familyName Solin
256 schema:givenName Olof
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656631675.01
258 rdf:type schema:Person
259 sg:person.0700413711.55 schema:affiliation grid-institutes:grid.1374.1
260 schema:familyName Minn
261 schema:givenName Heikki
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700413711.55
263 rdf:type schema:Person
264 sg:pub.10.1007/978-1-4615-0205-0_47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030408834
265 https://doi.org/10.1007/978-1-4615-0205-0_47
266 rdf:type schema:CreativeWork
267 sg:pub.10.1007/bf01081524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020842283
268 https://doi.org/10.1007/bf01081524
269 rdf:type schema:CreativeWork
270 sg:pub.10.1007/s00259-002-1037-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029511921
271 https://doi.org/10.1007/s00259-002-1037-5
272 rdf:type schema:CreativeWork
273 sg:pub.10.1007/s00259-004-1573-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039480227
274 https://doi.org/10.1007/s00259-004-1573-2
275 rdf:type schema:CreativeWork
276 sg:pub.10.1007/s00259-008-0907-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023774517
277 https://doi.org/10.1007/s00259-008-0907-x
278 rdf:type schema:CreativeWork
279 sg:pub.10.1007/s002800100324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002101901
280 https://doi.org/10.1007/s002800100324
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/nrc1367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052255963
283 https://doi.org/10.1038/nrc1367
284 rdf:type schema:CreativeWork
285 grid-institutes:grid.1374.1 schema:alternateName Department of Oncology and Radiotherapy and Turku PET Centre, University of Turku, Turku, Finland
286 schema:name Department of Oncology and Radiotherapy and Turku PET Centre, University of Turku, Turku, Finland
287 rdf:type schema:Organization
288 grid-institutes:grid.4514.4 schema:alternateName Department of Laboratory Medicine, MAS University Hospital, Lund University, Lund, Sweden
289 schema:name Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Turku, Finland
290 Department of Laboratory Medicine, MAS University Hospital, Lund University, Lund, Sweden
291 rdf:type schema:Organization
292 grid-institutes:grid.452714.1 schema:alternateName Pharmatest Services Ltd, Turku, Finland
293 schema:name Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Turku, Finland
294 Pharmatest Services Ltd, Turku, Finland
295 rdf:type schema:Organization
296 grid-institutes:grid.470895.7 schema:alternateName Turku PET Centre, Accelerator Laboratory, Åbo Akademi University, Turku, Finland
297 Turku PET Centre, Medicity/PET Preclinical Imaging, University of Turku, Turku, Finland
298 Turku PET Centre, Radiopharmaceutical Chemistry Laboratory, University of Turku, Turku, Finland
299 schema:name Turku PET Centre, Accelerator Laboratory, Åbo Akademi University, Turku, Finland
300 Turku PET Centre, Medicity/PET Preclinical Imaging, University of Turku, Turku, Finland
301 Turku PET Centre, Radiopharmaceutical Chemistry Laboratory, University of Turku, Turku, Finland
302 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...