Comparison of 2β-Carbomethoxy-3β-(4-[18F]Fluorophenyl)Tropane and N-(3-[18F]Fluoropropyl)-2β-Carbomethoxy-3β-(4-Fluorophenyl)Nortropane, Tracers for Imaging Dopamine Transporter in Rat View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-12-01

AUTHORS

Päivi Marjamäki, Merja Haaparanta, Sarita Forsback, Veronica Fagerholm, Olli Eskola, Tove Grönroos, Teija Koivula, Olof Solin

ABSTRACT

PurposeThis study compares 2β-carbomethoxy-3β-(4-[18F]fluorophenyl)tropane ([18F]β-CFT) and N-(3-[18F]fluoropropyl)-2β-carbomethoxy-3β-(4-fluorophenyl)nortropane ([18F]β-CFT-FP) as radiotracers for imaging the dopamine transporter (DAT) in rat.ProceduresBiodistribution, specificity and selectivity of the radiotracers were studied ex vivo in rats pre-treated with specific antagonists for DAT, serotonin transporter (SERT) and noradrenalin transporter (NET) and in control rats. Positron emission tomography (PET) studies were performed using an HRRT scanner. Radiolabelled metabolites were analyzed with thin-layer chromatography.Results[18F]β-CFT showed slow kinetics with a maximum striatum/cerebellum uptake ratio of 9.2 at 120 min. [18F]β-CFT-FP showed fast kinetics with a maximum ratio of 3.1 at 5 min. Both tracers bound to DAT. [18F]β-CFT also bound to NET. [18F]β-CFT was more resistant to metabolism than [18F]β-CFT-FP.ConclusionsStructural modifications of [18F]β-CFT significantly changed its biological properties, as shown by [18F]β-CFT-FP. [18F]β-CFT is a suitable tracer for both preclinical and human PET studies, but [18F]β-CFT-FP is less suitable as a PET tracer. More... »

PAGES

269-277

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11307-009-0278-0

DOI

http://dx.doi.org/10.1007/s11307-009-0278-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018120799

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19949983


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