In Vivo Imaging of Sentinel Nodes Using Fluorescent Silica Nanoparticles in Living Mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-10-15

AUTHORS

Yong Hyun Jeon, Young-Hwa Kim, Kihwan Choi, Jing Yu Piao, Bo Quan, Yun-Sang Lee, Jae Min Jeong, June-Key Chung, Dong Soo Lee, Myung Chul Lee, Jaetae Lee, Doo Soo Chung, Keon Wook Kang

ABSTRACT

PurposeWe examine the feasibility of fluorescent imaging system for sentinel lymph node detection by using functionalized silica nanoparticles.Materials and MethodsWe developed a functionalized RITC-SiO2 nanoparticles containing fluorescent dye, C28H31N2O3Cl (rhodamine B isothiocyanate) inside, and subsequently synthesized 68Ga-NOTA-RITC-SiO2 nanoparticles.ResultsAt 5 min after RITC-doped silica nanoparticles injection, fluorescent signals were shown in both right axillary lymph node (ALN) and injection site of living mice. Fluorescent signals were also observed at these locations in a biodistribution study. In addition, fluorescence was detected in frozen ALN sections microscopically. The percentages of doses injected per gram of tissue of axillary and brachial lymph nodes near footpad treated with 68Ga-NOTA-RITC-SiO2 nanoparticles were 308.3 ± 3.4 and 41.5 ± 6.1, respectively. Little 68Ga radioactivity was found in other organs.ConclusionOur data provide strong evidence that functionalized silica nanoparticles has a promising potential as organic lymphatic tracer in biomedical imaging such as pre- and intraoperative surgical guidance. More... »

PAGES

155-162

References to SciGraph publications

Journal

TITLE

Molecular Imaging and Biology

ISSUE

2

VOLUME

12

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11307-009-0262-8

DOI

http://dx.doi.org/10.1007/s11307-009-0262-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046597456

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19830500


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30 schema:description PurposeWe examine the feasibility of fluorescent imaging system for sentinel lymph node detection by using functionalized silica nanoparticles.Materials and MethodsWe developed a functionalized RITC-SiO2 nanoparticles containing fluorescent dye, C28H31N2O3Cl (rhodamine B isothiocyanate) inside, and subsequently synthesized 68Ga-NOTA-RITC-SiO2 nanoparticles.ResultsAt 5 min after RITC-doped silica nanoparticles injection, fluorescent signals were shown in both right axillary lymph node (ALN) and injection site of living mice. Fluorescent signals were also observed at these locations in a biodistribution study. In addition, fluorescence was detected in frozen ALN sections microscopically. The percentages of doses injected per gram of tissue of axillary and brachial lymph nodes near footpad treated with 68Ga-NOTA-RITC-SiO2 nanoparticles were 308.3 ± 3.4 and 41.5 ± 6.1, respectively. Little 68Ga radioactivity was found in other organs.ConclusionOur data provide strong evidence that functionalized silica nanoparticles has a promising potential as organic lymphatic tracer in biomedical imaging such as pre- and intraoperative surgical guidance.
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37 MethodsWe
38 PurposeWe
39 ResultsAt 5
40 addition
41 axillary lymph nodes
42 biodistribution studies
43 biomedical imaging
44 brachial lymph nodes
45 data
46 detection
47 doses
48 dye
49 evidence
50 feasibility
51 fluorescence
52 fluorescent dye
53 fluorescent imaging system
54 fluorescent signal
55 fluorescent silica nanoparticles
56 footpad
57 guidance
58 imaging
59 imaging system
60 injection
61 injection site
62 intraoperative surgical guidance
63 location
64 lymph
65 lymph nodes
66 lymphatic tracer
67 materials
68 mice
69 min
70 nanoparticle injection
71 nanoparticles
72 nodes
73 organs
74 percentage
75 percentage of doses
76 potential
77 promising potential
78 radioactivity
79 right axillary lymph node
80 sections
81 sentinel lymph
82 sentinel nodes
83 signals
84 silica nanoparticles
85 sites
86 strong evidence
87 study
88 surgical guidance
89 system
90 tissue
91 tracer
92 vivo imaging
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