Limitations of Small Animal PET Imaging with [18F]FDDNP and FDG for Quantitative Studies in a Transgenic Mouse Model of Alzheimer’s ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-07

AUTHORS

Claudia Kuntner, Adam L. Kesner, Martin Bauer, Robert Kremslehner, Thomas Wanek, Markus Mandler, Rudolf Karch, Johann Stanek, Tanja Wolf, Markus Müller, Oliver Langer

ABSTRACT

PURPOSE: We evaluated the usefulness of small animal brain positron emission tomography (PET) imaging with the amyloid-beta (A beta) probe 2-(1-{6-[(2-[(18)F]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malonitrile ([(18)F]FDDNP) and with 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) for detection and quantification of pathological changes occurring in a transgenic mouse model of Alzheimer's disease (Tg2576 mice). PROCEDURES: [(18)F]FDDNP (n = 6) and FDG-PET scans (n = 3) were recorded in Tg2576 mice (age 13-15 months) and age-matched wild-type litter mates. Brain volumes of interest were defined by co-registration of PET images with a 3D MOBY digital mouse phantom. Regional [(18)F]FDDNP retention in mouse brain was quantified in terms of the relative distribution volume (DVR) using Logan's graphical analysis with cerebellum as a reference region. RESULTS: Except for a lower maximum brain uptake of radioactivity in transgenic animals, the regional brain kinetics as well as DVR values of [(18)F]FDDNP appeared to be similar in both groups of animals. Also for FDG, regional radioactivity retention was almost identical in the brains of transgenic and control animals. CONCLUSIONS: We could not detect regionally increased [(18)F]FDDNP binding and regionally decreased FDG binding in the brains of Tg2576 transgenic versus wild-type mice. However, small group differences in signal might have been masked by inter-animal variability. In addition, technical limitations of the applied method (partial volume effect, spatial resolution) for measurements in such small organs as mouse brain have to be taken into consideration. More... »

PAGES

236-240

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11307-009-0198-z

DOI

http://dx.doi.org/10.1007/s11307-009-0198-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014247392

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19214638


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alzheimer Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amyloid beta-Peptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorodeoxyglucose F18", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Imaging, Three-Dimensional", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nitriles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phantoms, Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Positron-Emission Tomography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiopharmaceuticals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Statistics, Nonparametric", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Radiopharmaceuticals & microPET Imaging, Austrian Research Centers GmbH\u2014ARC, 2444, Seibersdorf, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuntner", 
        "givenName": "Claudia", 
        "id": "sg:person.0706137155.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706137155.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California Los Angeles", 
          "id": "https://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kesner", 
        "givenName": "Adam L.", 
        "id": "sg:person.01123401632.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123401632.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bauer", 
        "givenName": "Martin", 
        "id": "sg:person.01230665756.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230665756.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "TU Wien", 
          "id": "https://www.grid.ac/institutes/grid.5329.d", 
          "name": [
            "Department of Radiopharmaceuticals & microPET Imaging, Austrian Research Centers GmbH\u2014ARC, 2444, Seibersdorf, Austria", 
            "Institute of Solid State Physics, University of Technology, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kremslehner", 
        "givenName": "Robert", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Radiopharmaceuticals & microPET Imaging, Austrian Research Centers GmbH\u2014ARC, 2444, Seibersdorf, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wanek", 
        "givenName": "Thomas", 
        "id": "sg:person.01136614155.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136614155.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "AFFiRiS (Austria)", 
          "id": "https://www.grid.ac/institutes/grid.452292.a", 
          "name": [
            "AFFiRiS GmbH, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mandler", 
        "givenName": "Markus", 
        "id": "sg:person.01025177211.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025177211.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Medical Computer Sciences, Medical University of Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karch", 
        "givenName": "Rudolf", 
        "id": "sg:person.01247206647.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247206647.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Radiopharmaceuticals & microPET Imaging, Austrian Research Centers GmbH\u2014ARC, 2444, Seibersdorf, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stanek", 
        "givenName": "Johann", 
        "id": "sg:person.01331535741.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331535741.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Toxicology, Austrian Research Centers GmbH\u2014ARC, 2444, Seibersdorf, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wolf", 
        "givenName": "Tanja", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00fcller", 
        "givenName": "Markus", 
        "id": "sg:person.012520567642.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012520567642.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.22937.3d", 
          "name": [
            "Department of Radiopharmaceuticals & microPET Imaging, Austrian Research Centers GmbH\u2014ARC, 2444, Seibersdorf, Austria", 
            "Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Langer", 
        "givenName": "Oliver", 
        "id": "sg:person.01267677252.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267677252.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1523/jneurosci.2990-05.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003907894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2006.07.097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006533686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/14737175.4.5.831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013256875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/00004647-199609000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013680179", 
          "https://doi.org/10.1097/00004647-199609000-00008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-005-1780-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018362785", 
          "https://doi.org/10.1007/s00259-005-1780-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-005-1780-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018362785", 
          "https://doi.org/10.1007/s00259-005-1780-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.20009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019367853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020729861", 
          "https://doi.org/10.1038/nrd2075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020729861", 
          "https://doi.org/10.1038/nrd2075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa054625", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027774750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mibio.2003.09.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028116566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.drudis.2006.10.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028346079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.0673-07.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028644428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/22124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032623302", 
          "https://doi.org/10.1038/22124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00019442-200201000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033439565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001756-200004070-00018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035132698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001756-200004070-00018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035132698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.jcbfm.9600146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036289302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.jcbfm.9600146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036289302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.jcbfm.9600146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036289302"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2006.06.126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038862873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11307-006-0061-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049313688", 
          "https://doi.org/10.1007/s11307-006-0061-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wco.0b013e3281a47744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050094898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/wco.0b013e3281a47744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050094898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/138161205774370771", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069165625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.23-06-02086.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075258286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077264495", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.17-20-07805.1997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083154357"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-07", 
    "datePublishedReg": "2009-07-01", 
    "description": "PURPOSE: We evaluated the usefulness of small animal brain positron emission tomography (PET) imaging with the amyloid-beta (A beta) probe 2-(1-{6-[(2-[(18)F]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malonitrile ([(18)F]FDDNP) and with 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) for detection and quantification of pathological changes occurring in a transgenic mouse model of Alzheimer's disease (Tg2576 mice).\nPROCEDURES: [(18)F]FDDNP (n = 6) and FDG-PET scans (n = 3) were recorded in Tg2576 mice (age 13-15 months) and age-matched wild-type litter mates. Brain volumes of interest were defined by co-registration of PET images with a 3D MOBY digital mouse phantom. Regional [(18)F]FDDNP retention in mouse brain was quantified in terms of the relative distribution volume (DVR) using Logan's graphical analysis with cerebellum as a reference region.\nRESULTS: Except for a lower maximum brain uptake of radioactivity in transgenic animals, the regional brain kinetics as well as DVR values of [(18)F]FDDNP appeared to be similar in both groups of animals. Also for FDG, regional radioactivity retention was almost identical in the brains of transgenic and control animals.\nCONCLUSIONS: We could not detect regionally increased [(18)F]FDDNP binding and regionally decreased FDG binding in the brains of Tg2576 transgenic versus wild-type mice. However, small group differences in signal might have been masked by inter-animal variability. In addition, technical limitations of the applied method (partial volume effect, spatial resolution) for measurements in such small organs as mouse brain have to be taken into consideration.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11307-009-0198-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1118463", 
        "issn": [
          "1536-1632", 
          "1878-5751"
        ], 
        "name": "Molecular Imaging and Biology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "name": "Limitations of Small Animal PET Imaging with [18F]FDDNP and FDG for Quantitative Studies in a Transgenic Mouse Model of Alzheimer\u2019s Disease", 
    "pagination": "236-240", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "43dff1e6f807e61ffd666b1033d5eb94b55cf9b991b0167306360800e4c5c6d0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19214638"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101125610"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11307-009-0198-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1014247392"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11307-009-0198-z", 
      "https://app.dimensions.ai/details/publication/pub.1014247392"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000521.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11307-009-0198-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11307-009-0198-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11307-009-0198-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11307-009-0198-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11307-009-0198-z'


 

This table displays all metadata directly associated to this object as RDF triples.

287 TRIPLES      21 PREDICATES      66 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11307-009-0198-z schema:about N1158d6e89f094cb8ba37912109a0259e
2 N1e261f52ad7745528727aa5df3f7ef6f
3 N2a2b9b7d134a4764a2903168b16faa1c
4 N2bcd53328b5644c19364fe9dbec6968e
5 N3ca8ea3700af4e53b302317daf650266
6 N516a8531df6b488ea6b5fc470ae85a3c
7 N54e233f086a0470986dcd2fb38fb9c83
8 N6370f5071eea4542939b96dc8c5c525f
9 N7383e55647f549638f412dad3eb25def
10 N7556ae9714ff4aa39fc5877b19e4d077
11 N8b3c4c871cab4d3bb260126a0f9f1117
12 N9107128f94494851b7d719e1f90bf996
13 N93f1d964bfd94d38a356ea871d90d3bf
14 N9b6b0bf06fba48e6a788ad7c6ed43f07
15 Nf9411a24139a491c98c3cd01d0b82363
16 anzsrc-for:11
17 anzsrc-for:1109
18 schema:author N2208d1802d7f45889bf1f9f76c0776aa
19 schema:citation sg:pub.10.1007/s00259-005-1780-5
20 sg:pub.10.1007/s11307-006-0061-4
21 sg:pub.10.1038/22124
22 sg:pub.10.1038/nrd2075
23 sg:pub.10.1097/00004647-199609000-00008
24 https://app.dimensions.ai/details/publication/pub.1077264495
25 https://doi.org/10.1002/ana.20009
26 https://doi.org/10.1016/j.bbrc.2006.06.126
27 https://doi.org/10.1016/j.brainres.2006.07.097
28 https://doi.org/10.1016/j.drudis.2006.10.008
29 https://doi.org/10.1016/j.mibio.2003.09.010
30 https://doi.org/10.1038/sj.jcbfm.9600146
31 https://doi.org/10.1056/nejmoa054625
32 https://doi.org/10.1097/00001756-200004070-00018
33 https://doi.org/10.1097/00019442-200201000-00004
34 https://doi.org/10.1097/wco.0b013e3281a47744
35 https://doi.org/10.1523/jneurosci.0673-07.2007
36 https://doi.org/10.1523/jneurosci.17-20-07805.1997
37 https://doi.org/10.1523/jneurosci.23-06-02086.2003
38 https://doi.org/10.1523/jneurosci.2990-05.2005
39 https://doi.org/10.1586/14737175.4.5.831
40 https://doi.org/10.2174/138161205774370771
41 schema:datePublished 2009-07
42 schema:datePublishedReg 2009-07-01
43 schema:description PURPOSE: We evaluated the usefulness of small animal brain positron emission tomography (PET) imaging with the amyloid-beta (A beta) probe 2-(1-{6-[(2-[(18)F]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malonitrile ([(18)F]FDDNP) and with 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) for detection and quantification of pathological changes occurring in a transgenic mouse model of Alzheimer's disease (Tg2576 mice). PROCEDURES: [(18)F]FDDNP (n = 6) and FDG-PET scans (n = 3) were recorded in Tg2576 mice (age 13-15 months) and age-matched wild-type litter mates. Brain volumes of interest were defined by co-registration of PET images with a 3D MOBY digital mouse phantom. Regional [(18)F]FDDNP retention in mouse brain was quantified in terms of the relative distribution volume (DVR) using Logan's graphical analysis with cerebellum as a reference region. RESULTS: Except for a lower maximum brain uptake of radioactivity in transgenic animals, the regional brain kinetics as well as DVR values of [(18)F]FDDNP appeared to be similar in both groups of animals. Also for FDG, regional radioactivity retention was almost identical in the brains of transgenic and control animals. CONCLUSIONS: We could not detect regionally increased [(18)F]FDDNP binding and regionally decreased FDG binding in the brains of Tg2576 transgenic versus wild-type mice. However, small group differences in signal might have been masked by inter-animal variability. In addition, technical limitations of the applied method (partial volume effect, spatial resolution) for measurements in such small organs as mouse brain have to be taken into consideration.
44 schema:genre research_article
45 schema:inLanguage en
46 schema:isAccessibleForFree false
47 schema:isPartOf Nda9e59d240d943eaabc8e8dce4404d95
48 Nf684292142754f5abacf0396163e0d98
49 sg:journal.1118463
50 schema:name Limitations of Small Animal PET Imaging with [18F]FDDNP and FDG for Quantitative Studies in a Transgenic Mouse Model of Alzheimer’s Disease
51 schema:pagination 236-240
52 schema:productId N46fd3542169b456a895d190cb31349ac
53 N6c3bbcba0e7242018ede259a1d89a620
54 Naf0dcee10f6849649a3d4ee0d0856eb6
55 Ncef11b26962b40019dee447f32cb7520
56 Nd19bcef86e93413c9e5ced50cfde6f5d
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014247392
58 https://doi.org/10.1007/s11307-009-0198-z
59 schema:sdDatePublished 2019-04-10T15:53
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher N5a6624a9280f4fa8ab9448b41c8840d6
62 schema:url http://link.springer.com/10.1007%2Fs11307-009-0198-z
63 sgo:license sg:explorer/license/
64 sgo:sdDataset articles
65 rdf:type schema:ScholarlyArticle
66 N05c9077380f3478686907992897f44e1 schema:name Department of Radiopharmaceuticals & microPET Imaging, Austrian Research Centers GmbH—ARC, 2444, Seibersdorf, Austria
67 rdf:type schema:Organization
68 N1158d6e89f094cb8ba37912109a0259e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Mice, Transgenic
70 rdf:type schema:DefinedTerm
71 N19e3a1a089844a078b7d6bb09ee54a09 schema:name Department of Radiopharmaceuticals & microPET Imaging, Austrian Research Centers GmbH—ARC, 2444, Seibersdorf, Austria
72 rdf:type schema:Organization
73 N1e261f52ad7745528727aa5df3f7ef6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Disease Models, Animal
75 rdf:type schema:DefinedTerm
76 N2208d1802d7f45889bf1f9f76c0776aa rdf:first sg:person.0706137155.60
77 rdf:rest Nfa01357796d341e8b250ef1f89b4b82f
78 N2a2b9b7d134a4764a2903168b16faa1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Nitriles
80 rdf:type schema:DefinedTerm
81 N2bcd53328b5644c19364fe9dbec6968e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Imaging, Three-Dimensional
83 rdf:type schema:DefinedTerm
84 N3ca8ea3700af4e53b302317daf650266 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Positron-Emission Tomography
86 rdf:type schema:DefinedTerm
87 N405c11a47fab4c6f9c13041ab1092d97 rdf:first N6d1066fa754b4311af1cf066633aa9e4
88 rdf:rest Na1b5693294d447d0a6ee3e7089adb108
89 N46fd3542169b456a895d190cb31349ac schema:name nlm_unique_id
90 schema:value 101125610
91 rdf:type schema:PropertyValue
92 N47b14c948f3649659ba74e3cd40397e4 schema:name Department of Toxicology, Austrian Research Centers GmbH—ARC, 2444, Seibersdorf, Austria
93 rdf:type schema:Organization
94 N4ad95d2fb5f045aa9311ee6e3cd677f1 schema:name Department of Radiopharmaceuticals & microPET Imaging, Austrian Research Centers GmbH—ARC, 2444, Seibersdorf, Austria
95 rdf:type schema:Organization
96 N516a8531df6b488ea6b5fc470ae85a3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Alzheimer Disease
98 rdf:type schema:DefinedTerm
99 N54e233f086a0470986dcd2fb38fb9c83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Amyloid beta-Peptides
101 rdf:type schema:DefinedTerm
102 N59239fd9847b411295f175fbd22aebbf rdf:first sg:person.01331535741.94
103 rdf:rest N405c11a47fab4c6f9c13041ab1092d97
104 N5a6624a9280f4fa8ab9448b41c8840d6 schema:name Springer Nature - SN SciGraph project
105 rdf:type schema:Organization
106 N6140909319904e15bd8470da515f7518 schema:affiliation https://www.grid.ac/institutes/grid.5329.d
107 schema:familyName Kremslehner
108 schema:givenName Robert
109 rdf:type schema:Person
110 N6370f5071eea4542939b96dc8c5c525f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Brain Chemistry
112 rdf:type schema:DefinedTerm
113 N6c3bbcba0e7242018ede259a1d89a620 schema:name pubmed_id
114 schema:value 19214638
115 rdf:type schema:PropertyValue
116 N6d1066fa754b4311af1cf066633aa9e4 schema:affiliation N47b14c948f3649659ba74e3cd40397e4
117 schema:familyName Wolf
118 schema:givenName Tanja
119 rdf:type schema:Person
120 N7383e55647f549638f412dad3eb25def schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Brain
122 rdf:type schema:DefinedTerm
123 N7556ae9714ff4aa39fc5877b19e4d077 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Animals
125 rdf:type schema:DefinedTerm
126 N79665d23f38f401cbfa748fae8a99929 rdf:first N6140909319904e15bd8470da515f7518
127 rdf:rest Ne08016d324b649618378676cd0a512d7
128 N7dfb418adad44c50a3c1f9f212249bb9 rdf:first sg:person.01247206647.98
129 rdf:rest N59239fd9847b411295f175fbd22aebbf
130 N8b3c4c871cab4d3bb260126a0f9f1117 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Fluorodeoxyglucose F18
132 rdf:type schema:DefinedTerm
133 N9107128f94494851b7d719e1f90bf996 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Statistics, Nonparametric
135 rdf:type schema:DefinedTerm
136 N93f1d964bfd94d38a356ea871d90d3bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Phantoms, Imaging
138 rdf:type schema:DefinedTerm
139 N9b6b0bf06fba48e6a788ad7c6ed43f07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Mice
141 rdf:type schema:DefinedTerm
142 Na1b5693294d447d0a6ee3e7089adb108 rdf:first sg:person.012520567642.95
143 rdf:rest Nf8df17950c39454bbf5c6b6589ed6821
144 Naf0dcee10f6849649a3d4ee0d0856eb6 schema:name dimensions_id
145 schema:value pub.1014247392
146 rdf:type schema:PropertyValue
147 Nbb6a20680add4d3f9be8fe72dbb971a4 rdf:first sg:person.01230665756.50
148 rdf:rest N79665d23f38f401cbfa748fae8a99929
149 Ncef11b26962b40019dee447f32cb7520 schema:name doi
150 schema:value 10.1007/s11307-009-0198-z
151 rdf:type schema:PropertyValue
152 Nd19bcef86e93413c9e5ced50cfde6f5d schema:name readcube_id
153 schema:value 43dff1e6f807e61ffd666b1033d5eb94b55cf9b991b0167306360800e4c5c6d0
154 rdf:type schema:PropertyValue
155 Nda9e59d240d943eaabc8e8dce4404d95 schema:issueNumber 4
156 rdf:type schema:PublicationIssue
157 Ne08016d324b649618378676cd0a512d7 rdf:first sg:person.01136614155.70
158 rdf:rest Ne0ef560910024c1d9dbfbea9b7aac43c
159 Ne0ef560910024c1d9dbfbea9b7aac43c rdf:first sg:person.01025177211.85
160 rdf:rest N7dfb418adad44c50a3c1f9f212249bb9
161 Nf684292142754f5abacf0396163e0d98 schema:volumeNumber 11
162 rdf:type schema:PublicationVolume
163 Nf8df17950c39454bbf5c6b6589ed6821 rdf:first sg:person.01267677252.12
164 rdf:rest rdf:nil
165 Nf9411a24139a491c98c3cd01d0b82363 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Radiopharmaceuticals
167 rdf:type schema:DefinedTerm
168 Nfa01357796d341e8b250ef1f89b4b82f rdf:first sg:person.01123401632.26
169 rdf:rest Nbb6a20680add4d3f9be8fe72dbb971a4
170 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
171 schema:name Medical and Health Sciences
172 rdf:type schema:DefinedTerm
173 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
174 schema:name Neurosciences
175 rdf:type schema:DefinedTerm
176 sg:journal.1118463 schema:issn 1536-1632
177 1878-5751
178 schema:name Molecular Imaging and Biology
179 rdf:type schema:Periodical
180 sg:person.01025177211.85 schema:affiliation https://www.grid.ac/institutes/grid.452292.a
181 schema:familyName Mandler
182 schema:givenName Markus
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025177211.85
184 rdf:type schema:Person
185 sg:person.01123401632.26 schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
186 schema:familyName Kesner
187 schema:givenName Adam L.
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123401632.26
189 rdf:type schema:Person
190 sg:person.01136614155.70 schema:affiliation N4ad95d2fb5f045aa9311ee6e3cd677f1
191 schema:familyName Wanek
192 schema:givenName Thomas
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136614155.70
194 rdf:type schema:Person
195 sg:person.01230665756.50 schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
196 schema:familyName Bauer
197 schema:givenName Martin
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230665756.50
199 rdf:type schema:Person
200 sg:person.01247206647.98 schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
201 schema:familyName Karch
202 schema:givenName Rudolf
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247206647.98
204 rdf:type schema:Person
205 sg:person.012520567642.95 schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
206 schema:familyName Müller
207 schema:givenName Markus
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012520567642.95
209 rdf:type schema:Person
210 sg:person.01267677252.12 schema:affiliation https://www.grid.ac/institutes/grid.22937.3d
211 schema:familyName Langer
212 schema:givenName Oliver
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267677252.12
214 rdf:type schema:Person
215 sg:person.01331535741.94 schema:affiliation N05c9077380f3478686907992897f44e1
216 schema:familyName Stanek
217 schema:givenName Johann
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331535741.94
219 rdf:type schema:Person
220 sg:person.0706137155.60 schema:affiliation N19e3a1a089844a078b7d6bb09ee54a09
221 schema:familyName Kuntner
222 schema:givenName Claudia
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706137155.60
224 rdf:type schema:Person
225 sg:pub.10.1007/s00259-005-1780-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018362785
226 https://doi.org/10.1007/s00259-005-1780-5
227 rdf:type schema:CreativeWork
228 sg:pub.10.1007/s11307-006-0061-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049313688
229 https://doi.org/10.1007/s11307-006-0061-4
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/22124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032623302
232 https://doi.org/10.1038/22124
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/nrd2075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020729861
235 https://doi.org/10.1038/nrd2075
236 rdf:type schema:CreativeWork
237 sg:pub.10.1097/00004647-199609000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013680179
238 https://doi.org/10.1097/00004647-199609000-00008
239 rdf:type schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1077264495 schema:CreativeWork
241 https://doi.org/10.1002/ana.20009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019367853
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/j.bbrc.2006.06.126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038862873
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.brainres.2006.07.097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006533686
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/j.drudis.2006.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028346079
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/j.mibio.2003.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028116566
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1038/sj.jcbfm.9600146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036289302
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1056/nejmoa054625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027774750
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1097/00001756-200004070-00018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035132698
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1097/00019442-200201000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033439565
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1097/wco.0b013e3281a47744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050094898
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1523/jneurosci.0673-07.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028644428
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1523/jneurosci.17-20-07805.1997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083154357
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1523/jneurosci.23-06-02086.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075258286
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1523/jneurosci.2990-05.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003907894
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1586/14737175.4.5.831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013256875
270 rdf:type schema:CreativeWork
271 https://doi.org/10.2174/138161205774370771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069165625
272 rdf:type schema:CreativeWork
273 https://www.grid.ac/institutes/grid.19006.3e schema:alternateName University of California Los Angeles
274 schema:name Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
275 rdf:type schema:Organization
276 https://www.grid.ac/institutes/grid.22937.3d schema:alternateName Medical University of Vienna
277 schema:name Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
278 Department of Medical Computer Sciences, Medical University of Vienna, Vienna, Austria
279 Department of Radiopharmaceuticals & microPET Imaging, Austrian Research Centers GmbH—ARC, 2444, Seibersdorf, Austria
280 rdf:type schema:Organization
281 https://www.grid.ac/institutes/grid.452292.a schema:alternateName AFFiRiS (Austria)
282 schema:name AFFiRiS GmbH, Vienna, Austria
283 rdf:type schema:Organization
284 https://www.grid.ac/institutes/grid.5329.d schema:alternateName TU Wien
285 schema:name Department of Radiopharmaceuticals & microPET Imaging, Austrian Research Centers GmbH—ARC, 2444, Seibersdorf, Austria
286 Institute of Solid State Physics, University of Technology, Vienna, Austria
287 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...