Ontology type: schema:ScholarlyArticle
2018-12
AUTHORSAnne Julie Overgaard, Jacquelyn M. Weir, Kaushala Jayawardana, Henrik Bindesbøl Mortensen, Flemming Pociot, Peter J. Meikle
ABSTRACTINTRODUCTION: The identification of metabolomic dysregulation appears promising for the prediction of type 1 diabetes and may also reveal metabolic pathways leading to beta-cell destruction. Recent studies indicate that regulation of multiple phospholipids precede the presence of autoantigens in the development of type 1 diabetes. OBJECTIVES: We hypothesize that lipid biomarkers in plasma from children with recent onset type 1 diabetes will reflect their remaining beta-cell function and predict future changes in beta-cell function. METHODS: We performed targeted lipidomic profiling by electrospray ionization tandem mass spectrometry to acquire comparative measures of 354 lipid species covering 25 lipid classes and subclasses in plasma samples from 123 patients < 17 years of age followed prospectively at 1, 3, 6 and 12 months after diagnosis. Lipidomic profiles were analysed using liner regression to investigate the relationship between plasma lipids and meal stimulated C-peptide levels at each time point. P-values were corrected for multiple comparisons by the method of Benjamini and Hochberg. RESULTS: Linear regression analysis showed that the relative levels of cholesteryl ester, diacylglycerol and triacylglycerol at 1 month were associated to the change in c-peptide levels from 1 to 6 months (corrected p-values of 4.06E-03, 1.72E-02 and 1.72E02, respectively). Medium chain saturated and monounsaturated fatty acids were the major constituents of the di- and triacylglycerol species suggesting a link with increased lipogenesis. CONCLUSION: These observations support the hypothesis of lipid disturbances as explanatory factors for residual beta-cell function in children with new onset type 1 diabetes. More... »
PAGES158
http://scigraph.springernature.com/pub.10.1007/s11306-018-1456-3
DOIhttp://dx.doi.org/10.1007/s11306-018-1456-3
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1110375377
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30830451
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Steno Diabetes Center",
"id": "https://www.grid.ac/institutes/grid.419658.7",
"name": [
"Steno Diabetes Center Copenhagen, Niels Steensensvej 2, 2820, Gentofte, Denmark",
"Baker IDI Heart and Diabetes Research Institute, 75 Commercial Road, Melbourne, Australia"
],
"type": "Organization"
},
"familyName": "Overgaard",
"givenName": "Anne Julie",
"id": "sg:person.01012776177.01",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012776177.01"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Baker IDI Heart and Diabetes Research Institute, 75 Commercial Road, Melbourne, Australia"
],
"type": "Organization"
},
"familyName": "Weir",
"givenName": "Jacquelyn M.",
"id": "sg:person.01356530725.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356530725.52"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Baker IDI Heart and Diabetes Research Institute, 75 Commercial Road, Melbourne, Australia"
],
"type": "Organization"
},
"familyName": "Jayawardana",
"givenName": "Kaushala",
"id": "sg:person.0727572314.27",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727572314.27"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Steno Diabetes Center",
"id": "https://www.grid.ac/institutes/grid.419658.7",
"name": [
"Steno Diabetes Center Copenhagen, Niels Steensensvej 2, 2820, Gentofte, Denmark"
],
"type": "Organization"
},
"familyName": "Mortensen",
"givenName": "Henrik Bindesb\u00f8l",
"id": "sg:person.015545147554.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015545147554.46"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Copenhagen",
"id": "https://www.grid.ac/institutes/grid.5254.6",
"name": [
"Steno Diabetes Center Copenhagen, Niels Steensensvej 2, 2820, Gentofte, Denmark",
"Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"
],
"type": "Organization"
},
"familyName": "Pociot",
"givenName": "Flemming",
"id": "sg:person.01043742117.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043742117.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Melbourne",
"id": "https://www.grid.ac/institutes/grid.1008.9",
"name": [
"Baker IDI Heart and Diabetes Research Institute, 75 Commercial Road, Melbourne, Australia",
"Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Australia"
],
"type": "Organization"
},
"familyName": "Meikle",
"givenName": "Peter J.",
"id": "sg:person.01117113727.68",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117113727.68"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.3390/metabo5020389",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007220321"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.molmet.2016.04.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007663139"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri2192",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010066260",
"https://doi.org/10.1038/nri2192"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0076577",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010273115"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/db10-1652",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012883412"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/atvbaha.111.234096",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013469864"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/atvbaha.111.234096",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013469864"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/atvbaha.111.234096",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013469864"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.apsb.2012.05.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013832701"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/db13-0215",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017242856"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.atv.0000217957.93135.c2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019391847"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.atv.0000217957.93135.c2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019391847"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1399-5448.2012.00857.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020869433"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1194/jlr.p035808",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021495926"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(09)60568-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022836597"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1399-5448.2007.00280.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023614338"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diabetes.53.1.250",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025629105"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2217/clp.14.30",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025941038"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00125-012-2571-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026167897",
"https://doi.org/10.1007/s00125-012-2571-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00125-012-2571-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026167897",
"https://doi.org/10.1007/s00125-012-2571-8"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1464-5491.2011.03544.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029667317"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1399-5448.2008.00483.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030631064"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0074341",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031668091"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(16)30507-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032098402"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/adc.80.4.367",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032194019"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1084/jem.20081800",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032823615"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/circulationaha.111.077487",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033021293"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/circulationaha.111.077487",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033021293"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/med.21330",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035839566"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4161/isl.20102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039803970"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00216-015-8633-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043897247",
"https://doi.org/10.1007/s00216-015-8633-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11745-012-3723-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044044102",
"https://doi.org/10.1007/s11745-012-3723-9"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1399-5448.2009.00566.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047530807"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1399-5448.2009.00566.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047530807"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/jaut.2001.0550",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049751805"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00400261",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050734400",
"https://doi.org/10.1007/bf00400261"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00400261",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050734400",
"https://doi.org/10.1007/bf00400261"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00400261",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050734400",
"https://doi.org/10.1007/bf00400261"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7326/0003-4819-128-7-199804010-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1073702134"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079695590",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.clinms.2017.11.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092691602"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci.insight.121326",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1106679321"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci.insight.121326",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1106679321"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.2517-6161.1995.tb02031.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1110458929"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.2517-6161.1995.tb02031.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1110458929"
],
"type": "CreativeWork"
}
],
"datePublished": "2018-12",
"datePublishedReg": "2018-12-01",
"description": "INTRODUCTION: The identification of metabolomic dysregulation appears promising for the prediction of type 1 diabetes and may also reveal metabolic pathways leading to beta-cell destruction. Recent studies indicate that regulation of multiple phospholipids precede the presence of autoantigens in the development of type 1 diabetes.\nOBJECTIVES: We hypothesize that lipid biomarkers in plasma from children with recent onset type 1 diabetes will reflect their remaining beta-cell function and predict future changes in beta-cell function.\nMETHODS: We performed targeted lipidomic profiling by electrospray ionization tandem mass spectrometry to acquire comparative measures of 354 lipid species covering 25 lipid classes and subclasses in plasma samples from 123 patients <\u200917\u00a0years of age followed prospectively at 1, 3, 6 and 12\u00a0months after diagnosis. Lipidomic profiles were analysed using liner regression to investigate the relationship between plasma lipids and meal stimulated C-peptide levels at each time point. P-values were corrected for multiple comparisons by the method of Benjamini and Hochberg.\nRESULTS: Linear regression analysis showed that the relative levels of cholesteryl ester, diacylglycerol and triacylglycerol at 1\u00a0month were associated to the change in c-peptide levels from 1 to 6\u00a0months (corrected p-values of 4.06E-03, 1.72E-02 and 1.72E02, respectively). Medium chain saturated and monounsaturated fatty acids were the major constituents of the di- and triacylglycerol species suggesting a link with increased lipogenesis.\nCONCLUSION: These observations support the hypothesis of lipid disturbances as explanatory factors for residual beta-cell function in children with new onset type 1 diabetes.",
"genre": "research_article",
"id": "sg:pub.10.1007/s11306-018-1456-3",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1036887",
"issn": [
"1573-3882",
"1573-3890"
],
"name": "Metabolomics",
"type": "Periodical"
},
{
"issueNumber": "12",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "14"
}
],
"name": "Plasma lipid species at type 1 diabetes onset predict residual beta-cell function after 6 months",
"pagination": "158",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"86ceb33a4582312e3d788c9b4078cb35eb88c886903de797dd28d65e15e9bba6"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30830451"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101274889"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s11306-018-1456-3"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1110375377"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s11306-018-1456-3",
"https://app.dimensions.ai/details/publication/pub.1110375377"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T11:17",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000354_0000000354/records_11698_00000002.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1007%2Fs11306-018-1456-3"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11306-018-1456-3'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11306-018-1456-3'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11306-018-1456-3'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11306-018-1456-3'
This table displays all metadata directly associated to this object as RDF triples.
226 TRIPLES
21 PREDICATES
64 URIs
21 LITERALS
9 BLANK NODES