Gender-specific pathway differences in the human serum metabolome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Jan Krumsiek, Kirstin Mittelstrass, Kieu Trinh Do, Ferdinand Stückler, Janina Ried, Jerzy Adamski, Annette Peters, Thomas Illig, Florian Kronenberg, Nele Friedrich, Matthias Nauck, Maik Pietzner, Dennis O. Mook-Kanamori, Karsten Suhre, Christian Gieger, Harald Grallert, Fabian J. Theis, Gabi Kastenmüller

ABSTRACT

The susceptibility for various diseases as well as the response to treatments differ considerably between men and women. As a basis for a gender-specific personalized healthcare, an extensive characterization of the molecular differences between the two genders is required. In the present study, we conducted a large-scale metabolomics analysis of 507 metabolic markers measured in serum of 1756 participants from the German KORA F4 study (903 females and 853 males). One-third of the metabolites show significant differences between males and females. A pathway analysis revealed strong differences in steroid metabolism, fatty acids and further lipids, a large fraction of amino acids, oxidative phosphorylation, purine metabolism and gamma-glutamyl dipeptides. We then extended this analysis by a network-based clustering approach. Metabolite interactions were estimated using Gaussian graphical models to get an unbiased, fully data-driven metabolic network representation. This approach is not limited to possibly arbitrary pathway boundaries and can even include poorly or uncharacterized metabolites. The network analysis revealed several strongly gender-regulated submodules across different pathways. Finally, a gender-stratified genome-wide association study was performed to determine whether the observed gender differences are caused by dimorphisms in the effects of genetic polymorphisms on the metabolome. With only a single genome-wide significant hit, our results suggest that this scenario is not the case. In summary, we report an extensive characterization and interpretation of gender-specific differences of the human serum metabolome, providing a broad basis for future analyses. More... »

PAGES

1815-1833

References to SciGraph publications

  • 2014-12. Sex differences in the human peripheral blood transcriptome in BMC GENOMICS
  • 2011-12. Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data in BMC SYSTEMS BIOLOGY
  • 2007-08. The Metabolomics Standards Initiative in NATURE BIOTECHNOLOGY
  • 2012-03. Sex differences in disease risk from reported genome-wide association study findings in HUMAN GENETICS
  • 2013-03. Insulin resistance and the metabolism of branched-chain amino acids in FRONTIERS OF MEDICINE
  • 2012-04. MSEA: metabolite set enrichment analysis in the MeltDB metabolomics software platform: metabolic profiling of Corynebacterium glutamicum as an example in METABOLOMICS
  • 2011-04. Lipid parameters for measuring risk of cardiovascular disease in NATURE REVIEWS CARDIOLOGY
  • 2014-02. Metabolite profiling reveals new insights into the regulation of serum urate in humans in METABOLOMICS
  • 2010-05. Sex differences in glucose levels: a consequence of physiology or methodological convenience? The Inter99 study in DIABETOLOGIA
  • 2014-11. Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study in INTERNATIONAL JOURNAL OF OBESITY
  • 2013-01. Improved whole-chromosome phasing for disease and population genetic studies in NATURE METHODS
  • 2010-06. Sex bias in trials and treatment must end in NATURE
  • 2012-03. Genome-wide association study identifies multiple loci influencing human serum metabolite levels in NATURE GENETICS
  • 2014-06. An atlas of genetic influences on human blood metabolites in NATURE GENETICS
  • 2015-02. Molecular phenotyping of a UK population: defining the human serum metabolome in METABOLOMICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11306-015-0829-0

    DOI

    http://dx.doi.org/10.1007/s11306-015-0829-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000861926

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26491425


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "German Center for Diabetes Research", 
              "id": "https://www.grid.ac/institutes/grid.452622.5", 
              "name": [
                "Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany", 
                "German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Krumsiek", 
            "givenName": "Jan", 
            "id": "sg:person.015172732374.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015172732374.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
              "id": "https://www.grid.ac/institutes/grid.4567.0", 
              "name": [
                "Research Unit of Molecular Epidemiology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany", 
                "Institute of Epidemiology II, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mittelstrass", 
            "givenName": "Kirstin", 
            "id": "sg:person.0641716575.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641716575.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
              "id": "https://www.grid.ac/institutes/grid.4567.0", 
              "name": [
                "Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Do", 
            "givenName": "Kieu Trinh", 
            "id": "sg:person.01321230721.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321230721.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
              "id": "https://www.grid.ac/institutes/grid.4567.0", 
              "name": [
                "Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "St\u00fcckler", 
            "givenName": "Ferdinand", 
            "id": "sg:person.01147670402.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147670402.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
              "id": "https://www.grid.ac/institutes/grid.4567.0", 
              "name": [
                "Institute of Genetic Epidemiology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ried", 
            "givenName": "Janina", 
            "id": "sg:person.01230632011.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230632011.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Technical University Munich", 
              "id": "https://www.grid.ac/institutes/grid.6936.a", 
              "name": [
                "German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany", 
                "Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany", 
                "Lehrstuhl f\u00fcr Experimentelle Genetik, Technische Universit\u00e4t M\u00fcnchen, Freising-Weihenstephan, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Adamski", 
            "givenName": "Jerzy", 
            "id": "sg:person.01227277645.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227277645.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
              "id": "https://www.grid.ac/institutes/grid.4567.0", 
              "name": [
                "German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany", 
                "Institute of Epidemiology II, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany", 
                "German Center for Cardiovascular Disease Research (DZHK e.V.), Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peters", 
            "givenName": "Annette", 
            "id": "sg:person.01117072553.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117072553.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hannover Medical School", 
              "id": "https://www.grid.ac/institutes/grid.10423.34", 
              "name": [
                "Hannover Unified Biobank, Hannover Medical School, Hannover, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Illig", 
            "givenName": "Thomas", 
            "id": "sg:person.01364120657.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364120657.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Innsbruck Medical University", 
              "id": "https://www.grid.ac/institutes/grid.5361.1", 
              "name": [
                "Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kronenberg", 
            "givenName": "Florian", 
            "id": "sg:person.01135477613.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135477613.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Centre for Cardiovascular Research", 
              "id": "https://www.grid.ac/institutes/grid.452396.f", 
              "name": [
                "Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany", 
                "DZHK (German Center for Cardiovascular Research), Greifswald, Greifswald, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Friedrich", 
            "givenName": "Nele", 
            "id": "sg:person.01122034607.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122034607.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Centre for Cardiovascular Research", 
              "id": "https://www.grid.ac/institutes/grid.452396.f", 
              "name": [
                "Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany", 
                "DZHK (German Center for Cardiovascular Research), Greifswald, Greifswald, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nauck", 
            "givenName": "Matthias", 
            "id": "sg:person.015350356542.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015350356542.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Centre for Cardiovascular Research", 
              "id": "https://www.grid.ac/institutes/grid.452396.f", 
              "name": [
                "Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany", 
                "DZHK (German Center for Cardiovascular Research), Greifswald, Greifswald, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pietzner", 
            "givenName": "Maik", 
            "id": "sg:person.01130556140.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130556140.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Qatar Foundation", 
              "id": "https://www.grid.ac/institutes/grid.418818.c", 
              "name": [
                "Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands", 
                "Department of Endocrinology, Leiden University Medical Center, Leiden, Netherlands", 
                "Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Qatar Foundation, Doha, Qatar"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mook-Kanamori", 
            "givenName": "Dennis O.", 
            "id": "sg:person.01345347020.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345347020.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
              "id": "https://www.grid.ac/institutes/grid.4567.0", 
              "name": [
                "Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Qatar Foundation, Doha, Qatar", 
                "Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suhre", 
            "givenName": "Karsten", 
            "id": "sg:person.01113051245.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113051245.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
              "id": "https://www.grid.ac/institutes/grid.4567.0", 
              "name": [
                "Research Unit of Molecular Epidemiology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany", 
                "Institute of Epidemiology II, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gieger", 
            "givenName": "Christian", 
            "id": "sg:person.011673465237.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011673465237.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
              "id": "https://www.grid.ac/institutes/grid.4567.0", 
              "name": [
                "Research Unit of Molecular Epidemiology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany", 
                "Institute of Epidemiology II, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Grallert", 
            "givenName": "Harald", 
            "id": "sg:person.0712635675.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712635675.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Technical University Munich", 
              "id": "https://www.grid.ac/institutes/grid.6936.a", 
              "name": [
                "Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany", 
                "Department of Mathematics, Technische Universit\u00e4t M\u00fcnchen, Garching, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Theis", 
            "givenName": "Fabian J.", 
            "id": "sg:person.01304403211.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304403211.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
              "id": "https://www.grid.ac/institutes/grid.4567.0", 
              "name": [
                "German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany", 
                "Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen, Neuherberg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kastenm\u00fcller", 
            "givenName": "Gabi", 
            "id": "sg:person.0620106734.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620106734.75"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1161/01.atv.14.4.567", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000767818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jxb/erj013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000800290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1002215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002943793"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0009-8981(01)00805-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006245621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gepi.20303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008645052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci42344", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011181146"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci42344", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011181146"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1214/aos/1176344552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012894299"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2009.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013089119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/465688a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013103104", 
              "https://doi.org/10.1038/465688a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/465688a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013103104", 
              "https://doi.org/10.1038/465688a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jval.2013.06.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015051673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.105.553198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015731857"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1003005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016134453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00439-011-1081-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017546298", 
              "https://doi.org/10.1007/s00439-011-1081-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00439-011-1081-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017546298", 
              "https://doi.org/10.1007/s00439-011-1081-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11306-013-0565-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018376713", 
              "https://doi.org/10.1007/s11306-013-0565-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11306-013-0565-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018376713", 
              "https://doi.org/10.1007/s11306-013-0565-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrcardio.2010.223", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019366659", 
              "https://doi.org/10.1038/nrcardio.2010.223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/embor.2012.87", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021120759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-15-33", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021134350", 
              "https://doi.org/10.1186/1471-2164-15-33"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/all.12110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022314274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/14737159.8.1.9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022701482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11306-014-0707-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024965129", 
              "https://doi.org/10.1007/s11306-014-0707-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11306-014-0707-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024965129", 
              "https://doi.org/10.1007/s11306-014-0707-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpendo.00173.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026709283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/dia.2011.0275", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027230591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.1073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027410569", 
              "https://doi.org/10.1038/ng.1073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btg115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028034818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1002270", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028439271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt0807-846b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028899298", 
              "https://doi.org/10.1038/nbt0807-846b"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1752-0509-5-21", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029129105", 
              "https://doi.org/10.1186/1752-0509-5-21"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/15257770802138558", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029336145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.pharmtox.44.101802.121453", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029921124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btm108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031184798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11684-013-0255-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033475624", 
              "https://doi.org/10.1007/s11684-013-0255-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/msb.2011.99", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034119217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/msb.2011.99", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034119217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1000504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034121059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tips.2009.12.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035046311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11306-011-0311-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035063940", 
              "https://doi.org/10.1007/s11306-011-0311-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-010-1673-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035619901", 
              "https://doi.org/10.1007/s00125-010-1673-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-010-1673-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035619901", 
              "https://doi.org/10.1007/s00125-010-1673-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-010-1673-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035619901", 
              "https://doi.org/10.1007/s00125-010-1673-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0506580102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037705714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0506580102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037705714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj3270449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038253679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj3270449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038253679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ab.2006.02.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039527423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/10408390601062054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040225067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pcbi.1000217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040370538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.194241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041203900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0377-0427(87)90125-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041584630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2013.06.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041995293"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1000529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043446290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043747449", 
              "https://doi.org/10.1038/nmeth.2307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0376-8716(02)00015-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044893662"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2982", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044995197", 
              "https://doi.org/10.1038/ng.2982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ije/dyp394", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046967006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1745-9125.1998.tb01268.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047249593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1745-9125.1998.tb01268.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047249593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.11-198093", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047473398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ijo.2014.39", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050615680", 
              "https://doi.org/10.1038/ijo.2014.39"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0026-0495(97)90273-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050982712"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/cir.0b013e31828124ad", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052501077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/cir.0b013e31828124ad", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052501077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jchromb.2008.09.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052619043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac0708588", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054999511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac0708588", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054999511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jf00103a017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055896774"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1024/0300-9831.70.5.221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056317695"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1055/s-2005-858235", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1057441646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1055/s-2007-972875", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1057505166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/01621459.1951.10500769", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058298962"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2010-2061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064292441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/jappl.2001.91.1.357", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074835623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpendo.2001.281.6.e1333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074952565"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076141836", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajcn/83.6.1351", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077259119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078820989", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000459034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1081577772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081934917", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajcn/36.2.332", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082151991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082221484", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1201/b13973", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1095905620"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-12", 
        "datePublishedReg": "2015-12-01", 
        "description": "The susceptibility for various diseases as well as the response to treatments differ considerably between men and women. As a basis for a gender-specific personalized healthcare, an extensive characterization of the molecular differences between the two genders is required. In the present study, we conducted a large-scale metabolomics analysis of 507 metabolic markers measured in serum of 1756 participants from the German KORA F4 study (903 females and 853 males). One-third of the metabolites show significant differences between males and females. A pathway analysis revealed strong differences in steroid metabolism, fatty acids and further lipids, a large fraction of amino acids, oxidative phosphorylation, purine metabolism and gamma-glutamyl dipeptides. We then extended this analysis by a network-based clustering approach. Metabolite interactions were estimated using Gaussian graphical models to get an unbiased, fully data-driven metabolic network representation. This approach is not limited to possibly arbitrary pathway boundaries and can even include poorly or uncharacterized metabolites. The network analysis revealed several strongly gender-regulated submodules across different pathways. Finally, a gender-stratified genome-wide association study was performed to determine whether the observed gender differences are caused by dimorphisms in the effects of genetic polymorphisms on the metabolome. With only a single genome-wide significant hit, our results suggest that this scenario is not the case. In summary, we report an extensive characterization and interpretation of gender-specific differences of the human serum metabolome, providing a broad basis for future analyses.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s11306-015-0829-0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3797914", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1036887", 
            "issn": [
              "1573-3882", 
              "1573-3890"
            ], 
            "name": "Metabolomics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "11"
          }
        ], 
        "name": "Gender-specific pathway differences in the human serum metabolome", 
        "pagination": "1815-1833", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "041b0b92833b615c78831a64e7367ee3c5edc1b8fc2cbac4fc96ce3967bbd201"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26491425"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101274889"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11306-015-0829-0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1000861926"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11306-015-0829-0", 
          "https://app.dimensions.ai/details/publication/pub.1000861926"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:06", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88218_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs11306-015-0829-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11306-015-0829-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11306-015-0829-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11306-015-0829-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11306-015-0829-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    450 TRIPLES      21 PREDICATES      101 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11306-015-0829-0 schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author Nf828ced4315a49a59ea1d8ea8cc0e3bf
    4 schema:citation sg:pub.10.1007/s00125-010-1673-4
    5 sg:pub.10.1007/s00439-011-1081-y
    6 sg:pub.10.1007/s11306-011-0311-6
    7 sg:pub.10.1007/s11306-013-0565-2
    8 sg:pub.10.1007/s11306-014-0707-1
    9 sg:pub.10.1007/s11684-013-0255-5
    10 sg:pub.10.1038/465688a
    11 sg:pub.10.1038/ijo.2014.39
    12 sg:pub.10.1038/nbt0807-846b
    13 sg:pub.10.1038/ng.1073
    14 sg:pub.10.1038/ng.2982
    15 sg:pub.10.1038/nmeth.2307
    16 sg:pub.10.1038/nrcardio.2010.223
    17 sg:pub.10.1186/1471-2164-15-33
    18 sg:pub.10.1186/1752-0509-5-21
    19 https://app.dimensions.ai/details/publication/pub.1076141836
    20 https://app.dimensions.ai/details/publication/pub.1078820989
    21 https://app.dimensions.ai/details/publication/pub.1081934917
    22 https://app.dimensions.ai/details/publication/pub.1082221484
    23 https://doi.org/10.1002/gepi.20303
    24 https://doi.org/10.1016/0377-0427(87)90125-7
    25 https://doi.org/10.1016/j.ab.2006.02.033
    26 https://doi.org/10.1016/j.cmet.2009.02.002
    27 https://doi.org/10.1016/j.cmet.2013.06.013
    28 https://doi.org/10.1016/j.jchromb.2008.09.033
    29 https://doi.org/10.1016/j.jval.2013.06.005
    30 https://doi.org/10.1016/j.tips.2009.12.001
    31 https://doi.org/10.1016/s0009-8981(01)00805-1
    32 https://doi.org/10.1016/s0026-0495(97)90273-0
    33 https://doi.org/10.1016/s0376-8716(02)00015-7
    34 https://doi.org/10.1021/ac0708588
    35 https://doi.org/10.1021/jf00103a017
    36 https://doi.org/10.1024/0300-9831.70.5.221
    37 https://doi.org/10.1038/embor.2012.87
    38 https://doi.org/10.1038/msb.2011.99
    39 https://doi.org/10.1042/bj3270449
    40 https://doi.org/10.1055/s-2005-858235
    41 https://doi.org/10.1055/s-2007-972875
    42 https://doi.org/10.1073/pnas.0506580102
    43 https://doi.org/10.1074/jbc.m110.194241
    44 https://doi.org/10.1080/01621459.1951.10500769
    45 https://doi.org/10.1080/10408390601062054
    46 https://doi.org/10.1080/15257770802138558
    47 https://doi.org/10.1089/dia.2011.0275
    48 https://doi.org/10.1093/ajcn/36.2.332
    49 https://doi.org/10.1093/ajcn/83.6.1351
    50 https://doi.org/10.1093/bioinformatics/btg115
    51 https://doi.org/10.1093/bioinformatics/btm108
    52 https://doi.org/10.1093/ije/dyp394
    53 https://doi.org/10.1093/jxb/erj013
    54 https://doi.org/10.1096/fj.11-198093
    55 https://doi.org/10.1111/all.12110
    56 https://doi.org/10.1111/j.1745-9125.1998.tb01268.x
    57 https://doi.org/10.1146/annurev.pharmtox.44.101802.121453
    58 https://doi.org/10.1152/ajpendo.00173.2006
    59 https://doi.org/10.1152/ajpendo.2001.281.6.e1333
    60 https://doi.org/10.1152/jappl.2001.91.1.357
    61 https://doi.org/10.1159/000459034
    62 https://doi.org/10.1161/01.atv.14.4.567
    63 https://doi.org/10.1161/cir.0b013e31828124ad
    64 https://doi.org/10.1161/circulationaha.105.553198
    65 https://doi.org/10.1172/jci42344
    66 https://doi.org/10.1201/b13973
    67 https://doi.org/10.1210/jc.2010-2061
    68 https://doi.org/10.1214/aos/1176344552
    69 https://doi.org/10.1371/journal.pcbi.1000217
    70 https://doi.org/10.1371/journal.pgen.1000504
    71 https://doi.org/10.1371/journal.pgen.1000529
    72 https://doi.org/10.1371/journal.pgen.1002215
    73 https://doi.org/10.1371/journal.pgen.1002270
    74 https://doi.org/10.1371/journal.pgen.1003005
    75 https://doi.org/10.1586/14737159.8.1.9
    76 schema:datePublished 2015-12
    77 schema:datePublishedReg 2015-12-01
    78 schema:description The susceptibility for various diseases as well as the response to treatments differ considerably between men and women. As a basis for a gender-specific personalized healthcare, an extensive characterization of the molecular differences between the two genders is required. In the present study, we conducted a large-scale metabolomics analysis of 507 metabolic markers measured in serum of 1756 participants from the German KORA F4 study (903 females and 853 males). One-third of the metabolites show significant differences between males and females. A pathway analysis revealed strong differences in steroid metabolism, fatty acids and further lipids, a large fraction of amino acids, oxidative phosphorylation, purine metabolism and gamma-glutamyl dipeptides. We then extended this analysis by a network-based clustering approach. Metabolite interactions were estimated using Gaussian graphical models to get an unbiased, fully data-driven metabolic network representation. This approach is not limited to possibly arbitrary pathway boundaries and can even include poorly or uncharacterized metabolites. The network analysis revealed several strongly gender-regulated submodules across different pathways. Finally, a gender-stratified genome-wide association study was performed to determine whether the observed gender differences are caused by dimorphisms in the effects of genetic polymorphisms on the metabolome. With only a single genome-wide significant hit, our results suggest that this scenario is not the case. In summary, we report an extensive characterization and interpretation of gender-specific differences of the human serum metabolome, providing a broad basis for future analyses.
    79 schema:genre research_article
    80 schema:inLanguage en
    81 schema:isAccessibleForFree true
    82 schema:isPartOf N0c49ce97ba0c4d1786b115161fc97c2e
    83 N9f36b783f3574fb897c37e52afe2f8de
    84 sg:journal.1036887
    85 schema:name Gender-specific pathway differences in the human serum metabolome
    86 schema:pagination 1815-1833
    87 schema:productId N40809b18ccca443aabddc1e0fe312a38
    88 N585151b2f35a4c919474f2d58b268cb4
    89 N8677bfaa271c4c66b1560d366a249af9
    90 Na262ba4530f24fa795c97cbdcc9c5e55
    91 Nef82c2ab52fb44cd9b6a1a9f229cad6b
    92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000861926
    93 https://doi.org/10.1007/s11306-015-0829-0
    94 schema:sdDatePublished 2019-04-11T13:06
    95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    96 schema:sdPublisher Na114fe664a8c4cdfb005c6a80d68c6ce
    97 schema:url https://link.springer.com/10.1007%2Fs11306-015-0829-0
    98 sgo:license sg:explorer/license/
    99 sgo:sdDataset articles
    100 rdf:type schema:ScholarlyArticle
    101 N0c49ce97ba0c4d1786b115161fc97c2e schema:volumeNumber 11
    102 rdf:type schema:PublicationVolume
    103 N127fc588b4884945ad7eb69a2819f286 rdf:first sg:person.0641716575.81
    104 rdf:rest N3aee490c35014806b7a66ad6398951f2
    105 N195d87d9023e46bf8a55b7a9ad62b060 rdf:first sg:person.01135477613.94
    106 rdf:rest N6f90a615a5a045d2b0689033b0124e6e
    107 N1b0969f97ef945c6a3847932280598d2 rdf:first sg:person.01345347020.14
    108 rdf:rest N6edb00f969f04b6695fd778b49e6ba5a
    109 N2c2c2d25b3d141469d10c4699d033912 rdf:first sg:person.01304403211.40
    110 rdf:rest Nf9465d604de14d158dc237169752623e
    111 N3aee490c35014806b7a66ad6398951f2 rdf:first sg:person.01321230721.07
    112 rdf:rest Nb35791004be848869415cdedb43145d6
    113 N40809b18ccca443aabddc1e0fe312a38 schema:name doi
    114 schema:value 10.1007/s11306-015-0829-0
    115 rdf:type schema:PropertyValue
    116 N501637733a3d48128bbc95c1d82b27d3 rdf:first sg:person.015350356542.51
    117 rdf:rest Na567ea3dd1694373bd4c8d88a365fc2b
    118 N585151b2f35a4c919474f2d58b268cb4 schema:name readcube_id
    119 schema:value 041b0b92833b615c78831a64e7367ee3c5edc1b8fc2cbac4fc96ce3967bbd201
    120 rdf:type schema:PropertyValue
    121 N6d52a64040cc49b689b2e1837a806937 rdf:first sg:person.01230632011.15
    122 rdf:rest N872c1819afa54f21958184e8f18bb78b
    123 N6edb00f969f04b6695fd778b49e6ba5a rdf:first sg:person.01113051245.30
    124 rdf:rest Nff19d991a45e4f54ab266cf82d7c5589
    125 N6f90a615a5a045d2b0689033b0124e6e rdf:first sg:person.01122034607.14
    126 rdf:rest N501637733a3d48128bbc95c1d82b27d3
    127 N8677bfaa271c4c66b1560d366a249af9 schema:name pubmed_id
    128 schema:value 26491425
    129 rdf:type schema:PropertyValue
    130 N872c1819afa54f21958184e8f18bb78b rdf:first sg:person.01227277645.30
    131 rdf:rest Ne76e52ab069648c6bf5d343ee941acc6
    132 N9f36b783f3574fb897c37e52afe2f8de schema:issueNumber 6
    133 rdf:type schema:PublicationIssue
    134 Na114fe664a8c4cdfb005c6a80d68c6ce schema:name Springer Nature - SN SciGraph project
    135 rdf:type schema:Organization
    136 Na262ba4530f24fa795c97cbdcc9c5e55 schema:name nlm_unique_id
    137 schema:value 101274889
    138 rdf:type schema:PropertyValue
    139 Na567ea3dd1694373bd4c8d88a365fc2b rdf:first sg:person.01130556140.04
    140 rdf:rest N1b0969f97ef945c6a3847932280598d2
    141 Nb35791004be848869415cdedb43145d6 rdf:first sg:person.01147670402.78
    142 rdf:rest N6d52a64040cc49b689b2e1837a806937
    143 Nbca1765cc5cb41b2b36a7b002d79bee9 rdf:first sg:person.0712635675.19
    144 rdf:rest N2c2c2d25b3d141469d10c4699d033912
    145 Ne4d2ad108d7c43fba1a1ec8c34032c6c rdf:first sg:person.01364120657.92
    146 rdf:rest N195d87d9023e46bf8a55b7a9ad62b060
    147 Ne76e52ab069648c6bf5d343ee941acc6 rdf:first sg:person.01117072553.44
    148 rdf:rest Ne4d2ad108d7c43fba1a1ec8c34032c6c
    149 Nef82c2ab52fb44cd9b6a1a9f229cad6b schema:name dimensions_id
    150 schema:value pub.1000861926
    151 rdf:type schema:PropertyValue
    152 Nf828ced4315a49a59ea1d8ea8cc0e3bf rdf:first sg:person.015172732374.68
    153 rdf:rest N127fc588b4884945ad7eb69a2819f286
    154 Nf9465d604de14d158dc237169752623e rdf:first sg:person.0620106734.75
    155 rdf:rest rdf:nil
    156 Nff19d991a45e4f54ab266cf82d7c5589 rdf:first sg:person.011673465237.05
    157 rdf:rest Nbca1765cc5cb41b2b36a7b002d79bee9
    158 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    159 schema:name Biological Sciences
    160 rdf:type schema:DefinedTerm
    161 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    162 schema:name Genetics
    163 rdf:type schema:DefinedTerm
    164 sg:grant.3797914 http://pending.schema.org/fundedItem sg:pub.10.1007/s11306-015-0829-0
    165 rdf:type schema:MonetaryGrant
    166 sg:journal.1036887 schema:issn 1573-3882
    167 1573-3890
    168 schema:name Metabolomics
    169 rdf:type schema:Periodical
    170 sg:person.01113051245.30 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
    171 schema:familyName Suhre
    172 schema:givenName Karsten
    173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113051245.30
    174 rdf:type schema:Person
    175 sg:person.01117072553.44 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
    176 schema:familyName Peters
    177 schema:givenName Annette
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117072553.44
    179 rdf:type schema:Person
    180 sg:person.01122034607.14 schema:affiliation https://www.grid.ac/institutes/grid.452396.f
    181 schema:familyName Friedrich
    182 schema:givenName Nele
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122034607.14
    184 rdf:type schema:Person
    185 sg:person.01130556140.04 schema:affiliation https://www.grid.ac/institutes/grid.452396.f
    186 schema:familyName Pietzner
    187 schema:givenName Maik
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130556140.04
    189 rdf:type schema:Person
    190 sg:person.01135477613.94 schema:affiliation https://www.grid.ac/institutes/grid.5361.1
    191 schema:familyName Kronenberg
    192 schema:givenName Florian
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135477613.94
    194 rdf:type schema:Person
    195 sg:person.01147670402.78 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
    196 schema:familyName Stückler
    197 schema:givenName Ferdinand
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147670402.78
    199 rdf:type schema:Person
    200 sg:person.011673465237.05 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
    201 schema:familyName Gieger
    202 schema:givenName Christian
    203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011673465237.05
    204 rdf:type schema:Person
    205 sg:person.01227277645.30 schema:affiliation https://www.grid.ac/institutes/grid.6936.a
    206 schema:familyName Adamski
    207 schema:givenName Jerzy
    208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227277645.30
    209 rdf:type schema:Person
    210 sg:person.01230632011.15 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
    211 schema:familyName Ried
    212 schema:givenName Janina
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230632011.15
    214 rdf:type schema:Person
    215 sg:person.01304403211.40 schema:affiliation https://www.grid.ac/institutes/grid.6936.a
    216 schema:familyName Theis
    217 schema:givenName Fabian J.
    218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304403211.40
    219 rdf:type schema:Person
    220 sg:person.01321230721.07 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
    221 schema:familyName Do
    222 schema:givenName Kieu Trinh
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321230721.07
    224 rdf:type schema:Person
    225 sg:person.01345347020.14 schema:affiliation https://www.grid.ac/institutes/grid.418818.c
    226 schema:familyName Mook-Kanamori
    227 schema:givenName Dennis O.
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345347020.14
    229 rdf:type schema:Person
    230 sg:person.01364120657.92 schema:affiliation https://www.grid.ac/institutes/grid.10423.34
    231 schema:familyName Illig
    232 schema:givenName Thomas
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364120657.92
    234 rdf:type schema:Person
    235 sg:person.015172732374.68 schema:affiliation https://www.grid.ac/institutes/grid.452622.5
    236 schema:familyName Krumsiek
    237 schema:givenName Jan
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015172732374.68
    239 rdf:type schema:Person
    240 sg:person.015350356542.51 schema:affiliation https://www.grid.ac/institutes/grid.452396.f
    241 schema:familyName Nauck
    242 schema:givenName Matthias
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015350356542.51
    244 rdf:type schema:Person
    245 sg:person.0620106734.75 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
    246 schema:familyName Kastenmüller
    247 schema:givenName Gabi
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620106734.75
    249 rdf:type schema:Person
    250 sg:person.0641716575.81 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
    251 schema:familyName Mittelstrass
    252 schema:givenName Kirstin
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641716575.81
    254 rdf:type schema:Person
    255 sg:person.0712635675.19 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
    256 schema:familyName Grallert
    257 schema:givenName Harald
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712635675.19
    259 rdf:type schema:Person
    260 sg:pub.10.1007/s00125-010-1673-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035619901
    261 https://doi.org/10.1007/s00125-010-1673-4
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1007/s00439-011-1081-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1017546298
    264 https://doi.org/10.1007/s00439-011-1081-y
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1007/s11306-011-0311-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035063940
    267 https://doi.org/10.1007/s11306-011-0311-6
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1007/s11306-013-0565-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018376713
    270 https://doi.org/10.1007/s11306-013-0565-2
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1007/s11306-014-0707-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024965129
    273 https://doi.org/10.1007/s11306-014-0707-1
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1007/s11684-013-0255-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033475624
    276 https://doi.org/10.1007/s11684-013-0255-5
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/465688a schema:sameAs https://app.dimensions.ai/details/publication/pub.1013103104
    279 https://doi.org/10.1038/465688a
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/ijo.2014.39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050615680
    282 https://doi.org/10.1038/ijo.2014.39
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/nbt0807-846b schema:sameAs https://app.dimensions.ai/details/publication/pub.1028899298
    285 https://doi.org/10.1038/nbt0807-846b
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/ng.1073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027410569
    288 https://doi.org/10.1038/ng.1073
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/ng.2982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044995197
    291 https://doi.org/10.1038/ng.2982
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/nmeth.2307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043747449
    294 https://doi.org/10.1038/nmeth.2307
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/nrcardio.2010.223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019366659
    297 https://doi.org/10.1038/nrcardio.2010.223
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1186/1471-2164-15-33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021134350
    300 https://doi.org/10.1186/1471-2164-15-33
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1186/1752-0509-5-21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029129105
    303 https://doi.org/10.1186/1752-0509-5-21
    304 rdf:type schema:CreativeWork
    305 https://app.dimensions.ai/details/publication/pub.1076141836 schema:CreativeWork
    306 https://app.dimensions.ai/details/publication/pub.1078820989 schema:CreativeWork
    307 https://app.dimensions.ai/details/publication/pub.1081934917 schema:CreativeWork
    308 https://app.dimensions.ai/details/publication/pub.1082221484 schema:CreativeWork
    309 https://doi.org/10.1002/gepi.20303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008645052
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/0377-0427(87)90125-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041584630
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/j.ab.2006.02.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039527423
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/j.cmet.2009.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013089119
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/j.cmet.2013.06.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041995293
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/j.jchromb.2008.09.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052619043
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/j.jval.2013.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015051673
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/j.tips.2009.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035046311
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/s0009-8981(01)00805-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006245621
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/s0026-0495(97)90273-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050982712
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/s0376-8716(02)00015-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044893662
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1021/ac0708588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054999511
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1021/jf00103a017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055896774
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1024/0300-9831.70.5.221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056317695
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1038/embor.2012.87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021120759
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1038/msb.2011.99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034119217
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1042/bj3270449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038253679
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1055/s-2005-858235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057441646
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1055/s-2007-972875 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057505166
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1073/pnas.0506580102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037705714
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1074/jbc.m110.194241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041203900
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1080/01621459.1951.10500769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058298962
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1080/10408390601062054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040225067
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1080/15257770802138558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029336145
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1089/dia.2011.0275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027230591
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1093/ajcn/36.2.332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082151991
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1093/ajcn/83.6.1351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077259119
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1093/bioinformatics/btg115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028034818
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1093/bioinformatics/btm108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031184798
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1093/ije/dyp394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046967006
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1093/jxb/erj013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000800290
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1096/fj.11-198093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047473398
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1111/all.12110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022314274
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1111/j.1745-9125.1998.tb01268.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047249593
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1146/annurev.pharmtox.44.101802.121453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029921124
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1152/ajpendo.00173.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026709283
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1152/ajpendo.2001.281.6.e1333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074952565
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1152/jappl.2001.91.1.357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074835623
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1159/000459034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081577772
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1161/01.atv.14.4.567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000767818
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1161/cir.0b013e31828124ad schema:sameAs https://app.dimensions.ai/details/publication/pub.1052501077
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1161/circulationaha.105.553198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015731857
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1172/jci42344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011181146
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1201/b13973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1095905620
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1210/jc.2010-2061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064292441
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1214/aos/1176344552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012894299
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1371/journal.pcbi.1000217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040370538
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1371/journal.pgen.1000504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034121059
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1371/journal.pgen.1000529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043446290
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1371/journal.pgen.1002215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002943793
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1371/journal.pgen.1002270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028439271
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1371/journal.pgen.1003005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016134453
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1586/14737159.8.1.9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022701482
    414 rdf:type schema:CreativeWork
    415 https://www.grid.ac/institutes/grid.10423.34 schema:alternateName Hannover Medical School
    416 schema:name Hannover Unified Biobank, Hannover Medical School, Hannover, Germany
    417 rdf:type schema:Organization
    418 https://www.grid.ac/institutes/grid.418818.c schema:alternateName Qatar Foundation
    419 schema:name Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
    420 Department of Endocrinology, Leiden University Medical Center, Leiden, Netherlands
    421 Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Qatar Foundation, Doha, Qatar
    422 rdf:type schema:Organization
    423 https://www.grid.ac/institutes/grid.452396.f schema:alternateName German Centre for Cardiovascular Research
    424 schema:name DZHK (German Center for Cardiovascular Research), Greifswald, Greifswald, Germany
    425 Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
    426 rdf:type schema:Organization
    427 https://www.grid.ac/institutes/grid.452622.5 schema:alternateName German Center for Diabetes Research
    428 schema:name German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
    429 Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany
    430 rdf:type schema:Organization
    431 https://www.grid.ac/institutes/grid.4567.0 schema:alternateName Helmholtz Zentrum München
    432 schema:name Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Qatar Foundation, Doha, Qatar
    433 German Center for Cardiovascular Disease Research (DZHK e.V.), Munich, Germany
    434 German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
    435 Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, Neuherberg, Germany
    436 Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany
    437 Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany
    438 Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany
    439 Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany
    440 rdf:type schema:Organization
    441 https://www.grid.ac/institutes/grid.5361.1 schema:alternateName Innsbruck Medical University
    442 schema:name Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
    443 rdf:type schema:Organization
    444 https://www.grid.ac/institutes/grid.6936.a schema:alternateName Technical University Munich
    445 schema:name Department of Mathematics, Technische Universität München, Garching, Germany
    446 German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany
    447 Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany
    448 Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, Neuherberg, Germany
    449 Lehrstuhl für Experimentelle Genetik, Technische Universität München, Freising-Weihenstephan, Germany
    450 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...