Molecular phenotyping of a UK population: defining the human serum metabolome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-02

AUTHORS

Warwick B. Dunn, Wanchang Lin, David Broadhurst, Paul Begley, Marie Brown, Eva Zelena, Andrew A. Vaughan, Antony Halsall, Nadine Harding, Joshua D. Knowles, Sue Francis-McIntyre, Andy Tseng, David I. Ellis, Steve O’Hagan, Gill Aarons, Boben Benjamin, Stephen Chew-Graham, Carly Moseley, Paula Potter, Catherine L. Winder, Catherine Potts, Paula Thornton, Catriona McWhirter, Mohammed Zubair, Martin Pan, Alistair Burns, J. Kennedy Cruickshank, Gordon C. Jayson, Nitin Purandare, Frederick C. W. Wu, Joe D. Finn, John N. Haselden, Andrew W. Nicholls, Ian D. Wilson, Royston Goodacre, Douglas B. Kell

ABSTRACT

Phenotyping of 1,200 'healthy' adults from the UK has been performed through the investigation of diverse classes of hydrophilic and lipophilic metabolites present in serum by applying a series of chromatography-mass spectrometry platforms. These data were made robust to instrumental drift by numerical correction; this was prerequisite to allow detection of subtle metabolic differences. The variation in observed metabolite relative concentrations between the 1,200 subjects ranged from less than 5 % to more than 200 %. Variations in metabolites could be related to differences in gender, age, BMI, blood pressure, and smoking. Investigations suggest that a sample size of 600 subjects is both necessary and sufficient for robust analysis of these data. Overall, this is a large scale and non-targeted chromatographic MS-based metabolomics study, using samples from over 1,000 individuals, to provide a comprehensive measurement of their serum metabolomes. This work provides an important baseline or reference dataset for understanding the 'normal' relative concentrations and variation in the human serum metabolome. These may be related to our increasing knowledge of the human metabolic network map. Information on the Husermet study is available at http://www.husermet.org/. Importantly, all of the data are made freely available at MetaboLights (http://www.ebi.ac.uk/metabolights/). More... »

PAGES

9-26

References to SciGraph publications

  • 2013-05. A community-driven global reconstruction of human metabolism in NATURE BIOTECHNOLOGY
  • 2008-05-15. Human metabolic phenotype diversity and its association with diet and blood pressure in NATURE
  • 2007-09. Proposed minimum reporting standards for data analysis in metabolomics in METABOLOMICS
  • 2013-08. An analysis of a ‘community-driven’ reconstruction of the human metabolic network in METABOLOMICS
  • 2011-07. Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry in NATURE PROTOCOLS
  • 2013-04. Translational biomarker discovery in clinical metabolomics: an introductory tutorial in METABOLOMICS
  • 2005-03. The origin of correlations in metabolomics data in METABOLOMICS
  • 2009-12. Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases in BMC MEDICAL GENOMICS
  • 2001-10. Random Forests in MACHINE LEARNING
  • 2001-01. A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations in NATURE BIOTECHNOLOGY
  • 2012-06. Metabolomic study of plasma of patients with abdominal aortic aneurysm in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 2011-09. Human metabolic individuality in biomedical and pharmaceutical research in NATURE
  • 2001-12. Biochemistry and molecular cell biology of diabetic complications in NATURE
  • 2006-12. Statistical strategies for avoiding false discoveries in metabolomics and related experiments in METABOLOMICS
  • 2010-02. Common and Unique Biological Pathways Associated with Smoking Initiation/Progression, Nicotine Dependence, and Smoking Cessation in NEUROPSYCHOPHARMACOLOGY
  • 2012-11. Genetic variation in metabolic phenotypes: study designs and applications in NATURE REVIEWS GENETICS
  • 2007-09. Proposed minimum reporting standards for chemical analysis in METABOLOMICS
  • 2013-05. Power failure: why small sample size undermines the reliability of neuroscience in NATURE REVIEWS NEUROSCIENCE
  • 2013-12. A novel untargeted metabolomics correlation-based network analysis incorporating human metabolic reconstructions in BMC SYSTEMS BIOLOGY
  • 2011-04. Metabolite profiles and the risk of developing diabetes in NATURE MEDICINE
  • 1993. An Introduction to the Bootstrap in NONE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11306-014-0707-1

    DOI

    http://dx.doi.org/10.1007/s11306-014-0707-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024965129

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25598764


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    563 Faculty of Engineering and Physical Sciences, School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, M1 7DN, Manchester, UK
    564 Faculty of Medical and Human Sciences, Centre for Endocrinology and Diabetes, Institute of Human Development, The University of Manchester, Manchester, UK
    565 School of Biosciences, University of Birmingham, B15 2TT, Edgbaston, Birmingham, UK
    566 rdf:type schema:Organization
     




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