Combining an in vitro reporter gene assay with metabolomics to identify tomato phytochemicals responsible for inducing electrophile-responsive element (EpRE)-mediated gene ... View Full Text


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Article Info

DATE

2014-07-17

AUTHORS

Henriëtte D. L. M. van Eekelen, Linda Gijsbers, Chris A. Maliepaard, Robert A. M. Vreeburg, Richard Finkers, Yury M. Tikunov, Victoria M. Gomez Roldan, Laura H. J. de Haan, Ric C. H. de Vos, Jac M. M. J. G. Aarts, Ivonne M. C. M. Rietjens, Arnaud G. Bovy

ABSTRACT

The electrophile-responsive element (EpRE) is a transcriptional enhancer involved in cancer-chemoprotective gene expression effects of certain dietary compounds. In this study we measured the ability of extracts of glycosidase treated tomato fruits from 97 different accessions to induce EpRE-mediated luciferase expression using EpRE-LUX reporter cells and analyzed the same extracts using LC–MS-based untargeted metabolomics profiling. We were able to pinpoint those tomato compounds that were most correlated with EpRE-mediated luciferase induction, by combining reporter gene assay data with the metabolic profiles of the same extracts. Flavonoids were the compounds showing the strongest positive correlation with EpRE-LUX activity. These results were validated using a transgenic tomato line accumulating high levels of flavonoids. Results obtained corroborated that flavonoids are an important determinant of the ability of tomato fruit extracts to induce EpRE-mediated beneficial health effects. Overall, these results indicate that combining untargeted metabolomics with reporter gene assays provides a powerful tool for nutritionists, plant breeders and food chemists towards identification of potential health-beneficial constituents of tomato fruits, as well as of other crops and products derived thereof. More... »

PAGES

302-311

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11306-014-0694-2

DOI

http://dx.doi.org/10.1007/s11306-014-0694-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000804163


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