Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn’s disease and healthy individuals View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-06-01

AUTHORS

Jacob Tveiten Bjerrum, Yulan Wang, Fuhua Hao, Mehmet Coskun, Christian Ludwig, Ulrich Günther, Ole Haagen Nielsen

ABSTRACT

This study employs spectroscopy-based metabolic profiling of fecal extracts from healthy subjects and patients with active or inactive ulcerative colitis (UC) and Crohn's disease (CD) to substantiate the potential use of spectroscopy as a non-invasive diagnostic tool and to characterize the fecal metabolome in inflammatory bowel disease (IBD). Stool samples from 113 individuals (UC 48, CD 44, controls 21) were analyzed by 1H nuclear magnetic resonance (NMR) spectroscopy (Bruker 600 MHz, Bruker BioSpin, Rheinstetten, Germany). Data were analyzed with principal component analysis and orthogonal-projection to latent structure-discriminant analysis using SIMCA-P + 12 and MATLAB. Significant differences were found in the metabolic profiles making it possible to differentiate between active IBD and controls and between UC and CD. The metabolites holding differential power primarily belonged to a range of amino acids, microbiota-related short chain fatty acids, and lactate suggestive of an inflammation-driven malabsorption and dysbiosis of the normal bacterial ecology. However, removal of patients with intestinal surgery and anti-TNF-α antibody treatment eliminated the discriminative power regarding UC versus CD. This study consequently demonstrates that 1H NMR spectroscopy of fecal extracts is a potential non-invasive diagnostic tool and able to characterize the inflammation-driven changes in the metabolic profiles related to malabsorption and dysbiosis. Intestinal surgery and medication are to be accounted for in future studies, as it seems to be factors of importance in the discriminative process. More... »

PAGES

122-133

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11306-014-0677-3

DOI

http://dx.doi.org/10.1007/s11306-014-0677-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039966884

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25598765


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