Plasma metabolomics reveals a potential panel of biomarkers for early diagnosis in acute coronary syndrome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-10-26

AUTHORS

Carlos M. Laborde, Laura Mourino-Alvarez, María Posada-Ayala, Gloria Alvarez-Llamas, Manuel Gómez Serranillos-Reus, José Moreu, Fernando Vivanco, Luis R. Padial, María G. Barderas

ABSTRACT

Discovery of new biomarkers is critical for early diagnosis of acute coronary syndrome (ACS). Recent advances in metabolomic technologies have drastically enhanced the possibility of improving the knowledge of its physiopathology through the identification of the altered metabolic pathways. In this study, analyses of peripheral plasma from non-ST segment elevation ACS patients and healthy controls by gas chromatography-mass spectrometry (GC-MC) permitted the identification of 15 metabolites with statistical differences (p < 0.05) between experimental groups. Additionally, validation by GC-MC and liquid chromatography-MC permitted us to identify a potential panel of biomarkers formed by 5-OH-tryptophan, 2-OH-butyric acid and 3-OH-butyric acid. This panel of biomarkers reflects the oxidative stress and the hypoxic state that suffers the myocardial cells and consequently constitutes a metabolomic signature of the atherogenesis process that could be used for early diagnosis of ACS. More... »

PAGES

414-424

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11306-013-0595-9

DOI

http://dx.doi.org/10.1007/s11306-013-0595-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043970038

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25814918


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191 Department of Cardiology, Hospital Virgen de la Salud, SESCAM, Toledo, Spain
192 Department of Hemodynamic, Hospital Virgen de la Salud, SESCAM, Toledo, Spain
193 schema:name Department of Biochemistry, Hospital Virgen de la Salud, SESCAM, Toledo, Spain
194 Department of Cardiology, Hospital Virgen de la Salud, SESCAM, Toledo, Spain
195 Department of Hemodynamic, Hospital Virgen de la Salud, SESCAM, Toledo, Spain
196 rdf:type schema:Organization
197 grid-institutes:grid.419651.e schema:alternateName Department of Immunology, IIS-Fundación Jiménez Díaz, Madrid, Spain
198 schema:name Department of Immunology, IIS-Fundación Jiménez Díaz, Madrid, Spain
199 rdf:type schema:Organization
200 grid-institutes:grid.4795.f schema:alternateName Department of Biochemistry and Molecular Biology I, Facultad de Biología, UCM, Madrid, Spain
201 schema:name Department of Biochemistry and Molecular Biology I, Facultad de Biología, UCM, Madrid, Spain
202 Department of Immunology, IIS-Fundación Jiménez Díaz, Madrid, Spain
203 rdf:type schema:Organization
 




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