Comparative analysis of plasma metabolomics response to metabolic challenge tests in healthy subjects and influence of the FTO obesity risk ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-06

AUTHORS

Simone Wahl, Susanne Krug, Cornelia Then, Anna Kirchhofer, Gabi Kastenmüller, Tina Brand, Thomas Skurk, Melina Claussnitzer, Cornelia Huth, Margit Heier, Christa Meisinger, Annette Peters, Barbara Thorand, Christian Gieger, Cornelia Prehn, Werner Römisch-Margl, Jerzy Adamski, Karsten Suhre, Thomas Illig, Harald Grallert, Helmut Laumen, Jochen Seissler, Hans Hauner

ABSTRACT

The measurement of metabolites during intravenous or nutritional challenges may improve the identification of novel metabolic signatures which are not detectable in the fasting state. Here, we comprehensively characterized the plasma metabolomics response to five defined challenge tests and explored their use to identify interactions with the FTO rs9939609 obesity risk genotype. Fifty-six non-diabetic male participants of the KORA S4/F4 cohort, including 25 homozygous carriers of the FTO risk allele (AA genotype) and 31 carriers of the TT genotype were recruited. Challenges comprised an oral glucose tolerance test, a standardized high-fat high-carbohydrate meal and a lipid tolerance test, as well as an intravenous glucose tolerance test and a euglycemic hyperinsulinemic clamp. Blood was sampled for biochemical and metabolomics measurement before and during the challenges. Plasma samples were analyzed using a mass spectrometry-based metabolomics approach targeting 163 metabolites. Linear mixed-effects models and cluster analysis were performed. In both genotype groups, we observed significant challenge-induced changes for all major metabolite classes (amino acids, hexose, acylcarnitines, phosphatidylcholines, lysophosphatidylcholines and sphingomyelins, with corrected p-values ranging from 0.05 to 6.7E−37), which clustered in five distinct metabolic response profiles. Our data contribute to the understanding of plasma metabolomics response to diverse metabolic challenges, including previously unreported metabolite changes in response to intravenous challenges. The FTO genotype had only minor effects on the metabolite fluxes after standardized metabolic challenges. More... »

PAGES

386-401

References to SciGraph publications

  • 2006-01. The in vivo effects of the Pro12Ala PPARγ2 polymorphism on adipose tissue NEFA metabolism: the first use of the Oxford Biobank in DIABETOLOGIA
  • 2012-04. Plasma metabolomics and proteomics profiling after a postprandial challenge reveal subtle diet effects on human metabolic status in METABOLOMICS
  • 2012-02. Procedure for tissue sample preparation and metabolite extraction for high-throughput targeted metabolomics in METABOLOMICS
  • 2009-06. Assessing individual metabolic responsiveness to a lipid challenge using a targeted metabolomic approach in METABOLOMICS
  • 2013-01. Direct effect of GLP-1 infusion on endogenous glucose production in humans in DIABETOLOGIA
  • 2010-06. KmL: k-means for longitudinal data in COMPUTATIONAL STATISTICS
  • 2011-09. New metabolic interdependencies revealed by plasma metabolite profiling after two dietary challenges in METABOLOMICS
  • 2010. Estimation of the Number of Clusters Using Multiple Clustering Validity Indices in MULTIPLE CLASSIFIER SYSTEMS
  • 2010-10. Genes and lifestyle factors in obesity: results from 12 462 subjects from MONICA/KORA in INTERNATIONAL JOURNAL OF OBESITY
  • 2009-01. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity in NATURE GENETICS
  • 2004-12. Sample size and power estimation for studies with health related quality of life outcomes: a comparison of four methods using the SF-36 in HEALTH AND QUALITY OF LIFE OUTCOMES
  • 2011-09. Human metabolic individuality in biomedical and pharmaceutical research in NATURE
  • 2011-12. Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data in BMC SYSTEMS BIOLOGY
  • 2007-03. PPARGC1A coding variation may initiate impaired NEFA clearance during glucose challenge in DIABETOLOGIA
  • 2013-10. Targeted Metabolomics of Dried Blood Spot Extracts in CHROMATOGRAPHIA
  • 2010-02. A genome-wide perspective of genetic variation in human metabolism in NATURE GENETICS
  • 2009-01. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation in NATURE GENETICS
  • 2010-09. The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels in EUROPEAN JOURNAL OF HUMAN GENETICS
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    URI

    http://scigraph.springernature.com/pub.10.1007/s11306-013-0586-x

    DOI

    http://dx.doi.org/10.1007/s11306-013-0586-x

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    https://app.dimensions.ai/details/publication/pub.1052697522


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