Characterization of the natural variation in Arabidopsis thaliana metabolome by the analysis of metabolic distance View Full Text


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Article Info

DATE

2011-10-19

AUTHORS

Benyamin Houshyani, Patrick Kabouw, Dorota Muth, Ric C. H. de Vos, Raoul J. Bino, Harro J. Bouwmeester

ABSTRACT

Metabolite fingerprinting is widely used to unravel the chemical characteristics of biological samples. Multivariate data analysis and other statistical tools are subsequently used to analyze and visualize the plasticity of the metabolome and/or the relationship between those samples. However, there are limitations to these approaches for example because of the multi-dimensionality of the data that makes interpretation of the data obtained from untargeted analysis almost impossible for an average human being. These limitations make the biological information that is of prime importance in untargeted studies be partially exploited. Even in the case of full exploitation, current methods for relationship elucidation focus mainly on between groups variation and differences. Therefore, a measure that is capable of exploiting both between- and within-group biological variation would be of great value. Here, we examined the natural variation in the metabolome of nine Arabidopsis thaliana accessions grown under various environmental conditions and established a measure for the metabolic distance between accessions and across environments. This data analysis approach shows that there is just a minor correlation between genetic and metabolic diversity of the nine accessions. On the other hand, it delivers so far in Arabidopsis unexplored chemical information and is shown to be biologically relevant for resistance studies. More... »

PAGES

131-145

References to SciGraph publications

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  • 2005-06-02. New insight into the biosynthesis and regulation of indole compounds in Arabidopsis thaliana in PLANTA
  • 2006-06-04. The genetics of plant metabolism in NATURE GENETICS
  • 2009-12-01. Correlation exploration of metabolic and genomic diversity in rice in BMC GENOMICS
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  • 2009-07. Variation in metabolites constituent in leaves of downy mildew resistant and susceptible genotypes of pearl millet in PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS
  • 2000-11. Metabolite profiling for plant functional genomics in NATURE BIOTECHNOLOGY
  • 2009-04-10. Chemotype of Senecio jacobaea affects damage by pathogens and insect herbivores in the field in EVOLUTIONARY ECOLOGY
  • 2008-12-23. Rapid discrimination of commercial strawberry cultivars using Fourier transform infrared spectroscopy data combined by multivariate analysis in PLANT BIOTECHNOLOGY REPORTS
  • 2003-01-30. A novel high efficiency, low maintenance, hydroponic system for synchronous growth and flowering of Arabidopsis thaliana in BMC PLANT BIOLOGY
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  • 1988-06. CANOCO—an extension of DECORANA to analyze species-environment relationships in PLANT ECOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11306-011-0375-3

    DOI

    http://dx.doi.org/10.1007/s11306-011-0375-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1033308624

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22593725


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