MSEA: metabolite set enrichment analysis in the MeltDB metabolomics software platform: metabolic profiling of Corynebacterium glutamicum as an example View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-04

AUTHORS

Marcus Persicke, Christian Rückert, Jens Plassmeier, Leonhardt Jonathan Stutz, Nikolas Kessler, Jörn Kalinowski, Alexander Goesmann, Heiko Neuweger

ABSTRACT

Gene set enrichment analysis (GSEA) has been successfully employed in transcriptomics and proteomics research for over 5 years. We have applied a modified GSEA approach to metabolomics, called metabolite set enrichment analysis (MSEA), and have integrated this method into the MeltDB platform. With the novel integrated functionality, we evaluate the applicability of the approach for metabolomics research by analyzing the metabolic profiles of industrial amino acid producer strains of Corynebacteriumglutamicum. Metabolite sets are obtained from metabolic pathways defined in the KEGG and the newly created CglCyc databases. In the first experiment using MSEA, the metabolic profiling analyses compared glucose- and acetate-grown strains, and, in the second, a production strain series in which the carbon flow is shifted step-wise from the lysine pathway to the branching threonine, isoleucine, and methionine pathways. By identifying changes of the metabolic profile MSEA was able to identify the metabolic pathways activated while utilizing different carbon sources or those that have been genetically modified. The presented experimental results are publicly available at http://meltdb.cebitec.uni-bielefeld.de. More... »

PAGES

310-322

References to SciGraph publications

  • 2004-09. Metabolite profiling: from diagnostics to systems biology in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2003-10. Methionine biosynthesis and its regulation in Corynebacterium glutamicum: parallel pathways of transsulfuration and direct sulfhydrylation in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2002-01. A novel methodology employing Corynebacterium glutamicum genome information to generate a new L-lysine-producing mutant in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2006-12. Centering, scaling, and transformations: improving the biological information content of metabolomics data in BMC GENOMICS
  • 2002-06. Influence of glucose, fructose and sucrose as carbon sources on kinetics and stoichiometry of lysine production by Corynebacterium glutamicum in JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
  • 2006-07. A genome-based approach to create a minimally mutated Corynebacterium glutamicum strain for efficient l-lysine production in JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
  • 2008-10. Metabolic responses to pyruvate kinase deletion in lysine producing Corynebacterium glutamicum in MICROBIAL CELL FACTORIES
  • 2001-12. Metabolic redirection of carbon flow toward isoleucine by expressing a catabolic threonine dehydratase in a threonine-overproducing Corynebacterium glutamicum in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2005-12. Functional genomics and expression analysis of the Corynebacterium glutamicum fpr2-cysIXHDNYZ gene cluster involved in assimilatory sulphate reduction in BMC GENOMICS
  • 2003-07. PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes in NATURE GENETICS
  • 2002-01. Metabolomics – the link between genotypes and phenotypes in PLANT MOLECULAR BIOLOGY
  • 2010-05. Carbohydrate metabolism in Corynebacterium glutamicum and applications for the metabolic engineering of l-lysine production strains in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2005-11. Biotechnological production of amino acids and derivatives: current status and prospects in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2009-12. Visualizing post genomics data-sets on customized pathway maps by ProMeTra – aeration-dependent gene expression and metabolism of Corynebacterium glutamicum as an example in BMC SYSTEMS BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11306-011-0311-6

    DOI

    http://dx.doi.org/10.1007/s11306-011-0311-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035063940


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Bielefeld University", 
              "id": "https://www.grid.ac/institutes/grid.7491.b", 
              "name": [
                "Institut f\u00fcr Genomforschung und Systembiologie, Centrum f\u00fcr Biotechnologie (CeBiTec), University of Bielefeld, Universit\u00e4tsstrasse 27, 33615, Bielefeld, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Persicke", 
            "givenName": "Marcus", 
            "id": "sg:person.01102252405.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102252405.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Bielefeld University", 
              "id": "https://www.grid.ac/institutes/grid.7491.b", 
              "name": [
                "Institut f\u00fcr Genomforschung und Systembiologie, Centrum f\u00fcr Biotechnologie (CeBiTec), University of Bielefeld, Universit\u00e4tsstrasse 27, 33615, Bielefeld, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "R\u00fcckert", 
            "givenName": "Christian", 
            "id": "sg:person.0606773566.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606773566.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Massachusetts Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Institut f\u00fcr Genomforschung und Systembiologie, Centrum f\u00fcr Biotechnologie (CeBiTec), University of Bielefeld, Universit\u00e4tsstrasse 27, 33615, Bielefeld, Germany", 
                "Department of Biology, Massachusetts Institute of Technology, 31 Ames Street, Bldg. 68-346, 02142, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Plassmeier", 
            "givenName": "Jens", 
            "id": "sg:person.0766024005.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766024005.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Bielefeld University", 
              "id": "https://www.grid.ac/institutes/grid.7491.b", 
              "name": [
                "Computational Genomics, Centrum f\u00fcr Biotechnologie (CeBiTec), University of Bielefeld, Universit\u00e4tsstrasse 27, 33615, Bielefeld, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stutz", 
            "givenName": "Leonhardt Jonathan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Bielefeld University", 
              "id": "https://www.grid.ac/institutes/grid.7491.b", 
              "name": [
                "Computational Genomics, Centrum f\u00fcr Biotechnologie (CeBiTec), University of Bielefeld, Universit\u00e4tsstrasse 27, 33615, Bielefeld, Germany", 
                "Biodata Mining & Applied Neuroinformatics, Centrum f\u00fcr Biotechnologie (CeBiTec), University of Bielefeld, Universit\u00e4tsstrasse 27, 33615, Bielefeld, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kessler", 
            "givenName": "Nikolas", 
            "id": "sg:person.0717367405.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717367405.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Bielefeld University", 
              "id": "https://www.grid.ac/institutes/grid.7491.b", 
              "name": [
                "Institut f\u00fcr Genomforschung und Systembiologie, Centrum f\u00fcr Biotechnologie (CeBiTec), University of Bielefeld, Universit\u00e4tsstrasse 27, 33615, Bielefeld, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kalinowski", 
            "givenName": "J\u00f6rn", 
            "id": "sg:person.014617723637.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014617723637.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Bielefeld University", 
              "id": "https://www.grid.ac/institutes/grid.7491.b", 
              "name": [
                "Computational Genomics, Centrum f\u00fcr Biotechnologie (CeBiTec), University of Bielefeld, Universit\u00e4tsstrasse 27, 33615, Bielefeld, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Goesmann", 
            "givenName": "Alexander", 
            "id": "sg:person.01066570355.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066570355.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Bielefeld University", 
              "id": "https://www.grid.ac/institutes/grid.7491.b", 
              "name": [
                "Computational Genomics, Centrum f\u00fcr Biotechnologie (CeBiTec), University of Bielefeld, Universit\u00e4tsstrasse 27, 33615, Bielefeld, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Neuweger", 
            "givenName": "Heiko", 
            "id": "sg:person.01154133575.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154133575.82"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/s0168-1656(03)00154-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003459821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-1656(03)00154-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003459821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1357-2725(99)00139-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003959369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-7-142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004880490", 
              "https://doi.org/10.1186/1471-2164-7-142"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1096-7176(03)00004-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004987005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1096-7176(03)00004-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004987005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-1656(03)00149-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007111340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-1656(03)00149-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007111340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbiotec.2008.10.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007748060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-005-0155-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009820334", 
              "https://doi.org/10.1007/s00253-005-0155-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-005-0155-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009820334", 
              "https://doi.org/10.1007/s00253-005-0155-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbiotec.2007.04.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009841216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbiotec.2006.11.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009892971"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bib/bbp043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010319270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bib/bbp043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010319270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btq567", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012080988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10295-006-0104-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012186661", 
              "https://doi.org/10.1007/s10295-006-0104-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10295-006-0104-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012186661", 
              "https://doi.org/10.1007/s10295-006-0104-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymben.2006.03.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013160347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jb.184.5.1277-1286.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013502136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymben.2007.05.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014131959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-1656(02)00136-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014181390"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1180", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014377811", 
              "https://doi.org/10.1038/ng1180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1180", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014377811", 
              "https://doi.org/10.1038/ng1180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1752-0509-3-82", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017282635", 
              "https://doi.org/10.1186/1752-0509-3-82"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-010-2537-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019541937", 
              "https://doi.org/10.1007/s00253-010-2537-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-010-2537-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019541937", 
              "https://doi.org/10.1007/s00253-010-2537-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/0471250953.bi0703s21", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019973752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbiotec.2003.08.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020711382"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/abio.1999.4048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020841176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aem.71.6.3255-3268.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021960127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0003-2697(92)90149-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022403335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pmic.200500144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023116054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pmic.200500144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023116054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbiotec.2008.12.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023451891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bib/bbl013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023582021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/9783527620883.ch14a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024550083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.trac.2004.11.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025000244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2164-6-121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025087037", 
              "https://doi.org/10.1186/1471-2164-6-121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-1656(03)00073-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025717080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-1656(03)00073-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025717080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jb.182.11.3088-3096.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026082672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1013713905833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027843923", 
              "https://doi.org/10.1023/a:1013713905833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkj102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028128110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ab.2005.01.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028973618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1469-8137.2005.01632.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030680989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1096-7176(03)00005-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031347185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1096-7176(03)00005-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031347185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000117614", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031841446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1271/bbb.66.1337", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031960134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-1656(03)00167-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034115435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-1656(03)00167-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034115435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2003.10.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035163952"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bit.10915", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035684925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aem.01942-09", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036151935"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jb.186.6.1769-1784.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036345053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-001-0829-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037326212", 
              "https://doi.org/10.1007/s00253-001-0829-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0506580102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037705714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0506580102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037705714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2859-7-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037804004", 
              "https://doi.org/10.1186/1475-2859-7-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibtech.2004.03.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037967197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aem.02912-08", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038870194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-1656(02)00159-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039964997"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbiotec.2010.08.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040338842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btn452", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041114967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-003-1306-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041292024", 
              "https://doi.org/10.1007/s00253-003-1306-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbiotec.2005.12.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043045716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbiotec.2005.12.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044315043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-001-0883-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045162392", 
              "https://doi.org/10.1007/s00253-001-0883-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/0471973165.ch10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047139560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkn923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047610281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aem.70.12.7277-7287.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047872680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-1656(03)00158-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047988021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-1656(03)00158-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047988021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051079961", 
              "https://doi.org/10.1038/nrm1451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051079961", 
              "https://doi.org/10.1038/nrm1451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkq329", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051951318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkq329", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051951318"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2958.2005.04586.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051954905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btm369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052471554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi991710o", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055218378"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi991710o", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055218378"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj/jim/7000252", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056648569", 
              "https://doi.org/10.1038/sj/jim/7000252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1099/mic.0.023614-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060394397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jb.175.17.5595-5603.1993", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062721944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074496824", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074816854", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077202304", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083291921", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-04", 
        "datePublishedReg": "2012-04-01", 
        "description": "Gene set enrichment analysis (GSEA) has been successfully employed in transcriptomics and proteomics research for over 5 years. We have applied a modified GSEA approach to metabolomics, called metabolite set enrichment analysis (MSEA), and have integrated this method into the MeltDB platform. With the novel integrated functionality, we evaluate the applicability of the approach for metabolomics research by analyzing the metabolic profiles of industrial amino acid producer strains of Corynebacteriumglutamicum. Metabolite sets are obtained from metabolic pathways defined in the KEGG and the newly created CglCyc databases. In the first experiment using MSEA, the metabolic profiling analyses compared glucose- and acetate-grown strains, and, in the second, a production strain series in which the carbon flow is shifted step-wise from the lysine pathway to the branching threonine, isoleucine, and methionine pathways. By identifying changes of the metabolic profile MSEA was able to identify the metabolic pathways activated while utilizing different carbon sources or those that have been genetically modified. The presented experimental results are publicly available at http://meltdb.cebitec.uni-bielefeld.de.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s11306-011-0311-6", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1036887", 
            "issn": [
              "1573-3882", 
              "1573-3890"
            ], 
            "name": "Metabolomics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "8"
          }
        ], 
        "name": "MSEA: metabolite set enrichment analysis in the MeltDB metabolomics software platform: metabolic profiling of Corynebacterium glutamicum as an example", 
        "pagination": "310-322", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "a708131b3fda32754c8758890e09aa91b5d151f00984a016bc909fdf49f7d548"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11306-011-0311-6"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1035063940"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11306-011-0311-6", 
          "https://app.dimensions.ai/details/publication/pub.1035063940"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T19:59", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000523.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs11306-011-0311-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11306-011-0311-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11306-011-0311-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11306-011-0311-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11306-011-0311-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    341 TRIPLES      21 PREDICATES      99 URIs      19 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11306-011-0311-6 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author N9186af72d9de47efbe90a62624a15c73
    4 schema:citation sg:pub.10.1007/s00253-001-0829-z
    5 sg:pub.10.1007/s00253-001-0883-6
    6 sg:pub.10.1007/s00253-003-1306-7
    7 sg:pub.10.1007/s00253-005-0155-y
    8 sg:pub.10.1007/s00253-010-2537-z
    9 sg:pub.10.1007/s10295-006-0104-5
    10 sg:pub.10.1023/a:1013713905833
    11 sg:pub.10.1038/ng1180
    12 sg:pub.10.1038/nrm1451
    13 sg:pub.10.1038/sj/jim/7000252
    14 sg:pub.10.1186/1471-2164-6-121
    15 sg:pub.10.1186/1471-2164-7-142
    16 sg:pub.10.1186/1475-2859-7-8
    17 sg:pub.10.1186/1752-0509-3-82
    18 https://app.dimensions.ai/details/publication/pub.1074496824
    19 https://app.dimensions.ai/details/publication/pub.1074816854
    20 https://app.dimensions.ai/details/publication/pub.1077202304
    21 https://app.dimensions.ai/details/publication/pub.1083291921
    22 https://doi.org/10.1002/0471250953.bi0703s21
    23 https://doi.org/10.1002/0471973165.ch10
    24 https://doi.org/10.1002/9783527620883.ch14a
    25 https://doi.org/10.1002/bit.10915
    26 https://doi.org/10.1002/pmic.200500144
    27 https://doi.org/10.1006/abio.1999.4048
    28 https://doi.org/10.1016/0003-2697(92)90149-2
    29 https://doi.org/10.1016/j.ab.2005.01.027
    30 https://doi.org/10.1016/j.jbiotec.2003.08.006
    31 https://doi.org/10.1016/j.jbiotec.2005.12.002
    32 https://doi.org/10.1016/j.jbiotec.2005.12.027
    33 https://doi.org/10.1016/j.jbiotec.2006.11.015
    34 https://doi.org/10.1016/j.jbiotec.2007.04.026
    35 https://doi.org/10.1016/j.jbiotec.2008.10.012
    36 https://doi.org/10.1016/j.jbiotec.2008.12.014
    37 https://doi.org/10.1016/j.jbiotec.2010.08.016
    38 https://doi.org/10.1016/j.jmb.2003.10.008
    39 https://doi.org/10.1016/j.tibtech.2004.03.007
    40 https://doi.org/10.1016/j.trac.2004.11.021
    41 https://doi.org/10.1016/j.ymben.2006.03.002
    42 https://doi.org/10.1016/j.ymben.2007.05.001
    43 https://doi.org/10.1016/s0168-1656(02)00136-0
    44 https://doi.org/10.1016/s0168-1656(02)00159-1
    45 https://doi.org/10.1016/s0168-1656(03)00073-7
    46 https://doi.org/10.1016/s0168-1656(03)00149-4
    47 https://doi.org/10.1016/s0168-1656(03)00154-8
    48 https://doi.org/10.1016/s0168-1656(03)00158-5
    49 https://doi.org/10.1016/s0168-1656(03)00167-6
    50 https://doi.org/10.1016/s1096-7176(03)00004-1
    51 https://doi.org/10.1016/s1096-7176(03)00005-3
    52 https://doi.org/10.1016/s1357-2725(99)00139-9
    53 https://doi.org/10.1021/bi991710o
    54 https://doi.org/10.1073/pnas.0506580102
    55 https://doi.org/10.1093/bib/bbl013
    56 https://doi.org/10.1093/bib/bbp043
    57 https://doi.org/10.1093/bioinformatics/btm369
    58 https://doi.org/10.1093/bioinformatics/btn452
    59 https://doi.org/10.1093/bioinformatics/btq567
    60 https://doi.org/10.1093/nar/gkj102
    61 https://doi.org/10.1093/nar/gkn923
    62 https://doi.org/10.1093/nar/gkq329
    63 https://doi.org/10.1099/mic.0.023614-0
    64 https://doi.org/10.1111/j.1365-2958.2005.04586.x
    65 https://doi.org/10.1111/j.1469-8137.2005.01632.x
    66 https://doi.org/10.1128/aem.01942-09
    67 https://doi.org/10.1128/aem.02912-08
    68 https://doi.org/10.1128/aem.70.12.7277-7287.2004
    69 https://doi.org/10.1128/aem.71.6.3255-3268.2005
    70 https://doi.org/10.1128/jb.175.17.5595-5603.1993
    71 https://doi.org/10.1128/jb.182.11.3088-3096.2000
    72 https://doi.org/10.1128/jb.184.5.1277-1286.2002
    73 https://doi.org/10.1128/jb.186.6.1769-1784.2004
    74 https://doi.org/10.1159/000117614
    75 https://doi.org/10.1271/bbb.66.1337
    76 schema:datePublished 2012-04
    77 schema:datePublishedReg 2012-04-01
    78 schema:description Gene set enrichment analysis (GSEA) has been successfully employed in transcriptomics and proteomics research for over 5 years. We have applied a modified GSEA approach to metabolomics, called metabolite set enrichment analysis (MSEA), and have integrated this method into the MeltDB platform. With the novel integrated functionality, we evaluate the applicability of the approach for metabolomics research by analyzing the metabolic profiles of industrial amino acid producer strains of Corynebacteriumglutamicum. Metabolite sets are obtained from metabolic pathways defined in the KEGG and the newly created CglCyc databases. In the first experiment using MSEA, the metabolic profiling analyses compared glucose- and acetate-grown strains, and, in the second, a production strain series in which the carbon flow is shifted step-wise from the lysine pathway to the branching threonine, isoleucine, and methionine pathways. By identifying changes of the metabolic profile MSEA was able to identify the metabolic pathways activated while utilizing different carbon sources or those that have been genetically modified. The presented experimental results are publicly available at http://meltdb.cebitec.uni-bielefeld.de.
    79 schema:genre research_article
    80 schema:inLanguage en
    81 schema:isAccessibleForFree false
    82 schema:isPartOf N0a5a7cacafbb48e0b7cc7a5284fb1d4e
    83 Nb24adbb64c9e4a728a5b0a39383be668
    84 sg:journal.1036887
    85 schema:name MSEA: metabolite set enrichment analysis in the MeltDB metabolomics software platform: metabolic profiling of Corynebacterium glutamicum as an example
    86 schema:pagination 310-322
    87 schema:productId N8923eeff8fe749f9b72da1890b3f3bda
    88 N97ca6f36a2e84a559481e642eda8f03e
    89 Nf2e60dc165ab47cbadc723d33bc83c56
    90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035063940
    91 https://doi.org/10.1007/s11306-011-0311-6
    92 schema:sdDatePublished 2019-04-10T19:59
    93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    94 schema:sdPublisher N57a299427f7a47a1aed3542f3ddf22e1
    95 schema:url http://link.springer.com/10.1007%2Fs11306-011-0311-6
    96 sgo:license sg:explorer/license/
    97 sgo:sdDataset articles
    98 rdf:type schema:ScholarlyArticle
    99 N08ab9f6c1b19438fa3055c050fa194b6 rdf:first sg:person.014617723637.36
    100 rdf:rest N6e0325f2900b41b9908a778080a558e5
    101 N0a5a7cacafbb48e0b7cc7a5284fb1d4e schema:volumeNumber 8
    102 rdf:type schema:PublicationVolume
    103 N1aeed3d66ed84e6083e617cd81a889cb rdf:first N2322e53cc3d740b580b9c11cde117170
    104 rdf:rest N92144202f7704db8a35213e3a05189f2
    105 N1d40dbd29f3d486b84d95ee186e0e49c rdf:first sg:person.0606773566.85
    106 rdf:rest N3fc2d72d12f14839b7fa92a764c4423a
    107 N2322e53cc3d740b580b9c11cde117170 schema:affiliation https://www.grid.ac/institutes/grid.7491.b
    108 schema:familyName Stutz
    109 schema:givenName Leonhardt Jonathan
    110 rdf:type schema:Person
    111 N3fc2d72d12f14839b7fa92a764c4423a rdf:first sg:person.0766024005.43
    112 rdf:rest N1aeed3d66ed84e6083e617cd81a889cb
    113 N57a299427f7a47a1aed3542f3ddf22e1 schema:name Springer Nature - SN SciGraph project
    114 rdf:type schema:Organization
    115 N6e0325f2900b41b9908a778080a558e5 rdf:first sg:person.01066570355.23
    116 rdf:rest Nad996776acfe4c53b593588cf0267acd
    117 N8923eeff8fe749f9b72da1890b3f3bda schema:name doi
    118 schema:value 10.1007/s11306-011-0311-6
    119 rdf:type schema:PropertyValue
    120 N9186af72d9de47efbe90a62624a15c73 rdf:first sg:person.01102252405.43
    121 rdf:rest N1d40dbd29f3d486b84d95ee186e0e49c
    122 N92144202f7704db8a35213e3a05189f2 rdf:first sg:person.0717367405.04
    123 rdf:rest N08ab9f6c1b19438fa3055c050fa194b6
    124 N97ca6f36a2e84a559481e642eda8f03e schema:name readcube_id
    125 schema:value a708131b3fda32754c8758890e09aa91b5d151f00984a016bc909fdf49f7d548
    126 rdf:type schema:PropertyValue
    127 Nad996776acfe4c53b593588cf0267acd rdf:first sg:person.01154133575.82
    128 rdf:rest rdf:nil
    129 Nb24adbb64c9e4a728a5b0a39383be668 schema:issueNumber 2
    130 rdf:type schema:PublicationIssue
    131 Nf2e60dc165ab47cbadc723d33bc83c56 schema:name dimensions_id
    132 schema:value pub.1035063940
    133 rdf:type schema:PropertyValue
    134 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    135 schema:name Biological Sciences
    136 rdf:type schema:DefinedTerm
    137 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    138 schema:name Biochemistry and Cell Biology
    139 rdf:type schema:DefinedTerm
    140 sg:journal.1036887 schema:issn 1573-3882
    141 1573-3890
    142 schema:name Metabolomics
    143 rdf:type schema:Periodical
    144 sg:person.01066570355.23 schema:affiliation https://www.grid.ac/institutes/grid.7491.b
    145 schema:familyName Goesmann
    146 schema:givenName Alexander
    147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066570355.23
    148 rdf:type schema:Person
    149 sg:person.01102252405.43 schema:affiliation https://www.grid.ac/institutes/grid.7491.b
    150 schema:familyName Persicke
    151 schema:givenName Marcus
    152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102252405.43
    153 rdf:type schema:Person
    154 sg:person.01154133575.82 schema:affiliation https://www.grid.ac/institutes/grid.7491.b
    155 schema:familyName Neuweger
    156 schema:givenName Heiko
    157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154133575.82
    158 rdf:type schema:Person
    159 sg:person.014617723637.36 schema:affiliation https://www.grid.ac/institutes/grid.7491.b
    160 schema:familyName Kalinowski
    161 schema:givenName Jörn
    162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014617723637.36
    163 rdf:type schema:Person
    164 sg:person.0606773566.85 schema:affiliation https://www.grid.ac/institutes/grid.7491.b
    165 schema:familyName Rückert
    166 schema:givenName Christian
    167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606773566.85
    168 rdf:type schema:Person
    169 sg:person.0717367405.04 schema:affiliation https://www.grid.ac/institutes/grid.7491.b
    170 schema:familyName Kessler
    171 schema:givenName Nikolas
    172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717367405.04
    173 rdf:type schema:Person
    174 sg:person.0766024005.43 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
    175 schema:familyName Plassmeier
    176 schema:givenName Jens
    177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766024005.43
    178 rdf:type schema:Person
    179 sg:pub.10.1007/s00253-001-0829-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1037326212
    180 https://doi.org/10.1007/s00253-001-0829-z
    181 rdf:type schema:CreativeWork
    182 sg:pub.10.1007/s00253-001-0883-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045162392
    183 https://doi.org/10.1007/s00253-001-0883-6
    184 rdf:type schema:CreativeWork
    185 sg:pub.10.1007/s00253-003-1306-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041292024
    186 https://doi.org/10.1007/s00253-003-1306-7
    187 rdf:type schema:CreativeWork
    188 sg:pub.10.1007/s00253-005-0155-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1009820334
    189 https://doi.org/10.1007/s00253-005-0155-y
    190 rdf:type schema:CreativeWork
    191 sg:pub.10.1007/s00253-010-2537-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1019541937
    192 https://doi.org/10.1007/s00253-010-2537-z
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1007/s10295-006-0104-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012186661
    195 https://doi.org/10.1007/s10295-006-0104-5
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1023/a:1013713905833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027843923
    198 https://doi.org/10.1023/a:1013713905833
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1038/ng1180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014377811
    201 https://doi.org/10.1038/ng1180
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1038/nrm1451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051079961
    204 https://doi.org/10.1038/nrm1451
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1038/sj/jim/7000252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056648569
    207 https://doi.org/10.1038/sj/jim/7000252
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1186/1471-2164-6-121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025087037
    210 https://doi.org/10.1186/1471-2164-6-121
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1186/1471-2164-7-142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004880490
    213 https://doi.org/10.1186/1471-2164-7-142
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1186/1475-2859-7-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037804004
    216 https://doi.org/10.1186/1475-2859-7-8
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1186/1752-0509-3-82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017282635
    219 https://doi.org/10.1186/1752-0509-3-82
    220 rdf:type schema:CreativeWork
    221 https://app.dimensions.ai/details/publication/pub.1074496824 schema:CreativeWork
    222 https://app.dimensions.ai/details/publication/pub.1074816854 schema:CreativeWork
    223 https://app.dimensions.ai/details/publication/pub.1077202304 schema:CreativeWork
    224 https://app.dimensions.ai/details/publication/pub.1083291921 schema:CreativeWork
    225 https://doi.org/10.1002/0471250953.bi0703s21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019973752
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1002/0471973165.ch10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047139560
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1002/9783527620883.ch14a schema:sameAs https://app.dimensions.ai/details/publication/pub.1024550083
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1002/bit.10915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035684925
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1002/pmic.200500144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023116054
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1006/abio.1999.4048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020841176
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1016/0003-2697(92)90149-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022403335
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1016/j.ab.2005.01.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028973618
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1016/j.jbiotec.2003.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020711382
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1016/j.jbiotec.2005.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043045716
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1016/j.jbiotec.2005.12.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044315043
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/j.jbiotec.2006.11.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009892971
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/j.jbiotec.2007.04.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009841216
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1016/j.jbiotec.2008.10.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007748060
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/j.jbiotec.2008.12.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023451891
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/j.jbiotec.2010.08.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040338842
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1016/j.jmb.2003.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035163952
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1016/j.tibtech.2004.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037967197
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/j.trac.2004.11.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025000244
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1016/j.ymben.2006.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013160347
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/j.ymben.2007.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014131959
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/s0168-1656(02)00136-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014181390
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/s0168-1656(02)00159-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039964997
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/s0168-1656(03)00073-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025717080
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/s0168-1656(03)00149-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007111340
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/s0168-1656(03)00154-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003459821
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/s0168-1656(03)00158-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047988021
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/s0168-1656(03)00167-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034115435
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/s1096-7176(03)00004-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004987005
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/s1096-7176(03)00005-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031347185
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/s1357-2725(99)00139-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003959369
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1021/bi991710o schema:sameAs https://app.dimensions.ai/details/publication/pub.1055218378
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1073/pnas.0506580102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037705714
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1093/bib/bbl013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023582021
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1093/bib/bbp043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010319270
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1093/bioinformatics/btm369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052471554
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1093/bioinformatics/btn452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041114967
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1093/bioinformatics/btq567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012080988
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1093/nar/gkj102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028128110
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1093/nar/gkn923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047610281
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1093/nar/gkq329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051951318
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1099/mic.0.023614-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060394397
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1111/j.1365-2958.2005.04586.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051954905
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1111/j.1469-8137.2005.01632.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030680989
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1128/aem.01942-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036151935
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1128/aem.02912-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038870194
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1128/aem.70.12.7277-7287.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047872680
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1128/aem.71.6.3255-3268.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021960127
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1128/jb.175.17.5595-5603.1993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062721944
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1128/jb.182.11.3088-3096.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026082672
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1128/jb.184.5.1277-1286.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013502136
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1128/jb.186.6.1769-1784.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036345053
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1159/000117614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031841446
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1271/bbb.66.1337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031960134
    332 rdf:type schema:CreativeWork
    333 https://www.grid.ac/institutes/grid.116068.8 schema:alternateName Massachusetts Institute of Technology
    334 schema:name Department of Biology, Massachusetts Institute of Technology, 31 Ames Street, Bldg. 68-346, 02142, Cambridge, MA, USA
    335 Institut für Genomforschung und Systembiologie, Centrum für Biotechnologie (CeBiTec), University of Bielefeld, Universitätsstrasse 27, 33615, Bielefeld, Germany
    336 rdf:type schema:Organization
    337 https://www.grid.ac/institutes/grid.7491.b schema:alternateName Bielefeld University
    338 schema:name Biodata Mining & Applied Neuroinformatics, Centrum für Biotechnologie (CeBiTec), University of Bielefeld, Universitätsstrasse 27, 33615, Bielefeld, Germany
    339 Computational Genomics, Centrum für Biotechnologie (CeBiTec), University of Bielefeld, Universitätsstrasse 27, 33615, Bielefeld, Germany
    340 Institut für Genomforschung und Systembiologie, Centrum für Biotechnologie (CeBiTec), University of Bielefeld, Universitätsstrasse 27, 33615, Bielefeld, Germany
    341 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...