A single enteral feed prior to the commencement of parenteral nutrition ameliorates the incidence of steatosis in parenterally fed neonatal ... View Full Text


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Article Info

DATE

2011-03

AUTHORS

Matthew J. Hyde, Lynne Clarke, Julian L. Griffin, Emilio Herrera, Christopher D. Byrne, Paul R. Kemp

ABSTRACT

Total parenteral nutrition (TPN) in neonates is associated with liver dysfunction. The initial post-partum enteral feed plays a key role in establishing post-partum metabolic regulation. Therefore absence of enteral nutrition, in neonates commencing TPN immediately post-partum, may induce metabolic abnormalities driving liver dysfunction associated with TPN. To study the effect of a single enteral feed prior to commencing TPN on the aetiology of liver dysfunction in neonatal piglets maintained on TPN for 7 days. Piglets were delivered by caesarean section on day 112 of gestation. They were divided into two groups, receiving either no enteral intake (N) or a single 10 ml feed of sows milk (EF) before being fed by TPN for 7 days, after which tissue samples were taken. Hepatic lipid metabolism and enzyme activity were assessed coupled with metabolomic profiles. Piglets receiving no enteral nutrition accumulated more hepatic lipid (N 7.58 ± 0.84, EF 5.21 ± 0.30 g lipid·100 g of liver−1, P = 0.013). Hepatic PEPCK activity was increased in EF piglets (N 8.59 ± 0.95, EF 10.57 ± 1.38 U·mg protein−1, P = 0.024), alongside reduced hepatic lactate and key amino acid concentrations and increased muscle glucose. A single enteral feed immediately after birth alters hepatic metabolism, possibly by switching from lipid biosynthesis to gluconeogenesis, thereby reducing hepatic steatosis that occurs in response to TPN. More... »

PAGES

118-125

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11306-010-0237-4

DOI

http://dx.doi.org/10.1007/s11306-010-0237-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046361078


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