Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-12

AUTHORS

Warwick B. Dunn, David I. Broadhurst, Sasalu M. Deepak, Mamta H. Buch, Garry McDowell, Irena Spasic, David I. Ellis, Nicholas Brooks, Douglas B. Kell, Ludwig Neyses

ABSTRACT

There is intense interest in the identification of novel biomarkers which improve the diagnosis of heart failure. Serum samples from 52 patients with systolic heart failure (EF < 40% plus signs and symptoms of failure) and 57 controls were analyzed by gas chromatography – time of flight – mass spectrometry and the raw data reduced to 272 statistically robust metabolite peaks. 38 peaks showed a significant difference between case and control (p < 5 × 10−5). Two such metabolites were pseudouridine, a modified nucleotide present in t- and rRNA and a marker of cell turnover, as well as the tricarboxylic acid cycle intermediate 2-oxoglutarate. Furthermore, 3 further new compounds were also excellent discriminators between patients and controls: 2-hydroxy, 2-methylpropanoic acid, erythritol and 2,4,6-trihydroxypyrimidine. Although renal disease may be associated with heart failure, and metabolites associated with renal disease and other markers were also elevated (e.g. urea, creatinine and uric acid), there was no correlation within the patient group between these metabolites and our heart failure biomarkers, indicating that these were indeed biomarkers of heart failure and not renal disease per se. These findings demonstrate the power of data-driven metabolomics approaches to identify such markers of disease. More... »

PAGES

413-426

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11306-007-0063-5

DOI

http://dx.doi.org/10.1007/s11306-007-0063-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043894656


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