Unnatural amino acids: production and biotechnological potential. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Tanja Narancic, Sarah A Almahboub, Kevin E O'Connor

ABSTRACT

Unnatural amino acids (UAAs) are valuable building blocks in the manufacture of a wide range of pharmaceuticals. UAAs exhibit biological activity as free acids and they can be incorporated into linear or cyclic peptides with biological activity. However, the scope of biotechnological application of UAAs goes beyond this, as they can be used to investigate the structure and dynamics of proteins, to study protein interactions, or to modulate the activity of proteins in living cells. The means to expand nature's repertoire of amino acids include chemical and biological routes. An UAA can be made through chemical modifications of natural amino acids, or related compounds. These modifications typically rely on utilisation of ligands and palladium catalysts. Employing biocatalysts in the synthesis of UAAs can also afford novel molecules with different physical and chemical properties. A number of transaminases for example have been identified and employed in the production of UAAs. This review will compare the chemical and biological routes for the synthesis of UAAs and provide an overview of their applications. More... »

PAGES

67

References to SciGraph publications

  • 2012-12. Transaminases for the synthesis of enantiopure beta-amino acids in AMB EXPRESS
  • 2007-09-02. Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial in NATURE MEDICINE
  • 2006-12. Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies in NATURE BIOTECHNOLOGY
  • 2011. Biotransformations in Organic Chemistry, A Textbook in NONE
  • 2002-11-13. The Threonine Story in MICROBIAL PRODUCTION OF L-AMINO ACIDS
  • 1999-11. Purification of recombinant proteins by fusion with thermally-responsive polypeptides in NATURE BIOTECHNOLOGY
  • 2016-04. Expanding the amino acid repertoire of ribosomal polypeptide synthesis via the artificial division of codon boxes in NATURE CHEMISTRY
  • 2016-09. Construction of a tunable multi-enzyme-coordinate expression system for biosynthesis of chiral drug intermediates in SCIENTIFIC REPORTS
  • 2018-04. Antimicrobial peptides: biochemical determinants of activity and biophysical techniques of elucidating their functionality in WORLD JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
  • 2016-07. Directed evolution of leucine dehydrogenase for improved efficiency of l-tert-leucine synthesis in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 1983-01. Determination of the enantiomeric purity of oxfenicine by high-performance liquid chromatography in CHROMATOGRAPHIA
  • 2009-02. A phase II multicenter study of L-alanosine, a potent inhibitor of adenine biosynthesis, in patients with MTAP-deficient cancer in INVESTIGATIONAL NEW DRUGS
  • 2018-12. Single point mutations reveal amino acid residues important for Chromobacterium violaceum transaminase activity in the production of unnatural amino acids in SCIENTIFIC REPORTS
  • 2009-10. Transaminase-catalyzed asymmetric synthesis of l-2-aminobutyric acid from achiral reactants in BIOTECHNOLOGY LETTERS
  • 2018-01. Biosynthesis of 2-aminooctanoic acid and its use to terminally modify a lactoferricin B peptide derivative for improved antimicrobial activity in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2017-09. An overview on d-amino acids in AMINO ACIDS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11274-019-2642-9

    DOI

    http://dx.doi.org/10.1007/s11274-019-2642-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113300989

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30963257


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University College Dublin", 
              "id": "https://www.grid.ac/institutes/grid.7886.1", 
              "name": [
                "UCD Earth Institute and School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland. tanja.narancic@ucd.ie.", 
                "School of Biomolecular and Biomedical Sciences, Earth Institute & BEACON - Bioeconomy Research Centre, O'Brien Centre for Science, University College Dublin, Belfield, Dublin 4, Ireland. tanja.narancic@ucd.ie."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Narancic", 
            "givenName": "Tanja", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University College Dublin", 
              "id": "https://www.grid.ac/institutes/grid.7886.1", 
              "name": [
                "UCD Earth Institute and School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Almahboub", 
            "givenName": "Sarah A", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University College Dublin", 
              "id": "https://www.grid.ac/institutes/grid.7886.1", 
              "name": [
                "UCD Earth Institute and School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland.", 
                "School of Biomolecular and Biomedical Sciences, Earth Institute & BEACON - Bioeconomy Research Centre, O'Brien Centre for Science, University College Dublin, Belfield, Dublin 4, Ireland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "O'Connor", 
            "givenName": "Kevin E", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00253-016-7371-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002610852", 
              "https://doi.org/10.1007/s00253-016-7371-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmcl.2011.05.123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003255726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.enzmictec.2007.05.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003402430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1267", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003850162", 
              "https://doi.org/10.1038/nbt1267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1267", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003850162", 
              "https://doi.org/10.1038/nbt1267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/ph6081055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004075097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2014-06-537514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005065294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0168-1656(96)01657-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005906226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/febs.13293", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005928196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tetlet.2015.01.063", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006104633"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bst0160606", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008947363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bst0160606", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008947363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1211023109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008988227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/adsc.200700013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009211489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.e14-04-0916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010258768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c0cc00050g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011252053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c0cc00050g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011252053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1520-636x(1996)8:6<418::aid-chir2>3.0.co;2-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012000884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bcp.2016.09.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012800287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.jmedchem.6b00319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013084180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/b902995h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013848286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/b902995h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013848286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cctc.201200906", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015826654"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0912903107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016098876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cctc.200900110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016233015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cctc.200900110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016233015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10529-009-0057-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018097330", 
              "https://doi.org/10.1007/s10529-009-0057-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10529-009-0057-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018097330", 
              "https://doi.org/10.1007/s10529-009-0057-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10529-009-0057-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018097330", 
              "https://doi.org/10.1007/s10529-009-0057-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-04-0789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018518472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0958-1669(03)00096-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019445805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0958-1669(03)00096-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019445805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1381-1177(98)00009-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019487931"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0290(19970720)55:2<348::aid-bit12>3.0.co;2-d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023513006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10637-008-9160-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023736485", 
              "https://doi.org/10.1007/s10637-008-9160-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10637-008-9160-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023736485", 
              "https://doi.org/10.1007/s10637-008-9160-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/3-540-45989-8_4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024943052", 
              "https://doi.org/10.1007/3-540-45989-8_4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/3-540-45989-8_4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024943052", 
              "https://doi.org/10.1007/3-540-45989-8_4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02265103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026359715", 
              "https://doi.org/10.1007/bf02265103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02265103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026359715", 
              "https://doi.org/10.1007/bf02265103"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tetlet.2016.11.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026605922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bmcl.2014.10.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026942080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cctc.200900220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026997186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cctc.200900220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026997186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibtech.2010.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028156382"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-17393-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028849276", 
              "https://doi.org/10.1007/978-3-642-17393-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-17393-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028849276", 
              "https://doi.org/10.1007/978-3-642-17393-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tetasy.2010.03.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031542410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1271/bbb.65.1782", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031776600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tetlet.2009.02.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032027075"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/iai.71.5.2373-2383.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033874347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1632", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036528671", 
              "https://doi.org/10.1038/nm1632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/fmb.13.39", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037305330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/anie.201507321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037791642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja0603960", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038307458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja0603960", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038307458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/cshperspect.a023945", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038837753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cc800184v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039840486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cc800184v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039840486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bit.10718", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039916864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cctc.201100487", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039979214"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c3ob40495a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040848998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep30462", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040986346", 
              "https://doi.org/10.1038/srep30462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1188934", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041167428"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbiotec.2016.04.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041377738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbiotec.2016.04.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041377738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/15100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042379113", 
              "https://doi.org/10.1038/15100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/15100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042379113", 
              "https://doi.org/10.1038/15100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/anie.201610129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043053215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/anie.201610129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043053215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/anie.201610129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043053215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jlcr.696", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043152222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/pr.55.1.2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044333831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchem.2446", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045088595", 
              "https://doi.org/10.1038/nchem.2446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2007.04.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045241259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bit.10661", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045446297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cs300116n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046376986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-09-2069", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046986345"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/p19880000305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047718664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0337684100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048272391"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.drudis.2014.10.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049305902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/adsc.200800496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050469617"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcatb.2015.07.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050898620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2191-0855-2-11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051082040", 
              "https://doi.org/10.1186/2191-0855-2-11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cbpa.2009.11.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052587816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c2cc37232k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053279915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s1740925x11000093", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054941827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.jmedchem.5b00301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055099430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.joc.5b00314", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055101299"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.joc.5b02707", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055102334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/am504973d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055146478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi00716a006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055186265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja00213a031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055714693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja01187a057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055780435"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm301646k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055953507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ml400164t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056211642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/15680266113136660226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069194722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aac.43.6.1317", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074467584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079159083", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080662634", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/anie.201612462", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084807419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/anie.201612462", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084807419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/adsc.201700356", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084936132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tetlet.2017.05.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085181991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tetlet.2017.05.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085181991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chempr.2017.04.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085392100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chempr.2017.04.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085392100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.chemrev.6b00824", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085465815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/0471264180.os004.02", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090057124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00726-017-2459-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090355905", 
              "https://doi.org/10.1007/s00726-017-2459-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00726-017-2459-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090355905", 
              "https://doi.org/10.1007/s00726-017-2459-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-017-8655-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1093010390", 
              "https://doi.org/10.1007/s00253-017-8655-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/9781444305364", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1098662520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/adma.201704878", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099637766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/adma.201704878", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099637766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.chemrev.7b00437", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099699843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jacs.7b12918", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100086726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c7cs00253j", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100589868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ejoc.201800323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101289773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11274-018-2444-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103236616", 
              "https://doi.org/10.1007/s11274-018-2444-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.biomac.8b00248", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103768127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-018-35688-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110066027", 
              "https://doi.org/10.1038/s41598-018-35688-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-018-35688-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110066027", 
              "https://doi.org/10.1038/s41598-018-35688-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-018-35688-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110066027", 
              "https://doi.org/10.1038/s41598-018-35688-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-018-35688-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110066027", 
              "https://doi.org/10.1038/s41598-018-35688-7"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-04", 
        "datePublishedReg": "2019-04-01", 
        "description": "Unnatural amino acids (UAAs) are valuable building blocks in the manufacture of a wide range of pharmaceuticals. UAAs exhibit biological activity as free acids and they can be incorporated into linear or cyclic peptides with biological activity. However, the scope of biotechnological application of UAAs goes beyond this, as they can be used to investigate the structure and dynamics of proteins, to study protein interactions, or to modulate the activity of proteins in living cells. The means to expand nature's repertoire of amino acids include chemical and biological routes. An UAA can be made through chemical modifications of natural amino acids, or related compounds. These modifications typically rely on utilisation of ligands and palladium catalysts. Employing biocatalysts in the synthesis of UAAs can also afford novel molecules with different physical and chemical properties. A number of transaminases for example have been identified and employed in the production of UAAs. This review will compare the chemical and biological routes for the synthesis of UAAs and provide an overview of their applications.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s11274-019-2642-9", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1096771", 
            "issn": [
              "0959-3993", 
              "1573-0972"
            ], 
            "name": "World Journal of Microbiology and Biotechnology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "35"
          }
        ], 
        "name": "Unnatural amino acids: production and biotechnological potential.", 
        "pagination": "67", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s11274-019-2642-9"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113300989"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9012472"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30963257"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s11274-019-2642-9", 
          "https://app.dimensions.ai/details/publication/pub.1113300989"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-15T09:14", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000376_0000000376/records_56164_00000006.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007/s11274-019-2642-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11274-019-2642-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11274-019-2642-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11274-019-2642-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11274-019-2642-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    387 TRIPLES      21 PREDICATES      126 URIs      20 LITERALS      8 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s11274-019-2642-9 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author N124d0585152c4a2487ee9a69f2e01f98
    4 schema:citation sg:pub.10.1007/3-540-45989-8_4
    5 sg:pub.10.1007/978-3-642-17393-6
    6 sg:pub.10.1007/bf02265103
    7 sg:pub.10.1007/s00253-016-7371-5
    8 sg:pub.10.1007/s00253-017-8655-0
    9 sg:pub.10.1007/s00726-017-2459-5
    10 sg:pub.10.1007/s10529-009-0057-7
    11 sg:pub.10.1007/s10637-008-9160-1
    12 sg:pub.10.1007/s11274-018-2444-5
    13 sg:pub.10.1038/15100
    14 sg:pub.10.1038/nbt1267
    15 sg:pub.10.1038/nchem.2446
    16 sg:pub.10.1038/nm1632
    17 sg:pub.10.1038/s41598-018-35688-7
    18 sg:pub.10.1038/srep30462
    19 sg:pub.10.1186/2191-0855-2-11
    20 https://app.dimensions.ai/details/publication/pub.1079159083
    21 https://app.dimensions.ai/details/publication/pub.1080662634
    22 https://doi.org/10.1002/(sici)1097-0290(19970720)55:2<348::aid-bit12>3.0.co;2-d
    23 https://doi.org/10.1002/(sici)1520-636x(1996)8:6<418::aid-chir2>3.0.co;2-8
    24 https://doi.org/10.1002/0471264180.os004.02
    25 https://doi.org/10.1002/9781444305364
    26 https://doi.org/10.1002/adma.201704878
    27 https://doi.org/10.1002/adsc.200700013
    28 https://doi.org/10.1002/adsc.200800496
    29 https://doi.org/10.1002/adsc.201700356
    30 https://doi.org/10.1002/anie.201507321
    31 https://doi.org/10.1002/anie.201610129
    32 https://doi.org/10.1002/anie.201612462
    33 https://doi.org/10.1002/bit.10661
    34 https://doi.org/10.1002/bit.10718
    35 https://doi.org/10.1002/cctc.200900110
    36 https://doi.org/10.1002/cctc.200900220
    37 https://doi.org/10.1002/cctc.201100487
    38 https://doi.org/10.1002/cctc.201200906
    39 https://doi.org/10.1002/ejoc.201800323
    40 https://doi.org/10.1002/jlcr.696
    41 https://doi.org/10.1016/j.bcp.2016.09.018
    42 https://doi.org/10.1016/j.bmcl.2011.05.123
    43 https://doi.org/10.1016/j.bmcl.2014.10.016
    44 https://doi.org/10.1016/j.canlet.2007.04.010
    45 https://doi.org/10.1016/j.cbpa.2009.11.018
    46 https://doi.org/10.1016/j.chempr.2017.04.009
    47 https://doi.org/10.1016/j.drudis.2014.10.003
    48 https://doi.org/10.1016/j.enzmictec.2007.05.011
    49 https://doi.org/10.1016/j.jbiotec.2016.04.033
    50 https://doi.org/10.1016/j.molcatb.2015.07.011
    51 https://doi.org/10.1016/j.tetasy.2010.03.004
    52 https://doi.org/10.1016/j.tetlet.2009.02.041
    53 https://doi.org/10.1016/j.tetlet.2015.01.063
    54 https://doi.org/10.1016/j.tetlet.2016.11.022
    55 https://doi.org/10.1016/j.tetlet.2017.05.007
    56 https://doi.org/10.1016/j.tibtech.2010.03.003
    57 https://doi.org/10.1016/s0168-1656(96)01657-4
    58 https://doi.org/10.1016/s0958-1669(03)00096-x
    59 https://doi.org/10.1016/s1381-1177(98)00009-5
    60 https://doi.org/10.1017/s1740925x11000093
    61 https://doi.org/10.1021/acs.biomac.8b00248
    62 https://doi.org/10.1021/acs.chemrev.6b00824
    63 https://doi.org/10.1021/acs.chemrev.7b00437
    64 https://doi.org/10.1021/acs.jmedchem.5b00301
    65 https://doi.org/10.1021/acs.jmedchem.6b00319
    66 https://doi.org/10.1021/acs.joc.5b00314
    67 https://doi.org/10.1021/acs.joc.5b02707
    68 https://doi.org/10.1021/am504973d
    69 https://doi.org/10.1021/bi00716a006
    70 https://doi.org/10.1021/cc800184v
    71 https://doi.org/10.1021/cs300116n
    72 https://doi.org/10.1021/ja00213a031
    73 https://doi.org/10.1021/ja01187a057
    74 https://doi.org/10.1021/ja0603960
    75 https://doi.org/10.1021/jacs.7b12918
    76 https://doi.org/10.1021/jm301646k
    77 https://doi.org/10.1021/ml400164t
    78 https://doi.org/10.1039/b902995h
    79 https://doi.org/10.1039/c0cc00050g
    80 https://doi.org/10.1039/c2cc37232k
    81 https://doi.org/10.1039/c3ob40495a
    82 https://doi.org/10.1039/c7cs00253j
    83 https://doi.org/10.1039/p19880000305
    84 https://doi.org/10.1042/bst0160606
    85 https://doi.org/10.1073/pnas.0337684100
    86 https://doi.org/10.1073/pnas.0912903107
    87 https://doi.org/10.1073/pnas.1211023109
    88 https://doi.org/10.1091/mbc.e14-04-0916
    89 https://doi.org/10.1101/cshperspect.a023945
    90 https://doi.org/10.1111/febs.13293
    91 https://doi.org/10.1124/pr.55.1.2
    92 https://doi.org/10.1126/science.1188934
    93 https://doi.org/10.1128/aac.43.6.1317
    94 https://doi.org/10.1128/iai.71.5.2373-2383.2003
    95 https://doi.org/10.1158/1078-0432.ccr-04-0789
    96 https://doi.org/10.1158/1078-0432.ccr-09-2069
    97 https://doi.org/10.1182/blood-2014-06-537514
    98 https://doi.org/10.1271/bbb.65.1782
    99 https://doi.org/10.2174/15680266113136660226
    100 https://doi.org/10.2217/fmb.13.39
    101 https://doi.org/10.3390/ph6081055
    102 schema:datePublished 2019-04
    103 schema:datePublishedReg 2019-04-01
    104 schema:description Unnatural amino acids (UAAs) are valuable building blocks in the manufacture of a wide range of pharmaceuticals. UAAs exhibit biological activity as free acids and they can be incorporated into linear or cyclic peptides with biological activity. However, the scope of biotechnological application of UAAs goes beyond this, as they can be used to investigate the structure and dynamics of proteins, to study protein interactions, or to modulate the activity of proteins in living cells. The means to expand nature's repertoire of amino acids include chemical and biological routes. An UAA can be made through chemical modifications of natural amino acids, or related compounds. These modifications typically rely on utilisation of ligands and palladium catalysts. Employing biocatalysts in the synthesis of UAAs can also afford novel molecules with different physical and chemical properties. A number of transaminases for example have been identified and employed in the production of UAAs. This review will compare the chemical and biological routes for the synthesis of UAAs and provide an overview of their applications.
    105 schema:genre research_article
    106 schema:inLanguage en
    107 schema:isAccessibleForFree false
    108 schema:isPartOf N5fc7275143854e608a47cb9bb9076f63
    109 Ncf4e488c77174935a540b774d9d3ed7c
    110 sg:journal.1096771
    111 schema:name Unnatural amino acids: production and biotechnological potential.
    112 schema:pagination 67
    113 schema:productId N40860fe3141f4fc1932289f339bf2d72
    114 N413d6ca4c5b44c67bccf1a58925f3782
    115 Nc336fa89ac1d4cacbd86ba294f2db9d1
    116 Nfb59bf3a4525455ca76b3c54558cb938
    117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113300989
    118 https://doi.org/10.1007/s11274-019-2642-9
    119 schema:sdDatePublished 2019-04-15T09:14
    120 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    121 schema:sdPublisher N0fd3e9e790b34c519858254f24b525b7
    122 schema:url http://link.springer.com/10.1007/s11274-019-2642-9
    123 sgo:license sg:explorer/license/
    124 sgo:sdDataset articles
    125 rdf:type schema:ScholarlyArticle
    126 N0b4d63a31ade49c89b5b0d5d21c80116 rdf:first Nf40eee36ad0d4837ad8bc3d85dbbd10b
    127 rdf:rest rdf:nil
    128 N0fd3e9e790b34c519858254f24b525b7 schema:name Springer Nature - SN SciGraph project
    129 rdf:type schema:Organization
    130 N124d0585152c4a2487ee9a69f2e01f98 rdf:first N6f9d0ff18c3d47e9b66a6eca12f4a188
    131 rdf:rest Nb0217320168f4c76ab67521d283df6fe
    132 N40860fe3141f4fc1932289f339bf2d72 schema:name doi
    133 schema:value 10.1007/s11274-019-2642-9
    134 rdf:type schema:PropertyValue
    135 N413d6ca4c5b44c67bccf1a58925f3782 schema:name pubmed_id
    136 schema:value 30963257
    137 rdf:type schema:PropertyValue
    138 N5fc7275143854e608a47cb9bb9076f63 schema:issueNumber 4
    139 rdf:type schema:PublicationIssue
    140 N6f9d0ff18c3d47e9b66a6eca12f4a188 schema:affiliation https://www.grid.ac/institutes/grid.7886.1
    141 schema:familyName Narancic
    142 schema:givenName Tanja
    143 rdf:type schema:Person
    144 N78a972f867ca43efa2580c4bb0eb9dd6 schema:affiliation https://www.grid.ac/institutes/grid.7886.1
    145 schema:familyName Almahboub
    146 schema:givenName Sarah A
    147 rdf:type schema:Person
    148 Nb0217320168f4c76ab67521d283df6fe rdf:first N78a972f867ca43efa2580c4bb0eb9dd6
    149 rdf:rest N0b4d63a31ade49c89b5b0d5d21c80116
    150 Nc336fa89ac1d4cacbd86ba294f2db9d1 schema:name dimensions_id
    151 schema:value pub.1113300989
    152 rdf:type schema:PropertyValue
    153 Ncf4e488c77174935a540b774d9d3ed7c schema:volumeNumber 35
    154 rdf:type schema:PublicationVolume
    155 Nf40eee36ad0d4837ad8bc3d85dbbd10b schema:affiliation https://www.grid.ac/institutes/grid.7886.1
    156 schema:familyName O'Connor
    157 schema:givenName Kevin E
    158 rdf:type schema:Person
    159 Nfb59bf3a4525455ca76b3c54558cb938 schema:name nlm_unique_id
    160 schema:value 9012472
    161 rdf:type schema:PropertyValue
    162 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    163 schema:name Biological Sciences
    164 rdf:type schema:DefinedTerm
    165 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    166 schema:name Biochemistry and Cell Biology
    167 rdf:type schema:DefinedTerm
    168 sg:journal.1096771 schema:issn 0959-3993
    169 1573-0972
    170 schema:name World Journal of Microbiology and Biotechnology
    171 rdf:type schema:Periodical
    172 sg:pub.10.1007/3-540-45989-8_4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024943052
    173 https://doi.org/10.1007/3-540-45989-8_4
    174 rdf:type schema:CreativeWork
    175 sg:pub.10.1007/978-3-642-17393-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028849276
    176 https://doi.org/10.1007/978-3-642-17393-6
    177 rdf:type schema:CreativeWork
    178 sg:pub.10.1007/bf02265103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026359715
    179 https://doi.org/10.1007/bf02265103
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1007/s00253-016-7371-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002610852
    182 https://doi.org/10.1007/s00253-016-7371-5
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1007/s00253-017-8655-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093010390
    185 https://doi.org/10.1007/s00253-017-8655-0
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1007/s00726-017-2459-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090355905
    188 https://doi.org/10.1007/s00726-017-2459-5
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1007/s10529-009-0057-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018097330
    191 https://doi.org/10.1007/s10529-009-0057-7
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1007/s10637-008-9160-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023736485
    194 https://doi.org/10.1007/s10637-008-9160-1
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1007/s11274-018-2444-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103236616
    197 https://doi.org/10.1007/s11274-018-2444-5
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/15100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042379113
    200 https://doi.org/10.1038/15100
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/nbt1267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003850162
    203 https://doi.org/10.1038/nbt1267
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/nchem.2446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045088595
    206 https://doi.org/10.1038/nchem.2446
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/nm1632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036528671
    209 https://doi.org/10.1038/nm1632
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/s41598-018-35688-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110066027
    212 https://doi.org/10.1038/s41598-018-35688-7
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/srep30462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040986346
    215 https://doi.org/10.1038/srep30462
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1186/2191-0855-2-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051082040
    218 https://doi.org/10.1186/2191-0855-2-11
    219 rdf:type schema:CreativeWork
    220 https://app.dimensions.ai/details/publication/pub.1079159083 schema:CreativeWork
    221 https://app.dimensions.ai/details/publication/pub.1080662634 schema:CreativeWork
    222 https://doi.org/10.1002/(sici)1097-0290(19970720)55:2<348::aid-bit12>3.0.co;2-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1023513006
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1002/(sici)1520-636x(1996)8:6<418::aid-chir2>3.0.co;2-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012000884
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1002/0471264180.os004.02 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090057124
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1002/9781444305364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1098662520
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1002/adma.201704878 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099637766
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1002/adsc.200700013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009211489
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1002/adsc.200800496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050469617
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1002/adsc.201700356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084936132
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1002/anie.201507321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037791642
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1002/anie.201610129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043053215
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1002/anie.201612462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084807419
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1002/bit.10661 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045446297
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1002/bit.10718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039916864
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1002/cctc.200900110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016233015
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1002/cctc.200900220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026997186
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1002/cctc.201100487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039979214
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1002/cctc.201200906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015826654
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1002/ejoc.201800323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101289773
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1002/jlcr.696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043152222
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1016/j.bcp.2016.09.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012800287
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1016/j.bmcl.2011.05.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003255726
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1016/j.bmcl.2014.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026942080
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1016/j.canlet.2007.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045241259
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1016/j.cbpa.2009.11.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052587816
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1016/j.chempr.2017.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085392100
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1016/j.drudis.2014.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049305902
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1016/j.enzmictec.2007.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003402430
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1016/j.jbiotec.2016.04.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041377738
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1016/j.molcatb.2015.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050898620
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.tetasy.2010.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031542410
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/j.tetlet.2009.02.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032027075
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1016/j.tetlet.2015.01.063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006104633
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1016/j.tetlet.2016.11.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026605922
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1016/j.tetlet.2017.05.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085181991
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1016/j.tibtech.2010.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028156382
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1016/s0168-1656(96)01657-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005906226
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1016/s0958-1669(03)00096-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019445805
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1016/s1381-1177(98)00009-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019487931
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1017/s1740925x11000093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054941827
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1021/acs.biomac.8b00248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103768127
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1021/acs.chemrev.6b00824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085465815
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1021/acs.chemrev.7b00437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099699843
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1021/acs.jmedchem.5b00301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055099430
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1021/acs.jmedchem.6b00319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013084180
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1021/acs.joc.5b00314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055101299
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1021/acs.joc.5b02707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055102334
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1021/am504973d schema:sameAs https://app.dimensions.ai/details/publication/pub.1055146478
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1021/bi00716a006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055186265
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1021/cc800184v schema:sameAs https://app.dimensions.ai/details/publication/pub.1039840486
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1021/cs300116n schema:sameAs https://app.dimensions.ai/details/publication/pub.1046376986
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1021/ja00213a031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055714693
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1021/ja01187a057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055780435
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1021/ja0603960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038307458
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1021/jacs.7b12918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100086726
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1021/jm301646k schema:sameAs https://app.dimensions.ai/details/publication/pub.1055953507
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1021/ml400164t schema:sameAs https://app.dimensions.ai/details/publication/pub.1056211642
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1039/b902995h schema:sameAs https://app.dimensions.ai/details/publication/pub.1013848286
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1039/c0cc00050g schema:sameAs https://app.dimensions.ai/details/publication/pub.1011252053
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1039/c2cc37232k schema:sameAs https://app.dimensions.ai/details/publication/pub.1053279915
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1039/c3ob40495a schema:sameAs https://app.dimensions.ai/details/publication/pub.1040848998
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1039/c7cs00253j schema:sameAs https://app.dimensions.ai/details/publication/pub.1100589868
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1039/p19880000305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047718664
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1042/bst0160606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008947363
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1073/pnas.0337684100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048272391
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1073/pnas.0912903107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016098876
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1073/pnas.1211023109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008988227
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1091/mbc.e14-04-0916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010258768
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1101/cshperspect.a023945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038837753
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1111/febs.13293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005928196
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1124/pr.55.1.2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044333831
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1126/science.1188934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041167428
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1128/aac.43.6.1317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074467584
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1128/iai.71.5.2373-2383.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033874347
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1158/1078-0432.ccr-04-0789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018518472
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1158/1078-0432.ccr-09-2069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046986345
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1182/blood-2014-06-537514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005065294
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1271/bbb.65.1782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031776600
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.2174/15680266113136660226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069194722
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.2217/fmb.13.39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037305330
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.3390/ph6081055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004075097
    381 rdf:type schema:CreativeWork
    382 https://www.grid.ac/institutes/grid.7886.1 schema:alternateName University College Dublin
    383 schema:name School of Biomolecular and Biomedical Sciences, Earth Institute & BEACON - Bioeconomy Research Centre, O'Brien Centre for Science, University College Dublin, Belfield, Dublin 4, Ireland.
    384 School of Biomolecular and Biomedical Sciences, Earth Institute & BEACON - Bioeconomy Research Centre, O'Brien Centre for Science, University College Dublin, Belfield, Dublin 4, Ireland. tanja.narancic@ucd.ie.
    385 UCD Earth Institute and School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland.
    386 UCD Earth Institute and School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland. tanja.narancic@ucd.ie.
    387 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...