Transcriptional regulator GntR of Brucella abortus regulates cytotoxicity, induces the secretion of inflammatory cytokines and affects expression of the type ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-02-27

AUTHORS

Zhiqiang Li, Shuli Wang, Hui Zhang, Jinliang Zhang, Li Xi, Junbo Zhang, Chuangfu Chen

ABSTRACT

The pathogenic mechanisms of Brucella are still poorly understood. GntR is a transcriptional regulator and plays an important role in the intracellular survival of Brucella. To investigate whether GntR is involved in the cytotoxicity of Brucella abortus (B. abortus), we created a 2308ΔgntR mutant of B. abortus 2308 (S2308). Lactate dehydrogenase (LDH) cytotoxicity assays using a murine macrophage cell line (RAW 264.7) show that high-dose infection with the parental strain produces a high level of cytotoxicity to macrophages, but the 2308ΔgntR mutant exhibits a very low level of cytotoxicity, indicating that mutation of GntR impairs the cytotoxicity of B. abortus to macrophages. After the macrophages are infected with 2308ΔgntR, the levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) increase and are slightly higher than that for the S2308 infected group, indicating that the 2308ΔgntR mutant could induce the secretion of inflammatory cytokines. The virulence factor detection experiments indicate that genes involved in the type IV secretion system (T4SS) and quorum sensing system (QSS) are down-regulated in 2308ΔgntR. The lower levels of survival of 2308ΔgntR under various stress conditions and the increased sensitivity of 2308ΔgntR to polymyxin B suggest that GntR is a virulence factor and that deletion of gntR reduces of B. abortus to stress conditions. Taken together, our results demonstrate that GntR is involved in the cytotoxicity, virulence and intracellular survival of B. abortus during its infection. More... »

PAGES

60

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11274-017-2230-9

DOI

http://dx.doi.org/10.1007/s11274-017-2230-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084030808

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28243986


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