Biosynthesis of nicotinic acid from 3-cyanopyridine by a newly isolated Fusarium proliferatum ZJB-09150 View Full Text


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Article Info

DATE

2012-10-21

AUTHORS

Li-Qun Jin, Zhi-Qiang Liu, Jian-Miao Xu, Yu-Guo Zheng

ABSTRACT

In this study, nitriles were used as sole sources of nitrogen in the enrichments to isolate nitrile-converting microorganisms. A novel fungus named ZJB-09150 possessing nitrile-converting enzymes was obtained with 3-cyanopyridine as sole source of nitrogen, which was identified by morphology, biology and 18S rDNA gene sequence as Fusarium proliferatum. It was found that F. proliferatum had ability to convert nitriles to corresponding acids or amides and showed wide substrate specificity to aliphatic nitriles, aromatic nitriles and ortho-substituted heterocyclic nitriles. The nitrile converting enzymes including nitrilase and nitrile hydratase in ZJB-09150 were induced by ε-caprolactam. Nitrilase obtained in this study showed high activity toward 3-cyanopyridine. It was active within pH 3.0–12.0 and temperature ranging from 25 to 65 °C with optimal at pH 9.0 and temperature 50–55 °C. The enzyme was thermostable and its half-life was 12.5 and 6 h at 45 and 55 °C, respectively. Under optimized reaction conditions, 60 mM 3-cyanopyridine was converted to nicotinic acid in 15 min, which indicated ZJB-09150 has potentials of application in large scale production of nicotinic acid. More... »

PAGES

431-440

References to SciGraph publications

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  • 2006-07-20. A propionitrile-induced nitrilase of Rhodococcus sp. NDB 1165 and its application in nicotinic acid synthesis in WORLD JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
  • 2005-12. Nitrile- and Amide-hydrolysing Activity in Kluyveromyces thermotolerans MGBY 37 in WORLD JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
  • 2006-07. Mild hydrolysis of nitriles byFusarium solani strain O1 in FOLIA MICROBIOLOGICA
  • 2007-03-15. Isolation and characterization of a nitrile hydrolysing acidotolerant black yeast—Exophiala oligosperma R1 in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2006-08-15. Hyperinduction of nitrilases in filamentous fungi in JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
  • 1997-06. Enrichment strategies for nitrile-hydrolysing bacteria in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2010-11-21. An improved nitrilase-mediated bioprocess for synthesis of nicotinic acid from 3-cyanopyridine with hyperinduced Nocardia globerula NHB-2 in JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
  • 2010-07-18. Enantioselective biocatalytic hydrolysis of (R,S)-mandelonitrile for production of (R)-(−)-mandelic acid by a newly isolated mutant strain in JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
  • 2009-06-25. Continuous hydrolysis of 4-cyanopyridine by nitrilases from Fusarium solani O1 and Aspergillus niger K10 in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2006-10-24. Purification and characterization of a nitrilase from Aspergillus niger K10 in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
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    URI

    http://scigraph.springernature.com/pub.10.1007/s11274-012-1195-y

    DOI

    http://dx.doi.org/10.1007/s11274-012-1195-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1023951171

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23085954


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