Apoptin Induces Chromatin Condensation in Normal Cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-08

AUTHORS

Xiangjun He, Qi Zhang, Yujing Liu, Peiying He

ABSTRACT

Apoptin, a chicken anemia virus protein, was reported to induce tumor specific apoptosis, which was correlated with the nuclear localization of the protein in tumor cells. While in normal human cells, Apoptin was detected mainly in the cytoplasm and did not induce apoptosis. Using a recombinant adenovirus expressing Apoptin, we have found that Apoptin induced G(2)-M cell cycle arrest and chromatin condensation in cancer cells. Here we report that adenovirus mediated Apoptin expression also induces G(2)-M arrest in normal cells. In normal cells Apoptin is localized mainly in the cytoplasm but is also found in the nucleus of a subset of cells. Apoptin induces chromatin condensation not only when it is expressed in the nucleus but also when it is expressed in the cytoplasm. Our results indicate that Apoptin-induced chromatin condensation in the normal cells may not correlate with its nuclear localization and the mechanism of regulating the G(2)-M transition might be a target for Apoptin. More... »

PAGES

49-55

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11262-005-2200-4

DOI

http://dx.doi.org/10.1007/s11262-005-2200-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012029586

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15965608


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